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GB1001949A - Penetrating agents - Google Patents

Penetrating agents

Info

Publication number
GB1001949A
GB1001949A GB2787562A GB2787562A GB1001949A GB 1001949 A GB1001949 A GB 1001949A GB 2787562 A GB2787562 A GB 2787562A GB 2787562 A GB2787562 A GB 2787562A GB 1001949 A GB1001949 A GB 1001949A
Authority
GB
United Kingdom
Prior art keywords
carbon atoms
cycloaliphatic
aliphatic
penetration
aid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2787562A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of GB1001949A publication Critical patent/GB1001949A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31—Hydrocarbons
    • A61K8/315—Halogenated hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Birds (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

An ointment, liniment, lotion or like preparation for topical application, comprises an active agent which is to penetrate the epidermis, and, as an aid for assisting penetration of aid active agent into the epidermis, a monovalent saturated or unsaturated aliphatic, cycloaliphatic or aromatic alcohol having from 4 to 12 carbon atoms; an aliphatic, cycloaliphatic or aromatic hydrocarbon having from 5 to 12 carbon atoms; a terpene having from 9 to 15 carbon atoms; an aliphatic, cycloaliphatic or aromatic aldehyde, ketone or ester having from 4 to 10 carbon atoms; an essential oil or a substance containing an essential oil; a halogenated or nitrated aliphatic, cycloaliphatic or aromatic hydrocarbon having from 2 to 8 carbon atoms; or a mixture of two or more of such penetration aids, and any inert carrier necessary for forming said preparation, the carrier being such or being present in an amount such as not to prevent penetration by said penetration aid. Examples relate to lotions or ointments containing (a) malachite green, cyclohexane and ethyl glycol; (b) rhodamine B, cyclohexane and ethyl glycol; (c) tetracycline, n-undecane and and ethylene glycol; (d) as in (c) plus silica; (e) as in (c) using n-docosane, stearyl alcohol or cetyl alcohol in place of ethylene glycol; (f) tetracycline, n-undecone, ethylene glycol and cetyl alcohol. Numerous examples of penetrating agents are given. The preparations may be cosmetics.
GB2787562A 1961-07-20 1962-07-19 Penetrating agents Expired GB1001949A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEM49750A DE1227616B (en) 1961-07-20 1961-07-20 Penetration agent

Publications (1)

Publication Number Publication Date
GB1001949A true GB1001949A (en) 1965-08-18

Family

ID=7306610

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2787562A Expired GB1001949A (en) 1961-07-20 1962-07-19 Penetrating agents

Country Status (6)

Country Link
AT (2) AT258471B (en)
BR (1) BR6241165D0 (en)
DE (1) DE1227616B (en)
FR (1) FR1329357A (en)
GB (1) GB1001949A (en)
NL (1) NL281225A (en)

Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2308354A1 (en) * 1975-04-22 1976-11-19 Bus Louise Cosmetic lotion for the treatment of acne - contg. benzaldehyde and emollients such as benzoin
FR2369867A1 (en) * 1976-11-08 1978-06-02 Manetti & Roberts Italo Brit ACTIVATOR FOR COSMETIC COMPOSITIONS AND COSMETIC COMPOSITIONS CONTAINING IT
FR2399834A2 (en) * 1977-08-09 1979-03-09 Bus Louise Skin lotion for treating acne - contains benzaldehyde, softening agent, sodium alginate and tri:ethanolamine
FR2520233A1 (en) * 1982-01-28 1983-07-29 Oreal COMPOSITION OF ANTHRALIN OR ONE OF ITS DERIVATIVES IN AN AROMATIC ESTER AND ITS USE IN THE TREATMENT OF SKIN DISEASES
EP0091964A1 (en) * 1981-09-28 1983-10-26 Nitto Denko Corporation Base composition for preparing medicine for external application, medicinal composition for external application, and method for accelerating percutaneous absorption of medicinal agent
EP0116401A2 (en) * 1983-01-10 1984-08-22 Robert Young & Company Limited Endoparasiticidal compositions
EP0136033A2 (en) * 1983-08-22 1985-04-03 Ici Australia Limited Pour-on formulation for the control of parasites
FR2558729A1 (en) * 1984-02-01 1985-08-02 Nitto Electric Ind Co COMPOSITION FOR PERCUTANEOUS ADMINISTRATION OF METOCLOPRAMIDE
FR2566661A1 (en) * 1984-07-02 1986-01-03 Gendler El Method for dissolving griseofulvin for the purpose of preparing a solution of this substance, which is chemically stable and possesses biological activity, for local applications.
US4568343A (en) * 1984-10-09 1986-02-04 Alza Corporation Skin permeation enhancer compositions
US4865848A (en) * 1987-02-26 1989-09-12 Alza Corporation Skin permeation enhancer compositions using sucrose esters
US4885154A (en) * 1988-03-01 1989-12-05 Alza Corporation Method for reducing sensitization or irritation in transdermal drug delivery and means therefor
US4906475A (en) 1988-02-16 1990-03-06 Paco Pharmaceutical Services Estradiol transdermal delivery system
EP0380047A2 (en) * 1989-01-23 1990-08-01 Freund Industrial Co., Ltd. A percutaneous or trans-mucosal absorption enhancer and a percutaneous or trans-mucosal medicine
WO1993007874A1 (en) * 1991-10-26 1993-04-29 Ian Flockhart Medicament composition for topical application
WO1993007901A1 (en) * 1991-10-26 1993-04-29 Ian Flockhart Composition for topical application
US5411740A (en) * 1992-05-13 1995-05-02 Alza Corporation Transdermal administration of oxybutynin
WO1995020403A1 (en) * 1994-01-31 1995-08-03 The Procter & Gamble Company Aqueous topical compositions
US5900250A (en) 1992-05-13 1999-05-04 Alza Corporation Monoglyceride/lactate ester permeation enhancer for oxybutnin
US6426208B1 (en) 1999-11-12 2002-07-30 Harbor-Ucla Research And Education Institute Recombinant α-L-iduronidase, methods for producing and purifying the same and methods for treating diseases caused by deficiencies thereof
US6569661B1 (en) 1999-11-12 2003-05-27 Biomarin Pharmaceutical Inc. Recombinant α-L-iduronidase, methods for producing and purifying the same and methods for treating diseases caused by deficiencies thereof
US6585971B1 (en) 1999-11-12 2003-07-01 Harbor-Ucla Research And Education Institute Recombinant α-L-iduronidase, methods for producing and purifying the same and methods for treating disease caused by deficiencies thereof
EP1454624A1 (en) * 2001-11-23 2004-09-08 Wei Wang Antiviral, antibacterial pharmaceutical composition of cantharidic anhydride and method of preparation thereof
WO2004080443A1 (en) 2003-03-14 2004-09-23 Epistem Limited Treatment and/or prevention of non-viral epithelial damage
WO2011027128A1 (en) 2009-09-03 2011-03-10 The University Of Manchester Use of non-digestible oligosaccharides
EP2327414A1 (en) 2002-11-07 2011-06-01 BioMarin Pharmaceutical Inc. Precursor N-acetylgalactosamine-4-sulfatase, methods of treatment using said enzyme and methods for producing and purifying said enzyme

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4005032A (en) * 1974-09-25 1977-01-25 Xerox Corporation Liquid crystalline composition having mixed cholesteric-nematic properties
JPS58189115A (en) * 1982-04-30 1983-11-04 Kowa Co Drug for external use
JPS5948413A (en) * 1982-09-14 1984-03-19 Grelan Pharmaceut Co Ltd Anti-inflammatory and analgesic agent for external use containing clidanac
JPS6013720A (en) * 1983-07-01 1985-01-24 Nitto Electric Ind Co Ltd Percutaneous administration of physiological activator using adjuvant, solvent and diol modulator
DE102004031210A1 (en) * 2004-06-28 2006-02-09 Trommsdorff Gmbh & Co. Kg MLV cosmetic

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE870323C (en) * 1948-10-02 1953-03-12 Johann Schmid Process for the preparation of a liniment
DE801283C (en) * 1948-10-02 1950-12-28 Johann Schmid Process for the preparation of a liniment

Cited By (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2308354A1 (en) * 1975-04-22 1976-11-19 Bus Louise Cosmetic lotion for the treatment of acne - contg. benzaldehyde and emollients such as benzoin
FR2369867A1 (en) * 1976-11-08 1978-06-02 Manetti & Roberts Italo Brit ACTIVATOR FOR COSMETIC COMPOSITIONS AND COSMETIC COMPOSITIONS CONTAINING IT
FR2399834A2 (en) * 1977-08-09 1979-03-09 Bus Louise Skin lotion for treating acne - contains benzaldehyde, softening agent, sodium alginate and tri:ethanolamine
EP0091964A1 (en) * 1981-09-28 1983-10-26 Nitto Denko Corporation Base composition for preparing medicine for external application, medicinal composition for external application, and method for accelerating percutaneous absorption of medicinal agent
EP0091964A4 (en) * 1981-09-28 1985-07-01 Nitto Electric Ind Co Base composition for preparing medicine for external application, medicinal composition for external application, and method for accelerating percutaneous absorption of medicinal agent.
FR2520233A1 (en) * 1982-01-28 1983-07-29 Oreal COMPOSITION OF ANTHRALIN OR ONE OF ITS DERIVATIVES IN AN AROMATIC ESTER AND ITS USE IN THE TREATMENT OF SKIN DISEASES
EP0116401A3 (en) * 1983-01-10 1985-08-07 Robert Young & Company Limited Endoparasiticidal compositions
EP0116401A2 (en) * 1983-01-10 1984-08-22 Robert Young & Company Limited Endoparasiticidal compositions
EP0136033A3 (en) * 1983-08-22 1986-03-12 Ici Australia Limited Pour-on formulation for the control of parasites
EP0136033A2 (en) * 1983-08-22 1985-04-03 Ici Australia Limited Pour-on formulation for the control of parasites
FR2558729A1 (en) * 1984-02-01 1985-08-02 Nitto Electric Ind Co COMPOSITION FOR PERCUTANEOUS ADMINISTRATION OF METOCLOPRAMIDE
FR2566661A1 (en) * 1984-07-02 1986-01-03 Gendler El Method for dissolving griseofulvin for the purpose of preparing a solution of this substance, which is chemically stable and possesses biological activity, for local applications.
US4568343A (en) * 1984-10-09 1986-02-04 Alza Corporation Skin permeation enhancer compositions
US4865848A (en) * 1987-02-26 1989-09-12 Alza Corporation Skin permeation enhancer compositions using sucrose esters
US4906475A (en) 1988-02-16 1990-03-06 Paco Pharmaceutical Services Estradiol transdermal delivery system
US5304379A (en) * 1988-03-01 1994-04-19 Alza Corporation Method for reducing sensitization or irritation in transdermal drug delivery and means therefor
US4885154A (en) * 1988-03-01 1989-12-05 Alza Corporation Method for reducing sensitization or irritation in transdermal drug delivery and means therefor
EP0380047A2 (en) * 1989-01-23 1990-08-01 Freund Industrial Co., Ltd. A percutaneous or trans-mucosal absorption enhancer and a percutaneous or trans-mucosal medicine
EP0380047A3 (en) * 1989-01-23 1991-07-31 Freund Industrial Co., Ltd. A percutaneous or trans-mucosal absorption enhancer and a percutaneous or trans-mucosal medicine
WO1993007874A1 (en) * 1991-10-26 1993-04-29 Ian Flockhart Medicament composition for topical application
WO1993007901A1 (en) * 1991-10-26 1993-04-29 Ian Flockhart Composition for topical application
US5411740A (en) * 1992-05-13 1995-05-02 Alza Corporation Transdermal administration of oxybutynin
US5500222A (en) * 1992-05-13 1996-03-19 Alza Corporation Transdermal administration of oxybutynin
US5900250A (en) 1992-05-13 1999-05-04 Alza Corporation Monoglyceride/lactate ester permeation enhancer for oxybutnin
WO1995020403A1 (en) * 1994-01-31 1995-08-03 The Procter & Gamble Company Aqueous topical compositions
US6858206B2 (en) 1999-11-12 2005-02-22 Emil D. Kakkis Methods for treating diseases caused by deficiencies of recombinant alpha-L-iduronidase
US6426208B1 (en) 1999-11-12 2002-07-30 Harbor-Ucla Research And Education Institute Recombinant α-L-iduronidase, methods for producing and purifying the same and methods for treating diseases caused by deficiencies thereof
US6569661B1 (en) 1999-11-12 2003-05-27 Biomarin Pharmaceutical Inc. Recombinant α-L-iduronidase, methods for producing and purifying the same and methods for treating diseases caused by deficiencies thereof
US6585971B1 (en) 1999-11-12 2003-07-01 Harbor-Ucla Research And Education Institute Recombinant α-L-iduronidase, methods for producing and purifying the same and methods for treating disease caused by deficiencies thereof
US7041487B2 (en) 1999-11-12 2006-05-09 Kakkis Emil D Recombinant α-L-iduronidase, methods for producing and purifying the same and methods for treating diseases caused by deficiencies thereof
EP1454624A1 (en) * 2001-11-23 2004-09-08 Wei Wang Antiviral, antibacterial pharmaceutical composition of cantharidic anhydride and method of preparation thereof
EP1454624A4 (en) * 2001-11-23 2006-05-31 Wei Wang Antiviral, antibacterial pharmaceutical composition of cantharidic anhydride and method of preparation thereof
EP2327414A1 (en) 2002-11-07 2011-06-01 BioMarin Pharmaceutical Inc. Precursor N-acetylgalactosamine-4-sulfatase, methods of treatment using said enzyme and methods for producing and purifying said enzyme
WO2004080443A1 (en) 2003-03-14 2004-09-23 Epistem Limited Treatment and/or prevention of non-viral epithelial damage
WO2011027128A1 (en) 2009-09-03 2011-03-10 The University Of Manchester Use of non-digestible oligosaccharides
US10265335B2 (en) 2009-09-03 2019-04-23 Curapel (Scotland) Limited Use of non-digestible oligosaccharides

Also Published As

Publication number Publication date
FR1329357A (en) 1963-06-07
NL281225A (en)
DE1227616B (en) 1966-10-27
BR6241165D0 (en) 1973-06-14
AT249268B (en) 1966-09-12
AT258471B (en) 1967-11-27

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