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GB1124973A - Alpha-indolyl-aliphatic acid amides - Google Patents

Alpha-indolyl-aliphatic acid amides

Info

Publication number
GB1124973A
GB1124973A GB3528/68A GB352868A GB1124973A GB 1124973 A GB1124973 A GB 1124973A GB 3528/68 A GB3528/68 A GB 3528/68A GB 352868 A GB352868 A GB 352868A GB 1124973 A GB1124973 A GB 1124973A
Authority
GB
United Kingdom
Prior art keywords
amino
alkyl
pyrrolidino
free acids
aralkylamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3528/68A
Inventor
Tsung-Ying Shen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB1124973A publication Critical patent/GB1124973A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Novel compounds of the formula <FORM:1124973/C2/1> wherein A, R2, R8, R4, R5, R3 and R13 are as defined in Specification 1,124,972, and M is amino, alkylamino, dialkylamino, alkenylamino, aralkylamino, N - alkyl - N - aralkylamino, anilino, haloanilino, alkoxyanilino, piperidino, pyrrolidino, morpholino, alkylpiperazinyl, N-phenyl - piperazino, 1 - (b - hydroxyethyl)-piperazino, N - [b - (N - alkyl - pyrrolidino)]-N - alkyl - amino, N - [b - (N - alkyl - piperidino)] - N - alkyl - amino, tetrahydrofurfurylamino, N - carbobenzyloxy - N - alkyl - amino, 1,2,5,6 - tetrahydropyridino, D - glycosylamino, N - (N1,N1 - dialkylcarboxamido)-N - methylamino, N - methyl - 3 - aminopiperidino, N - methyl - 3 - amino - pyrrolidino, b - ethoxyethylamino or di - (b -ethoxyethyl)-amino, and acid-addition salts thereof are prepared from the corresponding free acids (via their halides) and the appropriate amines, or by methods analogous to those described in Specification 1,124,972, for the preparation of the free acids. On reaction with nitrous acid the amides are reconverted to the free acids. The indole derivatives of the invention, which are stated to be anti-inflammatory agents, may be incorporated in pharmaceutical compositions for oral administration.
GB3528/68A 1964-12-31 1965-12-29 Alpha-indolyl-aliphatic acid amides Expired GB1124973A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US42251164A 1964-12-31 1964-12-31

Publications (1)

Publication Number Publication Date
GB1124973A true GB1124973A (en) 1968-08-21

Family

ID=23675212

Family Applications (2)

Application Number Title Priority Date Filing Date
GB55088/65A Expired GB1124972A (en) 1964-12-31 1965-12-29 Alpha-indolyl-aliphatic acids and their derivatives
GB3528/68A Expired GB1124973A (en) 1964-12-31 1965-12-29 Alpha-indolyl-aliphatic acid amides

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB55088/65A Expired GB1124972A (en) 1964-12-31 1965-12-29 Alpha-indolyl-aliphatic acids and their derivatives

Country Status (6)

Country Link
BR (1) BR6576168D0 (en)
CH (1) CH483421A (en)
DE (1) DE1595973A1 (en)
FR (2) FR1482845A (en)
GB (2) GB1124972A (en)
NL (1) NL6517262A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877202A (en) * 1994-02-22 1999-03-02 Bitonti; Alan J. Indole derivatives useful to treat estrogen-related neoplasms and disorders

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877202A (en) * 1994-02-22 1999-03-02 Bitonti; Alan J. Indole derivatives useful to treat estrogen-related neoplasms and disorders

Also Published As

Publication number Publication date
FR5920M (en) 1968-04-01
CH483421A (en) 1969-12-31
FR1482845A (en) 1967-06-02
BR6576168D0 (en) 1973-09-06
GB1124972A (en) 1968-08-21
NL6517262A (en) 1966-07-04
DE1595973A1 (en) 1970-02-05

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