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GB1094903A - Improvements in or relating to nitrofuran derivatives - Google Patents

Improvements in or relating to nitrofuran derivatives

Info

Publication number
GB1094903A
GB1094903A GB1306664A GB1306664A GB1094903A GB 1094903 A GB1094903 A GB 1094903A GB 1306664 A GB1306664 A GB 1306664A GB 1306664 A GB1306664 A GB 1306664A GB 1094903 A GB1094903 A GB 1094903A
Authority
GB
United Kingdom
Prior art keywords
group
hydrogen
novel
nitrofuran derivatives
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1306664A
Inventor
Patrick Michael Guy Bavin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith Kline and French Laboratories Ltd
Original Assignee
Smith Kline and French Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline and French Laboratories Ltd filed Critical Smith Kline and French Laboratories Ltd
Priority to GB1306664A priority Critical patent/GB1094903A/en
Publication of GB1094903A publication Critical patent/GB1094903A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

Nitrofuran derivatives, some of which are novel, of the formula <FORM:1094903/C2/1> in which Z is an oxygen atom or the group <FORM:1094903/C2/2> , where R is hydrogen, alkyl, aryl, hydrdroxyalkyl or dialkylaminoalkyl, and Y represents two atoms or groups, which are the same or different, selected from hydrogen, halogen, alkyl, trifluoromethyl, carboxy or esterified carboxy, are prepared by condensing a compound of the formula <FORM:1094903/C2/3> in which X is a hydroxy group or the group -NHR, with a methyl or ethyl 5-nitro-2-furimidate acid-addition salt in an alcohol under substantially anhydrous conditions. The novel compounds are those in which Y and Z are as defined above, with the proviso that Y represents at least one atom or group other than hydrogen when Z represents an oxygen atom or the group <FORM:1094903/C2/4> Antimicrobial compositions comprise one of the above novel nitrofuran derivatives in admixture with a pharmaceutically-acceptable diluent or carrier. The compositions may be in the form of an animal feedstuff or a premix for an animal feedstuff. Reference has been directed by the Comptroller to Specification 1,058,565.
GB1306664A 1964-03-26 1964-03-26 Improvements in or relating to nitrofuran derivatives Expired GB1094903A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB1306664A GB1094903A (en) 1964-03-26 1964-03-26 Improvements in or relating to nitrofuran derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1306664A GB1094903A (en) 1964-03-26 1964-03-26 Improvements in or relating to nitrofuran derivatives

Publications (1)

Publication Number Publication Date
GB1094903A true GB1094903A (en) 1967-12-13

Family

ID=10016171

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1306664A Expired GB1094903A (en) 1964-03-26 1964-03-26 Improvements in or relating to nitrofuran derivatives

Country Status (1)

Country Link
GB (1) GB1094903A (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0252028A1 (en) * 1986-06-25 1988-01-07 Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Process for preparing nitrofurylbenzimidazoles and pharmaceutical compositions having antimycotic, antibacterial and antitubercular activities containing same
US5852011A (en) * 1994-05-31 1998-12-22 Mitsui Chemicals, Inc. Benzimidazole derivatives
US6448281B1 (en) 2000-07-06 2002-09-10 Boehringer Ingelheim (Canada) Ltd. Viral polymerase inhibitors
US7803944B2 (en) 2001-07-25 2010-09-28 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7838537B2 (en) 2003-01-22 2010-11-23 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7879851B2 (en) 2004-02-20 2011-02-01 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7888363B2 (en) 2003-01-22 2011-02-15 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US8076365B2 (en) 2005-08-12 2011-12-13 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US8362268B2 (en) 2008-05-30 2013-01-29 University Of Notre Dame Du Lac Anti-bacterial agents from benzo[d]heterocyclic scaffolds for prevention and treatment of multidrug resistant bacteria

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0252028A1 (en) * 1986-06-25 1988-01-07 Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Process for preparing nitrofurylbenzimidazoles and pharmaceutical compositions having antimycotic, antibacterial and antitubercular activities containing same
US5852011A (en) * 1994-05-31 1998-12-22 Mitsui Chemicals, Inc. Benzimidazole derivatives
US6448281B1 (en) 2000-07-06 2002-09-10 Boehringer Ingelheim (Canada) Ltd. Viral polymerase inhibitors
US6479508B1 (en) 2000-07-06 2002-11-12 Boehringer Ingelheim (Canada) Ltd. Viral polymerase inhibitors
US6794404B2 (en) 2000-07-06 2004-09-21 Boehringer Ingelheim (Canada) Ltd. Viral polymerase inhibitors
US7439258B2 (en) 2000-07-06 2008-10-21 Boehringer Ingelheim (Canada) Ltd Viral polymerase inhibitors
US7803944B2 (en) 2001-07-25 2010-09-28 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7893084B2 (en) 2001-07-25 2011-02-22 Boehringer Ingelheim Canada Ltd. Viral polymerase inhibitors
US7838537B2 (en) 2003-01-22 2010-11-23 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7888363B2 (en) 2003-01-22 2011-02-15 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7879851B2 (en) 2004-02-20 2011-02-01 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US8030309B2 (en) 2004-02-20 2011-10-04 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US8076365B2 (en) 2005-08-12 2011-12-13 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US8362268B2 (en) 2008-05-30 2013-01-29 University Of Notre Dame Du Lac Anti-bacterial agents from benzo[d]heterocyclic scaffolds for prevention and treatment of multidrug resistant bacteria
US9617249B2 (en) 2008-05-30 2017-04-11 University Of Notre Dame Du Lac Benzoheterocyclic anti-bacterial agents

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