[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

GB2214486A - Container - Google Patents

Container Download PDF

Info

Publication number
GB2214486A
GB2214486A GB8801242A GB8801242A GB2214486A GB 2214486 A GB2214486 A GB 2214486A GB 8801242 A GB8801242 A GB 8801242A GB 8801242 A GB8801242 A GB 8801242A GB 2214486 A GB2214486 A GB 2214486A
Authority
GB
United Kingdom
Prior art keywords
container
bag
mouth portion
neck
reservoir
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB8801242A
Other versions
GB8801242D0 (en
Inventor
John David Yair
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to GB8801242A priority Critical patent/GB2214486A/en
Publication of GB8801242D0 publication Critical patent/GB8801242D0/en
Priority to ZA89393A priority patent/ZA89393B/en
Priority to IE890155A priority patent/IE890155L/en
Publication of GB2214486A publication Critical patent/GB2214486A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10Bag-type containers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

Container for liquid drugs or other substances to be adminstered by hypodermic injection includes a sealed flexible bag (12) e.g. of sheet plastics material forming a reservoir enabling any quantity or quantities of the substance to be withdrawn by suction without admitting air. The container includes a rigid mouth portion (10) bonded to the bag and defining an opening sealed by a rubber or elastomeric diaphragm (14) which can be pierced by the needle for withdrawal of the substance, and a protective cage (18) may be provided within the reservoir to prevent accidental piercing of the bag by the needle. The bag may be located in an outer box (20). <IMAGE>

Description

CONTINEF? This invention relates to vials or other containers for liquid drugs or other substances to be administered by hypodermic injection.
Present practice is to supply such substances in rigid containers, commonly glass vials, having a closure or cap which includes a diaphragm of rubber or other elastomeric material to be pierced by the needle of a hypodermic syringe when a dose is to be drawn off. The required quantity is drawn from the container by suction created by extending the piston or plunger of the syringe.
This will speedily create a vacuum within the container preventing further withdrawal of liquid as the container is otherwise airtight. The accepted technique for avoiding this is to use the syringe to inject a quantity of air into the container through the cap at least sufficient to enable the required dose to be withdrawn without difficulty. If a succession of doses are needed the container may be pre-pressurised by use of the syringe to inject a substantial volume of air.
In these manners of use it is necessary first to extend the syringe plunger, then to insert the needle through the cap, then to depress the plunger to inject the air, and then to withdraw the plunger once more to extract the required dose.
Because of the risk of cross-infection syringes and needles are desirably used for one injection only and to prevent any possibility of further usage designs of syringe are being developed which are impossible or extremely difficult to operate more than once. Thus they may incorporate some means of preventing a second withdrawal or operation of the plunger or piston after a single first operation, i.e. a working or injecting stroke. It will not be possible to use syringes of this type for pre-pressurising or othe,rwise injecting air into the container as above as this involves two working strokes of the piston or plunger.
Furthermore the air which is first drawn into the syringe through the needle and then injected into the container may not be sterile and may give rise to risk of infection bearing in mind that the drugs are normally supplied in quantities sufficient for a number of successive doses and that injections are often made in non-sterile surroundings, even out of doors in the tropics under primitive conditions as with mass immunisation programmes. Also some drugs or substances may be subject to deterioration in the presence of air which may mean that the remaining contents of the container has to be used quickly or will be wasted, or, if kept for too long with extra air (non-sterile) admitted, may be used in an ineffective or possibly even harmful form.
A further disadvantage of the known types of rigid container is that it is extremely difficult to extract all the contents through diaphragm by way of a needle.
As the container becomes empty a quantity of the liquid cannot be reached by the needle, again resulting in unnecessary wastage of possibly expensive drugs.
The object of the invention is to provide a container which is cheap and economical to manufacture and fill, which can be used effectively and simply with hypodermic needles and syringes of all kinds including non-re-usable syringes limited to single stroke operation, which improves standards of sterility even under adverse conditions, and which reduces wastage of the drugs or other substances.
According to the invention there is provided a container for liquid drugs or other substances to be administrated by hypodermic injection including a reservoir defined at least in part buy a sealed bag formed of a flexible impervious material to provide a variable volume chamber in which the substance is contained so enabling any required quantity of quantities of the substance to be withdrawn by suction without admitting any air to the reservoir.
Preferably the container includes a rigid neck or mouth portion to which the bag is attached provided with a rubber or elastomeric diaphragm which can be pierced by the hypodermic needle and preferably said cap or closure mounts a protective cage extending within the reservoir to prevent the needle piercing the wall of the bag from within the container.
The bag may be located within a rigid protective outer sleeve or box though this is not essential.
Some examples of the invention are now described with reference to the accompanying drawings wherein Figure 1 is an exploded perspective view of one form of drug container Figure 2 is a side view of the assembled container of Figure 1; Figure 3 is a vertical cross-section of another form of container; and Figure 4 is a side view of a yet further form of container.
Referring to Figure 1 a filled and sealed container comprises a rigid top or neck portion 10, e.g. a plastics moulding, a bag 12 formed from flexible impervious material e.g. transparent flexible polyethylene or other sheet plastics conveniently in tubular form, the neck of the bag being sonically welded or otherwise bonded to neck portion 10; a rubber or elastomeric diaphragm 14, and a top closure 16 secured to portion 10 to seal diaphragm 14 in place across a central mouth opening of the top. A protective cage 18 depends from neck portion 10 into bag 12 co-axial to the mouth and is slotted or otherwise pierced so that fluid can flow freely into the cage from the remaining part of bag 12 at all positions, particularly when the container is inverted.The reservoir defined by the assembled bag and top will normally be completely filled witch the liquid drug or other substance i.e. no air space need be left.
Preferably the top is in the form of an elongated oval or diamond in plan view so that it fits the neck of the bag 12 in the easiest way and facilitates the flattening of the bag around cage 18 as the contents are withdrawn.
The bag may locate within a rigid outer box or cover 20, possibly snap-engaged with the neck portion 10 or top closure 16 to prevent external pressure or possible puncturing of the bag during handling, transport or storage though this may not always be necessary. The outer box 20 need not be sterile or airtight, indeed it may include an aperture e.g. in its bottom to ensure that there is no vacuum resisting flattening of bag 12.
It will be seen that in order to withdraw any required quantity of liquid from the variable volume chamber defined by bag 12 it is only necessary to insert the hypodermic needle through diaphragm 14 without first withdrawing or operating the plunger or piston1 then the latter will be operated to suck out the required dose, the needle is then simply withdrawn from the diaphragm and the injection is ready to be made. It is not necessary to pre-pressurise or otherwise inject air into the reservoir to obtain the required quantity.
Successive doses will be withdrawn in the same way until the bag is completely flattened by external air pressure forcing the last remaining drops of liquid into the cage.
A small residue of liquid may remain trapped in the cage or against the neck portion 10 which will prevent the neck of the bag flattening but it is anticipated that this kind of wastage will be far less than in the case of a conventional rigid container e.g. a glass vial of conventional bottle shape.
The assembled and filled container is neat and compact in shape as seen in Figure 2, as it is formed from plastics it can be designed for the most economical use of materials, for low cost mass production manufacture -techniques, and for the most effective use of storage and transport space. The shape of container shown in Figure 2 can be packed much more densely and will weigh less than the equivalent capacity of round glass bottle or vial. Any size or capacity of container can readily be provided.
A container of more conventional shape but utilizing the principles of the invention is shown diagrammatically in Figure 3. Here a flexible bag 312 has a cylindrical body and a reduced diameter neck to fit within an outer rigid casing 320 of conventional bottle shape, the diaphragm 314 being sealed against a neck ring 315, which carries the cage 318 as previously described, by a screwon top closure in the form of a nut or cap 316.
Alternatively this cap could be a metal closure crimped or swaged onto the neck of body 320 or a plastics cap could be bonded or welded thereto.
Figure 4 illustrates another possible form of container in which the rigid neck portion 410 is reduced to a minimum and is circular in cross-section to define a mouth carrying the diaphragm 414, portion 410 being formed with an integral cage 418. A bag 412 formed from tubular plastics material has a welded seam at top and bottom, the central portion of the top of the bag being welded or otherwise bonded to the outer periphery of the neck portion 410. This design is economical of materials though care will be needed to ensure that there is adequate sealing at the junction between the top seams of the bag and the neck portion.

Claims (11)

CL A IFl,S
1. A container for liquid drugs or other substances to be administrated by hypodermic injection including a reservoir defined at least in part by a seal bag formed of a flexible impervious material to provide a variable volume chamber in which the substance is contained so enabling any required quantity or quantities of the substance to be withdrawn by suction without admitting any air to the reservoir.
2. A container as in Claim 1 including a rigid mouth portion to which the bag is attached provided with a diaphragm which can be pierced by a hypodermic needle to effect said withdrawal.
3. A container as in Claim 1 or 2 wherein said mouth portion includes a cap or closure sealing the diaphragm across an opening of the mouth portion.
4. A container as in Claim 2 or 3 including a protective cage extending from the mouth portion within the reservoir to prevent piercing of the wall of the bag by a hypodermic needle inserted through the mouth portion.
5. A container as in Claim 2 wherein said flexible impervious material is flexible sheet plastics and the mouth portion is also formed from plastics with the bac welded or otherwise bonded thereto.
6. A container as in any preceding claim including a rigid protective outer box or cover within which the bag is located.
7. A container as in Claim 6 so far as dependent on Claim 2 wherein said outer box or cover engages with said mouth portion.
8. A container as in Claim 2 or 7 wherein the mouth portion is in the form of an elongated oval or diamond in plan view so that it fits into a neck of the bag and facilitates the flattening of the bag as the contents are withdrawn.
9. A container as in Claim 2 wherein the mouth portion is in the form of a neck portion of circular crosssection and the bag is formed from tubular plastics material having a welded seam at top and bottom, the cental portion of the top of the bag being welded or otherwise bonded to the outer periphery of the neck portion.
10. A container as in Claim 6 or 7 wherein the bag has a cylindrical body and reduced diameter neck and the rigid outer cover is bottle shaped so that the bao fits therein, the mouth portion comprising a closure secured to a neck of the casing.
11. A container for liquid drugs or other substances to be adminstered by hypodermic injection substantially as hereinbefore described with reference to and as shown in rigures 1 and 2r Figure 3; or Figure 4 of the accompanying drawings.
GB8801242A 1988-01-20 1988-01-20 Container Withdrawn GB2214486A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
GB8801242A GB2214486A (en) 1988-01-20 1988-01-20 Container
ZA89393A ZA89393B (en) 1988-01-20 1989-01-17 Container
IE890155A IE890155L (en) 1988-01-20 1989-01-19 Drugs container

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8801242A GB2214486A (en) 1988-01-20 1988-01-20 Container

Publications (2)

Publication Number Publication Date
GB8801242D0 GB8801242D0 (en) 1988-02-17
GB2214486A true GB2214486A (en) 1989-09-06

Family

ID=10630256

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8801242A Withdrawn GB2214486A (en) 1988-01-20 1988-01-20 Container

Country Status (3)

Country Link
GB (1) GB2214486A (en)
IE (1) IE890155L (en)
ZA (1) ZA89393B (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2331065A (en) * 1997-11-10 1999-05-12 Gr Advanced Materials Ltd Flexible pouch for highly viscous liquids
WO2000003674A1 (en) * 1998-07-15 2000-01-27 Novartis Nutrition Ag Pouch for retaining and administering medical fluids
EP1447720A2 (en) * 1998-12-22 2004-08-18 Ricoh Company, Ltd. Toner container
GB2420554A (en) * 2004-11-26 2006-05-31 Gr Advanced Materials Ltd Depletion device for bag in box containing viscous liquid
WO2015091761A1 (en) * 2013-12-20 2015-06-25 Sanofi-Aventis Deutschland Gmbh Disposable cartridge for a drug delivery device

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB763177A (en) * 1953-09-14 1956-12-12 Abbott Lab Transfusion methods and apparatus therefor
US3647386A (en) * 1969-09-26 1972-03-07 Gilford Instr Labor Inc Sample processing container
GB1531024A (en) * 1975-08-15 1978-11-01 Laib J Ampoule and method for the manufacture thereof
GB2000744A (en) * 1977-07-11 1979-01-17 Diemoulders Pty Ltd Improvements in the packaging of liquids
GB2051018A (en) * 1979-05-18 1981-01-14 Terumo Corp Plastics container for medical liquid
GB2066210A (en) * 1979-12-26 1981-07-08 Abbott Lab Flexible container with integral ports and diaphragm
US4330066A (en) * 1980-11-21 1982-05-18 Robert Berliner Receptacle with collapsible internal container
WO1982004398A1 (en) * 1981-06-12 1982-12-23 Niklasson Tage Arrangement for bags especially for infusion and procedure for their production
GB2117349A (en) * 1982-03-24 1983-10-12 Metal Box Plc Bags
GB2132985A (en) * 1983-01-08 1984-07-18 Boots Co Plc Container
WO1985003433A1 (en) * 1983-12-23 1985-08-15 Bengt Gustavsson A volume variable vessel
GB2203118A (en) * 1987-04-07 1988-10-12 Fuso Pharmaceutical Ind Plastics transfusion containers

