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GB1480089A - Diluent composition for biologically active materials - Google Patents

Diluent composition for biologically active materials

Info

Publication number
GB1480089A
GB1480089A GB5160674A GB5160674A GB1480089A GB 1480089 A GB1480089 A GB 1480089A GB 5160674 A GB5160674 A GB 5160674A GB 5160674 A GB5160674 A GB 5160674A GB 1480089 A GB1480089 A GB 1480089A
Authority
GB
United Kingdom
Prior art keywords
ions
meq
liquid composition
composition
diluent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5160674A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EIDP Inc
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Publication of GB1480089A publication Critical patent/GB1480089A/en
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/96—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood or serum control standard
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Inorganic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

1480089 Diluent composition for diagnostic tests E I DU PONT DE NEMOURS & CO 28 Nov 1974 [29 Nov 1973] 51606/74 Heading G1B [ Also in Division C3] A liquid composition suitable for use as a diluent for a biologically active material e.g. in the diagnostic measurement of enzyme activity, comprises 4À5 to 8À0 g/dl of a bovine albumin 95- 145 meq/l of sodium ions, 90-112 meq/l of chloride ions, 1-4 mg/dl of magnesium ions, 7- 12 mg/dl of calcium ions, 3-5À5 meq/l of potassium ions, up to 4 mg/l of zinc ions, 2-6 mg/dl of phosphorus as phosphate ions and up to 4 mg/dl of sulphur as sulphate ions, in de-ionized water. The pH is typically 6À5-7À5, osmolarity 190-300 milliosmoles, viscosity 1À2-2À0 centipoise and ionic strength 0À11-0À14 Á. The composition may be stored in the form of porous spheres of diameter not exceeding 1 mm and pore volume of at least 90%, which spheres are produced by spraying the liquid composition into boiling dichlorodifluoromethane at -25‹C and freeze-drying the frozen droplets. The porous spheres are dissolved in de-ionized water prior to use. Examples are directed to the comparison of acid or alkaline phosphatase and creatine phosphokinase activities when measured in undiluted human serum and human serum diluted with distilled water, saline solution or the liquid composition of the invention.
GB5160674A 1973-11-29 1974-11-28 Diluent composition for biologically active materials Expired GB1480089A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US41997473A 1973-11-29 1973-11-29

Publications (1)

Publication Number Publication Date
GB1480089A true GB1480089A (en) 1977-07-20

Family

ID=23664542

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5160674A Expired GB1480089A (en) 1973-11-29 1974-11-28 Diluent composition for biologically active materials

Country Status (4)

Country Link
JP (1) JPS5082282A (en)
DE (1) DE2456628A1 (en)
FR (1) FR2253074B1 (en)
GB (1) GB1480089A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110159565A1 (en) * 2009-12-31 2011-06-30 Shenzhen Mindray Bio-Medical Electronics Co., Ltd. Reagents and processes for stabilizing alkaline phosphatase or conjugates thereof

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55156589A (en) * 1979-05-25 1980-12-05 Baiorisaac Center:Kk Enzymatic treatment of water-insoluble substrate
NL8500266A (en) * 1985-01-31 1986-08-18 Stichting Gastransport CALIBRATION SOLUTION FOR ION-SELECTIVE ELECTRODES, DRY MATERIAL FOR MAKING IT OUT, METHOD FOR PREPARING THE SAME, AND USE THEREOF.
US5227305A (en) * 1988-05-13 1993-07-13 Instrumentation Laboratory Spa Buffer solution systems for standardizing pH analyzers and electrolytes

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110159565A1 (en) * 2009-12-31 2011-06-30 Shenzhen Mindray Bio-Medical Electronics Co., Ltd. Reagents and processes for stabilizing alkaline phosphatase or conjugates thereof
US8753858B2 (en) * 2009-12-31 2014-06-17 Shenzhen Mindray Bio-Medical Electronics Co., Ltd. Reagents and processes for stabilizing alkaline phosphatase or conjugates thereof

Also Published As

Publication number Publication date
FR2253074B1 (en) 1978-09-22
FR2253074A1 (en) 1975-06-27
JPS5082282A (en) 1975-07-03
DE2456628A1 (en) 1975-06-05

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Legal Events

Date Code Title Description
CSNS Application of which complete specification have been accepted and published, but patent is not sealed