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GB1184023A - Process for the production of Substituted Tetrahydro-1,4-Oxazines - Google Patents

Process for the production of Substituted Tetrahydro-1,4-Oxazines

Info

Publication number
GB1184023A
GB1184023A GB1219168A GB1219168A GB1184023A GB 1184023 A GB1184023 A GB 1184023A GB 1219168 A GB1219168 A GB 1219168A GB 1219168 A GB1219168 A GB 1219168A GB 1184023 A GB1184023 A GB 1184023A
Authority
GB
United Kingdom
Prior art keywords
radical
formula
substituted
oxazines
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1219168A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CT EUROP DE RECH S MAUVERNAY
Centre Europeen de Recherches Mauvernay CERM
Original Assignee
CT EUROP DE RECH S MAUVERNAY
Centre Europeen de Recherches Mauvernay CERM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CT EUROP DE RECH S MAUVERNAY, Centre Europeen de Recherches Mauvernay CERM filed Critical CT EUROP DE RECH S MAUVERNAY
Publication of GB1184023A publication Critical patent/GB1184023A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/04—Saturated ethers
    • C07C43/12—Saturated ethers containing halogen
    • C07C43/123—Saturated ethers containing halogen both carbon chains are substituted by halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/17—Unsaturated ethers containing halogen
    • C07C43/174—Unsaturated ethers containing halogen containing six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

1,184,023. Substituted tetrahydro-1,4-oxazines. CENTRE EUROPEEN DE RECHERCHES MAUVERNAY. 13 March, 1968 [26 June, 1967], No. 12191/68. Heading C2C. The invention comprises novel 2,4- or 2,2,4- substituted tetrahydro - 1,4 - oxazines as described in Tables II and III (not shown) of the Specification, and a process for the production of tetrahydro-1,4-oxazines of the formula where R is a monovalent hydrocarbon radical, which may contain halogen substituents, R<SP>1</SP> is a hydrogen atom or an alkyl radical having up to 6 carbon atoms, and R 1 is hydrogen or an alkenyl radical or a linear, branched or cyclic alkyl radical optionally substituted by a hydroxy radical, alkoxy radical or aryl radical, which may itself be substituted, or a linear or branched alkyl radical substituted by a heterocyclic radical, comprising: (1) adding tertiary butyl hypobromite at a temperature below 0‹ C. to a mixture of glycol chlorohydrin and an olefin of the formula in which R and R<SP>1</SP> are as defined above, to form an intermediate compound of the formula and (2) condensing 1 mole of the said intermediate compound with 3 moles of a primary amine of the formula R 1 -NH 2 in which R 1 is as defined above. Intermediates of the formula where R is phenyl, p-chlorophenyl, methyl or p-fluorobenzyl when R<SP>1</SP> is H, and R is methyl when R<SP>1</SP> is methyl are prepared as in (1) above.
GB1219168A 1967-06-26 1968-03-13 Process for the production of Substituted Tetrahydro-1,4-Oxazines Expired GB1184023A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR111950A FR1535615A (en) 1967-06-26 1967-06-26 Process for obtaining tetrahydro-1, 4-oxazines substituted in 2, 4 and in 2, 2, 4

Publications (1)

Publication Number Publication Date
GB1184023A true GB1184023A (en) 1970-03-11

Family

ID=8633844

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1219168A Expired GB1184023A (en) 1967-06-26 1968-03-13 Process for the production of Substituted Tetrahydro-1,4-Oxazines

Country Status (6)

Country Link
BE (1) BE709011A (en)
CH (1) CH487919A (en)
DE (1) DE1643857A1 (en)
FR (1) FR1535615A (en)
GB (1) GB1184023A (en)
NL (1) NL147728B (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0140359A1 (en) * 1983-11-02 1985-05-08 Beecham Group Plc Morpholine derivatives
EP0507863A1 (en) * 1989-12-28 1992-10-14 Virginia Commonwealth University Sigma receptor ligands and the use thereof
WO1993015052A1 (en) * 1992-01-28 1993-08-05 Smithkline Beecham Plc Compounds as calcium channel antagonists
US6087346A (en) * 1993-06-23 2000-07-11 Cambridge Neuroscience, Inc. Sigma receptor ligands and the use thereof
WO2006077025A2 (en) * 2005-01-18 2006-07-27 F. Hoffmann-La Roche Ag Morpholines as 5ht2c agonists
US7132551B2 (en) 2000-09-11 2006-11-07 Sepracor Inc. Ligands for monoamine receptors and transporters, and methods of use thereof
US7294637B2 (en) 2000-09-11 2007-11-13 Sepracor, Inc. Method of treating addiction or dependence using a ligand for a monamine receptor or transporter

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2657476A1 (en) * 1976-12-18 1978-06-22 Basf Ag MORPHOLINE DERIVATIVES
FR2517305B1 (en) * 1981-12-01 1985-10-25 Lafon Labor NOVEL 2-PHENYL-MORPHOLINE DERIVATIVES AND THEIR USE IN THERAPEUTICS
FR2553411B1 (en) * 1983-10-14 1986-08-01 Lafon Labor 2-HALOGENOPHENYL-MORPHOLINE DERIVATIVES, METHOD OF PREPARATION AND THERAPEUTIC USE
FR2553412B1 (en) * 1983-10-17 1986-03-21 Lafon Labor 4-ALKYL-2-METHYL-2-PHENYL-MORPHOLINE DERIVATIVES, METHOD OF PREPARATION AND USE IN THERAPEUTICS

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0140359A1 (en) * 1983-11-02 1985-05-08 Beecham Group Plc Morpholine derivatives
EP0507863A1 (en) * 1989-12-28 1992-10-14 Virginia Commonwealth University Sigma receptor ligands and the use thereof
EP0507863A4 (en) * 1989-12-28 1993-07-07 Virginia Commonwealth University Sigma receptor ligands and the use thereof
US6057371A (en) * 1989-12-28 2000-05-02 Virginia Commonwealth University Sigma receptor ligands and the use thereof
WO1993015052A1 (en) * 1992-01-28 1993-08-05 Smithkline Beecham Plc Compounds as calcium channel antagonists
US6087346A (en) * 1993-06-23 2000-07-11 Cambridge Neuroscience, Inc. Sigma receptor ligands and the use thereof
US7294637B2 (en) 2000-09-11 2007-11-13 Sepracor, Inc. Method of treating addiction or dependence using a ligand for a monamine receptor or transporter
US7132551B2 (en) 2000-09-11 2006-11-07 Sepracor Inc. Ligands for monoamine receptors and transporters, and methods of use thereof
US7517892B2 (en) 2000-09-11 2009-04-14 Sepracor Inc. Ligands for monoamine receptors and transporters, and methods of use thereof
US7816375B2 (en) 2000-09-11 2010-10-19 Sepracor Inc. Ligands for monoamine receptors and transporters, and methods of use thereof
WO2006077025A3 (en) * 2005-01-18 2006-09-08 Hoffmann La Roche Morpholines as 5ht2c agonists
WO2006077025A2 (en) * 2005-01-18 2006-07-27 F. Hoffmann-La Roche Ag Morpholines as 5ht2c agonists
US7323466B2 (en) 2005-01-18 2008-01-29 Hoffman-La Roche Inc. Morpholine derivatives as 5HT2C receptor agonists for the treatment of obesity
KR100880997B1 (en) * 2005-01-18 2009-02-03 에프. 호프만-라 로슈 아게 Morpholines as 5ht2c agonists

Also Published As

Publication number Publication date
NL6801287A (en) 1968-12-27
CH487919A (en) 1970-03-31
FR1535615A (en) 1968-08-09
NL147728B (en) 1975-11-17
DE1643857A1 (en) 1971-04-15
BE709011A (en) 1968-07-05

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Legal Events

Date Code Title Description
PS Patent sealed
435 Patent endorsed 'licences of right' on the date specified (sect. 35/1949)
PCNP Patent ceased through non-payment of renewal fee