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GB2164333B - Antitussive and mucus regulating 2-substituted thiazolidines - Google Patents

Antitussive and mucus regulating 2-substituted thiazolidines

Info

Publication number
GB2164333B
GB2164333B GB08419254A GB8419254A GB2164333B GB 2164333 B GB2164333 B GB 2164333B GB 08419254 A GB08419254 A GB 08419254A GB 8419254 A GB8419254 A GB 8419254A GB 2164333 B GB2164333 B GB 2164333B
Authority
GB
United Kingdom
Prior art keywords
antitussive
substituted thiazolidines
mucus regulating
mucus
thiazolidines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB08419254A
Other versions
GB2164333A (en
GB8419254D0 (en
Inventor
Sergio Tognella
Carmelo A Gandolfi
Silvano Spinelli
Odoardo Tofanetti
Raimondo Russo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Italia SpA
Original Assignee
Boehringer Biochemia Robin SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Biochemia Robin SpA filed Critical Boehringer Biochemia Robin SpA
Priority to GB08419254A priority Critical patent/GB2164333B/en
Publication of GB8419254D0 publication Critical patent/GB8419254D0/en
Priority to US06/755,834 priority patent/US4798898A/en
Priority to HU852765A priority patent/HU195492B/en
Priority to NZ212831A priority patent/NZ212831A/en
Priority to AU45242/85A priority patent/AU582770B2/en
Priority to IL75891A priority patent/IL75891A/en
Priority to CA000487403A priority patent/CA1270250A/en
Priority to GR851845A priority patent/GR851845B/el
Priority to ZA855618A priority patent/ZA855618B/en
Priority to EP85109445A priority patent/EP0169581B1/en
Priority to AT85109445T priority patent/ATE48421T1/en
Priority to ES545575A priority patent/ES8605249A1/en
Priority to IE187985A priority patent/IE58518B1/en
Priority to JP60166620A priority patent/JPS6163669A/en
Priority to DE8585109445T priority patent/DE3574590D1/en
Priority to DK341985A priority patent/DK169474B1/en
Publication of GB2164333A publication Critical patent/GB2164333A/en
Priority to US07/266,559 priority patent/US4857643A/en
Application granted granted Critical
Publication of GB2164333B publication Critical patent/GB2164333B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/255—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/20—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 hydrogenated in the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB08419254A 1984-07-27 1984-07-27 Antitussive and mucus regulating 2-substituted thiazolidines Expired GB2164333B (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
GB08419254A GB2164333B (en) 1984-07-27 1984-07-27 Antitussive and mucus regulating 2-substituted thiazolidines
US06/755,834 US4798898A (en) 1984-07-27 1985-07-17 Antitussive and mucus regulating 2-substituted thiazolidines
HU852765A HU195492B (en) 1984-07-27 1985-07-18 Process for producing 2-substituted thiazolidine derivatives with antitussive and mucus regulating action and pharmaceuticals comprising these compounds as active ingredient
NZ212831A NZ212831A (en) 1984-07-27 1985-07-22 Thiazolidine derivatives and pharmaceutical compositions
AU45242/85A AU582770B2 (en) 1984-07-27 1985-07-22 Antitussive and mucus regulating 2-substituted thiazolidines
IL75891A IL75891A (en) 1984-07-27 1985-07-23 Antitussive and mucus regulating 2-substituted thiazolidines,their preparation and pharmaceutical compositions containing them
CA000487403A CA1270250A (en) 1984-07-27 1985-07-24 Antitussive and mucus regulating 2-substituted thiazolidines
ZA855618A ZA855618B (en) 1984-07-27 1985-07-25 Antitussive and mucus regulating 2-substituted thiazolidines
GR851845A GR851845B (en) 1984-07-27 1985-07-25
DE8585109445T DE3574590D1 (en) 1984-07-27 1985-07-26 Cough-relieving and mucus-regulating 2-substituted thiazoles.
AT85109445T ATE48421T1 (en) 1984-07-27 1985-07-26 COUGH SUPPRESSION AND MURPH REGULATOR 2-SUBSTITUTED THIAZOLE.
ES545575A ES8605249A1 (en) 1984-07-27 1985-07-26 Antitussive and mucus regulating 2-substituted thiazolidines.
IE187985A IE58518B1 (en) 1984-07-27 1985-07-26 Antitussive and mucus regulating 2-substituted thiazolidines
JP60166620A JPS6163669A (en) 1984-07-27 1985-07-26 2-substituted thiazolidine, manufacture and antitussive and mucus regulator containing same
EP85109445A EP0169581B1 (en) 1984-07-27 1985-07-26 Antitussive and mucus regulating 2-substituted thiazolidines
DK341985A DK169474B1 (en) 1984-07-27 1985-07-26 Anti-cough and mucus regulating 2-substituted thiazolidines, processes for their preparation, and pharmaceutical agents containing such
US07/266,559 US4857643A (en) 1984-07-27 1988-11-03 Antitussive and mucus regulating 2-substituted thiazolidines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB08419254A GB2164333B (en) 1984-07-27 1984-07-27 Antitussive and mucus regulating 2-substituted thiazolidines

Publications (3)

Publication Number Publication Date
GB8419254D0 GB8419254D0 (en) 1984-08-30
GB2164333A GB2164333A (en) 1986-03-19
GB2164333B true GB2164333B (en) 1988-11-16

Family

ID=10564581

Family Applications (1)

Application Number Title Priority Date Filing Date
GB08419254A Expired GB2164333B (en) 1984-07-27 1984-07-27 Antitussive and mucus regulating 2-substituted thiazolidines

Country Status (3)

Country Link
US (1) US4798898A (en)
GB (1) GB2164333B (en)
ZA (1) ZA855618B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2177690A (en) * 1985-07-11 1987-01-28 Boehringer Biochemia Srl Antitussive and mucus regulating 2-substituted thiazolidines
IT1228251B (en) * 1987-07-02 1991-06-05 Boehringer Biochemia Srl CYCLIC AMINO-THIOACETAL STARCHES, PROCEDURE FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM
IT1216119B (en) * 1988-03-17 1990-02-22 Boehringer Biochemia Srl BETA_CARBONIL_CARBOSSIAMIDI DI 1,3_TIAZOLIDINE.
US5420289A (en) * 1989-10-27 1995-05-30 American Home Products Corporation Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH540016A (en) * 1971-03-09 1973-08-15 Firmenich & Cie Flavoring composition
US4011233A (en) * 1973-06-28 1977-03-08 Givaudan Corporation 2-methyl-2-(4-methyl-3-pentene-1-yl) thiazolidine
US4430344A (en) * 1978-04-08 1984-02-07 Santen Pharmaceutical Co., Ltd. Antihypertensive 4-thiazolidinecarboxylic acids

Also Published As

Publication number Publication date
US4798898A (en) 1989-01-17
ZA855618B (en) 1986-03-26
GB2164333A (en) 1986-03-19
GB8419254D0 (en) 1984-08-30

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Legal Events

Date Code Title Description
7732 Case decided by the comptroller ** patent revoked (sect. 73(2)/1977)