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GB2232769B - Counting and volume measurement of particles and biological cells,and determination of their deformability - Google Patents

Counting and volume measurement of particles and biological cells,and determination of their deformability

Info

Publication number
GB2232769B
GB2232769B GB8913593A GB8913593A GB2232769B GB 2232769 B GB2232769 B GB 2232769B GB 8913593 A GB8913593 A GB 8913593A GB 8913593 A GB8913593 A GB 8913593A GB 2232769 B GB2232769 B GB 2232769B
Authority
GB
United Kingdom
Prior art keywords
deformability
counting
particles
determination
biological cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB8913593A
Other versions
GB8913593D0 (en
GB2232769A (en
Inventor
Timothy Charles Fisher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to GB8913593A priority Critical patent/GB2232769B/en
Publication of GB8913593D0 publication Critical patent/GB8913593D0/en
Publication of GB2232769A publication Critical patent/GB2232769A/en
Application granted granted Critical
Publication of GB2232769B publication Critical patent/GB2232769B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects
    • G01N15/12—Investigating individual particles by measuring electrical or magnetic effects by observing changes in resistance or impedance across apertures when traversed by individual particles, e.g. by using the Coulter principle
    • G01N15/134—Devices using two or more apertures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/012—Red blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1022—Measurement of deformation of individual particles by non-optical means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1024—Counting particles by non-optical means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/103—Particle shape

Landscapes

  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
GB8913593A 1989-06-13 1989-06-13 Counting and volume measurement of particles and biological cells,and determination of their deformability Expired - Fee Related GB2232769B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB8913593A GB2232769B (en) 1989-06-13 1989-06-13 Counting and volume measurement of particles and biological cells,and determination of their deformability

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8913593A GB2232769B (en) 1989-06-13 1989-06-13 Counting and volume measurement of particles and biological cells,and determination of their deformability

Publications (3)

Publication Number Publication Date
GB8913593D0 GB8913593D0 (en) 1989-08-02
GB2232769A GB2232769A (en) 1990-12-19
GB2232769B true GB2232769B (en) 1994-06-22

Family

ID=10658373

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8913593A Expired - Fee Related GB2232769B (en) 1989-06-13 1989-06-13 Counting and volume measurement of particles and biological cells,and determination of their deformability

Country Status (1)

Country Link
GB (1) GB2232769B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5376878A (en) * 1991-12-12 1994-12-27 Fisher; Timothy C. Multiple-aperture particle counting sizing and deformability-measuring apparatus
JPH07301595A (en) * 1994-05-09 1995-11-14 Toa Medical Electronics Co Ltd Method and apparatus for measuring particle
US5795782A (en) * 1995-03-17 1998-08-18 President & Fellows Of Harvard College Characterization of individual polymer molecules based on monomer-interface interactions
US6362002B1 (en) 1995-03-17 2002-03-26 President And Fellows Of Harvard College Characterization of individual polymer molecules based on monomer-interface interactions
US20120160687A1 (en) 1995-03-17 2012-06-28 President And Fellows Of Harvard College Characterization of individual polymer molecules based on monomer-interface interactions
EP1192453B1 (en) 1999-06-22 2012-02-15 President and Fellows of Harvard College Molecular and atomic scale evaluation of biopolymers
DE19946458C2 (en) * 1999-09-28 2002-10-24 Fraunhofer Ges Forschung Device and method for characterizing spheroids
DE10142393C1 (en) * 2001-08-30 2003-01-23 Fraunhofer Ges Forschung Apparatus measuring bioelectrical signals from spheroids, includes commensurately-sized chamber ringed internally with coplanar electrodes
EP1516170B1 (en) 2002-06-11 2017-08-09 Koninklijke Philips N.V. Lysing reagent, cartridge and automatic electronic cell counter for simultaneous enumeration of different types of white blood cells
WO2005017025A2 (en) 2003-08-15 2005-02-24 The President And Fellows Of Harvard College Study of polymer molecules and conformations with a nanopore
US7238485B2 (en) 2004-03-23 2007-07-03 President And Fellows Of Harvard College Methods and apparatus for characterizing polynucleotides
JP5096170B2 (en) 2005-02-10 2012-12-12 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ Dual sample cartridge and method for characterizing particles in a liquid
US8028566B2 (en) 2005-02-10 2011-10-04 Chempaq A/S Dual sample cartridge and method for characterizing particles in liquid
EP2580588B1 (en) 2010-06-08 2014-09-24 President and Fellows of Harvard College Nanopore device with graphene supported artificial lipid membrane
CN106442275B (en) * 2016-09-18 2019-08-09 中国人民武装警察部队总医院 A kind of method and kit of qualitative detection chyle

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1456599A (en) * 1973-10-12 1976-11-24 Us Energy Research Dev Adminis Potential sensing cell analyzer
US4055799A (en) * 1975-01-23 1977-10-25 Kernforschungsanlage Julich Gesellschaft Mit Beschrankter Haftung Method of and device for measuring elastic and di-electric properties of the diaphragm of living cells
GB1602134A (en) * 1977-06-27 1981-11-04 Contraves Ag Particle analysis
US4438390A (en) * 1981-03-23 1984-03-20 Coulter Electronics, Inc. Tandem sensing zones for improved signal-to-noise ratio in particle analyzer
GB2163555A (en) * 1984-08-24 1986-02-26 Descartes Universite Rene Apparatus and process for determining the deformability of the red corpuscles in the blood

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1456599A (en) * 1973-10-12 1976-11-24 Us Energy Research Dev Adminis Potential sensing cell analyzer
US4055799A (en) * 1975-01-23 1977-10-25 Kernforschungsanlage Julich Gesellschaft Mit Beschrankter Haftung Method of and device for measuring elastic and di-electric properties of the diaphragm of living cells
GB1602134A (en) * 1977-06-27 1981-11-04 Contraves Ag Particle analysis
US4438390A (en) * 1981-03-23 1984-03-20 Coulter Electronics, Inc. Tandem sensing zones for improved signal-to-noise ratio in particle analyzer
GB2163555A (en) * 1984-08-24 1986-02-26 Descartes Universite Rene Apparatus and process for determining the deformability of the red corpuscles in the blood

Also Published As

Publication number Publication date
GB8913593D0 (en) 1989-08-02
GB2232769A (en) 1990-12-19

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19960613