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GB2346883B - GluR5 receptor binding assay - Google Patents

GluR5 receptor binding assay

Info

Publication number
GB2346883B
GB2346883B GB0010488A GB0010488A GB2346883B GB 2346883 B GB2346883 B GB 2346883B GB 0010488 A GB0010488 A GB 0010488A GB 0010488 A GB0010488 A GB 0010488A GB 2346883 B GB2346883 B GB 2346883B
Authority
GB
United Kingdom
Prior art keywords
receptor binding
binding assay
glur5 receptor
glur5
assay
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB0010488A
Other versions
GB0010488D0 (en
GB2346883A (en
Inventor
David Bleakman
David Lodge
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lilly Industries Ltd
Original Assignee
Lilly Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Industries Ltd filed Critical Lilly Industries Ltd
Priority to GB0010488A priority Critical patent/GB2346883B/en
Publication of GB0010488D0 publication Critical patent/GB0010488D0/en
Publication of GB2346883A publication Critical patent/GB2346883A/en
Application granted granted Critical
Publication of GB2346883B publication Critical patent/GB2346883B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9406—Neurotransmitters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70571—Assays involving receptors, cell surface antigens or cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • General Physics & Mathematics (AREA)
  • Psychiatry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB0010488A 1996-09-02 1996-09-02 GluR5 receptor binding assay Expired - Fee Related GB2346883B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB0010488A GB2346883B (en) 1996-09-02 1996-09-02 GluR5 receptor binding assay

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0010488A GB2346883B (en) 1996-09-02 1996-09-02 GluR5 receptor binding assay
GB9618300A GB2316616A (en) 1996-09-02 1996-09-02 Modulation of GluR5 receptors in the hippocampus to treat psychiatric disorders

Publications (3)

Publication Number Publication Date
GB0010488D0 GB0010488D0 (en) 2000-06-14
GB2346883A GB2346883A (en) 2000-08-23
GB2346883B true GB2346883B (en) 2001-02-14

Family

ID=10799298

Family Applications (2)

Application Number Title Priority Date Filing Date
GB0010488A Expired - Fee Related GB2346883B (en) 1996-09-02 1996-09-02 GluR5 receptor binding assay
GB9618300A Withdrawn GB2316616A (en) 1996-09-02 1996-09-02 Modulation of GluR5 receptors in the hippocampus to treat psychiatric disorders

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB9618300A Withdrawn GB2316616A (en) 1996-09-02 1996-09-02 Modulation of GluR5 receptors in the hippocampus to treat psychiatric disorders

Country Status (1)

Country Link
GB (2) GB2346883B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6245521B1 (en) 1999-03-03 2001-06-12 Eli Lilly And Company Assay for evaluating the affinity of compounds to the glutamate GluR5 receptor
WO2002048345A2 (en) * 2000-12-13 2002-06-20 Deltagen, Inc. Transgenic mice containing glutamate receptor (grik5) gene disruptions
WO2002058691A1 (en) * 2001-01-23 2002-08-01 Neurosearch A/S Use of non-competitive and selective glur5 antagonists as glutamate receptor modulating compounds
EP2654742A4 (en) * 2010-12-26 2014-10-15 Univ Carmel Haifa Economic Cor Methods of improving cognitive function

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0578409A2 (en) * 1992-06-24 1994-01-12 Allelix Biopharmaceuticals Inc. Kainate-binding, human CNS (central nervous system) receptors of the EAA4 (excitatory amino acid) family
EP0588642A1 (en) * 1992-09-17 1994-03-23 Allelix Biopharmaceuticals Inc. Kainate-binding, human CNS receptors of the EAA5 family

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE910939A1 (en) * 1990-04-13 1991-10-23 Neurosearch As Use of benzodiazepine compounds
US5192792A (en) * 1990-12-07 1993-03-09 Warner-Lambert Company Isatine derivatives, and their method of use
US5622965A (en) * 1993-03-12 1997-04-22 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon 4-hydroxy-3-nitro-1,2-dihydroquinolin-2-ones and the use thereof as excitatory amino acid and glycine receptor antagonists
GB9400680D0 (en) * 1994-01-14 1994-03-09 Sandoz Ltd Improvements in or relating to organic compounds
EP0760819B1 (en) * 1994-05-24 2000-07-19 F. Hoffmann-La Roche Ag Tricyclic dicarbonyl derivatives
DE4436852A1 (en) * 1994-10-14 1996-04-18 Basf Ag Pyrrolyl-tetrahydrobenzoquinoxalinediones, their preparation and use
AU4152296A (en) * 1994-12-07 1996-06-26 Warner-Lambert Company Novel glutamate receptor antagonists: fused cycloalkylquinoxalinediones
ATE204852T1 (en) * 1995-02-15 2001-09-15 Bearsden Bio Inc ALKYLCARBOXY-AMINO ACID MODULATORS FOR THE KAINATE RECEPTOR

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0578409A2 (en) * 1992-06-24 1994-01-12 Allelix Biopharmaceuticals Inc. Kainate-binding, human CNS (central nervous system) receptors of the EAA4 (excitatory amino acid) family
EP0588642A1 (en) * 1992-09-17 1994-03-23 Allelix Biopharmaceuticals Inc. Kainate-binding, human CNS receptors of the EAA5 family

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Mol. Pharmacol.;Vol 49(4), pp 581-585 (1996). Bleakman et al *
Pharmacol.Ther.;Vol 7 (1), pp65-89 (1996). Fletcher & Lodge *
Recept. Channels.; Vol 3 (1), pp 41-49 (1995). Korczak et al *

Also Published As

Publication number Publication date
GB0010488D0 (en) 2000-06-14
GB2316616A (en) 1998-03-04
GB9618300D0 (en) 1996-10-16
GB2346883A (en) 2000-08-23

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20020902