GB1132614A - Cardenolides - Google Patents
CardenolidesInfo
- Publication number
- GB1132614A GB1132614A GB55385/65A GB5538565A GB1132614A GB 1132614 A GB1132614 A GB 1132614A GB 55385/65 A GB55385/65 A GB 55385/65A GB 5538565 A GB5538565 A GB 5538565A GB 1132614 A GB1132614 A GB 1132614A
- Authority
- GB
- United Kingdom
- Prior art keywords
- derivatives
- acetyldigoxin
- tetracetyl
- monoacetyl
- sandoz
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001738 cardenolides Chemical class 0.000 title abstract 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 2
- 229960000583 acetic acid Drugs 0.000 abstract 1
- 230000021736 acetylation Effects 0.000 abstract 1
- 238000006640 acetylation reaction Methods 0.000 abstract 1
- HWKJSYYYURVNQU-DXJNJSHLSA-N acetyldigoxin Chemical compound C1[C@H](OC(C)=O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)[C@H](O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O HWKJSYYYURVNQU-DXJNJSHLSA-N 0.000 abstract 1
- MGVYFNHJWXJYBE-UHFFFAOYSA-N alpha-Acetyl-digoxin Natural products CC1OC(CC(O)C1O)OC2C(O)CC(OC3C(C)OC(CC3OC(=O)C)OC4CCC5(C)C(CCC6C5CCC7(C)C(C(O)CC67O)C8=CC(=O)OC8)C4)OC2C MGVYFNHJWXJYBE-UHFFFAOYSA-N 0.000 abstract 1
- 230000003177 cardiotonic effect Effects 0.000 abstract 1
- KRVSOGSZCMJSLX-UHFFFAOYSA-L chromic acid Substances O[Cr](O)(=O)=O KRVSOGSZCMJSLX-UHFFFAOYSA-L 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229960005156 digoxin Drugs 0.000 abstract 1
- AWJWCTOOIBYHON-UHFFFAOYSA-N furo[3,4-b]pyrazine-5,7-dione Chemical compound C1=CN=C2C(=O)OC(=O)C2=N1 AWJWCTOOIBYHON-UHFFFAOYSA-N 0.000 abstract 1
- 239000012362 glacial acetic acid Substances 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J19/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 by a lactone ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
1,132,614. Cardenolide derivatives. SANDOZ Ltd. 31 Dec., 1965 [1 Feb., 1965], No. 55385/65. Heading C2U. The invention comprises 12-dehydro-digoxin and its α-monoacetyl and tetracetyl derivatives, and their preparation by oxidation of α-acetyldigoxin with chromic acid in glacial acetic acid, followed if desired by, in any order, acetylation and/or hydrolysis. The compounds of the invention have cardiotonic activity and may be used in pharmaceutical compositions in combination with a carrier, for example in forms suitable for oral or parenteral administration.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH136965A CH459190A (en) | 1965-02-01 | 1965-02-01 | Process for the production of a new cardenolide |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1132614A true GB1132614A (en) | 1968-11-06 |
Family
ID=4208797
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB55385/65A Expired GB1132614A (en) | 1965-02-01 | 1965-12-31 | Cardenolides |
Country Status (4)
Country | Link |
---|---|
CH (1) | CH459190A (en) |
FR (2) | FR1466165A (en) |
GB (1) | GB1132614A (en) |
NL (1) | NL6601041A (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BG17306A3 (en) * | 1969-06-10 | 1973-07-25 | Dr. Karl Thomae Gmbh | METHOD FOR OBTAINING NEW CARDENOLIDE-GLYCOSIDES |
DE2926026A1 (en) * | 1979-06-28 | 1981-01-08 | Boehringer Mannheim Gmbh | NEW DIGOXIN DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF |
-
1965
- 1965-02-01 CH CH136965A patent/CH459190A/en unknown
- 1965-12-31 GB GB55385/65A patent/GB1132614A/en not_active Expired
-
1966
- 1966-01-27 NL NL6601041A patent/NL6601041A/xx unknown
- 1966-01-31 FR FR47797A patent/FR1466165A/en not_active Expired
- 1966-04-29 FR FR59691A patent/FR5455M/fr not_active Expired
Also Published As
Publication number | Publication date |
---|---|
CH459190A (en) | 1968-07-15 |
FR1466165A (en) | 1967-01-13 |
FR5455M (en) | 1967-10-16 |
NL6601041A (en) | 1966-08-02 |
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