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GB0011278D0 - Repair of nerve damage - Google Patents

Repair of nerve damage

Info

Publication number
GB0011278D0
GB0011278D0 GBGB0011278.9A GB0011278A GB0011278D0 GB 0011278 D0 GB0011278 D0 GB 0011278D0 GB 0011278 A GB0011278 A GB 0011278A GB 0011278 D0 GB0011278 D0 GB 0011278D0
Authority
GB
United Kingdom
Prior art keywords
nerve
nerve damage
mgf
igf
acid sequences
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB0011278.9A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University College London
Original Assignee
University College London
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University College London filed Critical University College London
Priority to GBGB0011278.9A priority Critical patent/GB0011278D0/en
Publication of GB0011278D0 publication Critical patent/GB0011278D0/en
Priority to DE60135842T priority patent/DE60135842D1/en
Priority to PCT/GB2001/002054 priority patent/WO2001085781A2/en
Priority to AT01925761T priority patent/ATE408623T1/en
Priority to EP01925761A priority patent/EP1284999B1/en
Priority to AU52439/01A priority patent/AU5243901A/en
Priority to US09/852,261 priority patent/US6821946B2/en
Priority to JP2001582380A priority patent/JP2003532742A/en
Priority to CA002407698A priority patent/CA2407698A1/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
  • Saccharide Compounds (AREA)

Abstract

The invention provides a method of treating nerve damage involving administering to the damaged nerve an effective non-toxic amount of an MGF (mechano-growth factor) Insulin-like Growth Factor I (IGF-I) isoform which includes amino acid sequences encoded by nucleic acid sequences of IGF-I exons 4, 5 and 6 in the reading frame of MGF and having the ability to reduce motoneurone loss by 20% or greater in response to nerve avulsion.
GBGB0011278.9A 2000-05-10 2000-05-10 Repair of nerve damage Ceased GB0011278D0 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
GBGB0011278.9A GB0011278D0 (en) 2000-05-10 2000-05-10 Repair of nerve damage
DE60135842T DE60135842D1 (en) 2000-05-10 2001-05-10 RECOVERY AFTER NERVE DAMAGE
PCT/GB2001/002054 WO2001085781A2 (en) 2000-05-10 2001-05-10 Repair of nerve damage
AT01925761T ATE408623T1 (en) 2000-05-10 2001-05-10 RECOVERY AFTER NERVE DAMAGE
EP01925761A EP1284999B1 (en) 2000-05-10 2001-05-10 Repair of nerve damage
AU52439/01A AU5243901A (en) 2000-05-10 2001-05-10 Repair of nerve damage
US09/852,261 US6821946B2 (en) 2000-05-10 2001-05-10 Repair of nerve damage
JP2001582380A JP2003532742A (en) 2000-05-10 2001-05-10 Repair of nerve damage
CA002407698A CA2407698A1 (en) 2000-05-10 2001-05-10 Repair of nerve damage

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0011278.9A GB0011278D0 (en) 2000-05-10 2000-05-10 Repair of nerve damage

Publications (1)

Publication Number Publication Date
GB0011278D0 true GB0011278D0 (en) 2000-06-28

Family

ID=9891333

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB0011278.9A Ceased GB0011278D0 (en) 2000-05-10 2000-05-10 Repair of nerve damage

Country Status (9)

Country Link
US (1) US6821946B2 (en)
EP (1) EP1284999B1 (en)
JP (1) JP2003532742A (en)
AT (1) ATE408623T1 (en)
AU (1) AU5243901A (en)
CA (1) CA2407698A1 (en)
DE (1) DE60135842D1 (en)
GB (1) GB0011278D0 (en)
WO (1) WO2001085781A2 (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9926968D0 (en) * 1999-11-15 2000-01-12 Univ London Treatment of neurological disorders
GB0202906D0 (en) 2002-02-07 2002-03-27 Univ London Prevention of myocardial damage
US7172562B2 (en) 2002-11-22 2007-02-06 Mckinley Laurence M System, method and apparatus for locating, measuring and evaluating the enlargement of a foramen
GB0426154D0 (en) * 2004-11-29 2004-12-29 European Molecular Biology Lab Embl IGF-1 novel peptides
WO2006097682A1 (en) * 2005-03-18 2006-09-21 Ucl Business Plc Mechano growth factor peptides and their use
US20060239921A1 (en) * 2005-04-26 2006-10-26 Novadaq Technologies Inc. Real time vascular imaging during solid organ transplant
US8185176B2 (en) * 2005-04-26 2012-05-22 Novadaq Technologies, Inc. Method and apparatus for vasculature visualization with applications in neurosurgery and neurology
US10231624B2 (en) * 2005-08-10 2019-03-19 Nov Adaq Technologies Ulc Intra-operative head and neck nerve mapping
US20070122344A1 (en) * 2005-09-02 2007-05-31 University Of Rochester Medical Center Office Of Technology Transfer Intraoperative determination of nerve location
JP2007289634A (en) * 2006-03-30 2007-11-08 Gc Corp Bioabsorbable tube and its manufacturing method
WO2007141309A2 (en) 2006-06-09 2007-12-13 Novartis Ag Stabilized insulin-like growth factor polypeptides
US20080161744A1 (en) 2006-09-07 2008-07-03 University Of Rochester Medical Center Pre-And Intra-Operative Localization of Penile Sentinel Nodes
US8406860B2 (en) 2008-01-25 2013-03-26 Novadaq Technologies Inc. Method for evaluating blush in myocardial tissue
US10219742B2 (en) 2008-04-14 2019-03-05 Novadaq Technologies ULC Locating and analyzing perforator flaps for plastic and reconstructive surgery
WO2009135178A2 (en) 2008-05-02 2009-11-05 Flower Robert W Methods for production and use of substance-loaded erythrocytes (s-les) for observation and treatment of microvascular hemodynamics
US10492671B2 (en) 2009-05-08 2019-12-03 Novadaq Technologies ULC Near infra red fluorescence imaging for visualization of blood vessels during endoscopic harvest
US8758374B2 (en) 2010-09-15 2014-06-24 University Of Utah Research Foundation Method for connecting nerves via a side-to-side epineurial window using artificial conduits
JP6017317B2 (en) 2011-02-02 2016-10-26 第一三共株式会社 Peptide library
EP2768425B1 (en) 2011-10-17 2018-11-14 University of Utah Research Foundation Methods and devices for connecting nerves
US10842494B2 (en) 2011-10-17 2020-11-24 University Of Utah Research Foundation Methods and devices for connecting nerves
US10278585B2 (en) 2012-06-21 2019-05-07 Novadaq Technologies ULC Quantification and analysis of angiography and perfusion
AU2015327665B2 (en) 2014-09-29 2018-09-27 Stryker European Operations Limited Imaging a target fluorophore in a biological material in the presence of autofluorescence
KR102012880B1 (en) 2014-10-09 2019-08-22 노바다크 테크놀러지즈 유엘씨 Quantification of absolute blood flow in tissue using fluorescence-mediated photoplethysmography
EP3580609B1 (en) 2017-02-10 2023-05-24 Stryker European Operations Limited Open-field handheld fluorescence imaging systems and methods
CN111195350A (en) * 2020-01-15 2020-05-26 重庆大学 Application of combination of IGF1 and IGF1Ec24 in preparation of medicines for promoting tissue repair and regeneration

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4963665A (en) 1986-01-07 1990-10-16 Washington University Human preproinsulin-like growth factor I
SE8703625D0 (en) * 1987-09-18 1987-09-18 Kabivitrum Ab NEW MEDICAL USE
US5652214A (en) 1989-06-05 1997-07-29 Cephalon, Inc. Treating disorders by application of insulin-like growth factors and analogs
SE9100099D0 (en) 1991-01-11 1991-01-11 Kabi Pharmacia Ab USE OF GROWTH FACTOR
SE9101341D0 (en) 1991-05-03 1991-05-03 Kabi Pharmacia Ab NEW MEDICINAL USE
US5298422A (en) 1991-11-06 1994-03-29 Baylor College Of Medicine Myogenic vector systems
WO1993010806A1 (en) 1991-11-25 1993-06-10 Institute Of Molecular Biology, Inc. Medicament for promoting growth of mammalian nerve
WO1995013290A1 (en) 1993-11-12 1995-05-18 North Shore University Hospital Research Corporation Method of treating muscular dystrophy
US5650496A (en) 1995-04-14 1997-07-22 Cephalon, Inc. IGF-I purification process
GB9605124D0 (en) * 1996-03-11 1996-05-08 Royal Free Hosp School Med Method of treating muscular disorders
GB9926968D0 (en) 1999-11-15 2000-01-12 Univ London Treatment of neurological disorders

Also Published As

Publication number Publication date
CA2407698A1 (en) 2001-11-15
WO2001085781A2 (en) 2001-11-15
AU5243901A (en) 2001-11-20
US20020083477A1 (en) 2002-06-27
DE60135842D1 (en) 2008-10-30
EP1284999B1 (en) 2008-09-17
EP1284999A2 (en) 2003-02-26
JP2003532742A (en) 2003-11-05
ATE408623T1 (en) 2008-10-15
US6821946B2 (en) 2004-11-23
WO2001085781A3 (en) 2002-03-28

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Legal Events

Date Code Title Description
AT Applications terminated before publication under section 16(1)