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB763177A (en) * 1953-09-14 1956-12-12 Abbott Lab Transfusion methods and apparatus therefor
US3647386A (en) * 1969-09-26 1972-03-07 Gilford Instr Labor Inc Sample processing container
GB1531024A (en) * 1975-08-15 1978-11-01 Laib J Ampoule and method for the manufacture thereof
GB2000744A (en) * 1977-07-11 1979-01-17 Diemoulders Pty Ltd Improvements in the packaging of liquids
GB2051018A (en) * 1979-05-18 1981-01-14 Terumo Corp Plastics container for medical liquid
GB2066210A (en) * 1979-12-26 1981-07-08 Abbott Lab Flexible container with integral ports and diaphragm
US4330066A (en) * 1980-11-21 1982-05-18 Robert Berliner Receptacle with collapsible internal container
WO1982004398A1 (en) * 1981-06-12 1982-12-23 Niklasson Tage Arrangement for bags especially for infusion and procedure for their production
GB2117349A (en) * 1982-03-24 1983-10-12 Metal Box Plc Bags
GB2132985A (en) * 1983-01-08 1984-07-18 Boots Co Plc Container
WO1985003433A1 (en) * 1983-12-23 1985-08-15 Bengt Gustavsson A volume variable vessel
GB2203118A (en) * 1987-04-07 1988-10-12 Fuso Pharmaceutical Ind Plastics transfusion containers

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2331065A (en) * 1997-11-10 1999-05-12 Gr Advanced Materials Ltd Flexible pouch for highly viscous liquids
US6105821A (en) * 1997-11-10 2000-08-22 Gr Advanced Materials Ltd Dispensing container for highly viscous liquids
GB2331065B (en) * 1997-11-10 2002-01-16 Gr Advanced Materials Ltd Dispensing container for highly viscous liquids
WO2000003674A1 (en) * 1998-07-15 2000-01-27 Novartis Nutrition Ag Pouch for retaining and administering medical fluids
EP1447720A2 (en) * 1998-12-22 2004-08-18 Ricoh Company, Ltd. Toner container
EP1447720B1 (en) * 1998-12-22 2012-02-08 Ricoh Company, Ltd. Toner container
GB2420554A (en) * 2004-11-26 2006-05-31 Gr Advanced Materials Ltd Depletion device for bag in box containing viscous liquid
WO2015091761A1 (en) * 2013-12-20 2015-06-25 Sanofi-Aventis Deutschland Gmbh Disposable cartridge for a drug delivery device
CN106029129A (en) * 2013-12-20 2016-10-12 赛诺菲-安万特德国有限公司 Disposable cartridge for a drug delivery device
JP2016540579A (en) * 2013-12-20 2016-12-28 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Disposable cartridge for drug delivery device
EP3753592A1 (en) * 2013-12-20 2020-12-23 Sanofi-Aventis Deutschland GmbH Disposable cartridge for a drug delivery device
US11911591B2 (en) 2013-12-20 2024-02-27 Sanofi-Aventis Deutschland Gmbh Disposable cartridge for a drug delivery device

Also Published As

Publication number Publication date
ZA89393B (en) 1989-10-25
GB8801242D0 (en) 1988-02-17
IE890155L (en) 1989-07-20

Similar Documents

Publication Publication Date Title
US11724038B2 (en) Syringe assembly with inverse delivery
US4883473A (en) Single use injection device
US4668223A (en) Syringe
US10610647B2 (en) Syringe assembly with pivoting plunger and integral tip guard
US5232029A (en) Additive device for vial
EP0088056B1 (en) Filled unit dose container
JP3573431B2 (en) Method for filling drug capsules and articles made thereby
US4390016A (en) Prefillable hypodermic syringe and method of assembling the syringe
KR100399161B1 (en) Closing caps and methods for filling containers without generating air bubbles
US4548601A (en) Prepackaged, injectable pharmaceutical and hypodermic needle combination
US4236516A (en) Syringe and disposable container therefor
US4184593A (en) Package for disposable syringes
ES2896727T3 (en) Injector
US3739779A (en) Hypodermic syringe and needle construction
JP2824151B2 (en) Lyophilized and sealed similar to a lyophilized compound cartridge assembly forming the disposable part of an injector pen
US3608550A (en) Transfer needle assembly
AU682670B2 (en) Syringe needle isolation device
US4196732A (en) Automatic disposable syringe and method of filling the same
US4775376A (en) Method and apparatus for catching fluids purged from a syringe
HU210361B (en) Method for manufacturing prefilled plastic cartridge and syringe
JPH0638835B2 (en) Hazardous substance vial device and method
CA2059430A1 (en) Dual-chamber type syringe
US2695612A (en) Hypodermic syringe
GB2214486A (en) Container
US3890972A (en) Syringe injector with pop-top cap

Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)