GB1024809A - Process for the production of 6-acylamino-penicillanic acids - Google Patents
Process for the production of 6-acylamino-penicillanic acidsInfo
- Publication number
- GB1024809A GB1024809A GB3743664A GB3743664A GB1024809A GB 1024809 A GB1024809 A GB 1024809A GB 3743664 A GB3743664 A GB 3743664A GB 3743664 A GB3743664 A GB 3743664A GB 1024809 A GB1024809 A GB 1024809A
- Authority
- GB
- United Kingdom
- Prior art keywords
- prepared
- saccharin
- phenoxyacetyl
- phenoxypropionyl
- phthalimide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
Abstract
6-Acylaminopenicillanic acids are produced by reacting 6-aminopenicillanic acid (6-APA) with a compound of general formula <FORM:1024809/C2/1> in which X is -CO- or -SO2- and acyl is the radical of an organic carboxylic acid. The reaction may be carried out with anhydrous solvents, e.g. methylene chloride, or aqueous solvents, e.g. aqueous acetone, at room temperature or with cooling by ice. Phenoxyacetyl-6-aminopenicillanic acid is prepared from 6-APA and N-phenoxyacetylphthalimide or phenoxyacetyl saccharin; a -phenoxypropionyl-6-aminopenicillanic acid is prepared from N-(a -phenoxypropionyl)-phthalimide. N-Phenoxyacetyl phthalimide is prepared by reacting phenoxyacetylchloride with potassium phthalimide in acetone. N-(a -phenoxypropionyl)-phthalimide is similarly prepared. N-Phenoxyacetyl saccharin is prepared by reacting potassium saccharin with phenoxyacetyl chloride in acetone. N-(a -phenoxypropionyl) saccharin and N-a (-phenoxybutyryl)-saccharin are similarly prepared.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEF0040759 | 1963-09-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1024809A true GB1024809A (en) | 1966-04-06 |
Family
ID=7098378
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3743664A Expired GB1024809A (en) | 1963-09-14 | 1964-09-14 | Process for the production of 6-acylamino-penicillanic acids |
Country Status (9)
| Country | Link |
|---|---|
| AT (1) | AT259134B (en) |
| BR (1) | BR6462546D0 (en) |
| DE (1) | DE1745619B1 (en) |
| DK (1) | DK131288B (en) |
| FI (1) | FI46730C (en) |
| GB (1) | GB1024809A (en) |
| NL (1) | NL141514B (en) |
| NO (1) | NO129909B (en) |
| SE (1) | SE309041B (en) |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL276151A (en) * | ||||
| FR61E (en) * | 1901-08-21 | 1902-10-13 | Basf Ag | Production of azo dyes, likely to be chromed on the fiber |
| DE1146061C2 (en) * | 1958-07-31 | 1977-09-01 | Beecham-Group Limited, Brentford, Middlesex (Großbritannien) | PROCESS FOR THE PREPARATION OF DERIVATIVES OF 6-AMINOPENICILLANIC ACID |
| DE1149361B (en) * | 1959-09-24 | 1963-05-30 | Bayer Ag | Process for the production of 6-acylaminopenicillanic acids by enzymatic means |
| DE1151803B (en) * | 1959-12-04 | 1963-07-25 | Bayer Ag | Process for the preparation of 6-acylaminopenicillanic acids |
| US3161634A (en) * | 1960-12-21 | 1964-12-15 | Novo Terapeutisk Labor As | Process of making nu-acyl derivatives of 6-amino-penicillanic acid |
| US3094519A (en) * | 1961-01-16 | 1963-06-18 | Bristol Myers Co | Process for the preparation of derivatives of 6-amino-penicillanic acid |
| DE1249280B (en) * | 1962-11-02 | 1967-09-07 | Beecham GrouD Limited, Brentford Middlesex (Großbritannien) | Process for the preparation of Hydroxybenzyl y amino-pemciUmen |
-
1963
- 1963-09-14 DE DE19631745619 patent/DE1745619B1/en not_active Ceased
-
1964
- 1964-09-02 FI FI185564A patent/FI46730C/en active
- 1964-09-08 NL NL6410449A patent/NL141514B/en unknown
- 1964-09-11 DK DK450664A patent/DK131288B/en unknown
- 1964-09-11 BR BR16254664A patent/BR6462546D0/en unknown
- 1964-09-12 NO NO15474364A patent/NO129909B/no unknown
- 1964-09-14 SE SE1102264A patent/SE309041B/xx unknown
- 1964-09-14 AT AT786264A patent/AT259134B/en active
- 1964-09-14 GB GB3743664A patent/GB1024809A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| BR6462546D0 (en) | 1973-08-07 |
| NO129909B (en) | 1974-06-10 |
| FI46730B (en) | 1973-02-28 |
| DK131288C (en) | 1975-11-17 |
| NL6410449A (en) | 1965-03-15 |
| DK131288B (en) | 1975-06-23 |
| FI46730C (en) | 1973-06-11 |
| NL141514B (en) | 1974-03-15 |
| DE1745619B1 (en) | 1969-09-11 |
| SE309041B (en) | 1969-03-10 |
| AT259134B (en) | 1967-12-27 |
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