GB1524036A - Amines - Google Patents
AminesInfo
- Publication number
- GB1524036A GB1524036A GB37073/75A GB3707375A GB1524036A GB 1524036 A GB1524036 A GB 1524036A GB 37073/75 A GB37073/75 A GB 37073/75A GB 3707375 A GB3707375 A GB 3707375A GB 1524036 A GB1524036 A GB 1524036A
- Authority
- GB
- United Kingdom
- Prior art keywords
- propan
- ethylamino
- carbamylphenoxy
- allylphenoxy
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
For the preparation of novel hydroxyamines of the formula (I) <IMAGE> with the radicals as in Patent Claim 1, and of therapeutically acceptable acid addition salts of these compounds, a starting compound of the formula (II) <IMAGE> is used. This is reacted with an amine of the formula (III) <IMAGE> The resulting isomeric mixtures are separated into the pure isomers and the resulting racemates into the optical antipodes. The resulting free bases can be converted into their salts and the resulting salts converted into the corresponding free bases. Preferred compounds prepared are: 1) 1-[2-(4-carbamylphenoxy)ethylamino]-3-(2-allylphenoxy)propan-2-ol, 2) 1-[2-(4-carbamylphenoxy)ethylamino]-3-(2-methoxyethyl)phenoxy-propan-2 -ol, 3) 1-[1-methyl-2-(4-carbamylphenoxy)ethylamino]-3-(2-allyl-phenoxy)propan -2-ol, 4) 1-[1-methyl-2-(2-methylphenoxy)ethylamino]-3-(2-allylphenoxy)-propan-2 -ol, 5) 1-[1-methyl-2-(4-methylphenoxy)ethylamino]-3-(2-allylphenoxy)-propan-2 -ol, 6) 1-[1-methyl-2-(4-carbamylphenoxy)ethylamino]-3-(2-methylisonitrosometh ylphenoxy)propan-2-ol, 7) 1-[2-(4-carbamylphenoxy)ethylamino]-3-(3-allylphenoxy)-propan-2-ol. The compounds have a blocking effect on beta -receptors and can be employed for the treatment of cardiovascular disorders.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE7413789A SE422052B (en) | 1974-11-01 | 1974-11-01 | PROCEDURE FOR PREPARING CERTAIN STATED 1-PHENOXY-2-HYDROXY-3-AMINOPHENYL PROPYL DERIVATIVES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1524036A true GB1524036A (en) | 1978-09-06 |
Family
ID=20322597
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB37073/75A Expired GB1524036A (en) | 1974-11-01 | 1975-09-09 | Amines |
Country Status (24)
| Country | Link |
|---|---|
| JP (1) | JPS51131839A (en) |
| AT (1) | AT344142B (en) |
| AU (1) | AU498770B2 (en) |
| BE (2) | BE835090A (en) |
| CA (1) | CA1093095A (en) |
| CH (3) | CH618417A5 (en) |
| CS (1) | CS189726B2 (en) |
| DD (1) | DD119207A5 (en) |
| DE (1) | DE2531312A1 (en) |
| DK (1) | DK444475A (en) |
| FI (1) | FI752201A (en) |
| FR (1) | FR2289172A1 (en) |
| GB (1) | GB1524036A (en) |
| HK (1) | HK36081A (en) |
| HU (1) | HU172652B (en) |
| IE (1) | IE41652B1 (en) |
| LU (1) | LU73703A1 (en) |
| MY (1) | MY8200085A (en) |
| NL (1) | NL7509548A (en) |
| NO (1) | NO144773C (en) |
| NZ (1) | NZ178313A (en) |
| SE (1) | SE422052B (en) |
| SU (3) | SU906368A3 (en) |
| ZA (2) | ZA754241B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5001161A (en) * | 1984-01-10 | 1991-03-19 | Aktiebolaget Hassle | Pharmaceutical composition comprising metroprolol succinate |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4119718A (en) * | 1977-05-02 | 1978-10-10 | Merck & Co., Inc. | 3-Amino-2-oxy-propoxy-substituted isothiazoles |
| SE7807408L (en) * | 1978-06-30 | 1979-12-31 | Haessle Ab | HEART ACTIVE ASSOCIATIONS |
| DD150456A5 (en) * | 1979-03-01 | 1981-09-02 | Ciba Geigy Ag | PROCESS FOR THE PREPARATION OF DERIVATIVES OF 3-AMINO-1,2-PROPANDIOL |
| DE3125870C2 (en) * | 1980-07-09 | 1994-09-15 | William John Louis | 3-aminopropoxyphenyl derivatives, their preparation and medicaments containing them |
| US4410548A (en) * | 1980-07-09 | 1983-10-18 | Reckitt & Colman Products Limited | Propanolamine derivatives |
| FR2508032A1 (en) * | 1981-06-17 | 1982-12-24 | Delalande Sa | 3-Amino-2-aryloxy-methyl-1-propanol derivs. - are used to treat cardiovascular troubles, esp. angina esp 3-tri:methoxy-cinnamoyl-piperazino- 2-1,4-benzodioxan-5-yl-oxy-methyl cpds. |
| DE3151201A1 (en) * | 1981-12-23 | 1983-07-28 | Beiersdorf Ag, 2000 Hamburg | SUBSTITUTED PHENOXYALKANOLAMINE AND PHENOXYALKANOL-CYCLOALKYLAMINE, METHOD FOR THE PRODUCTION THEREOF, PHARMACEUTICAL PREPARATIONS CONTAINING THESE COMPOUNDS AND INTERMEDIATE PRODUCTS |
| DE3433616A1 (en) * | 1984-08-08 | 1986-02-20 | BBC Aktiengesellschaft Brown, Boveri & Cie., Baden, Aargau | PROTECTIVE DEVICE FOR AN ELECTRICAL NET |
| JPS6341451A (en) * | 1986-08-06 | 1988-02-22 | Nippon Kayaku Co Ltd | Ether derivative and miticidal and insecticidal composition containing said derivative as active component |
| US5321036A (en) * | 1993-02-10 | 1994-06-14 | Bristol-Myers Squibb Company | Thiazole and oxazole-based β3 adrenergic receptor agonists |
-
1974
- 1974-07-02 ZA ZA00754241A patent/ZA754241B/en unknown
- 1974-11-01 SE SE7413789A patent/SE422052B/en unknown
-
1975
- 1975-07-02 ZA ZA00754240A patent/ZA754240B/en unknown
- 1975-07-12 DE DE19752531312 patent/DE2531312A1/en not_active Ceased
- 1975-07-31 FI FI752201A patent/FI752201A/fi not_active Application Discontinuation
- 1975-07-31 AT AT592975A patent/AT344142B/en not_active IP Right Cessation
- 1975-08-04 AU AU83637/75A patent/AU498770B2/en not_active Expired
- 1975-08-06 NO NO752765A patent/NO144773C/en unknown
- 1975-08-06 NZ NZ178313A patent/NZ178313A/en unknown
- 1975-08-08 SU SU752163123A patent/SU906368A3/en active
- 1975-08-08 DD DD187775A patent/DD119207A5/xx unknown
- 1975-08-11 NL NL7509548A patent/NL7509548A/en not_active Application Discontinuation
- 1975-08-14 IE IE1809/75A patent/IE41652B1/en unknown
- 1975-09-09 GB GB37073/75A patent/GB1524036A/en not_active Expired
- 1975-09-16 CH CH1196775A patent/CH618417A5/en not_active IP Right Cessation
- 1975-10-02 DK DK444475A patent/DK444475A/en unknown
- 1975-10-21 FR FR7532204A patent/FR2289172A1/en active Granted
- 1975-10-30 HU HU75HE694A patent/HU172652B/en unknown
- 1975-10-30 CS CS757328A patent/CS189726B2/en unknown
- 1975-10-31 CA CA238,763A patent/CA1093095A/en not_active Expired
- 1975-10-31 BE BE161438A patent/BE835090A/en unknown
- 1975-10-31 LU LU73703A patent/LU73703A1/xx unknown
- 1975-10-31 BE BE161439A patent/BE835091A/en unknown
- 1975-10-31 JP JP50131345A patent/JPS51131839A/en active Pending
-
1976
- 1976-09-03 SU SU762393515A patent/SU637078A3/en active
- 1976-09-03 SU SU762393516A patent/SU625599A3/en active
-
1979
- 1979-08-28 CH CH780979A patent/CH622490A5/en not_active IP Right Cessation
- 1979-08-28 CH CH781079A patent/CH622491A5/en not_active IP Right Cessation
-
1981
- 1981-07-31 HK HK360/81A patent/HK36081A/en unknown
-
1982
- 1982-12-30 MY MY85/82A patent/MY8200085A/en unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5001161A (en) * | 1984-01-10 | 1991-03-19 | Aktiebolaget Hassle | Pharmaceutical composition comprising metroprolol succinate |
Also Published As
| Publication number | Publication date |
|---|---|
| ZA754240B (en) | 1976-06-30 |
| CA1093095A (en) | 1981-01-06 |
| HK36081A (en) | 1981-07-31 |
| BE835091A (en) | 1976-04-30 |
| CS189726B2 (en) | 1979-04-30 |
| ZA754241B (en) | 1976-06-30 |
| SE7413789L (en) | 1976-05-03 |
| CH622491A5 (en) | 1981-04-15 |
| JPS51131839A (en) | 1976-11-16 |
| IE41652B1 (en) | 1980-02-27 |
| NL7509548A (en) | 1976-05-04 |
| ATA592975A (en) | 1977-11-15 |
| SU906368A3 (en) | 1982-02-15 |
| NZ178313A (en) | 1978-06-02 |
| CH622490A5 (en) | 1981-04-15 |
| NO144773C (en) | 1981-11-04 |
| NO144773B (en) | 1981-07-27 |
| SU637078A3 (en) | 1978-12-05 |
| MY8200085A (en) | 1982-12-31 |
| FI752201A (en) | 1976-05-02 |
| SE422052B (en) | 1982-02-15 |
| NO752765L (en) | 1976-05-04 |
| IE41652L (en) | 1976-05-01 |
| DD119207A5 (en) | 1976-04-12 |
| FR2289172A1 (en) | 1976-05-28 |
| LU73703A1 (en) | 1976-08-13 |
| AU8363775A (en) | 1977-02-10 |
| HU172652B (en) | 1977-11-28 |
| DK444475A (en) | 1976-05-02 |
| CH618417A5 (en) | 1980-07-31 |
| AU498770B2 (en) | 1979-03-22 |
| BE835090A (en) | 1976-04-30 |
| FR2289172B1 (en) | 1980-11-21 |
| DE2531312A1 (en) | 1976-05-06 |
| SU625599A3 (en) | 1978-09-25 |
| AT344142B (en) | 1978-07-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |