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GB201504223D0 - Biallelic genetic modification - Google Patents

Biallelic genetic modification

Info

Publication number
GB201504223D0
GB201504223D0 GB201504223A GB201504223A GB201504223D0 GB 201504223 D0 GB201504223 D0 GB 201504223D0 GB 201504223 A GB201504223 A GB 201504223A GB 201504223 A GB201504223 A GB 201504223A GB 201504223 D0 GB201504223 D0 GB 201504223D0
Authority
GB
United Kingdom
Prior art keywords
genetic modification
biallelic genetic
biallelic
modification
genetic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GB201504223A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genome Research Ltd
Original Assignee
Genome Research Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genome Research Ltd filed Critical Genome Research Ltd
Priority to GB201504223A priority Critical patent/GB201504223D0/en
Publication of GB201504223D0 publication Critical patent/GB201504223D0/en
Priority to PCT/GB2016/050686 priority patent/WO2016142719A1/en
Ceased legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90Stable introduction of foreign DNA into chromosome
    • C12N15/902Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
GB201504223A 2015-03-12 2015-03-12 Biallelic genetic modification Ceased GB201504223D0 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB201504223A GB201504223D0 (en) 2015-03-12 2015-03-12 Biallelic genetic modification
PCT/GB2016/050686 WO2016142719A1 (en) 2015-03-12 2016-03-11 Biallelic genetic modification

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB201504223A GB201504223D0 (en) 2015-03-12 2015-03-12 Biallelic genetic modification

Publications (1)

Publication Number Publication Date
GB201504223D0 true GB201504223D0 (en) 2015-04-29

Family

ID=53016040

Family Applications (1)

Application Number Title Priority Date Filing Date
GB201504223A Ceased GB201504223D0 (en) 2015-03-12 2015-03-12 Biallelic genetic modification

Country Status (2)

Country Link
GB (1) GB201504223D0 (en)
WO (1) WO2016142719A1 (en)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2734621B1 (en) 2011-07-22 2019-09-04 President and Fellows of Harvard College Evaluation and improvement of nuclease cleavage specificity
HUE056903T2 (en) 2013-04-16 2022-04-28 Regeneron Pharma Targeted modification of rat genome
US20150044192A1 (en) 2013-08-09 2015-02-12 President And Fellows Of Harvard College Methods for identifying a target site of a cas9 nuclease
US9359599B2 (en) 2013-08-22 2016-06-07 President And Fellows Of Harvard College Engineered transcription activator-like effector (TALE) domains and uses thereof
US9526784B2 (en) 2013-09-06 2016-12-27 President And Fellows Of Harvard College Delivery system for functional nucleases
US9322037B2 (en) 2013-09-06 2016-04-26 President And Fellows Of Harvard College Cas9-FokI fusion proteins and uses thereof
US9228207B2 (en) 2013-09-06 2016-01-05 President And Fellows Of Harvard College Switchable gRNAs comprising aptamers
WO2015088643A1 (en) 2013-12-11 2015-06-18 Regeneron Pharmaceuticals, Inc. Methods and compositions for the targeted modification of a genome
US20150166985A1 (en) 2013-12-12 2015-06-18 President And Fellows Of Harvard College Methods for correcting von willebrand factor point mutations
PT3152312T (en) 2014-06-06 2020-04-23 Regeneron Pharma Methods and compositions for modifying a targeted locus
AU2015298571B2 (en) 2014-07-30 2020-09-03 President And Fellows Of Harvard College Cas9 proteins including ligand-dependent inteins
AU2015330699B2 (en) 2014-10-10 2021-12-02 Editas Medicine, Inc. Compositions and methods for promoting homology directed repair
SG11201702309RA (en) 2014-10-15 2017-04-27 Regeneron Pharma Methods and compositions for generating or maintaining pluripotent cells
AU2015342749B2 (en) 2014-11-07 2022-01-27 Editas Medicine, Inc. Methods for improving CRISPR/Cas-mediated genome-editing
CA3176380A1 (en) 2014-11-21 2016-05-26 Regeneron Pharmaceuticals, Inc. Methods and compositions for targeted genetic modification using paired guide rnas
AU2016326711B2 (en) 2015-09-24 2022-11-03 Editas Medicine, Inc. Use of exonucleases to improve CRISPR/Cas-mediated genome editing
EP3365357B1 (en) 2015-10-23 2024-02-14 President and Fellows of Harvard College Evolved cas9 proteins for gene editing
WO2017165826A1 (en) 2016-03-25 2017-09-28 Editas Medicine, Inc. Genome editing systems comprising repair-modulating enzyme molecules and methods of their use
US11236313B2 (en) 2016-04-13 2022-02-01 Editas Medicine, Inc. Cas9 fusion molecules, gene editing systems, and methods of use thereof
EP3457840B1 (en) 2016-05-20 2024-04-10 Regeneron Pharmaceuticals, Inc. Methods for breaking immunological tolerance using multiple guide rnas
BR112018074494A2 (en) 2016-06-01 2019-03-19 Kws Saat Se & Co Kgaa hybrid nucleic acid sequences for genomic engineering
CA3032699A1 (en) 2016-08-03 2018-02-08 President And Fellows Of Harvard College Adenosine nucleobase editors and uses thereof
US11661590B2 (en) 2016-08-09 2023-05-30 President And Fellows Of Harvard College Programmable CAS9-recombinase fusion proteins and uses thereof
WO2018039438A1 (en) 2016-08-24 2018-03-01 President And Fellows Of Harvard College Incorporation of unnatural amino acids into proteins using base editing
CA3039928A1 (en) 2016-10-14 2018-04-19 President And Fellows Of Harvard College Aav delivery of nucleobase editors
WO2018119359A1 (en) 2016-12-23 2018-06-28 President And Fellows Of Harvard College Editing of ccr5 receptor gene to protect against hiv infection
AU2018212624A1 (en) * 2017-01-30 2019-08-22 KWS SAAT SE & Co. KGaA Repair template linkage to endonucleases for genome engineering
EP3592853A1 (en) 2017-03-09 2020-01-15 President and Fellows of Harvard College Suppression of pain by gene editing
US11542496B2 (en) 2017-03-10 2023-01-03 President And Fellows Of Harvard College Cytosine to guanine base editor
CA3057192A1 (en) 2017-03-23 2018-09-27 President And Fellows Of Harvard College Nucleobase editors comprising nucleic acid programmable dna binding proteins
WO2018209320A1 (en) 2017-05-12 2018-11-15 President And Fellows Of Harvard College Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation
WO2019014564A1 (en) 2017-07-14 2019-01-17 Editas Medicine, Inc. Systems and methods for targeted integration and genome editing and detection thereof using integrated priming sites
WO2019023680A1 (en) 2017-07-28 2019-01-31 President And Fellows Of Harvard College Methods and compositions for evolving base editors using phage-assisted continuous evolution (pace)
JP7207665B2 (en) 2017-08-04 2023-01-18 北京大学 TALE RVDs that specifically recognize DNA bases modified by methylation and uses thereof
CN111278983A (en) 2017-08-08 2020-06-12 北京大学 gene knockout method
EP3676376B1 (en) 2017-08-30 2025-01-15 President and Fellows of Harvard College High efficiency base editors comprising gam
KR20200121782A (en) 2017-10-16 2020-10-26 더 브로드 인스티튜트, 인코퍼레이티드 Uses of adenosine base editor
CN108048537A (en) * 2017-12-25 2018-05-18 三峡大学 DNA molecular probe and the application detected to miRNA real-time quantitative PCRs in the tumour cell of S1 nucleases
CN110343724B (en) * 2018-04-02 2021-10-12 北京大学 Method for screening and identifying functional lncRNA
EP3797160A1 (en) 2018-05-23 2021-03-31 The Broad Institute Inc. Base editors and uses thereof
US12281338B2 (en) 2018-10-29 2025-04-22 The Broad Institute, Inc. Nucleobase editors comprising GeoCas9 and uses thereof
BR112021018607A2 (en) 2019-03-19 2021-11-23 Massachusetts Inst Technology Methods and compositions for editing nucleotide sequences
CN110564774B (en) * 2019-08-23 2021-10-15 华南农业大学 A method to improve the efficiency of site-directed modification of cellular genome by using modified ssODN
IL297761A (en) 2020-05-08 2022-12-01 Broad Inst Inc Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence
CN116926072B (en) * 2023-05-04 2024-03-08 广州飞来爱生命科技有限公司 Method for inhibiting neural stem cell induced differentiation and application thereof

Also Published As

Publication number Publication date
WO2016142719A1 (en) 2016-09-15

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Legal Events

Date Code Title Description
AT Applications terminated before publication under section 16(1)