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GB1496768A - 5-substituted ethyl-8-hydroxycarbostyril derivatives and production thereof - Google Patents

5-substituted ethyl-8-hydroxycarbostyril derivatives and production thereof

Info

Publication number
GB1496768A
GB1496768A GB5589974A GB5589974A GB1496768A GB 1496768 A GB1496768 A GB 1496768A GB 5589974 A GB5589974 A GB 5589974A GB 5589974 A GB5589974 A GB 5589974A GB 1496768 A GB1496768 A GB 1496768A
Authority
GB
United Kingdom
Prior art keywords
compound
dec
compounds
alkyl
iib
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5589974A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP744192A external-priority patent/JPS539227B2/ja
Priority claimed from JP5831674A external-priority patent/JPS539233B2/ja
Priority claimed from JP6000374A external-priority patent/JPS539234B2/ja
Priority claimed from JP6000474A external-priority patent/JPS539235B2/ja
Priority claimed from JP6000674A external-priority patent/JPS5310993B2/ja
Priority claimed from JP6000574A external-priority patent/JPS5310992B2/ja
Priority claimed from JP9766074A external-priority patent/JPS5126878A/en
Priority claimed from JP9766174A external-priority patent/JPS5126879A/en
Priority claimed from JP9766374A external-priority patent/JPS5126881A/en
Priority claimed from JP9766274A external-priority patent/JPS5126880A/en
Priority claimed from JP49101260A external-priority patent/JPS5129487A/en
Priority claimed from JP13072874A external-priority patent/JPS5156474A/en
Priority claimed from JP49130719A external-priority patent/JPS5156465A/en
Priority claimed from JP14033974A external-priority patent/JPS5165770A/en
Priority claimed from JP14034074A external-priority patent/JPS51125290A/en
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of GB1496768A publication Critical patent/GB1496768A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C07D215/32—Esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1496768 Carbostyril derivatives OTSUKA PHARMACEUTICAL CO Ltd 27 Dec 1974 [26 Dec 1973 22 May 1974 27 May 1974 (4)] 26 Aug 1974 (4) 2 Sept 1974 11 Nov 1974 (3) 4 Dec 1974 (2)] 55899/74 Heading C2C Novel compounds I (R<SP>1</SP> and R<SP>2</SP> are H, 1-4 C alkyl, aryl-1-4 C alkyl, or 4-6 C cycloalkyl or NR<SP>1</SP>R<SP>2</SP> is a 5- or 6- membered, substituted or unsubstituted heterocyclic ring containing 1 or 2 nitrogen, oxygen or sulphur atoms as heteroatoms) and acid addition salts thereof are prepared by catalytic hydrogenation of a compound IIb or by dealkylation of a compound IIa or by catalytic hydrogenation of a compound VIII, IX or X The compounds of Formulae IIa and IIb form the subject of Specification 1,496,873. The compounds of Formulae VIII, IX and X form the subjects of Specifications 1,496,770; 1,496,769 and 1,496,872 respectively. Pharmaceutical compositions, useful as bronchodilators, peripheral vasodilators, and antihypertensives, comprise a compound I together with a suitable diluent and/or carrier.
GB5589974A 1973-12-26 1974-12-27 5-substituted ethyl-8-hydroxycarbostyril derivatives and production thereof Expired GB1496768A (en)

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
JP744192A JPS539227B2 (en) 1973-12-26 1973-12-26
JP5831674A JPS539233B2 (en) 1974-05-22 1974-05-22
JP6000674A JPS5310993B2 (en) 1974-05-27 1974-05-27
JP6000574A JPS5310992B2 (en) 1974-05-27 1974-05-27
JP6000374A JPS539234B2 (en) 1974-05-27 1974-05-27
JP6000474A JPS539235B2 (en) 1974-05-27 1974-05-27
JP9766074A JPS5126878A (en) 1974-08-26 1974-08-26 55 harogenoasechiru 88 arukokishi 3*44 jihidorokarubosuchiriruno seizoho
JP9766174A JPS5126879A (en) 1974-08-26 1974-08-26 55 arukiruaminoasechiru 88 arukokishi 3*44 jihidorokarubosuchirirujudotaino seizoho
JP9766374A JPS5126881A (en) 1974-08-26 1974-08-26 55 arukiruaminoasechiru 88 hidorokishi 3*44 jihidorokarubosuchirirujudotaino seizoho
JP9766274A JPS5126880A (en) 1974-08-26 1974-08-26 55 arukiruaminoasechiru 88 hidorokishi 3*44 jihidorokarubosuchirirujudotainoseizoho
JP49101260A JPS5129487A (en) 1974-09-02 1974-09-02 55 * 22 amino 11 hidorokishi * echiru 88 hidorokishi 3 44 jihidorokarubosuchirirujudotai no seizohoho
JP13072874A JPS5156474A (en) 1974-11-11 1974-11-11 KARUBOSUCHIRIRU JUDOTAINO SEIZOHO
JP49130719A JPS5156465A (en) 1974-11-11 1974-11-11 Karubosuchirirujudotaino seizoho
JP14033974A JPS5165770A (en) 1974-12-04 1974-12-04 KARUBOSUCHIRIRU JUDOTAINO SEIZOHO
JP14034074A JPS51125290A (en) 1974-12-04 1974-12-04 A process for preparing carbostyryl

Publications (1)

Publication Number Publication Date
GB1496768A true GB1496768A (en) 1978-01-05

Family

ID=27585642

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5589974A Expired GB1496768A (en) 1973-12-26 1974-12-27 5-substituted ethyl-8-hydroxycarbostyril derivatives and production thereof

Country Status (1)

Country Link
GB (1) GB1496768A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0240015A2 (en) 1986-04-02 1987-10-07 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives, process for preparing them, pharmaceutical composition, and use

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0240015A2 (en) 1986-04-02 1987-10-07 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives, process for preparing them, pharmaceutical composition, and use

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Legal Events

Date Code Title Description
PS Patent sealed
704A Declaration that licence is not available as of right for an excepted use (par. 4a/1977)
PE20 Patent expired after termination of 20 years

Effective date: 19941226