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GB2234484A - Portable dispensing system - Google Patents

Portable dispensing system Download PDF

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Publication number
GB2234484A
GB2234484A GB9008758A GB9008758A GB2234484A GB 2234484 A GB2234484 A GB 2234484A GB 9008758 A GB9008758 A GB 9008758A GB 9008758 A GB9008758 A GB 9008758A GB 2234484 A GB2234484 A GB 2234484A
Authority
GB
United Kingdom
Prior art keywords
pack
dispensing
dispensing system
fluid
tube
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB9008758A
Other versions
GB9008758D0 (en
Inventor
Michael George Stratford
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SP Veterinary Ltd
Schering Plough Animal Health Ltd New Zealand
Original Assignee
Coopers Animal Health Ltd
Coopers Animal Health NZ Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Coopers Animal Health Ltd, Coopers Animal Health NZ Ltd filed Critical Coopers Animal Health Ltd
Publication of GB9008758D0 publication Critical patent/GB9008758D0/en
Priority to CA002022083A priority Critical patent/CA2022083A1/en
Priority to EP19900308334 priority patent/EP0411858A3/en
Priority to US07/560,042 priority patent/US5154324A/en
Priority to IE274390A priority patent/IE902743A1/en
Priority to PT94850A priority patent/PT94850B/en
Priority to AU59983/90A priority patent/AU645017B2/en
Publication of GB2234484A publication Critical patent/GB2234484A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61DVETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D7/00Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
    • AHUMAN NECESSITIES
    • A45HAND OR TRAVELLING ARTICLES
    • A45FTRAVELLING OR CAMP EQUIPMENT: SACKS OR PACKS CARRIED ON THE BODY
    • A45F5/00Holders or carriers for hand articles; Holders or carriers for use while travelling or camping

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

A portable dispensing system for administering fluids to livestock (eg. vaccines, nutrients, drenches/pour-ons) comprising a semi-rigid pack (1) for fluid materials attached to the operator by a waist or hip belt (5). In use, fluid is drawn from the interior of the pack via a dip tube (7) and through a flexible coiled delivery tube (10) by repeated operation of a dispensing syringe or gun (12). The dip tube and delivery tube are coupled via a connector in a draw-off cap (8). When not in use the gun can be attached to the pack by a clip or holster (18). <IMAGE>

Description

PORTABLE DISPENSING SYSTEM The present invention relates to a portable dispensing system for fluid materials which is worn around the hip or waist of the operator.
The invention is more particularly concerned with dispensing systems for administering fluids to livestock and is accordingly described in this context.
In situations where individual operators are dispensing predetermined volumes of fluids in a repetitive fashion, it is convenient if the supply of fluid to be dispensed is continuously supplied to the dispensing device such that after each fluid dose is dispensed, the dispensing device is automatically replenished. Typical dispensing devices include syringes, guns, applicators as well as other dispensing or administering means.
A portable dispensing system is desirable and is ideally carried about the operator's body for greater mobility and maximum operator freedom.
Such considerations are particularly relevant to operations in an agricultural context where, for example, dispensing of fluids (e.g.
medicaments, nutritional supplements etc.) occurs in the vaccinating, drenching or dosing of livestock as well as in the administration of "pour-on" products to livestock, udder washing, and in the use of intra-ruminal injectors and for intramuscular injections [for example, for administering porcine somatotrophin, (PST)]. Maximum operator freedom is very important when a large number of individual doses have to be carried out at any one time and where the stock personnel are needed both to administer and to restrain the animals in question.
Furthermore, in order to allow for the somewhat unpredictable and uncooperative nature of livestock during such operations, a particularly robust system is called for which minimises the risks of both operator and target animal becoming tangled in the dispensing apparatus.
The most basic systems presently used in the agricultural livestock industry typically consist of a dispensing syringe or gun which is replenished with fluid medicament through flexible delivery tubing which connects with a supply of fluid medicament such as for example, any one of a number of commercially available ready-filled medicament packs, cartridges, or containers. The ready-filled medicament packs generally have thin plastic walls which collapse as the fluid is removed and are often disposable. In use, the packs are commonly worn round the operator's neck by means of a loop or the like.
Unfortunately, there is a tendency for the pack to dangle when the operator bends and for the somewhat fragile pack to get caught or split and there is a real danger that the delivery tubing will become tangled up in the operator or target animal.
GB 2 150 814 B describes some general improvements on the basic type of system. This provides a specially adapted holder for a vaccine or drench cartridge which is secured to and carried on the arm of the operator such that the delivery tubing extends from the cartridge to the delivery syringe along the forearm of the operator. While the arrangement of the system on the arm of the operator offers less risk of the delivery tubing becoming tangled, there is a tendency for it to be initially uncomfortable for the user, if not distracting. Also, the results of leakages from the cartridge down the arm of the operator could be unpleasant. Furthermore, although there is some attraction in having a system to hold the cartridge in such an "out-of-the-way" fashion, it makes it inherently awkward to attach or detach the cartridge, even by the most. ambidexterous user.This is particularly inconvenient when the operator is interrupted from dosing for any reason, or is trying to alternate dosing with other jobs such that it will be necessary to keep detaching the system from the arm.
Indeed, the whole system becomes a problem when one arm of the operator is injured, absent or required for other activities such as restraining the animal to be administered.
According to the present invention a portable dispensing system is provided which comprises a pack (i.e. a fluid container) or the like for the fluid materials to be dispensed, dispensing means for administering material from the pack to the target and means for attaching the pack to the operator characterised in that the means for attaching the pack to the operator is a belt which secures the pack around the waist or hip of the operator. Suitably, the means for delivering the fluid from the pack to the dispensing device is a flexible coiled tube.
A major improvement of the present system is the secure and comfortable attachment of the pack to the operator. Most people are accustomed to wearing a belt and find it comfortable to wear. In addition the belt secures the pack firmly so that movement of the pack is minimal.
Simple belts are suitably made from a webbing material but other functional or hard wearing materials are easily substituted. The belt is fitted to the operator by any convenient or conventional means, e.g. ties, velcro (Trade Mark), a buckle or a clamp. The pack is fitted to the belt in such a way that it is readily accessible for attachment and detachment yet it is not in the way of the operator or the target animal.
Suitably, the pack has slots or loops for attachment to the belt or to lugs provided on the belt. The slots or loops can either be moulded in or attached to a retaining feature or supported by any other attaching means. For example, the pack may have fully formed flanges for location of the belt. One advantage of integrally-moulded split loops or slots is that they facilitate easy fitting and removal of the belt.
The pack is suitably constructed of a plastics material (eg polypropylene, low density polyethylene and high density polyethylene), preferably polypropylene, by blow-moulding or injection moulding processes, more suitably by blow-moulding. In a preferred aspect of the present invention the fluid container or pack is of a semi-rigid, largely non-collapsible construction which has the advantage that it is inherently less vulnerable and resists accidental puncturing and leakage. With a non-collapsible pack it means that the "panelling" phenomenon seen when flexible packs are emptying is absent. An important advantage with the present pack is that it is comparatively inert to even very aggressive chemicals and consequently the risks from seepage are low or absent.
Packs are suitably between 500 ml and 1 litre capacity. For convenience, the ready-made packs can be filled with the liquid to be dispensed and the packs sealed and stored if not immediately required.
Therefore, ideally the pack is compatible with conventional filling equipment and modern closures and appropriately, the pack has a threaded (screw) neck. Suitable closures to seal the open end of the pack include in particular conduction heated foil seals.
Suitably, the pack is provided with a sump-like feature in its base into which is directed the end of a dip-tube which provides the means for drawing the fluid out of the pack. Preferably the sump is positioned centrally at the bottom of the pack. In operation, the provision of this sump-like feature allows the user to move freely yet keep the end of the dip-tube immersed in the fluid, preventing airlocks and ensuring that the maximum volume of fluid is dispensed from the pack. Suitably, the end of the dip tube rests on the bottom of the sump but is notched or otherwise shaped so as to permit fluid into the dip tube from the sump.
The dip-tube is suitably secured in place by attachment of the upper end of the dip-tube to a draw-off cap which fits securely to the neck of the pack. The draw-off cap can also provide an air inlet means with a non-return valve. Suitably this is a split (flexible) valve, a vaccine spike or the like. The non-return valve can also be provided by the remains of a foil seal if present.
The draw-off cap suitably provides a connection for the upper end of the dip-tube to a flexible coiled delivery tube which delivers the fluid out from the pack into a dispensing device.
A compression joint fitting may be used to join the flexible coiled delivery tube and dip tube to the bottle cap. However, any suitable connecting means can be used eg. jubilee clips etc. A preferred means of connection is a brass connector (or similar) having at one end a spigot which projects outside the cap when the connector is fitted into a hole in the cap and onto which the coiled delivery tube is push fitted. Preferably the spigot is ridged so as to grip the delivery tube and resist its removal. A nut can then be tightened around the other end of the connector into which the dip tube is ultimately fitted, while still allowing the cap to rotate. To lock the threads of the nut and the connector, the nut is swaged over, for example, using a suitable tool.Therefore in use, the operator can rotate the cap on the bottle rather than having to rotate the bottle on the cap without the nut becoming loose. As alternatives to swaging, other suitable means for achieving this include using Locktite (Trade Mark), PVC tape (as used in plumbing) and lock nuts. Suitably, the dip tube can then be push fitted inside a cavity in the other end of the connector.
The use of the flexible coiled delivery tube significantly reduces the risk of the tube either tangling or getting caught up in the user or target animal. The flexible coiled delivery tube provided by the present invention is sufficiently flexible to extend when in use but has sufficient resilience or rigidity to return automatically to its condensed, compact form when not in use. The flexible delivery tube or hose is suitably made of a nylon or similar material with "memory" characteristics i.e. it has the property of returning to its former shape after flexing. This provides the springy, recoiling action of the flexible coiled delivery tube. (Thus the self-recoiling properties of the hose are somewhat analogous to the flex of a telephone or that of the coiled safety flex currently recommended for domestic kettles).
A further advantage of such a flexible coiled delivery tube is that if a suitable length of coil is employed it prevents the dispensing device (applicator gun or syringe) from falling to the ground if it is dropped or otherwise accidentally knocked from the hand.
It is always possible that through mis-use or excessive stretching of the tubing there can be some loss of the original springiness.
However, a useful property of the coiled nylon tubing provided in the present invention lies in its ability to regain its original springy nature after over-stretching. This is achieved simply by threading one end of the coil through the lumen of the coil and thereby turning the whole coil inside out.
In operation, fluid is drawn from and passes out of the container under the force provided by the operation of the aforementioned dispensing means. This means or device is suitably a disposable syringe but other suitable applicators including serviceable dispensing devices, e.g. guns can equally be used. When not in use, the syringe or other administration device can be attached to the pack or to the belt by means of a clip device or other means (e.g. a holster) for holding the dispensing device. The locating of the dispensing device in the clip or holster and removing it is furthermore a simple, single-handed operation.
The shape of the clip or holster can be readily adapted to accommodate the particular dispensing device employed. Suitably, the clip or holster device may be moulded in as an integral part of the pack or attached to a retaining feature, or to the belt.
Suitably the holster is not an integral part of the pack but is adapted to be retained onto the pack, for example by having flexible flaps which when pushed through the slits in the pack spring out so as to secure the holster. Alternatively, the belt can be threaded through slots provided on the holster so as to secure the holster.
The holster can also be secured by the bottle cap or by flanges which cover the pack slits so that when the belt is passed through the flanges and the slits the holster is retained.
The present invention further provides a dispensing system adapted or suitable for administering vaccines, (or similar) or ready-filled medicament packs. In these cases, the pack is suitably mounted in an upturned fashion so as to assist the drainage of fluid from the pack.
Suitably, a vaccine spike or similar device is fitted into the draw off cap to allow air into the pack.
In another aspect of the invention, there is provided a method of administering fluid treatments to livestock using a dispensing system according to the present invention.
The present invention will now be described in more detail by way of preferred forms of the system and with reference to the accompanying illustrations in which: Figure 1 is a perspective view of a pack according to the invention.
Figure 2 is a perspective view of a second pack according to the invention.
Figure 3 is a side view of the pack in Figure 2.
Figure 4 is a perspective view of the components a first dispensing system with belt, pack clip and delivery system assembled ready for use.
Figure 5 is a cross-section of part of the top of a draw-off cap fitted with a brass connector.
Figure 6 is a perspective view of a holster for use with a pack.
Figure 7 is a perspective view of a second system according to the invention showing a belt threaded through a holster.
Fluid to be dispensed is contained in a pack (1) as shown in Figures 1 or 2. The pack is of approximately 600 ml capacity, constructed of plastics (polypropylene) material by a blow moulding process so as to provide a semi-rigid non-collapsible pack. The pack has a screw neck (2) which can be sealed with a foil closure prior to use. The base of the pack tapers to form a sump (3) which is centrally situated at the bottom of the pack.
The pack is attached to a belt by means of integrally moulded projections (4) that form slots which may be split as in Figure 1.
The belt can either be threaded through the slots, or slipped through the gaps left between the two ends of the projections forming the split slot of the pack in Figure 1. Therefore attachment and detachment of the pack to the belt can be achieved without having to remove the belt from the operator.
To assemble the system for use as shown in Figure 4 or 7, the fluid filled sealed pack (1), is attached to a simple belt (5) made from a webbing material. The belt is worn around the waist/hip of the operator being held in place by a buckle (6). In a preferred belt, the buckle is substituted by a clamp-fitting.
The end of a dip-tube (7) is pushed through the neck of the fluid-filled pack (the foil seal, if present having been pierced beforehand) until it reaches the sump (3) which is centrally situated at the bottom of the pack. The upper end of the dip-tube is attached to the brass connector in a draw-off cap (8). The dip-tube is held in place by securing the draw-off cap to the neck (2) of the pack.
The draw-off cap is also connected to a flexible coiled delivery tube (10) so that fluid can pass from the upper end of the dip-tube into the flexible delivery tube. The flexible delivery tube is made of a nylon or similar material. The opposite end of the delivery tube is connected to a syringe (11) as shown in Figure 4 or an automatic refilling gun (12) (5ml size) (obtainable from N.J. Phillips Pty Co., Australia) as shown in Figure 7.
As shown in Figure 5, a brass connector (13) is fitted in the draw-off cap (8) to connect the dip tube (7) and the coiled delivery tube (10) to the draw-off cap (8). At one end of the connector is a spigot (14) which is outside the cap when the connector is in place onto which the coiled delivery tube is pushed. The spigot has a ribbed outer surface, which allows the coiled delivery tube to be pushed over it but resists removal of the coiled delivery tube as for example when the tube is pulled.
At the other end of the connector is a cavity (15) into which the dip tube (7) is push fitted. A brass nut (16) is tightened so that the cap will just rotate and then the nut is swaged over (17) to lock the threads together. This allows the operator to rotate the cap on the bottle rather than having to rotate the bottle on the cap.
The draw-off cap is provided with an air inlet with non-return valve such as a split rubber valve (9). Alternatively, the non-return valve can be provided by the remains of the foil seal, if present or a vent of some kind.
In operation, multiple doses of fluid are drawn from the interior of the pack, up the dip-tube and out of the pack through the flexible delivery tube by repeated operation of the syringe or dispensing gun.
When not in use, the syringe (or other suitable administration device) can be attached to the pack by means of a clip (18) as in Figure 4 or a holster (18) as in Figure 7. The shape of the clip or holster can be readily adapted to fit the particular dispensing device employed.
A clip for attachment of the dispensing device, can alternatively be fitted to holes in the flanges on the pack of Figure 7 or by a grommet or other attaching means.
Views of a holster for use with the pack of Figure 1 or 2 are shown in Figure 6. The holster in Figure 6 is made from injection moulded polypropylene of wall thickness 2mm, provided with strengthening ribs (19) of 4mm thickness. The holster has two slots (20) and flexible flaps (21) by which the holster can be retained on the pack. When fitted, the flaps are pushed through the slits on the pack. If desired, the operator can remove the flaps and thread the belt through the slots (20) on the holster as shown in Figure 7. Optionally, the holster can have flanges which cover the pack slits so that when the belt is passed through the flanges and slits, the holster is retained.
The above describes the invention including a preferred form thereof.

