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GB1474364A - Amidine compounds - Google Patents

Amidine compounds

Info

Publication number
GB1474364A
GB1474364A GB336076A GB336076A GB1474364A GB 1474364 A GB1474364 A GB 1474364A GB 336076 A GB336076 A GB 336076A GB 336076 A GB336076 A GB 336076A GB 1474364 A GB1474364 A GB 1474364A
Authority
GB
United Kingdom
Prior art keywords
carbon atoms
group containing
formula
lower alkyl
alkyl group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB336076A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CA242,165A priority Critical patent/CA1055493A/en
Priority to ZA412A priority patent/ZA76412B/en
Priority to SE7600806A priority patent/SE411756B/en
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Priority to GB336076A priority patent/GB1474364A/en
Priority to DE19762603627 priority patent/DE2603627A1/en
Priority to BE164074A priority patent/BE838243A/en
Priority to FR7602950A priority patent/FR2340091A1/en
Priority to CH133276A priority patent/CH629801A5/en
Priority to JP1044976A priority patent/JPS5295677A/en
Priority to NL7601276A priority patent/NL7601276A/en
Publication of GB1474364A publication Critical patent/GB1474364A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/38—[b, e]-condensed with two six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

1474364 Bis-pyrolidinyl tricyclic compounds BRISTOL-MYERS CO 28 Jan 1976 03360/76 Heading C2C Novel compounds of Formula I wherein X is a sulphur or oxygen atom, or a divalent methylene radical of the formula -C(Z 1 Z 2 )- wherein Z 1 and Z 2 are each independently a hydrogen atom or a straight chain lower alkyl group containing from 1 to 4 carbon atoms inclusive; Y is a hydrogen or halogen atom, a trifluoromethyl group, a lower alkyl group containing from 1 to 4 carbon atoms or a lower alkoxy group containing from 1 to 4 carbon atoms and R is a hydrogen atom or a straight chain lower alkyl group containing from 1 to 4 carbon atoms inclusive; or a pharmaceutically acceptable acid addition salt thereof are prepared by reacting a compound of Formula II with a compound of Formula III and POCl 3 or with 2-chlorro-1-(1-pyrolin-2-yl)- 2-pyrroline hydrochloride and optionally converting the product to a salt. Pharmaceutical compositions in conventional forms for oral and parenteral administration and having smooth relaxant, platelet aggregation inhibiting and diuretic activity comprise an above novel compound and a carrier or diluent.
GB336076A 1975-12-19 1976-01-28 Amidine compounds Expired GB1474364A (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
CA242,165A CA1055493A (en) 1975-12-19 1975-12-19 Phenothiazines, phenoxazines, and acridan bis-pyrrolinyl derivatives
ZA412A ZA76412B (en) 1975-12-19 1976-01-26 Phenothiazines phenoxazines and acridan bis-pyrrolinyl derivatives
SE7600806A SE411756B (en) 1975-12-19 1976-01-27 PROCEDURE FOR PREPARATION OF PHENOTIAZINES, PHENOXAZINES AND ACRIDAN-BIS-PYRROLINYL DERIVATIVES
GB336076A GB1474364A (en) 1975-12-19 1976-01-28 Amidine compounds
DE19762603627 DE2603627A1 (en) 1975-12-19 1976-01-30 NEW AMIDINE COMPOUNDS, THE METHOD OF MANUFACTURING THEM AND THE MEDICINAL PRODUCTS CONTAINING THEM
BE164074A BE838243A (en) 1975-12-19 1976-02-03 NEW AMIDINES, THEIR PREPARATION PROCESS AND THE MEDICINAL PRODUCT CONTAINING THEM
FR7602950A FR2340091A1 (en) 1975-12-19 1976-02-03 NEW AMIDINES, THEIR PREPARATION PROCESS AND THE MEDICINAL PRODUCT CONTAINING THEM
CH133276A CH629801A5 (en) 1975-12-19 1976-02-03 Process for the preparation of bispyrrolinyl derivatives of phenothiazines, phenoxazines and acridans
JP1044976A JPS5295677A (en) 1975-12-19 1976-02-04 Phenothiazines* phenoxazines and acridane biss pyrrolinyl derivatives
NL7601276A NL7601276A (en) 1975-12-19 1976-02-09 PROCESS FOR THE PREPARATION OF NEW AMIDINE COMPOUNDS AND SUCH COMPOUNDS CONTAINING PHARMACEUTICAL PREPARATIONS.

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
CA242,165A CA1055493A (en) 1975-12-19 1975-12-19 Phenothiazines, phenoxazines, and acridan bis-pyrrolinyl derivatives
ZA412A ZA76412B (en) 1975-12-19 1976-01-26 Phenothiazines phenoxazines and acridan bis-pyrrolinyl derivatives
SE7600806A SE411756B (en) 1975-12-19 1976-01-27 PROCEDURE FOR PREPARATION OF PHENOTIAZINES, PHENOXAZINES AND ACRIDAN-BIS-PYRROLINYL DERIVATIVES
GB336076A GB1474364A (en) 1975-12-19 1976-01-28 Amidine compounds
DE19762603627 DE2603627A1 (en) 1975-12-19 1976-01-30 NEW AMIDINE COMPOUNDS, THE METHOD OF MANUFACTURING THEM AND THE MEDICINAL PRODUCTS CONTAINING THEM
BE164074A BE838243A (en) 1975-12-19 1976-02-03 NEW AMIDINES, THEIR PREPARATION PROCESS AND THE MEDICINAL PRODUCT CONTAINING THEM
FR7602950A FR2340091A1 (en) 1975-12-19 1976-02-03 NEW AMIDINES, THEIR PREPARATION PROCESS AND THE MEDICINAL PRODUCT CONTAINING THEM
CH133276A CH629801A5 (en) 1975-12-19 1976-02-03 Process for the preparation of bispyrrolinyl derivatives of phenothiazines, phenoxazines and acridans
JP1044976A JPS5295677A (en) 1975-12-19 1976-02-04 Phenothiazines* phenoxazines and acridane biss pyrrolinyl derivatives
NL7601276A NL7601276A (en) 1975-12-19 1976-02-09 PROCESS FOR THE PREPARATION OF NEW AMIDINE COMPOUNDS AND SUCH COMPOUNDS CONTAINING PHARMACEUTICAL PREPARATIONS.

Publications (1)

Publication Number Publication Date
GB1474364A true GB1474364A (en) 1977-05-25

Family

ID=27578993

Family Applications (1)

Application Number Title Priority Date Filing Date
GB336076A Expired GB1474364A (en) 1975-12-19 1976-01-28 Amidine compounds

Country Status (10)

Country Link
JP (1) JPS5295677A (en)
BE (1) BE838243A (en)
CA (1) CA1055493A (en)
CH (1) CH629801A5 (en)
DE (1) DE2603627A1 (en)
FR (1) FR2340091A1 (en)
GB (1) GB1474364A (en)
NL (1) NL7601276A (en)
SE (1) SE411756B (en)
ZA (1) ZA76412B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5430973A (en) * 1977-08-09 1979-03-07 Kaoru Hasegawa Production of high grade carpets with long tuft by utilizing hand hook or automatic hook machine
JPH08657U (en) * 1992-01-14 1996-04-16 長沢 巌 Residual gas prevention device for simple gas stove
JPH0731992A (en) * 1993-06-30 1995-02-03 Takara Kogyo Kk Filter material

Also Published As

Publication number Publication date
ZA76412B (en) 1977-01-26
CA1055493A (en) 1979-05-29
DE2603627A1 (en) 1977-08-11
JPS5295677A (en) 1977-08-11
SE7600806L (en) 1977-07-28
SE411756B (en) 1980-02-04
FR2340091A1 (en) 1977-09-02
CH629801A5 (en) 1982-05-14
FR2340091B1 (en) 1981-12-24
NL7601276A (en) 1977-08-11
BE838243A (en) 1976-08-03

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee