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GB2028799B - Phenethanolamines - Google Patents

Phenethanolamines

Info

Publication number
GB2028799B
GB2028799B GB7922952A GB7922952A GB2028799B GB 2028799 B GB2028799 B GB 2028799B GB 7922952 A GB7922952 A GB 7922952A GB 7922952 A GB7922952 A GB 7922952A GB 2028799 B GB2028799 B GB 2028799B
Authority
GB
United Kingdom
Prior art keywords
phenethanolamines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB7922952A
Other versions
GB2028799A (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of GB2028799A publication Critical patent/GB2028799A/en
Application granted granted Critical
Publication of GB2028799B publication Critical patent/GB2028799B/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00Preparation of carboxylic acid nitriles
    • C07C253/06Preparation of carboxylic acid nitriles from N-formylated amino compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/24Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
    • C07C243/38Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to carbon atoms of six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/147Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42Separation; Purification; Stabilisation; Use of additives
    • C07C51/487Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D303/00Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02Compounds containing oxirane rings
    • C07D303/04Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Child & Adolescent Psychology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Fodder In General (AREA)
  • Dairy Products (AREA)
GB7922952A 1978-07-03 1979-07-02 Phenethanolamines Expired GB2028799B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US92167078A 1978-07-03 1978-07-03

Publications (2)

Publication Number Publication Date
GB2028799A GB2028799A (en) 1980-03-12
GB2028799B true GB2028799B (en) 1982-09-08

Family

ID=25445792

Family Applications (3)

Application Number Title Priority Date Filing Date
GB08135768A Expired GB2101582B (en) 1978-07-03 1979-07-02 Optically active 1-alkyl-3-(4-substituted-phenyl)-propylamines.
GB7922952A Expired GB2028799B (en) 1978-07-03 1979-07-02 Phenethanolamines
GB7922955A Expired GB2028802B (en) 1978-07-03 1979-07-02 Phenethanolamines

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB08135768A Expired GB2101582B (en) 1978-07-03 1979-07-02 Optically active 1-alkyl-3-(4-substituted-phenyl)-propylamines.

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB7922955A Expired GB2028802B (en) 1978-07-03 1979-07-02 Phenethanolamines

Country Status (31)

Country Link
EP (3) EP0006766B1 (en)
JP (2) JPS559097A (en)
KR (1) KR880002310B1 (en)
AR (4) AR225744A1 (en)
AT (2) AT367025B (en)
AU (2) AU523721B2 (en)
BE (2) BE877394A (en)
BG (4) BG31645A3 (en)
CA (2) CA1142954A (en)
CH (2) CH643529A5 (en)
CS (4) CS208663B2 (en)
DD (2) DD144761A5 (en)
DE (2) DE2964091D1 (en)
DK (2) DK160936C (en)
EG (1) EG14238A (en)
ES (4) ES482155A1 (en)
FI (2) FI792082A (en)
FR (3) FR2430411A1 (en)
GB (3) GB2101582B (en)
GR (2) GR74524B (en)
HU (2) HU179172B (en)
IE (2) IE48769B1 (en)
IL (2) IL57672A (en)
LU (2) LU81458A1 (en)
NZ (2) NZ190863A (en)
PH (2) PH14522A (en)
PL (4) PL117551B1 (en)
PT (2) PT69843A (en)
RO (4) RO83051B (en)
SU (4) SU965350A3 (en)
ZA (2) ZA793296B (en)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0006735B1 (en) * 1978-06-28 1983-06-15 Beecham Group Plc Secondary amines, their preparation, pharmaceutical compositions containing them and their use
DE3061693D1 (en) * 1979-10-25 1983-02-24 Beecham Group Plc Secondary amines, their preparation and use in pharmaceutical compositions
EP0029320B1 (en) * 1979-11-15 1985-07-10 Beecham Group Plc Secondary ethanol amines, their preparation and their use in pharmaceutical compositions
DE3161165D1 (en) * 1980-05-08 1983-11-17 Beecham Group Plc Arylethanolamine derivatives, their preparation and use in pharmaceutical compositions
DE3264364D1 (en) * 1981-03-06 1985-08-01 Beecham Group Plc Arylethanol amine derivatives, their preparation and use in pharmaceutical compositions
EP0061907B1 (en) * 1981-03-31 1984-08-01 Beecham Group Plc Secondary amines, their preparation, pharmaceutical compositions containing them and their use
EP0070133B1 (en) * 1981-07-11 1986-05-14 Beecham Group Plc Secondary phenylethanol amines, processes for their preparation and their pharmaceutical application
EP0089154A3 (en) * 1982-03-12 1984-08-08 Beecham Group Plc Ethanolamine derivatives, their preparation and use in pharmaceutical compositions
CA1219865A (en) * 1982-05-14 1987-03-31 Leo Alig Aziridine phenethanolamine derivatives
CA1258454A (en) * 1982-08-10 1989-08-15 Leo Alig Phenethanolamines
IL69788A (en) * 1982-09-27 1987-01-30 Lilly Co Eli Process for preparing 2-hydroxy-2-phenylethylamines,and novel silylated intermediates therefor
CA1247451A (en) * 1983-01-31 1988-12-28 David B. Anderson Phenethanolamines
US5166218A (en) * 1983-10-19 1992-11-24 Hoffmann-La Roche Inc. Phenoxypropanolamines and pharmaceutical compositions thereof
CA1262729A (en) * 1983-10-19 1989-11-07 Leo Alig Phenoxypropanolamines
US4602044A (en) * 1983-12-19 1986-07-22 Eli Lilly And Company β-phenethanolamine antiobesity agents
EP0151513A1 (en) * 1984-01-12 1985-08-14 Eli Lilly And Company Inotropic agent
GB8505284D0 (en) * 1985-03-01 1985-04-03 Beecham Group Plc Growth promoters
ES8800842A1 (en) * 1985-03-01 1987-12-01 Beecham Group Plc Ethanolamine derivatives for administering to livestock.
IT1204416B (en) * 1986-06-27 1989-03-01 Midy Spa PHENYLETHANOLAMINE ANALOGUE-BASED DRUGS FOR THE TREATMENT OF GASTRO-INTESTINAL AND UTERINE DISORDERS
JP2837408B2 (en) * 1987-05-30 1998-12-16 鐘紡株式会社 Acrylic fiber treatment method
US5135955A (en) * 1988-04-25 1992-08-04 Eli Lilly And Company Propanamine derivatives
FI892341A (en) * 1988-06-10 1989-12-11 Hoffmann La Roche PROPANOLAMINDERIVAT.
US5191112A (en) * 1989-10-17 1993-03-02 Nissan Chemical Industries, Ltd. Process for optical resolution of (±)-2-(3-benzoyl)-phenylpropionic acid
US6313146B1 (en) 1991-08-23 2001-11-06 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US6031003A (en) * 1991-08-23 2000-02-29 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US5688938A (en) * 1991-08-23 1997-11-18 The Brigham & Women's Hospital, Inc. Calcium receptor-active molecules
KR100251995B1 (en) * 1991-08-23 2000-06-01 젠센 제임스 유. Calcium receptor active molecules
US6001884A (en) * 1991-08-23 1999-12-14 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US5763569A (en) * 1991-08-23 1998-06-09 The Brigham And Women's Hospital, Inc Calcium receptor-active molecules
US5858684A (en) * 1991-08-23 1999-01-12 The Brigham And Women's Hospital, Inc. Method of screening calcium receptor-active molecules
US6011068A (en) * 1991-08-23 2000-01-04 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US5321036A (en) * 1993-02-10 1994-06-14 Bristol-Myers Squibb Company Thiazole and oxazole-based β3 adrenergic receptor agonists
US5962314A (en) * 1993-02-23 1999-10-05 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
KR100403094B1 (en) 1994-10-21 2003-11-13 엔피에스 파마슈티칼즈, 인코포레이티드 Calcium receptor-active compounds
ATE352537T1 (en) * 1996-05-01 2007-02-15 Nps Pharma Inc COMPOUNDS ACTING ON INORGANIC ION RECEPTORS
US7321065B2 (en) * 2003-04-18 2008-01-22 The Regents Of The University Of California Thyronamine derivatives and analogs and methods of use thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL56308C (en) * 1941-03-15
GB1200886A (en) * 1966-09-23 1970-08-05 Allen & Hanburys Ltd Phenylaminoethanol derivatives
GB1301134A (en) 1970-07-18 1972-12-29 Pfizer Ltd SUBSTITUTED 1-PHENYL-2-ALLYLAMINO-ALKANOLS, 1-PHENYL-2-ALLYLAMINO-ALKANES AND alpha-AMINOALKYLPHENYL KETONES
BE788850A (en) * 1972-09-15 1973-03-15 Hoffmann La Roche BENZOIC ACID DERIVATIVES
US4000192A (en) * 1973-05-07 1976-12-28 Allen & Hanburys Limited Pharmacologically active compounds
IE39247B1 (en) * 1973-05-07 1978-08-30 Allen & Hanburys Ltd Substituted benzamides
NZ190854A (en) * 1978-06-28 1984-10-19 Beecham Group Ltd 2-hydroxy-2-phenyl ethylamine derivatives;pharmaceutical compositions
IL57673A0 (en) * 1978-07-03 1979-10-31 Lilly Co Eli Optically active phenethanolamines and method for increasing cardiac contractility

Also Published As

Publication number Publication date
RO83052A (en) 1984-02-21
GB2101582B (en) 1983-06-08
LU81458A1 (en) 1979-10-30
EP0006766B1 (en) 1983-01-26
ES8104189A1 (en) 1981-04-16
EG14238A (en) 1983-12-31
RO83051B (en) 1984-02-28
PH14522A (en) 1981-08-26
FR2430410B1 (en) 1986-03-21
AU4848779A (en) 1980-01-10
ATA463679A (en) 1981-10-15
EP0007204A1 (en) 1980-01-23
JPS559096A (en) 1980-01-22
JPS559097A (en) 1980-01-22
HU179172B (en) 1982-08-28
DD144761A5 (en) 1980-11-05
GB2028799A (en) 1980-03-12
AR231434A1 (en) 1984-11-30
BG31646A3 (en) 1982-02-15
IL57672A0 (en) 1979-10-31
CA1142954A (en) 1983-03-15
SU849997A3 (en) 1981-07-23
RO83052B (en) 1984-02-28
PL216814A1 (en) 1980-03-24
CS208662B2 (en) 1981-09-15
KR880002310B1 (en) 1988-10-22
IE791228L (en) 1980-01-03
ZA793296B (en) 1981-02-25
DE2964091D1 (en) 1982-12-30
ZA793297B (en) 1981-02-25
ES490215A0 (en) 1981-04-16
HU179171B (en) 1982-08-28
FR2450806A1 (en) 1980-10-03
GR74524B (en) 1984-06-29
DE2964604D1 (en) 1983-03-03
FR2430411A1 (en) 1980-02-01
FR2430410A1 (en) 1980-02-01
EP0007204B1 (en) 1982-11-24
SU965350A3 (en) 1982-10-07
ATA463579A (en) 1983-04-15
CS208663B2 (en) 1981-09-15
KR830001187A (en) 1983-04-29
IL57671A (en) 1982-11-30
EP0048037A1 (en) 1982-03-24
AR227165A1 (en) 1982-09-30
CS209815B2 (en) 1981-12-31
DK268679A (en) 1980-01-04
PL117997B1 (en) 1981-09-30
BG31375A3 (en) 1981-12-15
AR225744A1 (en) 1982-04-30
CS208664B2 (en) 1981-09-15
FI792082A (en) 1980-01-04
FR2450806B1 (en) 1985-07-12
SU1007554A3 (en) 1983-03-23
PH15275A (en) 1982-11-02
PL117996B1 (en) 1981-09-30
AR229080A1 (en) 1983-06-15
BE877394A (en) 1980-01-02
IE791227L (en) 1980-01-03
GB2101582A (en) 1983-01-19
GB2028802B (en) 1983-03-30
JPS6254095B2 (en) 1987-11-13
BG31647A3 (en) 1982-02-15
AU4848979A (en) 1980-01-10
GB2028802A (en) 1980-03-12
CH643529A5 (en) 1984-06-15
DK160936C (en) 1991-10-21
GR72940B (en) 1984-01-16
IE48769B1 (en) 1985-05-15
BE877393A (en) 1980-01-02
SU957761A3 (en) 1982-09-07
FI792081A (en) 1980-01-04
IE48586B1 (en) 1985-03-20
PT69843A (en) 1979-07-01
ES490214A0 (en) 1981-04-16
BG31645A3 (en) 1982-02-15
CH642618A5 (en) 1984-04-30
ES482156A1 (en) 1980-08-16
AU523721B2 (en) 1982-08-12
FR2430411B1 (en) 1983-08-19
AU523720B2 (en) 1982-08-12
RO77732A (en) 1981-11-24
LU81457A1 (en) 1979-10-30
CA1145767A (en) 1983-05-03
IL57672A (en) 1983-03-31
ES482155A1 (en) 1980-08-16
PL117551B1 (en) 1981-08-31
NZ190863A (en) 1982-05-25
AT367025B (en) 1982-05-25
RO77728A (en) 1981-11-24
IL57671A0 (en) 1979-10-31
AT372937B (en) 1983-11-25
DD144762A5 (en) 1980-11-05
PL121297B1 (en) 1982-04-30
EP0006766A1 (en) 1980-01-09
ES8104190A1 (en) 1981-04-16
PL216811A1 (en) 1980-08-25
PT69839A (en) 1979-07-01
DK160936B (en) 1991-05-06
DK268779A (en) 1980-01-04
NZ190861A (en) 1981-12-15
RO83051A (en) 1984-02-21

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Legal Events

Date Code Title Description
7732 Case decided by the comptroller ** patent revoked (sect. 73(2)/1977)