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GB2121050B - Preparation of functional human urokinase proteins - Google Patents

Preparation of functional human urokinase proteins

Info

Publication number
GB2121050B
GB2121050B GB08310142A GB8310142A GB2121050B GB 2121050 B GB2121050 B GB 2121050B GB 08310142 A GB08310142 A GB 08310142A GB 8310142 A GB8310142 A GB 8310142A GB 2121050 B GB2121050 B GB 2121050B
Authority
GB
United Kingdom
Prior art keywords
preparation
functional human
human urokinase
proteins
urokinase proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB08310142A
Other versions
GB2121050A (en
GB8310142D0 (en
Inventor
Herbert Louis Heyneker
William Evans Holmes
Gordon Alan Vehar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/055,126 external-priority patent/US4342832A/en
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of GB8310142D0 publication Critical patent/GB8310142D0/en
Publication of GB2121050A publication Critical patent/GB2121050A/en
Application granted granted Critical
Publication of GB2121050B publication Critical patent/GB2121050B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
GB08310142A 1979-07-05 1983-04-14 Preparation of functional human urokinase proteins Expired GB2121050B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US06/055,126 US4342832A (en) 1979-07-05 1979-07-05 Method of constructing a replicable cloning vehicle having quasi-synthetic genes
US36877382A 1982-04-15 1982-04-15
US47493083A 1983-03-14 1983-03-14

Publications (3)

Publication Number Publication Date
GB8310142D0 GB8310142D0 (en) 1983-05-18
GB2121050A GB2121050A (en) 1983-12-14
GB2121050B true GB2121050B (en) 1986-03-26

Family

ID=27368777

Family Applications (1)

Application Number Title Priority Date Filing Date
GB08310142A Expired GB2121050B (en) 1979-07-05 1983-04-14 Preparation of functional human urokinase proteins

Country Status (1)

Country Link
GB (1) GB2121050B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4920051A (en) * 1988-02-03 1990-04-24 Damon Biotech, Inc. Recovery of urokinase compounds

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2252842B1 (en) * 1973-12-03 1977-11-04 Fabre Sa Pierre
US3957582A (en) * 1974-11-20 1976-05-18 Abbott Laboratories Purification of urokinase
FR2310133A2 (en) * 1975-05-05 1976-12-03 Fabre Sa Pierre NEW MEDICINAL PRODUCT CONTAINING AN IMPROVED PLASMINOGEN ACTIVATOR
JPS527485A (en) * 1975-07-04 1977-01-20 Asahi Chem Ind Co Ltd Isolation of urokinase
JPS5210486A (en) * 1975-07-16 1977-01-26 Hitachi Chem Co Ltd Isolation of urokinase
NL7800200A (en) * 1977-01-14 1978-07-18 Nippon Soda Co UROKINASE ADSORPTION AND METHOD FOR THE PREPARATION OF UROKINASE.
JPS53113080A (en) * 1977-03-10 1978-10-03 Sumitomo Chem Co Ltd Purification of urokinase
DE2812609A1 (en) * 1977-04-09 1978-10-19 Tanabe Seiyaku Co METHOD FOR PURIFYING CRUDE UROKINASE
JPS5935B2 (en) * 1977-06-03 1984-01-05 住友化学工業株式会社 Purification method of urokinase
CH643297A5 (en) * 1978-06-30 1984-05-30 Alpha Patent Ltd Method for preparation of pure urokinase.
DE3015699C2 (en) * 1979-04-26 1982-07-15 Asahi Kasei Kogyo K.K., Osaka Manufacture of a plasminogen activator
CA1154671A (en) * 1979-07-27 1983-10-04 Lucien D. D'hinterland Separation of a tissular activator of plasminogen

Also Published As

Publication number Publication date
GB2121050A (en) 1983-12-14
GB8310142D0 (en) 1983-05-18

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Legal Events

Date Code Title Description
PE20 Patent expired after termination of 20 years

Effective date: 20030413