FR2991874A1 - Composition, useful as hair cosmetic composition e.g. hair care lotion for treating human keratinous materials such as hair and/or scalp, comprises pyridine dicarboxylic acid ester, and vitamin B and/or its analogs or derivatives - Google Patents

Abstract

Composition comprises pyridine dicarboxylic acid ester (I) and its salts, and at least one vitamin B and/or its analogs or derivatives. Composition comprises pyridine dicarboxylic acid ester of formula (I) and its salts, and at least one vitamin B and/or its analogs or derivatives. R1, R2 : linear or branched, optionally saturated 1-18C-aliphatic hydrocarbyl (preferably alkyl), 6-18C-aryl (both optionally substituted by OH, NH 2, -OR, -OCOR or -NHR) or H; and R : 1-18C-alkyl, where substituents COOR1 and COOR2 are respectively in position 2 and 3 or 2 and 4, preferably 2 and 4 of pyridine ring. [Image].

Description

The present invention relates to a cosmetic or pharmaceutical composition comprising at least one pyridine-dicarboxylic acid derivative in combination with at least one vitamin B or one of its analogues, as well as its use in particular in the hair field.

Hair growth and renewal are mainly determined by the activity of hair follicles and their matrix environment. Their activity is cyclic and comprises essentially three phases, namely the anagen phase, the catagen phase and the telogen phase. The hair is constantly renewed and about 150 000 hairs of hair, about 10% are at rest and will be replaced in the coming months. The fall or natural loss of hair can be estimated, on average, to a few hundred hairs a day for a normal physiological state. This process of permanent physical renewal undergoes a natural evolution during aging, the hair becomes thinner and their cycles shorter. It is known, moreover, that certain factors such as a hormonal imbalance, a physiological stress, the malnutrition, can accentuate the phenomenon. In addition, the fall or the alteration of the hair can be in relation with seasonal phenomena.

It has thus been proposed in particular by the patent EP1352629, to use pyridine-dicarboxylic acid derivatives to induce and / or stimulate the growth of human keratin fibers such as the hair or the eyelashes, and / or to slow down their fall and / or or increase their density.

However, it has been found that the use of such compounds, particularly in the presence of a solvent, can cause sensations of discomfort of the scalp, such as tightness, or even problems of dryness. In some cases, dull hair has also been observed, without tone, or difficult to comb and discipline. The present invention is intended in particular to overcome these drawbacks by proposing a composition making it possible to obtain the widest possible beneficial effect, said composition acting in a broad manner on the scalp and all of the hair, from the bulb of the hair to the his tip. Thanks to the invention, one can thus obtain on the one hand the technical effect related to the use of pyridine-dicarboxylic acid derivatives, while having a good cosmetic effect on the whole of the hair.

The present invention relates to a composition comprising: - (i) at least one compound of general formula (I), or one of its salts: COOR 2 (I) COOR 1 in which R 1 and R 2 represent, independently of one of the other, a hydrogen atom, a linear or branched, saturated or unsaturated (alkyl) aliphatic hydrocarbon radical C1-C18; or a C6-C18 aryl radical; said aliphatic or aryl hydrocarbon radicals being optionally substituted by one or more groups selected from OH, NH2, -OR, -OCOR and -NHR with R representing a C1-C18 alkyl group, at least one of R1 and R2 being different from a hydrogen atom; and - (ii) at least one vitamin B and / or one of its analogues or derivatives. Another subject of the invention relates to the use of a composition thus defined for inducing and / or stimulating the growth of human keratinous fibers and / or slowing down their fall and / or increasing their density.

It has been found that the compositions according to the invention have good cosmetic performances, in terms of the quality of the hair, and also in terms of the comfort of the scalp. The scalp is soothed, and no tugging or heating is observed after the application of the composition. The hair is disciplined, easy to comb, the hair is stronger and more resistant. In the present description, the term "at least one" is equivalent to the term "one or more" and may be substituted therefor; and the term "between ... and ..." is equivalent to the phrase "from ... to ..." and may be substituted therefor. 1 / Pyridine dicarboxylic acid ester The composition according to the invention therefore comprises at least one compound which is a pyridine dicarboxylic acid ester. The ester may be a monoester or a diester, preferably a diester. It can also be a salt of such an ester. Said compounds correspond to the general formula (I), or one of its salts: COOR 2 (I) COOR 1 in which R 1 and R 2 represent, independently of one another, a hydrogen atom, a hydrocarbon radical C1-C18 aliphatic, linear or branched, saturated or unsaturated (especially alkyl); or a C6-C18 aryl radical; said aliphatic or aryl hydrocarbon radicals being optionally substituted by one or more groups selected from OH, NH2, -OR, -OCOR and -NHR with R representing a C1-C18 alkyl group, at least one of R1 and R2 being different from a hydrogen atom. Preferably, the substituents COOR 1 and COOR 2 are respectively in position 2 and 3, or 2 and 4 of the pyridine ring. Preferably, they are in position 2 and 4.

Preferably, the compounds correspond to formula (Ia), or a salt thereof: COOR 2 (la) COOR 1 in which R 1 and R 2 represent, independently of one another, a hydrogen atom, an aliphatic hydrocarbon radical in C1-C18, linear or branched, saturated or unsaturated (especially alkyl); or a C6-C18 aryl radical; said aliphatic or aryl hydrocarbon radicals being optionally substituted by one or more groups selected from OH, NH2, -OR, -OCOR and -NHR with R representing a C1-C18 alkyl group, at least one of R1 and R2 being different from a hydrogen atom.

Preferably, in the formulas (I) and (Ia), the aliphatic hydrocarbon radical, in particular C 1 -C 18 alkyl, is an aliphatic hydrocarbon radical, in particular C 1 -C 10 alkyl, especially C 1 -C 6, such as methyl, ethyl, tert-butyl, isopropyl, hexyl. Said aliphatic hydrocarbon radical may also contain at least one double bond or a carbon-carbon triple bond, for example -CH = CH2, -CH2-CH = CH-CH3 and -CH2-CECH. The aryl radical may represent the phenyl or naphthyl radical. In particular, in the formulas (I) and (Ia), R1 and R2 represent, independently of one another, a hydrogen atom, a saturated aliphatic hydrocarbon radical, in particular a linear or branched alkyl radical, C1-C18, more preferably C1-C10 or even C1-C6, optionally substituted with an alkoxy or acyloxy group (OR or OCOR with R denoting a C1-C18 alkyl radical), at least one of the groups R1 and R2 being different from a hydrogen atom.

Preferably, R1 and R2 are the same. Preferably, R1 and R2 are identical and represent a linear and saturated C1-C18, preferably C1-C10, and even more preferably C1-C6, alkyl radical; and most preferably an ethyl radical. The following compounds of formula (I) can especially be used: dimethyl pyridine-2,4-dicarboxylate, dimethyl pyridine-2,3-dicarboxylate, diethyl pyridine-2,4-dicarboxylate, diethyl pyridine-2,3-dicarboxylate, diethyl pyridine-2,5-dicarboxylate, dimethyl pyridine-2,5-dicarboxylate, diisopropyl pyridine-2,4-dicarboxylate, pyridine Di (acetyloxymethyl) -2,4-dicarboxylate (derivative of formula (I) such that R1 and R2 represent -CH2-O-COCH3), Preferably, the composition comprises, as compound of formula (I) or (la), pyridine-2,4-diethyl dicarboxylate. By salts of the compounds of formula (I) is meant according to the invention the organic or inorganic salts of a compound of formula (I), these salts being physiologically acceptable. As mineral salts, mention may be made of sodium or potassium salts as well as the salts of zinc (Zn2 +), calcium (Ca2 +), copper (Cu2 +), iron (Fe2 +), strontium (Sr2 +), magnesium (Mg 2+), manganese (Mn 2+); hydroxides, carbonates and chlorides. As organic salts, mention may be made of the triethanolamine, monoethanolamine, diethanolamine, hexadecylamine, N, N, N ', N'-tetrakis (hydroxypropyl) ethylene di-amine and tris-hydroxymethylaminomethane salts. The compounds of formula (I) are known as such; they are particularly described, as well as their manufacture, in patent EP1352629.

