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GB1120298A - Stabilised enzymes - Google Patents

Stabilised enzymes

Info

Publication number
GB1120298A
GB1120298A GB3106666A GB3106666A GB1120298A GB 1120298 A GB1120298 A GB 1120298A GB 3106666 A GB3106666 A GB 3106666A GB 3106666 A GB3106666 A GB 3106666A GB 1120298 A GB1120298 A GB 1120298A
Authority
GB
United Kingdom
Prior art keywords
stabilised
protamine
lysine
poly
enzymes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3106666A
Inventor
Lily Baxendale
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biorex Laboratories Ltd
Original Assignee
Biorex Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biorex Laboratories Ltd filed Critical Biorex Laboratories Ltd
Priority to GB3106666A priority Critical patent/GB1120298A/en
Publication of GB1120298A publication Critical patent/GB1120298A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Inorganic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Stabilized enzyme preparations comprise a minor amount of poly-L-lysine and/or albumin and/or protamine. The poly-L-lysine and protamine may be used in the form of salts with organic or inorganic acids. Lysozyme and glucuronoglycosaminoglycan-hyaluronate-lyase may be so stabilized.ALSO:Enzymes, e.g. glucuronoglycosaminoglycanhyaluronate-lyase or lysozyme, are stabilised by addition of albumin, or of poly-L-lysine or protamine or salts thereof with organic or inorganic acids. Such stabilised enzyme solutions may be used therapeutically by intravenous or intramuscular injection or by scanification. Compositions may also contain glucose, invert sugar, or wetting, emulsifying and dispersing agents.
GB3106666A 1966-07-11 1966-07-11 Stabilised enzymes Expired GB1120298A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB3106666A GB1120298A (en) 1966-07-11 1966-07-11 Stabilised enzymes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3106666A GB1120298A (en) 1966-07-11 1966-07-11 Stabilised enzymes

Publications (1)

Publication Number Publication Date
GB1120298A true GB1120298A (en) 1968-07-17

Family

ID=10317458

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3106666A Expired GB1120298A (en) 1966-07-11 1966-07-11 Stabilised enzymes

Country Status (1)

Country Link
GB (1) GB1120298A (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0065800A1 (en) * 1981-05-13 1982-12-01 Nederlandse Organisatie voor toegepast-natuurwetenschappelijk onderzoek TNO Enzyme solutions and method for the preparation thereof
EP0562624A2 (en) * 1992-03-26 1993-09-29 Modrovich, Ivan E. Stabilization of functional proteins
EP0599652A2 (en) * 1992-11-25 1994-06-01 Chisso Corporation Enzyme reaction stabilizers and enzyme preservatives
EP0603831A1 (en) * 1992-12-21 1994-06-29 Modrovich, Ivan E. Stable single liquid reagent for the determination of carbon dioxide in serum
WO2000039290A2 (en) * 1998-12-23 2000-07-06 Id Pharma Gmbh Pharmaceutical formulation containing a microbial enzyme which digests hyaluronic acid
EP2380593A1 (en) * 2010-04-23 2011-10-26 Arkray, Inc. Stabilizing labeled antibody using amino acids

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0065800A1 (en) * 1981-05-13 1982-12-01 Nederlandse Organisatie voor toegepast-natuurwetenschappelijk onderzoek TNO Enzyme solutions and method for the preparation thereof
EP0562624A2 (en) * 1992-03-26 1993-09-29 Modrovich, Ivan E. Stabilization of functional proteins
EP0562624A3 (en) * 1992-03-26 1994-10-05 Modrovich Ivan Endre Stabilization of functional proteins
EP0599652A2 (en) * 1992-11-25 1994-06-01 Chisso Corporation Enzyme reaction stabilizers and enzyme preservatives
EP0599652A3 (en) * 1992-11-25 1994-10-05 Chisso Corp Enzyme reaction stabilizers and enzyme preservatives.
US5674726A (en) * 1992-11-25 1997-10-07 Chisso Corporation Enzyme stabilization with poly-L-lysine
EP0603831A1 (en) * 1992-12-21 1994-06-29 Modrovich, Ivan E. Stable single liquid reagent for the determination of carbon dioxide in serum
WO2000039290A2 (en) * 1998-12-23 2000-07-06 Id Pharma Gmbh Pharmaceutical formulation containing a microbial enzyme which digests hyaluronic acid
WO2000039290A3 (en) * 1998-12-23 2001-03-08 Id Pharma Gmbh Pharmaceutical formulation containing a microbial enzyme which digests hyaluronic acid
EP2380593A1 (en) * 2010-04-23 2011-10-26 Arkray, Inc. Stabilizing labeled antibody using amino acids

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