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GB1421058A - Dibenzocycloheptenyl lactamimides - Google Patents

Dibenzocycloheptenyl lactamimides

Info

Publication number
GB1421058A
GB1421058A GB5521273A GB5521273A GB1421058A GB 1421058 A GB1421058 A GB 1421058A GB 5521273 A GB5521273 A GB 5521273A GB 5521273 A GB5521273 A GB 5521273A GB 1421058 A GB1421058 A GB 1421058A
Authority
GB
United Kingdom
Prior art keywords
formula
lactamimides
dibenzocycloheptenyl
merrell
cyclohepten
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5521273A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richardson Vicks Inc
Original Assignee
Richardson Merrell Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richardson Merrell Inc filed Critical Richardson Merrell Inc
Publication of GB1421058A publication Critical patent/GB1421058A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D227/00—Heterocyclic compounds containing rings having one nitrogen atom as the only ring hetero atom, according to more than one of groups C07D203/00 - C07D225/00
    • C07D227/02—Heterocyclic compounds containing rings having one nitrogen atom as the only ring hetero atom, according to more than one of groups C07D203/00 - C07D225/00 with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D227/06—Heterocyclic compounds containing rings having one nitrogen atom as the only ring hetero atom, according to more than one of groups C07D203/00 - C07D225/00 with only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D227/10—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1421058 Dibenzocycloheptenyl lactamimides RICHARDSON-MERRELL Inc 28 Nov 1973 [5 Jan 1973] 55212/73 Heading C2C Novel compounds of the Formula (I): wherein n is an integer of from 3 to 11, and pharmaceutically acceptable acid addition salts thereof, may be obtained by reacting 10,11- dihydro - 5H - dibenzo[a,d]cyclohepten - 5- amine with an excess of a lactim ether of the formula where the alkyl may be methyl, ethyl or the like, or with a complex of a corresponding lactam with phosphorous oxychloride, phosgene, boron trifluoride etherate, dimethyl sulphate, hydrogen halide or a combination of two or more of these reagents. Pharmaceutical compositions useful as diuretics, anti-inflammatory agents or anticoagulants, comprise a compound of Formula I, and a pharmaceutical carrier, in forms suitable for oral or parenteral use.
GB5521273A 1973-01-05 1973-11-28 Dibenzocycloheptenyl lactamimides Expired GB1421058A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US00321288A US3833559A (en) 1973-01-05 1973-01-05 Dibenzocycloheptenyl lactamimides

Publications (1)

Publication Number Publication Date
GB1421058A true GB1421058A (en) 1976-01-14

Family

ID=23249975

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5521273A Expired GB1421058A (en) 1973-01-05 1973-11-28 Dibenzocycloheptenyl lactamimides

Country Status (9)

Country Link
US (1) US3833559A (en)
JP (1) JPS604168B2 (en)
AU (1) AU476386B2 (en)
CA (1) CA1003826A (en)
DE (1) DE2361929A1 (en)
FR (1) FR2213064B1 (en)
GB (1) GB1421058A (en)
IL (1) IL43703A (en)
ZA (1) ZA738703B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5010072A (en) * 1988-06-28 1991-04-23 Merrell Dow Pharmaceuticals Inc. Lactamimides as calcium antagonists
US5198433A (en) * 1988-06-28 1993-03-30 Merrell Dow Pharmaceuticals Inc. Lactamimides as calcium antagonists
US5082837A (en) * 1988-06-28 1992-01-21 Merrell Dow Pharmaceuticals Lactamimides as calcium antagonists

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA722441B (en) * 1971-05-13 1973-01-31 Richardson Merrell Inc 9-fluorenyl lactamimides

Also Published As

Publication number Publication date
FR2213064A1 (en) 1974-08-02
IL43703A (en) 1977-07-31
CA1003826A (en) 1977-01-18
FR2213064B1 (en) 1977-06-03
JPS604168B2 (en) 1985-02-01
IL43703A0 (en) 1974-03-14
AU6251473A (en) 1975-05-15
AU476386B2 (en) 1976-09-16
DE2361929A1 (en) 1974-07-18
US3833559A (en) 1974-09-03
ZA738703B (en) 1975-02-26
JPS4995965A (en) 1974-09-11

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee