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GB1261872A - Crystalline cytidine-5'-diphosphate choline monohydrate and production thereof - Google Patents

Crystalline cytidine-5'-diphosphate choline monohydrate and production thereof

Info

Publication number
GB1261872A
GB1261872A GB09756/70A GB1975670A GB1261872A GB 1261872 A GB1261872 A GB 1261872A GB 09756/70 A GB09756/70 A GB 09756/70A GB 1975670 A GB1975670 A GB 1975670A GB 1261872 A GB1261872 A GB 1261872A
Authority
GB
United Kingdom
Prior art keywords
cytidine
crystalline
diphosphate choline
monohydrate
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB09756/70A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of GB1261872A publication Critical patent/GB1261872A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

1,261,872. Crystalline cytidine-5<SP>1</SP>-diphosphate choline monohydrate. TAKEDA YAKUHIN KOGYO K.K. 24 April, 1970 [24 April, 1969], No. 19756/70. Heading C2P. The invention comprises crystalline cytidine- 5<SP>1</SP>-diphosphate choline monohydrate. The crystalline form is produced by (a) adding a hydrophilic organic solvent to an aqueous solution of cytidine-5<SP>1</SP>-diphosphate choline at a pH of 2 to 4, or (b) allowing cytidine-5<SP>1</SP>-diphosphate choline to stand for not less than 5 days at a relative humidity of at least 32% and at a temperature of 17‹ to 70‹ C.
GB09756/70A 1969-04-24 1970-04-24 Crystalline cytidine-5'-diphosphate choline monohydrate and production thereof Expired GB1261872A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3207269 1969-04-24

Publications (1)

Publication Number Publication Date
GB1261872A true GB1261872A (en) 1972-01-26

Family

ID=12348661

Family Applications (1)

Application Number Title Priority Date Filing Date
GB09756/70A Expired GB1261872A (en) 1969-04-24 1970-04-24 Crystalline cytidine-5'-diphosphate choline monohydrate and production thereof

Country Status (10)

Country Link
US (1) US3687932A (en)
BE (1) BE749332A (en)
CA (1) CA954510A (en)
CH (2) CH542857A (en)
DE (1) DE2019308C3 (en)
FR (1) FR2042370B1 (en)
GB (1) GB1261872A (en)
LU (1) LU60789A1 (en)
NL (1) NL149812B (en)
PH (1) PH9528A (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1207106B (en) * 1980-04-18 1989-05-17 Made Italiana Srl Ora Searle I PHARMACEUTICAL PREPARATION CONTAINING CITIDIN DISFOFOCOLINA ABSORBABLE ORALLY
IT1188178B (en) * 1985-07-05 1988-01-07 Bioresearch Spa CITIDIN-DIPHOSPOCOLINE SALTS PARTICULARLY SUITABLE FOR ORAL USE
US5109126A (en) * 1988-12-06 1992-04-28 Worcester Foundation For Experimental Biology 5'[2'(3')-O-(2,4,6-trinitrophenyl) pyprimidine nucleoside]diphosphate 1-glycosides
US5215973A (en) * 1991-03-07 1993-06-01 Magis Farmaceutici S.P.A. Optically active and racemic hydrated diacetylesters of α-glycero-phosphoryl-choline
US6057301A (en) * 1997-12-24 2000-05-02 Interneuron Pharmaceuticals, Inc. Hyperhydrated citicoline, process and use
CN103509073B (en) * 2013-08-29 2016-01-06 洪军 A kind of Citicoline sodium compound
ES2985104T3 (en) * 2016-10-06 2024-11-04 Kyowa Hakko Bio Co Ltd Cytidine diphosphate choline crystal and its production process

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1071231A (en) * 1963-08-30 1967-06-07 Ajinomoto Kk Nucleosides
NL129626C (en) * 1964-04-08
US3317512A (en) * 1965-06-01 1967-05-02 Upjohn Co 5', 5'-dinucleoside phosphates
US3300479A (en) * 1965-08-05 1967-01-24 Upjohn Co Deazapurine riboside cyclic 3', 5'-phosphates and process therefor
US3471471A (en) * 1965-09-21 1969-10-07 Univ Sydney Adenosine derivatives and therapeutic preparations containing same

Also Published As

Publication number Publication date
CH542857A (en) 1973-10-15
US3687932A (en) 1972-08-29
LU60789A1 (en) 1970-06-29
CH542858A (en) 1973-11-30
FR2042370A1 (en) 1971-02-12
NL149812B (en) 1976-06-15
PH9528A (en) 1976-01-09
NL7005785A (en) 1970-10-27
DE2019308C3 (en) 1981-04-09
FR2042370B1 (en) 1974-08-09
CA954510A (en) 1974-09-10
DE2019308B2 (en) 1980-08-21
DE2019308A1 (en) 1971-05-13
BE749332A (en) 1970-10-22

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