GB1457796A - Metabolite a-27106 and process for its preparation and use - Google Patents
Metabolite a-27106 and process for its preparation and useInfo
- Publication number
- GB1457796A GB1457796A GB441474A GB441474A GB1457796A GB 1457796 A GB1457796 A GB 1457796A GB 441474 A GB441474 A GB 441474A GB 441474 A GB441474 A GB 441474A GB 1457796 A GB1457796 A GB 1457796A
- Authority
- GB
- United Kingdom
- Prior art keywords
- metabolite
- feed
- monensin
- carbon
- molecular weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Alternative & Traditional Medicine (AREA)
- Fodder In General (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Feed For Specific Animals (AREA)
- Saccharide Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Compounds Of Unknown Constitution (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
1457796 Metabolite A-27106 ELI LILLY & CO 30 Jan 1974 [1 Feb 1973] 04414/74 Headings C2A and C2C The invention relates to Metabolite A-27106 and the acid, ammonium, lithium, potassium, rubidium or cesium forms thereof. The metabolite is a white crystalline solid with (a) a molecular weight of 854, as determined by mass spectrometry; (b) an elemental composition of 58À78% carbon, 8À51% hydrogen, 27À85% oxygen and 3À63% sodium; (c) an empirical formula of C 42 H 71 O 16 Na; (d) an infra-red absorption spectrum in chloroform as shown in the accompanying drawing; (e) a mass spectrum having a molecular-ion peak at m./e. 854À44630 and characteristic peaks at m./e. 836À44129, 779À44690, 761À44740; and (f) an Rf value of 0À49 on silica gel thin layer chromatography in benzene-methanol (7 : 3); and the acid form is a white solid having a molecular weight of 832 and a titratable group with a pKa value of 7À2. The following structure is proposed for Metabolite A-27106. Metabolite A-27106 is prepared by cultivating Streptomyces candidus NRRL 5449 in a culture medium containing assimilable sources of carbon, nitrogen and inorganic salts under submerged aerobic conditions in the presence of glucose and monensin until monensin is converted into metabolite A-27106. The metabolite may be mixed with a physiologically-acceptable carrier, e.g. poultry feed, and administered to poultry for preventing or treating coccidiosis therein. The metabolite may also be mixed with ruminant feed for increasing the efficiency of feed utilization of ruminant animals.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32858673A | 1973-02-01 | 1973-02-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1457796A true GB1457796A (en) | 1976-12-08 |
Family
ID=23281582
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB441474A Expired GB1457796A (en) | 1973-02-01 | 1974-01-30 | Metabolite a-27106 and process for its preparation and use |
Country Status (27)
| Country | Link |
|---|---|
| JP (2) | JPS5730477B2 (en) |
| AR (1) | AR206509A1 (en) |
| AT (1) | AT328083B (en) |
| BE (1) | BE810416A (en) |
| BG (1) | BG26953A3 (en) |
| CA (1) | CA1016483A (en) |
| CH (1) | CH589140A5 (en) |
| CS (1) | CS193481B2 (en) |
| DD (1) | DD112441A5 (en) |
| DE (1) | DE2404958C2 (en) |
| DK (1) | DK143036C (en) |
| EG (1) | EG11287A (en) |
| ES (1) | ES422834A1 (en) |
| FI (1) | FI52993C (en) |
| FR (1) | FR2215943B1 (en) |
| GB (1) | GB1457796A (en) |
| HU (1) | HU167276B (en) |
| IE (1) | IE38780B1 (en) |
| IL (1) | IL44065A (en) |
| IN (1) | IN139462B (en) |
| NL (1) | NL181367C (en) |
| NO (1) | NO139788C (en) |
| PH (1) | PH12449A (en) |
| SE (1) | SE401930B (en) |
| SU (1) | SU539538A3 (en) |
| YU (1) | YU36990B (en) |
| ZA (1) | ZA74464B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6384471U (en) * | 1986-11-21 | 1988-06-02 | ||
| JPH0532866Y2 (en) * | 1987-10-27 | 1993-08-23 | ||
| JPH0483920U (en) * | 1990-11-30 | 1992-07-21 | ||
| JPH0512236U (en) * | 1991-07-26 | 1993-02-19 | 東京ラヂエーター製造株式会社 | Fuel tank backflow prevention structure |
-
1974
- 1974-01-01 AR AR252171A patent/AR206509A1/en active
- 1974-01-22 ZA ZA00740464A patent/ZA74464B/en unknown
- 1974-01-22 CA CA190,655A patent/CA1016483A/en not_active Expired
- 1974-01-22 IE IE129/74A patent/IE38780B1/en unknown
- 1974-01-22 IL IL44065A patent/IL44065A/en unknown
- 1974-01-24 PH PH15441A patent/PH12449A/en unknown
- 1974-01-25 YU YU0190/74A patent/YU36990B/en unknown
- 1974-01-29 IN IN191/CAL/74A patent/IN139462B/en unknown
- 1974-01-30 NL NLAANVRAGE7401311,A patent/NL181367C/en not_active IP Right Cessation
- 1974-01-30 NO NO740292A patent/NO139788C/en unknown
- 1974-01-30 GB GB441474A patent/GB1457796A/en not_active Expired
- 1974-01-31 HU HUEI523A patent/HU167276B/hu not_active IP Right Cessation
- 1974-01-31 SE SE7401314A patent/SE401930B/en not_active IP Right Cessation
- 1974-01-31 DD DD176301A patent/DD112441A5/xx unknown
- 1974-01-31 ES ES422834A patent/ES422834A1/en not_active Expired
- 1974-01-31 BE BE1005684A patent/BE810416A/en not_active IP Right Cessation
- 1974-01-31 DK DK51474A patent/DK143036C/en not_active IP Right Cessation
- 1974-01-31 AT AT76874*#A patent/AT328083B/en not_active IP Right Cessation
- 1974-02-01 FI FI283/74A patent/FI52993C/fi active
- 1974-02-01 FR FR7403437A patent/FR2215943B1/fr not_active Expired
- 1974-02-01 JP JP1403874A patent/JPS5730477B2/ja not_active Expired
- 1974-02-01 SU SU2002131A patent/SU539538A3/en active
- 1974-02-01 CH CH143874A patent/CH589140A5/xx not_active IP Right Cessation
- 1974-02-01 CS CS74699A patent/CS193481B2/en unknown
- 1974-02-01 DE DE2404958A patent/DE2404958C2/en not_active Expired
- 1974-02-01 BG BG025678A patent/BG26953A3/en unknown
- 1974-02-02 EG EG29/74A patent/EG11287A/en active
-
1981
- 1981-10-20 JP JP56168525A patent/JPS6026374B2/en not_active Expired
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| 704A | Declaration that licence is not available as of right for an excepted use (par. 4a/1977) | ||
| PCNP | Patent ceased through non-payment of renewal fee |