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GB1356263A - Modified double-stranded rna - Google Patents

Modified double-stranded rna

Info

Publication number
GB1356263A
GB1356263A GB194071A GB194071A GB1356263A GB 1356263 A GB1356263 A GB 1356263A GB 194071 A GB194071 A GB 194071A GB 194071 A GB194071 A GB 194071A GB 1356263 A GB1356263 A GB 1356263A
Authority
GB
United Kingdom
Prior art keywords
rna
natural
jan
stranded rna
modified double
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB194071A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Priority to GB194071A priority Critical patent/GB1356263A/en
Priority to CA132,060A priority patent/CA966830A/en
Priority to ZA720169A priority patent/ZA72169B/en
Priority to AT22572A priority patent/AT340604B/en
Priority to FR7200892A priority patent/FR2121772B1/fr
Priority to NL7200481A priority patent/NL7200481A/xx
Priority to CH45772A priority patent/CH568760A5/xx
Priority to DE19722201513 priority patent/DE2201513A1/en
Priority to SE7200373A priority patent/SE386450B/en
Priority to AU37964/72A priority patent/AU3796472A/en
Priority to BE778102A priority patent/BE778102A/en
Priority to DK20072AA priority patent/DK129709B/en
Priority to IE53/72A priority patent/IE35980B1/en
Publication of GB1356263A publication Critical patent/GB1356263A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1356263 Antiviral compositions containing modified double stranded RNA BEECHAM GROUP Ltd 11 Jan 1972 [14 Jan 1971] 1940/71 Heading A5B [Also in Division C3] A pharmaceutical composition useful generally in the prophylaxis of viral infections comprises a modified form of a natural ds. RNA having antiviral activity and a reduced acute toxicity relative to the normal form of ds. RNA from the same natural source which is obtained by (a) treating the natural form of ds. RNA with an alkali metal hydroxide at a pH between 11.0 and 12.5 in an aqueous electrolyte solution, under conditions of temperature, time and electrolyte concentration such that partial separation of the polynucleotide strands of each ds. RNA molecule commences immediately and no more than 25 phosphate di-ester linkages per strand are hydrolysed during the period of the reaction and then (b) neutralising the resultant solution. Detailed physical chemical and medicinal properties are given.
GB194071A 1971-01-14 1971-01-14 Modified double-stranded rna Expired GB1356263A (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
GB194071A GB1356263A (en) 1971-01-14 1971-01-14 Modified double-stranded rna
CA132,060A CA966830A (en) 1971-01-14 1972-01-10 Biologically active substance
ZA720169A ZA72169B (en) 1971-01-14 1972-01-11 Biologically active substance
AT22572A AT340604B (en) 1971-01-14 1972-01-12 PROCESS FOR PRODUCING A NEW FORM OF NATURAL DOUBLE STRANDED RIBONUCLEIC ACID
FR7200892A FR2121772B1 (en) 1971-01-14 1972-01-12
NL7200481A NL7200481A (en) 1971-01-14 1972-01-12
CH45772A CH568760A5 (en) 1971-01-14 1972-01-13
DE19722201513 DE2201513A1 (en) 1971-01-14 1972-01-13 New modification of natural double-stranded ribonucleic acids with antiviral activity and reduced acute toxic effect, processes for their production and medicinal preparations containing such a modification
SE7200373A SE386450B (en) 1971-01-14 1972-01-13 WAY TO TREAT A NATURAL DOUBLE-STEMED RIBONUCLEIC ACID TO GET A NEW FORM
AU37964/72A AU3796472A (en) 1971-01-14 1972-01-14 Biologically active substance
BE778102A BE778102A (en) 1971-01-14 1972-01-14 SUBSTANCE WITH BIOLOGICAL ACTIVITY
DK20072AA DK129709B (en) 1971-01-14 1972-01-14 Process for the preparation of an alkali metal hydroxide modified form of natural double-stranded ribonucleic acid.
IE53/72A IE35980B1 (en) 1971-01-14 1972-01-14 Modified double-stranded rna

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB194071A GB1356263A (en) 1971-01-14 1971-01-14 Modified double-stranded rna

Publications (1)

Publication Number Publication Date
GB1356263A true GB1356263A (en) 1974-06-12

Family

ID=9730714

Family Applications (1)

Application Number Title Priority Date Filing Date
GB194071A Expired GB1356263A (en) 1971-01-14 1971-01-14 Modified double-stranded rna

Country Status (13)

Country Link
AT (1) AT340604B (en)
AU (1) AU3796472A (en)
BE (1) BE778102A (en)
CA (1) CA966830A (en)
CH (1) CH568760A5 (en)
DE (1) DE2201513A1 (en)
DK (1) DK129709B (en)
FR (1) FR2121772B1 (en)
GB (1) GB1356263A (en)
IE (1) IE35980B1 (en)
NL (1) NL7200481A (en)
SE (1) SE386450B (en)
ZA (1) ZA72169B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4190649A (en) * 1976-06-03 1980-02-26 Mirko Beljanski Polyribonucleotides capable of promoting the genesis of leucocytes and blood platelets

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4190649A (en) * 1976-06-03 1980-02-26 Mirko Beljanski Polyribonucleotides capable of promoting the genesis of leucocytes and blood platelets

Also Published As

Publication number Publication date
SE386450B (en) 1976-08-09
BE778102A (en) 1972-07-14
CH568760A5 (en) 1975-11-14
FR2121772A1 (en) 1972-08-25
DK129709B (en) 1974-11-11
FR2121772B1 (en) 1975-08-01
ATA22572A (en) 1977-04-15
ZA72169B (en) 1972-09-27
DE2201513A1 (en) 1972-07-27
IE35980L (en) 1972-07-14
IE35980B1 (en) 1976-07-21
AT340604B (en) 1977-12-27
DK129709C (en) 1975-04-21
NL7200481A (en) 1972-07-18
CA966830A (en) 1975-04-29
AU3796472A (en) 1973-07-19

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee