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GB201118229D0 - Sensor stabilization by adjusting temperature gradient - Google Patents

Sensor stabilization by adjusting temperature gradient

Info

Publication number
GB201118229D0
GB201118229D0 GBGB1118229.2A GB201118229A GB201118229D0 GB 201118229 D0 GB201118229 D0 GB 201118229D0 GB 201118229 A GB201118229 A GB 201118229A GB 201118229 D0 GB201118229 D0 GB 201118229D0
Authority
GB
United Kingdom
Prior art keywords
temperature gradient
sensor array
fluid
detecting
flow sensors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GBGB1118229.2A
Other versions
GB2495777A (en
GB2495777B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Agilent Technologies Inc
Original Assignee
Agilent Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agilent Technologies Inc filed Critical Agilent Technologies Inc
Priority to GB1118229.2A priority Critical patent/GB2495777B/en
Publication of GB201118229D0 publication Critical patent/GB201118229D0/en
Publication of GB2495777A publication Critical patent/GB2495777A/en
Application granted granted Critical
Publication of GB2495777B publication Critical patent/GB2495777B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F1/00—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow
    • G01F1/68—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow by using thermal effects
    • G01F1/684—Structural arrangements; Mounting of elements, e.g. in relation to fluid flow
    • G01F1/6847—Structural arrangements; Mounting of elements, e.g. in relation to fluid flow where sensing or heating elements are not disturbing the fluid flow, e.g. elements mounted outside the flow duct
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F15/00—Details of, or accessories for, apparatus of groups G01F1/00 - G01F13/00 insofar as such details or appliances are not adapted to particular types of such apparatus
    • G01F15/02—Compensating or correcting for variations in pressure, density or temperature
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F1/00—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow
    • G01F1/68—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow by using thermal effects
    • G01F1/684—Structural arrangements; Mounting of elements, e.g. in relation to fluid flow
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F1/00—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow
    • G01F1/68—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow by using thermal effects
    • G01F1/696—Circuits therefor, e.g. constant-current flow meters
    • G01F1/698—Feedback or rebalancing circuits, e.g. self heated constant temperature flowmeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F1/00—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow
    • G01F1/68—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow by using thermal effects
    • G01F1/696—Circuits therefor, e.g. constant-current flow meters
    • G01F1/698—Feedback or rebalancing circuits, e.g. self heated constant temperature flowmeters
    • G01F1/699—Feedback or rebalancing circuits, e.g. self heated constant temperature flowmeters by control of a separate heating or cooling element
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/34—Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient

Landscapes

  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)

Abstract

A sensor array for a fluid handling system, particularly for controlling the mobile phase drive to a sample separation system such as a high performance liquid chromatography application, wherein the sensor array comprises a plurality of flow sensors 82, 84, 86 each configured for detecting data indicative of a flow of the fluid, a fluid conduit 88 in fluid communication with the plurality of flow sensors 82, 84, 86 and configured for conducting the fluid, a temperature gradient detecting unit comprising temperatures sensors 94, 96 and configured for detecting temperature gradient data indicative of a spatial temperature gradient in the sensor array, and a temperature regulating unit which activates heating units 99, 97 configured to spatially regulate temperature in the sensor array in response to the detected temperature gradient data to thereby stabilize the spatial temperature gradient over time. The flow sensors 82, 84, 86, the heating units 99, 97 and the fluidic conduits 88 may be integrated within a substrate 900.
GB1118229.2A 2011-10-21 2011-10-21 Sensor stabilization by adjusting temperature gradient Active GB2495777B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB1118229.2A GB2495777B (en) 2011-10-21 2011-10-21 Sensor stabilization by adjusting temperature gradient

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1118229.2A GB2495777B (en) 2011-10-21 2011-10-21 Sensor stabilization by adjusting temperature gradient

Publications (3)

Publication Number Publication Date
GB201118229D0 true GB201118229D0 (en) 2011-12-07
GB2495777A GB2495777A (en) 2013-04-24
GB2495777B GB2495777B (en) 2018-10-31

Family

ID=45373245

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1118229.2A Active GB2495777B (en) 2011-10-21 2011-10-21 Sensor stabilization by adjusting temperature gradient

Country Status (1)

Country Link
GB (1) GB2495777B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH709709A1 (en) * 2014-05-30 2015-11-30 Werner Döbelin System configuration for the injection of samples with automatic solid phase extraction with a single binary pump system to operate in the field of HPLC, ultra-, micro- and nano-HPLC.
DE102017125818A1 (en) * 2017-11-06 2019-05-09 Alexander Bozic System for pumping a compressible fluid
JP7070238B2 (en) * 2018-08-22 2022-05-18 株式会社島津製作所 Liquid chromatograph analyzer, mobile phase feeder, liquid chromatograph analysis method and mobile phase supply method
CN116829938A (en) * 2021-02-04 2023-09-29 沃特世科技公司 Thermally controlled low pressure mixing system for liquid chromatography
GB2626601A (en) * 2023-01-30 2024-07-31 Agilent Technologies Inc Analytical device for solvent characterisation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5142907A (en) * 1991-04-17 1992-09-01 Mks Instruments, Inc. Constant temperature gradient fluid mass flow transducer
JPH102773A (en) * 1996-06-19 1998-01-06 Hitachi Ltd Thermal air flowmeter
US6736005B2 (en) * 2002-05-28 2004-05-18 Mcmillan Company High accuracy measuring and control of low fluid flow rates
GB2429785B (en) * 2004-05-21 2009-11-18 Waters Investments Ltd Closed loop flow control of a hplc constant flow pump to enable low-flow operation
JP4836864B2 (en) * 2007-05-16 2011-12-14 日立オートモティブシステムズ株式会社 Thermal flow meter

Also Published As

Publication number Publication date
GB2495777A (en) 2013-04-24
GB2495777B (en) 2018-10-31

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