GB1554395A - Method for producing maytansinol and its derivatives - Google Patents
Method for producing maytansinol and its derivativesInfo
- Publication number
- GB1554395A GB1554395A GB42821/77A GB4282177A GB1554395A GB 1554395 A GB1554395 A GB 1554395A GB 42821/77 A GB42821/77 A GB 42821/77A GB 4282177 A GB4282177 A GB 4282177A GB 1554395 A GB1554395 A GB 1554395A
- Authority
- GB
- United Kingdom
- Prior art keywords
- maytansinol
- maytanacin
- derivatives
- propionate
- useful
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- QWPXBEHQFHACTK-KZVYIGENSA-N (10e,12e)-86-chloro-12,14,4-trihydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-15,16-dihydro-14h-7-aza-1(6,4)-oxazina-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-6-one Chemical compound CN1C(=O)CC(O)C2(C)OC2C(C)C(OC(=O)N2)CC2(O)C(OC)\C=C\C=C(C)\CC2=CC(OC)=C(Cl)C1=C2 QWPXBEHQFHACTK-KZVYIGENSA-N 0.000 title abstract 4
- QWPXBEHQFHACTK-UHFFFAOYSA-N Maytansinol Natural products CN1C(=O)CC(O)C2(C)OC2C(C)C(OC(=O)N2)CC2(O)C(OC)C=CC=C(C)CC2=CC(OC)=C(Cl)C1=C2 QWPXBEHQFHACTK-UHFFFAOYSA-N 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title 1
- MQYZCKOGTWYJAZ-UHFFFAOYSA-N ansamitocin P1 Natural products CN1C(=O)CC(OC(C)=O)C2(C)OC2C(C)C(OC(=O)N2)CC2(O)C(OC)C=CC=C(C)CC2=CC(OC)=C(Cl)C1=C2 MQYZCKOGTWYJAZ-UHFFFAOYSA-N 0.000 abstract 3
- DGBBXVWXOHSLTG-UMDRASRXSA-N ansamitocin p 2 Chemical compound C([C@@H]([C@@]1(O[C@H]1[C@@H]1C)C)OC(=O)CC)C(=O)N(C)C(C(=C(OC)C=2)Cl)=CC=2C\C(C)=C\C=C\[C@@H](OC)[C@]2(O)NC(=O)O[C@H]1C2 DGBBXVWXOHSLTG-UMDRASRXSA-N 0.000 abstract 3
- 241000187654 Nocardia Species 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 239000000824 cytostatic agent Substances 0.000 abstract 1
- 230000001085 cytostatic effect Effects 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
Abstract
Maytansinol, maytanacin and/or maytansinol propionate are prepared by culturing a microorganism belonging to the genus Nocardia, which is able to produce maytansinol, maytanacin and/or maytansinol propionate, with concentration of maytansinol, maytanacin and/or maytansinol propionate, and isolating it from the culture broth. These compounds are useful antitumour agents, i.e. useful cytostatics.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP52037167A JPS6010718B2 (en) | 1977-03-31 | 1977-03-31 | Process for producing maytansinol, maytanacin and maytansinol propionate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1554395A true GB1554395A (en) | 1979-10-17 |
Family
ID=12490032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB42821/77A Expired GB1554395A (en) | 1977-03-31 | 1977-10-14 | Method for producing maytansinol and its derivatives |
Country Status (20)
| Country | Link |
|---|---|
| JP (1) | JPS6010718B2 (en) |
| AT (1) | AT362058B (en) |
| AU (1) | AU507869B2 (en) |
| CA (1) | CA1092999A (en) |
| CH (1) | CH631740A5 (en) |
| CS (1) | CS214881B2 (en) |
| DE (1) | DE2746253C2 (en) |
| DK (1) | DK143570C (en) |
| ES (1) | ES463206A1 (en) |
| FR (1) | FR2385798A1 (en) |
| GB (1) | GB1554395A (en) |
| HU (1) | HU177391B (en) |
| IE (1) | IE45888B1 (en) |
| IT (1) | IT1094003B (en) |
| NL (1) | NL7711273A (en) |
| PL (1) | PL108863B1 (en) |
| PT (1) | PT67853B (en) |
| SE (1) | SE7711543L (en) |
| SU (1) | SU938746A3 (en) |
| YU (1) | YU243777A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001077360A2 (en) * | 2000-04-12 | 2001-10-18 | Smithkline Beecham P.L.C. | Methods for ansamitocin production |
| CN116239607A (en) * | 2023-01-04 | 2023-06-09 | 山东大学 | Novel maytansine derivative and biosynthesis method and application thereof |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6010720B2 (en) * | 1977-11-18 | 1985-03-19 | 武田薬品工業株式会社 | Production method of antibiotic C-15003 P-4 |
| JPS6016236B2 (en) * | 1977-11-18 | 1985-04-24 | 武田薬品工業株式会社 | Production method of antibiotic C-15003 P-3 |
| JPS55162791A (en) * | 1979-06-05 | 1980-12-18 | Takeda Chem Ind Ltd | Antibiotic c-15003pnd and its preparation |
| EP0028683A1 (en) * | 1979-09-21 | 1981-05-20 | Takeda Chemical Industries, Ltd. | Antibiotic C-15003 PHO and production thereof |
| US6333410B1 (en) | 2000-08-18 | 2001-12-25 | Immunogen, Inc. | Process for the preparation and purification of thiol-containing maytansinoids |
| US7432088B2 (en) | 2003-05-08 | 2008-10-07 | Immunogen Inc. | Methods for the production of ansamitocins |
-
1977
- 1977-03-31 JP JP52037167A patent/JPS6010718B2/en not_active Expired
- 1977-09-23 AU AU29073/77A patent/AU507869B2/en not_active Expired
- 1977-10-07 SU SU772533351A patent/SU938746A3/en active
- 1977-10-07 FR FR7730340A patent/FR2385798A1/en active Granted
- 1977-10-10 YU YU02437/77A patent/YU243777A/en unknown
- 1977-10-13 HU HU77TA1458A patent/HU177391B/en unknown
- 1977-10-13 SE SE7711543A patent/SE7711543L/en not_active Application Discontinuation
- 1977-10-13 CS CS776677A patent/CS214881B2/en unknown
- 1977-10-13 NL NL7711273A patent/NL7711273A/en not_active Application Discontinuation
- 1977-10-14 GB GB42821/77A patent/GB1554395A/en not_active Expired
- 1977-10-14 ES ES463206A patent/ES463206A1/en not_active Expired
- 1977-10-14 AT AT736377A patent/AT362058B/en not_active IP Right Cessation
- 1977-10-14 DK DK458977A patent/DK143570C/en not_active IP Right Cessation
- 1977-10-14 IE IE2100/77A patent/IE45888B1/en unknown
- 1977-10-14 DE DE2746253A patent/DE2746253C2/en not_active Expired
- 1977-10-14 CA CA288,732A patent/CA1092999A/en not_active Expired
- 1977-10-14 CH CH1260477A patent/CH631740A5/en not_active IP Right Cessation
- 1977-10-15 PL PL1977201539A patent/PL108863B1/en not_active IP Right Cessation
-
1978
- 1978-03-30 PT PT67853A patent/PT67853B/en unknown
- 1978-03-30 IT IT21819/78A patent/IT1094003B/en active
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001077360A2 (en) * | 2000-04-12 | 2001-10-18 | Smithkline Beecham P.L.C. | Methods for ansamitocin production |
| WO2001077360A3 (en) * | 2000-04-12 | 2002-09-12 | Smithkline Beecham Plc | Methods for ansamitocin production |
| US6573074B2 (en) | 2000-04-12 | 2003-06-03 | Smithkline Beecham Plc | Methods for ansamitocin production |
| AU2001293335B2 (en) * | 2000-04-12 | 2005-02-24 | Smithkline Beecham P.L.C. | Methods for ansamitocin production |
| CN116239607A (en) * | 2023-01-04 | 2023-06-09 | 山东大学 | Novel maytansine derivative and biosynthesis method and application thereof |
| CN116239607B (en) * | 2023-01-04 | 2024-04-09 | 山东大学 | Maytansine derivative and biosynthesis method and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| IT1094003B (en) | 1985-07-26 |
| FR2385798B1 (en) | 1980-04-25 |
| CS214881B2 (en) | 1982-06-25 |
| CA1092999A (en) | 1981-01-06 |
| IE45888B1 (en) | 1982-12-29 |
| HU177391B (en) | 1981-09-28 |
| SE7711543L (en) | 1978-10-01 |
| IT7821819A0 (en) | 1978-03-30 |
| IE45888L (en) | 1978-09-30 |
| PT67853A (en) | 1978-04-01 |
| SU938746A3 (en) | 1982-06-23 |
| ES463206A1 (en) | 1978-08-16 |
| DK458977A (en) | 1978-10-01 |
| PT67853B (en) | 1980-05-05 |
| AT362058B (en) | 1981-04-27 |
| YU243777A (en) | 1982-06-30 |
| DK143570B (en) | 1981-09-07 |
| AU507869B2 (en) | 1980-02-28 |
| JPS6010718B2 (en) | 1985-03-19 |
| NL7711273A (en) | 1978-10-03 |
| FR2385798A1 (en) | 1978-10-27 |
| PL201539A1 (en) | 1978-09-25 |
| ATA736377A (en) | 1980-09-15 |
| CH631740A5 (en) | 1982-08-31 |
| DK143570C (en) | 1982-02-08 |
| JPS53121998A (en) | 1978-10-24 |
| PL108863B1 (en) | 1980-05-31 |
| AU2907377A (en) | 1979-03-29 |
| DE2746253C2 (en) | 1986-08-21 |
| DE2746253A1 (en) | 1978-10-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| 704A | Declaration that licence is not available as of right for an excepted use (par. 4a/1977) | ||
| PE20 | Patent expired after termination of 20 years |
Effective date: 19971013 |