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GB1204946A - Improvements in or relating to sulphon anilides and the manufacture thereof - Google Patents

Improvements in or relating to sulphon anilides and the manufacture thereof

Info

Publication number
GB1204946A
GB1204946A GB27979/68A GB2797968A GB1204946A GB 1204946 A GB1204946 A GB 1204946A GB 27979/68 A GB27979/68 A GB 27979/68A GB 2797968 A GB2797968 A GB 2797968A GB 1204946 A GB1204946 A GB 1204946A
Authority
GB
United Kingdom
Prior art keywords
alkyl
phenoxyaniline
alkylated
halo
sulphon
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB27979/68A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of GB1204946A publication Critical patent/GB1204946A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/22—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing two or more pyridine rings directly linked together, e.g. bipyridyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1,204,946. Phenoxyalkanesulphonanilides. UPJOHN CO. 12 June, 1968 [18 July, 1967], No. 27979/68. Heading C2C. Novel compounds I (including salts thereof) wherein X is halo, C 1-4 alkyl or C 1-4 alkoxy, Y is halo, R<SP>1</SP> is H, C 1-4 alkyl, 3-piperidinopropyl, 2-piperidinoethyl, 3-pyrrolidinopropyl, 2-pyrrolidinoethyl, 3-morpholinopropyl, 2-morpholinoethyl or dialkylaminoalkyl of the formula -(CH 2 ) k .NR<SP>3</SP>R<SP>4</SP>, wherein R<SP>3</SP> and R<SP>4</SP> are the same or different C 1-4 alkyl, R<SP>2</SP> is C 1-6 alkyl, k is 2 or 3, m is 0, 1, 2 or 3 and n is 0, 1 or 2, are obtained by the interaction of an alkanesulphonyl halide, halogen-SO 2 -R<SP>2</SP>, and an appropriate phenoxyaniline or N-alkylated (C 1-4 )-phenoxyaniline; products wherein R<SP>1</SP> is a hydrogen atom may optionally be alkylated. Pharmaceutical preparations suitable for lowering cholesterol and triglyceride levels contain as active ingredient compounds I; administration is orally or parenterally.
GB27979/68A 1967-07-18 1968-06-12 Improvements in or relating to sulphon anilides and the manufacture thereof Expired GB1204946A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US65406467A 1967-07-18 1967-07-18

Publications (1)

Publication Number Publication Date
GB1204946A true GB1204946A (en) 1970-09-09

Family

ID=24623305

Family Applications (1)

Application Number Title Priority Date Filing Date
GB27979/68A Expired GB1204946A (en) 1967-07-18 1968-06-12 Improvements in or relating to sulphon anilides and the manufacture thereof

Country Status (5)

Country Link
US (1) US3531522A (en)
BE (1) BE718228A (en)
FR (1) FR1586894A (en)
GB (1) GB1204946A (en)
IL (1) IL30223A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0010249A2 (en) * 1978-10-23 1980-04-30 Bayer Ag Herbicidal agents, process for their preparation and their use in combating weeds

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1914367A1 (en) * 1969-03-21 1970-10-01 Bayer Ag 2,2 ', 4,4'-tetrachloro-5,5'-diamino-diphenyl ether
PT86407B (en) * 1986-12-31 1990-11-20 Fujisawa Pharmaceutical Co METHOD FOR PREPARING NEW ALCANO-SULFONANILIDA DERIVATIVES, AND OF PHARMACEUTICAL COMPOSITIONS UNDERSTANDING THE SAME
DE4300696A1 (en) * 1993-01-13 1994-07-14 Roemmers Sa Substituted N-aminoalkyl methanesulfanilides as antispasmodics

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE618643A (en) * 1961-06-07 1900-01-01

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0010249A2 (en) * 1978-10-23 1980-04-30 Bayer Ag Herbicidal agents, process for their preparation and their use in combating weeds
EP0010249A3 (en) * 1978-10-23 1980-06-25 Bayer Ag Herbicidal agents, process for their preparation and their use in combating weeds

Also Published As

Publication number Publication date
FR1586894A (en) 1970-03-06
BE718228A (en) 1969-01-20
IL30223A (en) 1971-08-25
US3531522A (en) 1970-09-29
IL30223A0 (en) 1968-08-22

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PLNP Patent lapsed through nonpayment of renewal fees