GB1317830A - Method for producing antibiotics namely rifamycins b and o - Google Patents
Method for producing antibiotics namely rifamycins b and oInfo
- Publication number
- GB1317830A GB1317830A GB2630170A GB2630170A GB1317830A GB 1317830 A GB1317830 A GB 1317830A GB 2630170 A GB2630170 A GB 2630170A GB 2630170 A GB2630170 A GB 2630170A GB 1317830 A GB1317830 A GB 1317830A
- Authority
- GB
- United Kingdom
- Prior art keywords
- ethyl acetate
- rifamycin
- extraction
- rifamycins
- crude
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
1317830 Antibiotics rifamycins B and O TAKEDA YAKUHIN KOGYO KK 1 June 1970 [30 May 1969] 26301/70 Heading C2A Rifamycin B and rifamycin O are produced by cultivating Streptomyces tolypophorus (I.F.O.-12554-cf. Specification 1,212,741) or its yellow mutant (I.F.O. 13151) in a nutrient medium containing at least one assimilable C source and at least one digestible N source in the presence of 0À005 to 0À5% of an inorganic iron compound under aerobic conditions. The medium is preferably aqueous and the iron may be ferrous or ferric chloride, sulphate, citrate, phosphate, iodide, oxide or hydroxide. Rifamycin O is obtained by extracting the culture broth at pH 7À2 with ethylacetate and adding a 1 : 10 mixture of diethyl ether and petroleum ether to the extract to precipitate a crude which is further purified by chromatography on carbon and then on silica gel. Rifamycin B is obtained from the aqueous layer after ethyl acetate extraction of the broth by adjusting to pH 2À5, extracting with ethyl acetate and precipitating a crude by the addition of petroleum ether. Further purification is by dissolution in ethyl acetate, extraction with aqueous phosphate, adjustment to pH 3À0, re-extraction into ethyl acetate and precipitation by addition of n-hexane, followed by crystallization from 1 : 1 ethyl acetate and acetone.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4230769 | 1969-05-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1317830A true GB1317830A (en) | 1973-05-23 |
Family
ID=12632347
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2630170A Expired GB1317830A (en) | 1969-05-30 | 1970-06-01 | Method for producing antibiotics namely rifamycins b and o |
Country Status (5)
| Country | Link |
|---|---|
| BE (1) | BE751182A (en) |
| CH (1) | CH547854A (en) |
| DE (1) | DE2026595A1 (en) |
| FR (1) | FR2043847A1 (en) |
| GB (1) | GB1317830A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102405223A (en) * | 2009-04-20 | 2012-04-04 | 意大利阿尔法韦士曼制药公司 | Rifamycin derivatives |
| US8518949B2 (en) | 2005-03-03 | 2013-08-27 | Alfa Wassermann S.P.A. | Polymorphous forms of rifaximin, processes for their production and use thereof in the medicinal preparations |
| US9452157B2 (en) | 2012-07-06 | 2016-09-27 | Alfa Wassermann S.P.A | Pharmaceutical compositions comprising rifaximin and amino acids, preparation methods and use thereof |
| US10285944B2 (en) | 2005-03-07 | 2019-05-14 | Alfasigma S.P.A. | Gastroresistant pharmaceutical formulations containing rifaximin |
-
1970
- 1970-05-29 BE BE751182D patent/BE751182A/en unknown
- 1970-05-29 CH CH813270A patent/CH547854A/en not_active IP Right Cessation
- 1970-05-29 FR FR7019857A patent/FR2043847A1/fr not_active Withdrawn
- 1970-05-30 DE DE19702026595 patent/DE2026595A1/en active Pending
- 1970-06-01 GB GB2630170A patent/GB1317830A/en not_active Expired
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8518949B2 (en) | 2005-03-03 | 2013-08-27 | Alfa Wassermann S.P.A. | Polymorphous forms of rifaximin, processes for their production and use thereof in the medicinal preparations |
| US10703763B2 (en) | 2005-03-03 | 2020-07-07 | Alfasigma S.P.A. | Polymorphous forms of rifaximin, processes for their production and use thereof in the medicinal preparations |
| US10285944B2 (en) | 2005-03-07 | 2019-05-14 | Alfasigma S.P.A. | Gastroresistant pharmaceutical formulations containing rifaximin |
| CN102405223A (en) * | 2009-04-20 | 2012-04-04 | 意大利阿尔法韦士曼制药公司 | Rifamycin derivatives |
| JP2012524060A (en) * | 2009-04-20 | 2012-10-11 | アルファ ワッセルマン ソシエタ ペル アチオニ | Rifamycin derivative |
| US8318763B2 (en) | 2009-04-20 | 2012-11-27 | Alfa Wassermann S.P.A. | Rifamycin derivatives |
| US9452157B2 (en) | 2012-07-06 | 2016-09-27 | Alfa Wassermann S.P.A | Pharmaceutical compositions comprising rifaximin and amino acids, preparation methods and use thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| DE2026595A1 (en) | 1970-12-10 |
| BE751182A (en) | 1970-11-03 |
| FR2043847A1 (en) | 1971-02-19 |
| CH547854A (en) | 1974-04-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FR6697M (en) | ||
| GB1317830A (en) | Method for producing antibiotics namely rifamycins b and o | |
| US3150046A (en) | Antibiotic rifamycin b and method of production | |
| GB1162027A (en) | Antibiotic SL 2266 | |
| GB1339032A (en) | Rabelomycin and processes for its production | |
| US3118823A (en) | Method for producing ferrioxamine | |
| US3917820A (en) | Antibiotic cochliodinol and production by chaetomium, cochliodes and chaetomium globsum | |
| GB1357538A (en) | New antibiotic | |
| EP0057349B1 (en) | Peptide antibiotic, component b, process for its preparation and its use in medicines | |
| GB1159568A (en) | Fermentation Process for the Process of Primycin | |
| ES438413A1 (en) | Lipolytic enzyme recovery method | |
| GB1178451A (en) | Lateriomycin F and production thereof | |
| GB1212741A (en) | A method for producing an antibiotic b-2847 | |
| GB1389714A (en) | Method for producing cephalosporin c | |
| US4206283A (en) | Protease inhibitors | |
| GB1139041A (en) | Chlorflavonin | |
| US3636197A (en) | Josamycin and production thereof | |
| GB1308843A (en) | Antibiotic and a process for its preparation | |
| US3794564A (en) | Process for the production of anticapsin | |
| GB1203164A (en) | New process for the preparation of daunorubicin | |
| US3023145A (en) | Protomycin and its production | |
| GB1226665A (en) | ||
| GB1433528A (en) | Method for producing deacetylcephalosporin c | |
| ES485529A1 (en) | Ravidomycin, process of preparation and pharmaceutical compositions containing same. | |
| GB1377339A (en) | Method for producing deacetoxycephalosporin c |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |