GB1588639A - 5-(substituted phenyl)-oxazolidinones and sulphur analogues thereof and also a process for their production - Google Patents

5-(substituted phenyl)-oxazolidinones and sulphur analogues thereof and also a process for their production Download PDF

Info

Publication number: GB1588639A
Authority: GB; United Kingdom
Prior art keywords: oxazolidinone; dimethoxyphenyl; methoxyphenyl; radical; substituted
Prior art date: 1976-12-03
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

GB50350/77A

Other languages

English (en)

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bayer Pharma AG

Original Assignee

Schering AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-12-03

Filing date

1977-12-02

Publication date

1981-04-29

1976-12-03 Priority claimed from DE19762655369 external-priority patent/DE2655369A1/de

1977-10-05 Priority claimed from DE19772745320 external-priority patent/DE2745320A1/de

1977-12-02 Application filed by Schering AG filed Critical Schering AG

1981-04-29 Publication of GB1588639A publication Critical patent/GB1588639A/en

Status Expired legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/14—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/16—Sulfur atoms

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Hematology (AREA)
Diabetes (AREA)
Anesthesiology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Dermatology (AREA)
Pulmonology (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

GB50350/77A 1976-12-03 1977-12-02 5-(substituted phenyl)-oxazolidinones and sulphur analogues thereof and also a process for their production Expired GB1588639A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19762655369 DE2655369A1 (de)	1976-12-03	1976-12-03	5-(subst. phenyl)-oxazolidinone und deren schwefelanaloga sowie verfahren zu deren herstellung
DE19772745320 DE2745320A1 (de)	1977-10-05	1977-10-05	5-(subst. phenyl)-oxazolidinone und deren schwefelanaloga sowie verfahren zu deren herstellung ii

Publications (1)

Publication Number	Publication Date
GB1588639A true GB1588639A (en)	1981-04-29

Family

ID=25771221

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GB50350/77A Expired GB1588639A (en)	1976-12-03	1977-12-02	5-(substituted phenyl)-oxazolidinones and sulphur analogues thereof and also a process for their production

Country Status (19)

Country	Link
JP (1)	JPS5382777A (fr)
AT (1)	AT357529B (fr)
AU (1)	AU519994B2 (fr)
CA (1)	CA1097657A (fr)
CH (1)	CH635578A5 (fr)
CS (1)	CS199694B2 (fr)
DD (1)	DD133667A5 (fr)
DK (1)	DK149850C (fr)
FR (1)	FR2372814A1 (fr)
GB (1)	GB1588639A (fr)
GR (1)	GR64964B (fr)
HU (1)	HU175676B (fr)
IE (1)	IE46435B1 (fr)
IL (1)	IL53520A (fr)
IT (1)	IT1089341B (fr)
LU (1)	LU78616A1 (fr)
NL (1)	NL7713153A (fr)
SE (1)	SE441446B (fr)
SU (1)	SU888821A3 (fr)

Cited By (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2923295A1 (de) *	1978-06-09	1979-12-13	Delalande Sa	Neue n-aryl-oxazolidinone, -oxazolidinthione, -pyrrolidinone, -pyrrolidine und -thiazolidinone, verfahren zu ihrer herstellung und solche verbindungen enthaltende arzneimittel
EP0247725A2 (fr) *	1986-04-29	1987-12-02	Pfizer Inc.	Camp phosphodiestrerase inhibiteur antidépresseur indépendant de calcium
EP0428313A2 (fr) *	1989-11-13	1991-05-22	Pfizer Inc.	Dérivés et analogues de pyrimidone dans le traitement de l'asthme et certains désordres de la peau
US5414127A (en) *	1988-01-19	1995-05-09	Pfizer Inc.	Calcium independent camp phosphodiesterase inhibitor antidepressant
US5461056A (en) *	1992-05-08	1995-10-24	Pfizer Inc.	Pyrimidone derivatives and analogs in the treatment of asthma or certain skin disorders
US5491147A (en) *	1992-10-23	1996-02-13	Celltech, Limited	Tri-substituted phenyl derivatives and their use in pharmaceutical compositions and methods of treatment
US5580888A (en) *	1992-12-23	1996-12-03	Celltech Therapeutics Limited	Styryl derivatives as anti-inflammatory agents
US5608070A (en) *	1993-12-22	1997-03-04	Celltech Therapeutics Limited	Enantioselective process for the preparation of chiral triaryl derivatives and chiral intermediates for use therein
US5622977A (en) *	1992-12-23	1997-04-22	Celltech Therapeutics Limited	Tri-substituted (aryl or heteroaryl) derivatives and pharmaceutical compositions containing the same
US5633257A (en) *	1993-03-10	1997-05-27	Celltech Therapeutics Limited	Cyclo(alkyl and alkenyl)phenyl-alkenylyl(aryl and heteroaryl)compounds and pharmaceutical compositions containing them
US5693659A (en) *	1994-06-23	1997-12-02	Celltech Therapeutics Limited	Substituted oxime derivatives and processes for their preparation
US5739144A (en) *	1993-03-10	1998-04-14	Celltech Therapeutics Limited	Trisubstituted phenyl derivatives
US5780477A (en) *	1994-06-22	1998-07-14	Celltech Therapeutics, Limited	Trisubstituted phenyl derivatives and processes for their preparation
US5780478A (en) *	1994-06-22	1998-07-14	Celltech Therapeutics, Limited	Tetra-substituted phenyl derivatives
US5786354A (en) *	1994-06-21	1998-07-28	Celltech Therapeutics, Limited	Tri-substituted phenyl derivatives and processes for their preparation
US5798373A (en) *	1995-12-21	1998-08-25	Celltech Therapeutics, Limited	Tri-substituted phenyl derivatives useful as PDE IV inhibitors
US5849770A (en) *	1995-12-21	1998-12-15	Celltech Therapeutics Ltd.	Tri-substituted phenyl derivatives useful as PDE IV inhibitors
US5859034A (en) *	1996-12-04	1999-01-12	Celltech Therapeutics, Limited	Tri-substituted phenyl compounds which have useful pharmaceutical activity
US5866593A (en) *	1993-12-22	1999-02-02	Celltech Therapeutics Ltd.	Trisubstituted phenyl derivatives and processes for their preparation
US5922741A (en) *	1996-04-24	1999-07-13	Celltech Therapeutics Ltd.	5-aminopyrazoles useful as tyrosine kinase inhibitors
US5958935A (en) *	1995-11-20	1999-09-28	Celltech Therapeutics Limited	Substituted 2-anilinopyrimidines useful as protein kinase inhibitors
US6048866A (en) *	1997-03-14	2000-04-11	Celltech Therapeutics, Limited	Substituted 2-anilinopryimidines useful as protein kinase inhibitors
US6057329A (en) *	1996-12-23	2000-05-02	Celltech Therapeutics Limited	Fused polycyclic 2-aminopyrimidine derivatives
US6093716A (en) *	1996-09-16	2000-07-25	Celltech Therapeutics, Limited	Substituted 2-pyrimidineamines and processes for their preparation
US6096747A (en) *	1992-06-15	2000-08-01	Celltech Therapeutics Limited	Phenylaminocarbonyl derivatives and processes for their preparation
US6114333A (en) *	1996-10-28	2000-09-05	Celltech Therapeutics Ltd.	2-Pyrimidineamine derivatives and processes for their preparation
US6133257A (en) *	1997-06-20	2000-10-17	Celltech Therapeutics Limited	Fused polycyclic 2-aminopyrimidine derivatives
US6245774B1 (en)	1994-06-21	2001-06-12	Celltech Therapeutics Limited	Tri-substituted phenyl or pyridine derivatives
US6579983B1 (en)	1999-06-18	2003-06-17	Celltech R&D Limited	5-cyano-2-aminopyrimidine derivatives
US6600037B1 (en)	1999-10-20	2003-07-29	Celltech R & D Limited	4,5-disubstituted-2-aminopyrimidines

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2701215C2 (de) *	1977-01-13	1982-10-14	Bayer Ag, 5090 Leverkusen	Verfahren zur Herstellung von Thiazolin-2-thionen
DE3438839A1 (de) *	1984-10-19	1986-04-24	Schering AG, 1000 Berlin und 4709 Bergkamen	Pharmazeutische praeparate
JPH01135098U (fr) *	1988-03-11	1989-09-14

1977
- 1977-11-28 SU SU772546252A patent/SU888821A3/ru active
- 1977-11-29 NL NL7713153A patent/NL7713153A/xx not_active Application Discontinuation
- 1977-12-01 LU LU78616A patent/LU78616A1/xx unknown
- 1977-12-01 DD DD7700202354A patent/DD133667A5/xx unknown
- 1977-12-01 SE SE7713635A patent/SE441446B/xx not_active IP Right Cessation
- 1977-12-01 IT IT30254/77A patent/IT1089341B/it active
- 1977-12-02 GR GR54913A patent/GR64964B/el unknown
- 1977-12-02 CA CA292,273A patent/CA1097657A/fr not_active Expired
- 1977-12-02 AU AU31175/77A patent/AU519994B2/en not_active Expired
- 1977-12-02 GB GB50350/77A patent/GB1588639A/en not_active Expired
- 1977-12-02 IL IL53520A patent/IL53520A/xx unknown
- 1977-12-02 DK DK536677A patent/DK149850C/da not_active IP Right Cessation
- 1977-12-02 CH CH1477977A patent/CH635578A5/de not_active IP Right Cessation
- 1977-12-02 IE IE2446/77A patent/IE46435B1/en not_active IP Right Cessation
- 1977-12-02 HU HU77SCHE632A patent/HU175676B/hu not_active IP Right Cessation
- 1977-12-02 JP JP14492277A patent/JPS5382777A/ja active Granted
- 1977-12-05 AT AT868677A patent/AT357529B/de not_active IP Right Cessation
- 1977-12-05 FR FR7736525A patent/FR2372814A1/fr active Granted
- 1977-12-05 CS CS778086A patent/CS199694B2/cs unknown

Cited By (47)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2923295A1 (de) *	1978-06-09	1979-12-13	Delalande Sa	Neue n-aryl-oxazolidinone, -oxazolidinthione, -pyrrolidinone, -pyrrolidine und -thiazolidinone, verfahren zu ihrer herstellung und solche verbindungen enthaltende arzneimittel
EP0247725A2 (fr) *	1986-04-29	1987-12-02	Pfizer Inc.	Camp phosphodiestrerase inhibiteur antidépresseur indépendant de calcium
AU576448B2 (en) *	1986-04-29	1988-08-25	Pfizer Inc.	Calcium independent camp phosphodiesterase inhibitor antidepressant
EP0247725A3 (en) *	1986-04-29	1990-01-17	Pfizer Inc.	Calcium independent camp phosphodiestrerase inhibitor antidepressant
US5414127A (en) *	1988-01-19	1995-05-09	Pfizer Inc.	Calcium independent camp phosphodiesterase inhibitor antidepressant
US5459145A (en) *	1988-01-19	1995-10-17	Pfizer Inc.	Calcium independent camp phosphodiesterase inhibitor antidepressant
US5342842A (en) *	1989-11-13	1994-08-30	Pfizer Inc.	Pyrimidone derivatives and analogs in the treatment of asthma or certain skin disorders
EP0428313A3 (en) *	1989-11-13	1991-11-06	Pfizer Inc.	Pyrimidone derivatives and analogs in the treatment of asthma or certain skin disorders
EP0428313A2 (fr) *	1989-11-13	1991-05-22	Pfizer Inc.	Dérivés et analogues de pyrimidone dans le traitement de l'asthme et certains désordres de la peau
US5461056A (en) *	1992-05-08	1995-10-24	Pfizer Inc.	Pyrimidone derivatives and analogs in the treatment of asthma or certain skin disorders
US6096747A (en) *	1992-06-15	2000-08-01	Celltech Therapeutics Limited	Phenylaminocarbonyl derivatives and processes for their preparation
US5674880A (en) *	1992-10-23	1997-10-07	Celltech Therapeutics Limited	Tri-substituted phenyl derivatives and processes for their preparation
US5491147A (en) *	1992-10-23	1996-02-13	Celltech, Limited	Tri-substituted phenyl derivatives and their use in pharmaceutical compositions and methods of treatment
US6080790A (en) *	1992-10-23	2000-06-27	Celltech Therapeutics, Limited	Tri-substituted phenyl derivatives and processes for their preparations
US5580888A (en) *	1992-12-23	1996-12-03	Celltech Therapeutics Limited	Styryl derivatives as anti-inflammatory agents
US5622977A (en) *	1992-12-23	1997-04-22	Celltech Therapeutics Limited	Tri-substituted (aryl or heteroaryl) derivatives and pharmaceutical compositions containing the same
US5962492A (en) *	1993-03-10	1999-10-05	Celltech Therapeutics Limited	2 cyclo(alkyl and alkenyl) phenyl-alkenylyl heteroaryl compounds and pharmaceutical compositions containing same
US5723460A (en) *	1993-03-10	1998-03-03	Celltech Therapeutics Limited	Cyclo (alkyl and alkenyl) phenyl-alkenylyl heteroaryl compounds and pharmaceutical compositions containing same
US5739144A (en) *	1993-03-10	1998-04-14	Celltech Therapeutics Limited	Trisubstituted phenyl derivatives
US5962483A (en) *	1993-03-10	1999-10-05	Celltech Therapeutics, Limited	Trisubstituted phenyl derivatives and processes for their preparation
US5633257A (en) *	1993-03-10	1997-05-27	Celltech Therapeutics Limited	Cyclo(alkyl and alkenyl)phenyl-alkenylyl(aryl and heteroaryl)compounds and pharmaceutical compositions containing them
US5608070A (en) *	1993-12-22	1997-03-04	Celltech Therapeutics Limited	Enantioselective process for the preparation of chiral triaryl derivatives and chiral intermediates for use therein
US5866593A (en) *	1993-12-22	1999-02-02	Celltech Therapeutics Ltd.	Trisubstituted phenyl derivatives and processes for their preparation
US6077854A (en) *	1994-06-21	2000-06-20	Celltech Therapeutics, Limited	Tri-substituted phenyl derivatives and processes for their preparation
US5786354A (en) *	1994-06-21	1998-07-28	Celltech Therapeutics, Limited	Tri-substituted phenyl derivatives and processes for their preparation
US6245774B1 (en)	1994-06-21	2001-06-12	Celltech Therapeutics Limited	Tri-substituted phenyl or pyridine derivatives
US5780477A (en) *	1994-06-22	1998-07-14	Celltech Therapeutics, Limited	Trisubstituted phenyl derivatives and processes for their preparation
US6297264B1 (en)	1994-06-22	2001-10-02	Celltech Therapeutics Limited	Trisubstituted phenyl derivatives and process for their preparation
US6197792B1 (en)	1994-06-22	2001-03-06	Celltech Therapeutics Limited	Tetra-substituted phenyl derivatives and processes for their preparation
US5780478A (en) *	1994-06-22	1998-07-14	Celltech Therapeutics, Limited	Tetra-substituted phenyl derivatives
US5693659A (en) *	1994-06-23	1997-12-02	Celltech Therapeutics Limited	Substituted oxime derivatives and processes for their preparation
US5958935A (en) *	1995-11-20	1999-09-28	Celltech Therapeutics Limited	Substituted 2-anilinopyrimidines useful as protein kinase inhibitors
US6235746B1 (en)	1995-11-20	2001-05-22	Celltech Therapeutics, Limited	Substituted 2-anilinopyrimidines useful as protein kinase inhibitors
US5849770A (en) *	1995-12-21	1998-12-15	Celltech Therapeutics Ltd.	Tri-substituted phenyl derivatives useful as PDE IV inhibitors
US5798373A (en) *	1995-12-21	1998-08-25	Celltech Therapeutics, Limited	Tri-substituted phenyl derivatives useful as PDE IV inhibitors
US5922741A (en) *	1996-04-24	1999-07-13	Celltech Therapeutics Ltd.	5-aminopyrazoles useful as tyrosine kinase inhibitors
US6093716A (en) *	1996-09-16	2000-07-25	Celltech Therapeutics, Limited	Substituted 2-pyrimidineamines and processes for their preparation
US6552029B1 (en)	1996-10-28	2003-04-22	Celltech R&D Limited	2-pyrimidineamine derivatives and processes for their preparation
US6114333A (en) *	1996-10-28	2000-09-05	Celltech Therapeutics Ltd.	2-Pyrimidineamine derivatives and processes for their preparation
US5859034A (en) *	1996-12-04	1999-01-12	Celltech Therapeutics, Limited	Tri-substituted phenyl compounds which have useful pharmaceutical activity
US6057329A (en) *	1996-12-23	2000-05-02	Celltech Therapeutics Limited	Fused polycyclic 2-aminopyrimidine derivatives
US6599908B1 (en)	1996-12-23	2003-07-29	Celltech R & D Limited	Fused polycyclic 2-aminopyrimidine derivatives
US6048866A (en) *	1997-03-14	2000-04-11	Celltech Therapeutics, Limited	Substituted 2-anilinopryimidines useful as protein kinase inhibitors
US6337335B1 (en)	1997-03-14	2002-01-08	Celltech Therapeutics Limited	Substituted 2-anilinopyrimidines useful as protein kinase inhibitors
US6133257A (en) *	1997-06-20	2000-10-17	Celltech Therapeutics Limited	Fused polycyclic 2-aminopyrimidine derivatives
US6579983B1 (en)	1999-06-18	2003-06-17	Celltech R&D Limited	5-cyano-2-aminopyrimidine derivatives
US6600037B1 (en)	1999-10-20	2003-07-29	Celltech R & D Limited	4,5-disubstituted-2-aminopyrimidines

Also Published As

Publication number	Publication date
CH635578A5 (en)	1983-04-15
CA1097657A (fr)	1981-03-17
ATA868677A (de)	1979-12-15
JPS6154792B2 (fr)	1986-11-25
AT357529B (de)	1980-07-10
IL53520A0 (en)	1978-03-10
DK536677A (da)	1978-06-04
AU519994B2 (en)	1982-01-07
IE46435B1 (en)	1983-06-15
IL53520A (en)	1981-07-31
DK149850B (da)	1986-10-13
LU78616A1 (fr)	1978-04-20
CS199694B2 (en)	1980-07-31
FR2372814B1 (fr)	1980-10-10
NL7713153A (nl)	1978-06-06
IE772446L (en)	1978-06-03
GR64964B (en)	1980-06-10
SE7713635L (sv)	1978-06-04
HU175676B (hu)	1980-09-28
FR2372814A1 (fr)	1978-06-30
IT1089341B (it)	1985-06-18
DK149850C (da)	1987-04-27
JPS5382777A (en)	1978-07-21
AU3117577A (en)	1979-06-07
DD133667A5 (de)	1979-01-17
SU888821A3 (ru)	1981-12-07
SE441446B (sv)	1985-10-07

Publication	Publication Date	Title
GB1588639A (en)	1981-04-29	5-(substituted phenyl)-oxazolidinones and sulphur analogues thereof and also a process for their production
US4186129A (en)	1980-01-29	5-(Substituted phenyl)-oxazolidinones and their sulfur analogs
KR101344989B1 (ko)	2013-12-24	Ｐｐａｒ 작용제 활성을 갖는 유도체
KR0142417B1 (ko)	1998-06-01	3급알킬작용성화된피레라진유도체
CA2212326C (fr)	2008-12-23	Composes de o-carbamyl-(d)-phenylalanilol et procede de preparation correspondant
CA2950807A1 (fr)	2015-12-03	Derive de cycles fusionnes dihydropyrimido a titre d'inhibiteur du vhb
US5318970A (en)	1994-06-07	Isoxazole compounds, pharmaceutically acceptable salts thereof and medical uses thereof
CS225802B2 (en)	1984-02-13	The production of new 4-/polyalkoxyphenoy 1/-2-pyrrolidone
FR2670491A1 (fr)	1992-06-19	Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les renfermant.
US3072653A (en)	1963-01-08	5-amino derivatives of 4-thiazolidinones and process therefor
HU215846B (hu)	1999-04-28	Eljárás aril-glicin-amid-származékok előállítására
FR2744448A1 (fr)	1997-08-08	Nouvelles piperidines derivees d'aryl piperazine, ainsi que leur procede de preparation, les compositions pharmaceutiques et leur utilisation comme medicaments
SK7602002A3 (en)	2003-02-04	Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
EP0005689A1 (fr)	1979-11-28	Nouveaux acides lactame-N-acétiques et leurs amides, leurs procédés de préparation et compositions thérapeutiques
IL91377A (en)	1996-09-12	Derivatives of botinylamine glycolate
EP0494817B1 (fr)	1995-09-06	Dérivés de benzisoxazole et de benzisothiazole, leur procédé de préparation et les compositions pharmaceutiques les renfermant
FR2662695A1 (fr)	1991-12-06	Amino-2 polyfluoroalcoxy-6 benzoselenazoles, leur preparation et les medicaments les contenant.
KR920005827B1 (ko)	1992-07-20	벤조티아디아제핀 유도체
JPS6058747B2 (ja)	1985-12-21	アミノ化合物の製法
ES2930284T3 (es)	2022-12-09	Método para preparar un compuesto de fenilalanina
EP0101380A2 (fr)	1984-02-22	Nicotinamide 1-oxyde N-substitué, ses sels, procédé pour leur préparation et compositions pharmaceutiques en contenant
KR20010005943A (ko)	2001-01-15	0-(3-아미노-2-히드록시-프로필)-히드록심산할라이드의 제조방법
NO170012B (no)	1992-05-25	Analogifremgangsmaate for fremstilling av terapeutisk aktive benzamider
US20040138232A1 (en)	2004-07-15	Acyl derivatives of 5-(2-(4-(1,2 benzisothiazole-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-2h-indol-2-one having neuroleptic activity
KR20110074875A (ko)	2011-07-04	치환된 페닐알라닌의 제조 방법

Legal Events

Date	Code	Title	Description
1981-07-15	PS	Patent sealed [section 19, patents act 1949]
1993-07-28	PCNP	Patent ceased through non-payment of renewal fee	Effective date: 19921202