Preferably, the composition according to the invention comprises the compound (s) of formula (I) in an amount of between 0.001 and 10% by weight, especially from 0.01 to 5% by weight, relative to the total weight of the composition. 2 / Vitamin B The composition according to the invention also comprises at least one vitamin B and / or one of their analogues or derivatives. Vitamin B means at least one of the vitamins belonging to this group, namely: vitamin B1 or thiamine; - vitamin B2 or riboflavin; vitamin B3 (or vitamin PP) or niacin or niacinamide; vitamin B5 or pantothenic acid; vitamin B6 or pyridoxine; - vitamin B8 (or vitamin H) or biotin; - vitamin B9 or folic acid, and - vitamin B12 or cyanocobalamin.

As analogues or derivatives of vitamin B, there may be mentioned the corresponding salts, such as calcium pantothenate, pro-vitamin B such as panthenol, which is the alcohol analog of vitamin B5, also called provitamin B5; mention may also be made of the corresponding ethers and esters, such as panthenyl ethyl ether, panthenyl ethyl ether acetate and panthenyl triacetate. It is of course possible to use a mixture of these different compounds. Preferably, the vitamin B that may be used in the context of the invention is chosen from vitamin B3, vitamin B5, vitamin B6 and vitamin B8, or one of their analogues or derivatives, and in particular pantothenate. calcium, panthenol, panthenyl ethyl ether, panthenyl ethyl ether acetate and panthenyl triacetate; as well as their mixtures.

Preferably, the composition according to the invention comprises the vitamin B or vitamin or analogues or derivatives in an amount of between 0.001 and 5% by weight, in particular 0.005 and 2% by weight, and more preferably between 0.01 and 1% by weight. , relative to the total weight of the composition. 3. Additional Ingredients The composition according to the invention may be for cosmetic or pharmaceutical use. Preferably, the composition according to the invention is for cosmetic use. By "cosmetic" is meant in the sense of the invention a composition of appearance, smell and pleasant touch. Preferably, the composition is applied topically to the skin and the keratinous fibers, and more particularly to the hairy leather, the hair and the eyelashes. Depending on the mode of application, this composition may be in any galenical form normally used in the field in question, in particular cosmetics. For topical application to the skin, including the scalp, the composition may be in the form of an aqueous, alcoholic or aqueous-alcoholic solution or suspension, a suspension or an oily solution, an emulsion 40 or dispersion of liquid or semi-liquid consistency obtained by dispersion of a fatty phase in an aqueous phase (HIE) or vice versa (W / O), a dispersion or emulsion of soft consistency, an aqueous or hydroalcoholic or oily gel (anhydrous), a free or compacted powder to be used as such or to incorporate in a physiologically acceptable medium (excipient), or microcapsules or microparticles, or vesicular dispersions of ionic and / or nonionic type. It is also possible to envisage a composition in the form of a foam or in the form of an aerosol composition also comprising a propellant under pressure. In particular, the composition according to the invention may be a hair composition, capable of being applied to the scalp or the hair, and may be in the form of a hair care lotion, for example of application daily or biweekly, a shampoo or a hair conditioner, particularly for biweekly or weekly application, a liquid soap or solid daily application scalp cleansing, a product implementation form of the hairstyle (lacquer, product for styling, styling gel), a mask, a cream or a foaming gel for cleaning the hair. It can still be in the form of hair dye or mascara to be applied by brush or comb. For an application on eyelashes or bristles, the composition according to the invention may be in the form of a mascara, pigmented or not, to be applied to the brush 20 on the eyelashes or on the beard or mustache hairs. According to a particular embodiment, the composition according to the invention is in the form of a hair cream or lotion, a shampoo, a hair conditioner, or a hair or eyelash mascara. The amounts of the various constituents of the composition according to the invention are those conventionally used in the fields under consideration. In addition, this composition is prepared according to the usual methods. It can thus be in the form of a lotion, serum, milk, O / W cream or W / O, gel, ointment, ointment, powder, balm, patch, soaked pad, soap, bread, mousse. When the composition is an emulsion, the proportion of the fatty phase may range from 2 to 80% by weight, preferably from 5 to 50% by weight relative to the total weight of the composition. The fatty phase may contain fatty or oily compounds which are liquid at room temperature (25 ° C.) and atmospheric pressure (1 atm), generally called oils. These oils may or may not be compatible with each other and form a macroscopically homogeneous liquid fatty phase or a two- or three-phase system. The fatty phase may, in addition to the oils, contain waxes, gums, lipophilic polymers, "pasty" or viscous products containing solid parts and liquid parts. The aqueous phase is adjusted according to the fatty phase content and compound (s) of formula (I) and that of any additional ingredients, to obtain 100% by weight. In practice, the aqueous phase is preferably 5 to 99.9% by weight. The aqueous phase contains water and optionally an organic solvent which is used in all proportions with water, such as lower C1 to C8 alcohols such as ethanol, isopropanol, polyols such as propylene glycol and glycerol. , sorbitol or acetone. The emulsifiers and coemulsifiers used in the composition in emulsion form may be chosen from those conventionally used in the cosmetics or pharmaceutical field. The emulsifier and / or the coemulsifier are preferably present in the composition in a proportion ranging from 0.1 to 30% by weight, preferably from 0.5 to 20% by weight relative to the total weight of the composition, better from 1 to 8%. Their nature is, moreover, a function of the meaning of the emulsion. The emulsion may further comprise lipid vesicles and especially liposomes. When the composition is a solution or an oily gel, the fatty phase may represent more than 90% of the total weight of the composition. Advantageously, for a capillary application, the composition is an aqueous, alcoholic or aqueous-alcoholic solution or suspension, and better a solution or a water / ethanol suspension. The alcoholic fraction can represent from 5% to 99.9% and better still from 8% to 80%. For a mascara application, the composition is preferably a wax-in-water or wax-in-oil dispersion, a gelled oil or an aqueous gel, pigmented or not. The composition according to the invention may also contain adjuvants customary in the cosmetic field, chosen, for example, from hydrophilic or lipophilic gelling agents or thickeners, hydrophilic or lipophilic additives, preservatives, antioxidants (carotenoids), perfumes, fillers. , odor absorbers, electrolytes, neutralizers, UV blocking agents such as sunscreens, film-forming polymers, cosmetic actives such as vitamins other than B vitamins, their analogues and derivatives; dyestuffs, soluble or not in the medium. The amounts of these various adjuvants are those conventionally used in the cosmetics field, for example from 0.01 to 20%, better still from 0.1 to 10% of the total weight of the composition. These adjuvants, depending on their nature, can be introduced into the fatty phase, into the aqueous phase and / or into the lipid vesicles and in particular liposomes. As oils or waxes that may be employed, mention may be made of mineral oils (liquid petroleum jelly, hydrogenated isoparaffin), vegetable oils (liquid fraction of shea butter, sunflower oil, soya bean oil, wheat germ oil). ), animal oils (perhydrosqualene), synthetic oils (Purcellin oil, fatty acid esters), silicone oils or waxes (linear or cyclic polydimethylsiloxanes, cyclomethicone, phenyltrimethicone), fluorinated oils (perfluoropolyethers), beeswax, Candelilla wax, rice wax, carnauba wax, paraffin wax or polyethylene wax. Mention may also be made of fatty alcohols and fatty acids (stearic acid, linoleic acid, linolenic acid for example).

As emulsifiers that can be used in the invention, mention may be made, for example, of oxyethylenated fatty alcohols, glycerol laurate or stearate, polyoxyethylenated sorbitol stearate or oleate (for example polysorbate 60 and the PEG6 / PEG-32 / glycol stearate mixture). sold under the name Tefose® 63 by the company Gattefosse), (alkyl) dimethicones copolyol.

As hydrophilic gelling agents that may be used in the invention, mention may be made of carboxyvinyl polymers (carbomer), acrylic copolymers such as acrylate / alkylacrylate copolymers, polyacrylamides, polysaccharides such as hydroxypropylcellulose, natural gums and clays. and, as lipophilic gelling agents, are modified clays such as Bentones, metal salts of fatty acids such as aluminum stearates, hydrophobically treated silica, ethylcellulose and mixtures thereof. The composition may comprise other actives that may be hydrophilic, such as proteins or protein hydrolysates, amino acids, polyols, urea, allantoin, sugars and sugar derivatives, water-soluble vitamins plant extracts, these extracts may then contain or not isoflavones; or which may be lipophilic, such as retinol (vitamin A) and its derivatives in particular ester (palmitate), tocopherol (vitamin E) and its derivatives, in particular ester (acetate palmitate), essential fatty acids such as eicosatetraenoic acids and eicosatrienoic or their esters and amides, ceramides, essential oils, esters of hydroxy acids, phospholipids such as lecithin; or which may be soluble in alcoholic solvents such as lactones (kawaïne); and their mixtures.

The composition may in particular comprise additional active agents that promote, in particular, the regrowth of human keratin fibers and / or limit their fall, in particular chosen from: hormones, in particular of plant origin, for example estriol or its analogs, thyroxine and its salts, progesterone; antibacterial agents such as macrolides, pyranosides and tetracyclines, and in particular erythromycin; calcium antagonists, such as cinnarizine, diltiazem, nimo-dipine, verapamil and nifedipine; extracts of microorganisms, especially bacterial extracts; agents that modulate skin differentiation and / or proliferation such as retindic acid and its isomers, retinol and its esters, vitamin D and its derivatives, estrogens such as rcestradiol; agents that modulate bacterial adhesion to the skin and / or mucous membranes such as honey, especially acacia honey and certain sugar derivatives; antiparasitics, in particular metronidazole, crotamiton or pyrethrinoids; antifungals, in particular compounds belonging to the imidazoles class such as econazole, ketoconazole or miconazole or their salts, nicotinic acid esters including, in particular, tocopherol nicotinate, benzyl nicotinate and C1-C6 alkyl nicotinates such as methyl or hexyl nicotinates; polyene compounds, such as amphotericin B, compounds of the allylamine family, such as terbinafine, or octopirox, selenium derivatives or anthralin; antiviral agents such as acyclovir; steroidal anti-inflammatory agents such as corticosteroids such as hydrocortisone, betamethasone valerate or clobestol propionate, or non-steroidal anti-inflammatory agents such as ibuprofen and its salts, diclofenac and its derivatives; salts, acetylsalicylic acid, acetaminophen or glycyrrhetinic acid, a-bisabolol; anesthetic agents such as lidocaine hydrochloride and its derivatives; antipruritic agents such as thenaldine, trimeprazine or cyproheptadine; keratolytic agents such as alpha- and betahydroxycarboxylic acids or beta-ketocarboxylic acids, their salts, amides or esters, lactones and their corresponding salts, and more particularly hydroxy acids such as glycolic acid, lactic acid, salicylic acid, citric acid and, in general, fruit acids, salicylic acid derivatives such as those bearing an alkanoyl radical having from 2 to 12 carbon atoms at the 5-position of the benzene ring, for example n-octanoyl-5-salicylic acid; anti-free radical agents such as alpha-tocopherol or its esters, su-peroxide dismutases, certain metal chelating agents or ascorbic acid and its esters - anti-seborrheic agents such as progesterone; anti-dandruff such as octopirox or zinc pyrithione; anti-acne drugs such as retinoic acid or benzoyl peroxide; vasodilators such as pyrimidine derivatives, such as 2,4-diamino-6-piperidinopyrimidine 3-oxide or "minoxidil" described in patents US4139619 and US4596812, diazoxide; hair loss reducing agents such as aminexil, 6-0 - [(9Z, 12Z) -octadeca-9,12-dienoyl] hexapyranose; antiandrogenic agents such as oxendolone, spironolactone, diethylstilbestrol and flutamide; steroidal or nonsteroidal inhibitors of 5-a-reductases such as finasteride; potassic agonists such as cromakalim and nicorandil; agonists of the FP receptor (F-type prostaglandin receptor) such as latanoprost, bimatoprost, travoprost, unoprostone; - their mixtures.

The composition according to the invention may further comprise substances such as substance P, CGRP or bradykinin antagonists and NO-synthase inhibitors, compounds described as being active in the treatment of sensitive skin and having anti-inflammatory effects. irritants, in particular vis-à-vis irritating compounds possibly present in the compositions.

The composition according to the invention, in particular cosmetic, can be applied to the alopecic areas of the scalp and hair, possibly left in contact for several hours and / or possibly rinsed. For example, it is possible to apply the composition according to the invention in the evening, keep it in contact all night long and possibly shampoo the morning. These applications can be renewed daily for one or more months depending on the individual. The present invention also relates to a process for the cosmetic treatment of human keratin materials, in particular the hair and / or the skin, including the scalp, in which a cosmetic composition as defined herein is applied to said keratin materials. above, and possibly rinsing said keratin materials. More particularly, said method is a method of cosmetic care of the hair and / or the scalp, with a view to improving their state and / or their appearance. This treatment method has the characteristics of a cosmetic process insofar as it makes it possible to improve the aesthetics of materials, especially human keratin fibers, by giving them greater vigor, an improved appearance and greater ease. styling. The invention is described in more detail in the following examples. Example 1 The following composition is prepared (`) / 0 by weight): - pyridine-2,4-dicarboxylic acid diethyl ester (INCI name: DIETHYLLUTIDINATE) 5% - ethanol 56.5% - vitamin B3 0.02% citric acid qs pH = 5.5 - water qs 100 ° C. This lotion is clear and stable over time (at least 2 months at 25 ° C. or 45 ° C.). Applied line by line on the scalp, this lotion has good qualities of use by promoting the distribution and distribution of active ingredients on the scalp. It also has good cosmetic performance. The hair is silky and light, the hair is disciplined and easy to comb.

EXAMPLE 2 The following composition is prepared (`) / 0 by weight): - pyridine-2,4-dicarboxylic acid diethyl ester (INCI name: DIETHYLLUTIDINATE) 5% 15 - ethanol 56.5% - vitamin B3 0, 01% - calcium pantothenate 0.01% - citric acid qs pH = 5.5 - water qs 100 ° A 20 This lotion is clear and stable over time (at least 2 months at 25 ° C or 45 ° C) . Applied line by line on the scalp, this lotion has good qualities of use by promoting the distribution and distribution of assets on the leather cheve25 read. It also has good cosmetic performance. The hair is silky and light, the hair is disciplined and easy to comb.

Claims (15)

REVENDICATIONS1. Composition comprising: - (i) at least one compound of general formula (I), or one of its salts: COOR 2 (I) COOR 1 in which R 1 and R 2 represent, independently of one another, an atom of hydrogen, a C1-C18 aliphatic hydrocarbon radical, linear or branched, saturated or unsaturated (alkyl in particular); or a C6-C18 aryl radical; said aliphatic or aryl hydrocarbon radicals being optionally substituted by one or more groups selected from OH, NH2, -OR, -OCOR and -NHR with R representing a C1-C18 alkyl group, at least one of R1 and R2 being different from a hydrogen atom; and - (ii) at least one vitamin B and / or one of its analogues or derivatives. 2. Composition according to claim 1, wherein the substituents COORi and COOR2 are respectively in position 2 and 3, or 2 and 4 of the pyridine ring; preferably in position 2 and 4. 3. Composition according to one of the preceding claims, wherein R1 and R2 are identical. 4. Composition according to one of the preceding claims, wherein R1 and R2 represent, independently of one another, a hydrogen atom, a saturated aliphatic hydrocarbon radical, in particular alkyl, linear or branched C 1 -C 18 more preferably C1-C10 or even C1-C6, optionally substituted with an alkoxy or acyloxy group (OR or OCOR with R denoting a C1-C18 alkyl radical), at least one of the groups R1 and R2 being different from a hydrogen atom. 5. Composition according to one of the preceding claims, wherein R1 and R2 are identical and represent a saturated and linear alkyl radical C1-C18, preferably C1-C10, and more preferably C1-C6; and most particularly an ethyl radical. 6. Composition according to one of the preceding claims, comprising as compound of formula (I), one of the following compounds: - dimethyl pyridine-2,4-dicarboxylate, - dimethyl pyridine-2,3-dicarboxylate diethyl pyridine-2,4-dicarboxylate, diethyl pyridine-2,3-dicarboxylate, diethyl pyridine-2,5-dicarboxylate, dimethyl pyridine-2,5-dicarboxylate, pyridine-2, Diisopropyl 4-dicarboxylate, di (acetyloxymethyl) pyridine-2,4-dicarboxylate (derivative of formula (I) such that R1 and R2 represent -CH2-O-COCH3), 7. Composition according to one of the preceding claims, wherein the compound or compounds of formula (I) are present in an amount of between 0.001 and 10% by weight, in particular from 0.01 to 5% by weight, relative to total weight of the composition. 8. Composition according to one of the preceding claims, comprising at least one vitamin B selected from: - vitamin B1 or thiamine; - vitamin B2 or riboflavin; vitamin B3 (or vitamin PP) or niacin or niacinamide; vitamin B5 or pantothenic acid; Vitamin B6 or pyridoxine; - vitamin B8 (or vitamin H) or biotin; - vitamin B9 or folic acid, and - vitamin B12 or cyanocobalamin; or one of their analogues or derivatives; or their mixtures. 25 9. Composition according to one of the preceding claims, comprising at least one vitamin B selected from vitamin B3, vitamin B5, vitamin B6 and vitamin B8, or one of their analogues or derivatives, and in particular the pantothenate of calcium, panthenol, panthenyl ethyl ether, panthenyl ethyl ether acetate and panthenyl triacetate; as well as their mixtures. 10. Composition according to one of the preceding claims, wherein the vitamin B or vitamins or analogues or derivatives are present in an amount of between 0.001 and 5% by weight, in particular 0.005 and 2% by weight, more preferably between 35 0, 01 and 1% by weight, based on the total weight of the composition. 11. Composition according to one of the preceding claims, in the form of a cosmetic or pharmaceutical composition, in particular a hair composition, such as a hair care lotion, a shampoo or a hair conditioner after 40 minutes. , a liquid or solid scalp cleansing soap, a hair styling product, a treatment mask, a cream or a foaming gel for cleaning the hair. 12. A process for the cosmetic treatment of human keratinous materials, in particular the hair and / or the skin, including the scalp, in which a cosmetic composition as defined in one of claims 1 to 11 is applied to said keratin materials. and optionally rinsing said keratin materials. 13. The method of claim 12, said method being a method of cosmetic care of the hair and / or scalp, to improve their condition and / or their appearance. 14. Use of a composition as defined in one of claims 1 to 11 for inducing and / or stimulating the growth of human keratin fibers and / or curbing their fall and / or increasing their density. 15