Claims (14)

1. A portable system for dispensing fluid materials comprising a pack for containment of fluid material to be dispensed, dispensing means for administering material from the pack to the target, and means for attaching the pack to an operator characterised in that the means for attaching the pack to the operator is a belt which secures the pack around the waist or hip of the operator.
2. A dispensing system according to claim 1 wherein the pack has slots or loops for attachment to the belt or to lugs provided on the belt.
3. A dispensing system according to claim 1 or 2 wherein the means for delivering the fluid from the pack to the dispensing device is a flexible coiled tube.
4. A dispensing system according to claim 3 wherein the flexible coiled tube is made of nylon.
5. A dispensing system according to claim 1, 2, 3 or 4 provided with a dip tube for transferring the fluid out of the pack to the delivery tube.
6. A dispensing device according to claims 1-5 wherein the pack has a sump to accommodate a dip tube through which fluid is transferred from the pack.
7. A pack for a dispensing system according to any of the preceding claims made of substantially rigid material.
8. A dispensing system according to any of preceding claims wherein the pack has a draw off cap with an air-inlet means.
9. A dispensing system according to claim 8 wherein the draw off cap is provided with a connection means for the dip tube and delivery tube so that in operation the cap can rotate on the pack.
10. A dispensing system according to any of the preceding claims provided with a clip or holster for location of the dispensing device when not in use.
11. A dispensing system according to any of the preceding claims for administering fluids to livestock.
12. The use of a dispensing system according to any one of the preceding claims as a method of administering fluid treatments to livestock.
13. A dispensing device substantially as described herein with reference to and as shown in Figures 4 or 7 of the accompanying drawings.
14. Any novel feature or combination of features disclosed herein.
GB9008758A 1989-07-31 1990-04-19 Portable dispensing system Withdrawn GB2234484A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA002022083A CA2022083A1 (en) 1989-07-31 1990-07-30 Portable dispensing system
EP19900308334 EP0411858A3 (en) 1989-07-31 1990-07-30 Portable dispensing system
US07/560,042 US5154324A (en) 1989-07-31 1990-07-30 Belt mounted portable dispensing system for veterinary fluids
IE274390A IE902743A1 (en) 1989-07-31 1990-07-30 Portable Dispensing system
PT94850A PT94850B (en) 1989-07-31 1990-07-30 PORTABLE PRODUCT DISTRIBUTION SYSTEM
AU59983/90A AU645017B2 (en) 1989-07-31 1990-07-30 Portable dispensing system

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898917464A GB8917464D0 (en) 1989-07-31 1989-07-31 Portable dispensing system

Publications (2)

Publication Number Publication Date
GB9008758D0 GB9008758D0 (en) 1990-06-13
GB2234484A true GB2234484A (en) 1991-02-06

Family

ID=10660915

Family Applications (2)

Application Number Title Priority Date Filing Date
GB898917464A Pending GB8917464D0 (en) 1989-07-31 1989-07-31 Portable dispensing system
GB9008758A Withdrawn GB2234484A (en) 1989-07-31 1990-04-19 Portable dispensing system

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB898917464A Pending GB8917464D0 (en) 1989-07-31 1989-07-31 Portable dispensing system

Country Status (2)

Country Link
GB (2) GB8917464D0 (en)
ZA (1) ZA905977B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19545685C1 (en) * 1995-12-07 1996-11-14 Thomas Wroblewski Applicator for transdermally absorbable veterinary medicines
WO2004014461A2 (en) * 2002-08-12 2004-02-19 Tracecompany Holding Aps Device for administration of fluids

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4090650A (en) * 1976-07-26 1978-05-23 Gotta Harold J Canteen with a straw
GB2059750A (en) * 1979-09-12 1981-04-29 Chubb Panorama Back-carrying harness assemblies
US4449654A (en) * 1980-12-18 1984-05-22 Cappis Lona P Belt supported backpack
US4526298A (en) * 1983-02-28 1985-07-02 Cardiosearch, Inc. Sport hydration system
GB2150814A (en) * 1983-10-28 1985-07-10 Alan Moana Alexander A holder for a vaccine cartridge
US4544087A (en) * 1981-08-14 1985-10-01 Ronald Modig Holder for liquids
US4588116A (en) * 1983-11-29 1986-05-13 Smith & Wesson Chemical Company, Inc. Holster for a chemical tear gas projector
US4629098A (en) * 1984-10-15 1986-12-16 Eger Douglas R Portable liquid dispenser
US4662551A (en) * 1985-11-12 1987-05-05 Corona Clipper Company Back-pack power supply for pneumatic hand tools
EP0276903A1 (en) * 1987-01-08 1988-08-03 L.B. Liqui-Box Israel Ltd. Flexible container with stopper valve
GB2213127A (en) * 1987-12-07 1989-08-09 Gordon Ronald Tripp Liquid storing and supply means

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4090650A (en) * 1976-07-26 1978-05-23 Gotta Harold J Canteen with a straw
GB2059750A (en) * 1979-09-12 1981-04-29 Chubb Panorama Back-carrying harness assemblies
US4449654A (en) * 1980-12-18 1984-05-22 Cappis Lona P Belt supported backpack
US4544087A (en) * 1981-08-14 1985-10-01 Ronald Modig Holder for liquids
US4526298A (en) * 1983-02-28 1985-07-02 Cardiosearch, Inc. Sport hydration system
GB2150814A (en) * 1983-10-28 1985-07-10 Alan Moana Alexander A holder for a vaccine cartridge
US4588116A (en) * 1983-11-29 1986-05-13 Smith & Wesson Chemical Company, Inc. Holster for a chemical tear gas projector
US4629098A (en) * 1984-10-15 1986-12-16 Eger Douglas R Portable liquid dispenser
US4662551A (en) * 1985-11-12 1987-05-05 Corona Clipper Company Back-pack power supply for pneumatic hand tools
EP0276903A1 (en) * 1987-01-08 1988-08-03 L.B. Liqui-Box Israel Ltd. Flexible container with stopper valve
GB2213127A (en) * 1987-12-07 1989-08-09 Gordon Ronald Tripp Liquid storing and supply means

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19545685C1 (en) * 1995-12-07 1996-11-14 Thomas Wroblewski Applicator for transdermally absorbable veterinary medicines
WO2004014461A2 (en) * 2002-08-12 2004-02-19 Tracecompany Holding Aps Device for administration of fluids
WO2004014461A3 (en) * 2002-08-12 2004-05-13 Tracecompany Holding Aps Device for administration of fluids
US7360501B2 (en) 2002-08-12 2008-04-22 Tracecompany Aps Device for administration of fluids

Also Published As

Publication number Publication date
GB9008758D0 (en) 1990-06-13
GB8917464D0 (en) 1989-09-13
ZA905977B (en) 1992-04-29

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WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)