GB1026401A - Isatin thiosemicarbazones,their preparation and pharmaceutical formulations containing them - Google Patents

Abstract

The invention comprises compounds of the general formula <FORM:1026401/C2/1> (wherein R1 is a hydrogen atom or an alkyl, hydroxyalkyl or alkenyl group containing up to 5 carbon atoms and the hydroxy group may itself be esterified by a C1- 5 aliphatic carboxylic acid radical, R2 is an optional substituent and if present is a halogen atom or a C1- 5 alkyl or alkoxy group, and R5 and R6 are the same or different and are straight or branched alkyl or alkenyl groups containing up to 5 carbon atoms each or -NR5R6 is a saturated or unsaturated heterocyclic group containing no further hetero atom, a morpholino group or a piperazino group wherein the second nitrogen atom may be substituted by a C1- 5 alkyl group) and acid addition salts of those compounds which are basic, pharmaceutical preparations containing them, and their preparation by reacting a compound of the formula <FORM:1026401/C2/2> with a compound of the formula H2N.NH.CS.NR5R6 optionally followed by acid addition salt formation when the product is basic. The preparation of a number of starting materials of the third general formula above and salts thereof, in most cases from the corresponding thiocarbamoylthioglycollic acids (preparation described), and of acetophenone 4,4 - (3 - methyl - 3 - azapentamethylene)thiosemicarbazone is described. The compounds of the invention have anti-viral activity and may be administered in the form of pharmaceutical preparations (e.g. tablets, capsules, cachets, ampoules, suppositories, powders, granules, solutions, suspensions and ointments) containing them together with a carrier.