GB1250531A - - Google Patents
Info
- Publication number
- GB1250531A GB1250531A GB10269A GB1250531DA GB1250531A GB 1250531 A GB1250531 A GB 1250531A GB 10269 A GB10269 A GB 10269A GB 1250531D A GB1250531D A GB 1250531DA GB 1250531 A GB1250531 A GB 1250531A
- Authority
- GB
- United Kingdom
- Prior art keywords
- unsubstituted
- lower alkyl
- substituted
- group
- spirocycloalkane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 230000000845 anti-microbial effect Effects 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- JYEUMXHLPRZUAT-UHFFFAOYSA-N 1,2,3-triazine Chemical group C1=CN=NN=C1 JYEUMXHLPRZUAT-UHFFFAOYSA-N 0.000 abstract 1
- -1 1-methyl-2 naphthyl Chemical group 0.000 abstract 1
- JNVLQWBZTYBYKN-UHFFFAOYSA-N 3-chloro-4-[4-[2-chloro-4-(4,6-diamino-2,2-dimethyl-1,3,5-triazin-1-yl)phenyl]butyl]benzenesulfonyl fluoride;ethanesulfonic acid Chemical compound CCS(O)(=O)=O.CC1(C)N=C(N)N=C(N)N1C(C=C1Cl)=CC=C1CCCCC1=CC=C(S(F)(=O)=O)C=C1Cl JNVLQWBZTYBYKN-UHFFFAOYSA-N 0.000 abstract 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 abstract 1
- 239000005977 Ethylene Substances 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 230000000078 anti-malarial effect Effects 0.000 abstract 1
- 239000003430 antimalarial agent Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- FDDDEECHVMSUSB-UHFFFAOYSA-N sulfanilamide Chemical compound NC1=CC=C(S(N)(=O)=O)C=C1 FDDDEECHVMSUSB-UHFFFAOYSA-N 0.000 abstract 1
- 229940124530 sulfonamide Drugs 0.000 abstract 1
- 239000000829 suppository Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/10—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- E—FIXED CONSTRUCTIONS
- E04—BUILDING
- E04D—ROOF COVERINGS; SKY-LIGHTS; GUTTERS; ROOF-WORKING TOOLS
- E04D13/00—Special arrangements or devices in connection with roof coverings; Protection against birds; Roof drainage ; Sky-lights
- E04D13/15—Trimming strips; Edge strips; Fascias; Expansion joints for roofs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Structural Engineering (AREA)
- Civil Engineering (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Architecture (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1,250,531. Antimicrobial compositions. BEECHAM GROUP Ltd. 16 Dec., 1969 [1 Jan., 1969], No. 102/69. Heading A5B. [Also in Division C2] A pharmaceutical antimicrobial composition. comprising an N-substituted symmetrical dihydrotriazine derivative where R 1 is an aromatic ring system, a heterocyclic group or a non-aryl C 3 -C 8 carbocyclic ring system, all of which may be substituted or unsubstituted, R 2 is a substituted or unsubstituted divalent C 2 -C 16 aliphatic group, R 3 is hydrogen or C 1 -C 4 lower alkyl and R 4 is C 1 -C 4 lower alkyl where R 3 and R 4 may be the same or different or together may form a spirocycloalkane or lower alkyl spirocycloalkane with the 2-C of the triazine ring, salts, and acylated derivatives thereof except that R 1 is not an unsubstituted phenyl group when R 2 is unsubstituted and R 1 is not 1-methyl-2 naphthyl when R 2 is ethylene, optionally with another anti-malarial compound such as a sulphonamide and the usual excipients, may be administered orally, parenterally or by suppository.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB10269 | 1969-01-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1250531A true GB1250531A (en) | 1971-10-20 |
Family
ID=9698455
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB10269A Expired GB1250531A (en) | 1969-01-01 | 1969-01-01 |
Country Status (11)
| Country | Link |
|---|---|
| AT (2) | AT299214B (en) |
| BE (1) | BE743964A (en) |
| CH (2) | CH555837A (en) |
| DE (2) | DE1965941A1 (en) |
| ES (1) | ES374947A1 (en) |
| FR (1) | FR2027616B1 (en) |
| GB (1) | GB1250531A (en) |
| NL (1) | NL6919621A (en) |
| OA (1) | OA03891A (en) |
| SE (1) | SE388612B (en) |
| SU (1) | SU368752A3 (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5322858A (en) * | 1992-02-14 | 1994-06-21 | Jacobus Pharmaceutical Co. Inc. | N,N'-substituted imidodicarbonimidic diamides derived from hydroxylamines |
| GR980100275A (en) * | 1998-07-13 | 2000-03-31 | Lipophylic speiranic, 4,6 -diamino-symmetric triazines and the respectively salts, their isomers, stereomers and enantiomers, inhibitors of the enzyme of the bihydropholic reductase | |
| US6551614B2 (en) | 2001-03-14 | 2003-04-22 | Jacobus Pharmaceutical Co., Inc. | Antimalarial N,N′-substituted biguanides derived from hydroxylamines |
| WO2004048320A1 (en) * | 2002-11-22 | 2004-06-10 | Jacobus Pharmaceutical Company, Inc. | Biguanide and dihydrotriazine derivatives |
| US6787561B1 (en) * | 1999-07-07 | 2004-09-07 | Fuji Photo Film Co., Ltd. | Benzimidazole compounds |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9423515D0 (en) * | 1994-11-22 | 1995-01-11 | Zeneca Ltd | Fungicidal composition |
| DE102008007314A1 (en) * | 2008-02-02 | 2009-08-06 | Merck Patent Gmbh | Process for the preparation of 3,6-dihydro-1,3,5-triazine derivatives |
-
1969
- 1969-01-01 GB GB10269A patent/GB1250531A/en not_active Expired
- 1969-12-23 AT AT1198069A patent/AT299214B/en not_active IP Right Cessation
- 1969-12-23 AT AT604171A patent/AT299217B/en not_active IP Right Cessation
- 1969-12-26 ES ES374947A patent/ES374947A1/en not_active Expired
- 1969-12-29 FR FR6945195A patent/FR2027616B1/fr not_active Expired
- 1969-12-29 SE SE6917957A patent/SE388612B/en unknown
- 1969-12-30 OA OA53818D patent/OA03891A/en unknown
- 1969-12-30 NL NL6919621A patent/NL6919621A/xx not_active Application Discontinuation
- 1969-12-30 SU SU1393032A patent/SU368752A3/ru active
- 1969-12-31 CH CH1939369A patent/CH555837A/en not_active IP Right Cessation
- 1969-12-31 DE DE19691965941 patent/DE1965941A1/en active Pending
- 1969-12-31 DE DE1965711A patent/DE1965711C3/en not_active Expired
- 1969-12-31 BE BE743964D patent/BE743964A/xx unknown
- 1969-12-31 CH CH1705373A patent/CH556855A/en not_active IP Right Cessation
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5322858A (en) * | 1992-02-14 | 1994-06-21 | Jacobus Pharmaceutical Co. Inc. | N,N'-substituted imidodicarbonimidic diamides derived from hydroxylamines |
| GR980100275A (en) * | 1998-07-13 | 2000-03-31 | Lipophylic speiranic, 4,6 -diamino-symmetric triazines and the respectively salts, their isomers, stereomers and enantiomers, inhibitors of the enzyme of the bihydropholic reductase | |
| US6787561B1 (en) * | 1999-07-07 | 2004-09-07 | Fuji Photo Film Co., Ltd. | Benzimidazole compounds |
| US6551614B2 (en) | 2001-03-14 | 2003-04-22 | Jacobus Pharmaceutical Co., Inc. | Antimalarial N,N′-substituted biguanides derived from hydroxylamines |
| WO2004048320A1 (en) * | 2002-11-22 | 2004-06-10 | Jacobus Pharmaceutical Company, Inc. | Biguanide and dihydrotriazine derivatives |
| US7256218B2 (en) | 2002-11-22 | 2007-08-14 | Jacobus Pharmaceutical Company, Inc. | Biguanide and dihydrotriazine derivatives |
| US7563792B2 (en) | 2002-11-22 | 2009-07-21 | Jacobus Pharmaceutical Company, Inc. | Biguanide and dihydrotriazine derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| ES374947A1 (en) | 1972-03-16 |
| SU368752A3 (en) | 1973-01-26 |
| DE1965711B2 (en) | 1978-07-13 |
| NL6919621A (en) | 1970-07-03 |
| AT299214B (en) | 1972-06-12 |
| FR2027616A1 (en) | 1970-10-02 |
| CH556855A (en) | 1974-12-13 |
| FR2027616B1 (en) | 1974-08-09 |
| DE1965711C3 (en) | 1979-04-19 |
| DE1965711A1 (en) | 1970-09-03 |
| CH555837A (en) | 1974-11-15 |
| OA03891A (en) | 1975-08-14 |
| AT299217B (en) | 1972-06-12 |
| SE388612B (en) | 1976-10-11 |
| DE1965941A1 (en) | 1970-09-03 |
| BE743964A (en) | 1970-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed |