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GB1443189A - Enhanced production of plasminogen activator - Google Patents

Enhanced production of plasminogen activator

Info

Publication number
GB1443189A
GB1443189A GB4919673A GB4919673A GB1443189A GB 1443189 A GB1443189 A GB 1443189A GB 4919673 A GB4919673 A GB 4919673A GB 4919673 A GB4919673 A GB 4919673A GB 1443189 A GB1443189 A GB 1443189A
Authority
GB
United Kingdom
Prior art keywords
cells
oct
activator
plasminogen activator
enhanced production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4919673A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of GB1443189A publication Critical patent/GB1443189A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

1443189 Culturing tissue-cells ELI LILLY & CO 23 Oct 1973 [24 Oct 1972] 49196/73 Heading C6F [Also in Division C3] In culturing mammalian cells capable of producing a polypeptide activator of plasminogen in an aqueous nutrient tissue culture medium, there is included in the medium 0À1-10 mcg/ml. of an alkaloid possessing anti-mitotic activity selected from colchicine, colcemide, desacetylcolchicine, desacetamidocolchicine, 4-cyanocolchicine, vinblastine and vincriotine whereby to enhance the yield of activator. Cells of specified percine, rabbit and rhesus monkey kidney celllines are employed.
GB4919673A 1972-10-24 1973-10-23 Enhanced production of plasminogen activator Expired GB1443189A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US30005472A 1972-10-24 1972-10-24

Publications (1)

Publication Number Publication Date
GB1443189A true GB1443189A (en) 1976-07-21

Family

ID=23157506

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4919673A Expired GB1443189A (en) 1972-10-24 1973-10-23 Enhanced production of plasminogen activator

Country Status (9)

Country Link
JP (1) JPS4975794A (en)
BE (1) BE806323A (en)
CH (1) CH589142A5 (en)
DE (1) DE2353318A1 (en)
FR (1) FR2203876B1 (en)
GB (1) GB1443189A (en)
IL (1) IL43343A (en)
NL (1) NL7314579A (en)
SE (2) SE392618B (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2119804A (en) * 1982-05-05 1983-11-23 Genentech Inc Human tissue plasminogen activator pharmaceutical compositions containing it processes for making it and dna and transformed cell intermediates therefor
US4736018A (en) * 1984-09-21 1988-04-05 Boehringer Ingelheim International Gmbh Blood coagulation inhibiting proteins, processes for preparing them and their uses
US4853330A (en) * 1983-04-07 1989-08-01 Genentech, Inc. Human tissue plasminogen activator
US5141863A (en) * 1986-08-11 1992-08-25 Mitsui Toatsu Chemicals, Incorporated Purification procedure of TPA from crude preparations
US5185259A (en) * 1982-05-05 1993-02-09 Genentech, Inc. Truncated human tissue plasminogen activator
US5587159A (en) * 1982-05-05 1996-12-24 Genentech, Inc. Human tissue plasminogen activator
US5763253A (en) * 1982-05-05 1998-06-09 Genentech, Inc. Methods of preparing tissue plasiminogen activator derivative composition

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5571496A (en) * 1978-11-24 1980-05-29 Asahi Chem Ind Co Ltd Preparation of living substance
IL69664A0 (en) * 1982-09-15 1983-12-30 Collaborative Res Inc Medium supplement and method for growing cells in vitro

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5763253A (en) * 1982-05-05 1998-06-09 Genentech, Inc. Methods of preparing tissue plasiminogen activator derivative composition
US5185259A (en) * 1982-05-05 1993-02-09 Genentech, Inc. Truncated human tissue plasminogen activator
US5587159A (en) * 1982-05-05 1996-12-24 Genentech, Inc. Human tissue plasminogen activator
US5702938A (en) * 1982-05-05 1997-12-30 Genetech, Inc. Human tissue plasminogen activator
US5728565A (en) * 1982-05-05 1998-03-17 Genentech, Inc. Methods of preparing tissue plasminogen activator derivatives
US5753486A (en) * 1982-05-05 1998-05-19 Genentech, Inc. Human tissue plasminogen activator
GB2119804A (en) * 1982-05-05 1983-11-23 Genentech Inc Human tissue plasminogen activator pharmaceutical compositions containing it processes for making it and dna and transformed cell intermediates therefor
US5869314A (en) * 1982-05-05 1999-02-09 Genentech, Inc. Tissue plasminogen activators and derivatives thereof as produced by recombinant means
US6274335B1 (en) 1982-05-05 2001-08-14 Genentech, Inc. Method of treatment using recombinant human tissue plasminogen activator
US6284247B1 (en) 1982-05-05 2001-09-04 Genentech, Inc. Human tissue plasminogen activators
US4853330A (en) * 1983-04-07 1989-08-01 Genentech, Inc. Human tissue plasminogen activator
US4736018A (en) * 1984-09-21 1988-04-05 Boehringer Ingelheim International Gmbh Blood coagulation inhibiting proteins, processes for preparing them and their uses
US5141863A (en) * 1986-08-11 1992-08-25 Mitsui Toatsu Chemicals, Incorporated Purification procedure of TPA from crude preparations

Also Published As

Publication number Publication date
JPS4975794A (en) 1974-07-22
FR2203876B1 (en) 1977-05-27
IL43343A0 (en) 1973-11-28
SE7609880L (en) 1976-09-07
DE2353318A1 (en) 1974-05-02
IL43343A (en) 1976-03-31
FR2203876A1 (en) 1974-05-17
SE392618B (en) 1977-04-04
NL7314579A (en) 1974-04-26
CH589142A5 (en) 1977-06-30
BE806323A (en) 1974-04-22

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee