GB1421559A - Cyclic phosphorus derivatives having pharmaceutical properties - Google Patents
Cyclic phosphorus derivatives having pharmaceutical propertiesInfo
- Publication number
- GB1421559A GB1421559A GB1259973A GB1259973A GB1421559A GB 1421559 A GB1421559 A GB 1421559A GB 1259973 A GB1259973 A GB 1259973A GB 1259973 A GB1259973 A GB 1259973A GB 1421559 A GB1421559 A GB 1421559A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- cyclic phosphorus
- pharmaceutical properties
- phosphorus derivatives
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 Cyclic phosphorus derivatives Chemical class 0.000 title abstract 3
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001188 haloalkyl group Chemical group 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000003635 deoxygenating effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- OJMIONKXNSYLSR-UHFFFAOYSA-N phosphorous acid Chemical compound OP(O)O OJMIONKXNSYLSR-UHFFFAOYSA-N 0.000 abstract 1
- 229910000073 phosphorus hydride Inorganic materials 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
- DHCDFWKWKRSZHF-UHFFFAOYSA-L thiosulfate(2-) Chemical compound [O-]S([S-])(=O)=O DHCDFWKWKRSZHF-UHFFFAOYSA-L 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
- C07F9/65846—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a six-membered ring which may be condensed with another ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Transplantation (AREA)
- Biochemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1421559 Pharmaceutically active cyclic phosphorus compounds SHIONOGI & CO Ltd 15 March 1973 [5 April 1972] 12599/73 Heading C2P Novel compounds of Formula I where R<SP>1</SP> and R<SP>2</SP> are H or C 2-6 haloalkyl and R<SP>3</SP> is C 2-6 haloalkyl may be prepared by reacting a compound of Formula II with a deoxygenating agent such as a triaryl or trialkyl phosphine, a trialkyl phosphite, an alkyl or aryl mercaptan, a thiosulphate or an iodide. The compounds of Formula I have pharmaceutical activity and may be used as the active ingredients in conventional pharmaceutical compositions. Reference has been directed by the Comptroller to Specification 1,344,552.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP47034129A JPS5230519B2 (en) | 1972-04-05 | 1972-04-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1421559A true GB1421559A (en) | 1976-01-21 |
Family
ID=12405609
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1259973A Expired GB1421559A (en) | 1972-04-05 | 1973-03-15 | Cyclic phosphorus derivatives having pharmaceutical properties |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JPS5230519B2 (en) |
| DE (1) | DE2317178A1 (en) |
| FR (1) | FR2182899B1 (en) |
| GB (1) | GB1421559A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010099213A1 (en) * | 2009-02-24 | 2010-09-02 | Dekk-Tec, Inc. | Complexes of 4-hydroperoxy ifosfamide as anti-tumor agents |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3132221A1 (en) * | 1981-08-14 | 1983-05-19 | Behringwerke Ag, 3550 Marburg | NEW CYCLOPHOSPHAMIDE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE |
| JPS6164596U (en) * | 1984-10-02 | 1986-05-01 |
-
1972
- 1972-04-05 JP JP47034129A patent/JPS5230519B2/ja not_active Expired
-
1973
- 1973-03-15 GB GB1259973A patent/GB1421559A/en not_active Expired
- 1973-03-26 FR FR7310775A patent/FR2182899B1/fr not_active Expired
- 1973-04-05 DE DE2317178A patent/DE2317178A1/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010099213A1 (en) * | 2009-02-24 | 2010-09-02 | Dekk-Tec, Inc. | Complexes of 4-hydroperoxy ifosfamide as anti-tumor agents |
| US20110319365A1 (en) * | 2009-02-24 | 2011-12-29 | Morgan Lee R | Complexes of 4-hydroperoxy ifosfamide as anti-tumor agents |
| US8361992B2 (en) | 2009-02-24 | 2013-01-29 | Dekk-Tec, Inc. | Complexes of 4-hydroperoxy ifosfamide as anti-tumor agents |
| AU2010218109B2 (en) * | 2009-02-24 | 2015-04-09 | Dekk-Tec, Inc. | Complexes of 4-hydroperoxy ifosfamide as anti-tumor agents |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS4899187A (en) | 1973-12-15 |
| FR2182899B1 (en) | 1976-03-05 |
| JPS5230519B2 (en) | 1977-08-09 |
| DE2317178A1 (en) | 1973-10-11 |
| FR2182899A1 (en) | 1973-12-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |