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FR2976285B1 - PROCESS FOR THE SYNTHESIS AND CRYSTALLINE FORM OF 4- {3- [CIS-HEXAHYDROCYPENTA [C] PYRROL-2 (1H) -YL] PROPOXY} BENZAMIDE HYDROCHLORIDE AS WELL AS THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME - Google Patents

PROCESS FOR THE SYNTHESIS AND CRYSTALLINE FORM OF 4- {3- [CIS-HEXAHYDROCYPENTA [C] PYRROL-2 (1H) -YL] PROPOXY} BENZAMIDE HYDROCHLORIDE AS WELL AS THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

Info

Publication number
FR2976285B1
FR2976285B1 FR1101746A FR1101746A FR2976285B1 FR 2976285 B1 FR2976285 B1 FR 2976285B1 FR 1101746 A FR1101746 A FR 1101746A FR 1101746 A FR1101746 A FR 1101746A FR 2976285 B1 FR2976285 B1 FR 2976285B1
Authority
FR
France
Prior art keywords
hexahydrocypenta
pyrrol
propoxy
cis
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR1101746A
Other languages
French (fr)
Other versions
FR2976285A1 (en
Inventor
Nicolas Robert
Jean Michel Lerestif
Jean Pierre Lecouve
Marina Gaillard
Loic Meunier
Philippe Letellier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Servier SAS
Original Assignee
Laboratoires Servier SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Servier SAS filed Critical Laboratoires Servier SAS
Priority to FR1101746A priority Critical patent/FR2976285B1/en
Priority to PE2012000695A priority patent/PE20130046A1/en
Priority to IL219925A priority patent/IL219925A0/en
Priority to CR20120274A priority patent/CR20120274A/en
Priority to AU2012203062A priority patent/AU2012203062B2/en
Priority to SG2012038055A priority patent/SG186546A1/en
Priority to TNP2012000254A priority patent/TN2012000254A1/en
Priority to AP2012006280A priority patent/AP2012006280A0/en
Priority to CA2779045A priority patent/CA2779045C/en
Priority to CU2012000087A priority patent/CU20120087A7/en
Priority to UY0001034110A priority patent/UY34110A/en
Priority to ECSP12011941 priority patent/ECSP12011941A/en
Priority to MA34937A priority patent/MA33883B1/en
Priority to KR1020120060635A priority patent/KR20120136296A/en
Priority to BRBR102012013573-6A priority patent/BR102012013573A2/en
Priority to GEAP201212735A priority patent/GEP20156395B/en
Priority to SV2012004237A priority patent/SV2012004237A/en
Priority to CO12095647A priority patent/CO6580197A1/en
Priority to NZ600474A priority patent/NZ600474B/en
Priority to US13/489,691 priority patent/US8664408B2/en
Priority to EP12171118.8A priority patent/EP2532651B1/en
Priority to SI201230309T priority patent/SI2532651T1/en
Priority to DK12171118.8T priority patent/DK2532651T3/en
Priority to ES12171118.8T priority patent/ES2554933T3/en
Priority to CL2012001500A priority patent/CL2012001500A1/en
Priority to PL12171118T priority patent/PL2532651T3/en
Priority to RS20150642A priority patent/RS54279B1/en
Priority to JP2012129440A priority patent/JP5680022B2/en
Priority to ARP120102010A priority patent/AR086848A1/en
Priority to MX2012006525A priority patent/MX2012006525A/en
Priority to MEP-2015-148A priority patent/ME02346B/en
Priority to PCT/FR2012/051272 priority patent/WO2012168657A1/en
Priority to ZA2012/04183A priority patent/ZA201204183B/en
Priority to PT121711188T priority patent/PT2532651E/en
Priority to HUE12171118A priority patent/HUE028050T2/en
Priority to GT201200182A priority patent/GT201200182A/en
Priority to RU2013158817/04A priority patent/RU2013158817A/en
Priority to MDA20120049A priority patent/MD4345C1/en
Priority to TW101120546A priority patent/TWI499584B/en
Priority to EA201200726A priority patent/EA022741B1/en
Priority to NI201200102A priority patent/NI201200102A/en
Priority to CN201210189156XA priority patent/CN102816102A/en
Publication of FR2976285A1 publication Critical patent/FR2976285A1/en
Application granted granted Critical
Publication of FR2976285B1 publication Critical patent/FR2976285B1/en
Priority to US14/103,006 priority patent/US8952179B2/en
Priority to US14/174,272 priority patent/US20140155453A1/en
Priority to KR1020140063712A priority patent/KR20140079346A/en
Priority to JP2014223181A priority patent/JP2015044840A/en
Priority to CY20151100875T priority patent/CY1116739T1/en
Priority to HRP20151073TT priority patent/HRP20151073T1/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
FR1101746A 2011-06-08 2011-06-08 PROCESS FOR THE SYNTHESIS AND CRYSTALLINE FORM OF 4- {3- [CIS-HEXAHYDROCYPENTA [C] PYRROL-2 (1H) -YL] PROPOXY} BENZAMIDE HYDROCHLORIDE AS WELL AS THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME Expired - Fee Related FR2976285B1 (en)

Priority Applications (48)

Application Number Priority Date Filing Date Title
FR1101746A FR2976285B1 (en) 2011-06-08 2011-06-08 PROCESS FOR THE SYNTHESIS AND CRYSTALLINE FORM OF 4- {3- [CIS-HEXAHYDROCYPENTA [C] PYRROL-2 (1H) -YL] PROPOXY} BENZAMIDE HYDROCHLORIDE AS WELL AS THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
PE2012000695A PE20130046A1 (en) 2011-06-08 2012-05-22 PROCEDURE FOR THE SYNTHESIS AND CRYSTALLINE HYDROCHLORIDE FORM OF 4- {3- [CIS-HEXAHYDROCYCLOPENTA [C] PYRROL-2 (1H) -IL] PROPOXI} BENZAMIDE AS WELL AS THE PHARMACEUTICAL COMPOSITIONS THAT CONTAIN IT
IL219925A IL219925A0 (en) 2011-06-08 2012-05-22 Synthesis process, and crystalline form of 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1h)-yl]propoxy}benzamide hydrochloride and pharmaceutical compositions containing it
CR20120274A CR20120274A (en) 2011-06-08 2012-05-23 HYDROCHLORIDE HYDROCHLORIDE SYSTESIS AND CRYSTAL PROCEDURE OF 4- {3 [CIS-HEXAHYDROCICLOPENTA [C] PIRROL-2- (1H) -IL] PROPOXI} BENZAMIDE AS WELL AS THE PHARMACEUTICAL COMPOSITIONS CONTAINING IT
AU2012203062A AU2012203062B2 (en) 2011-06-08 2012-05-24 Synthesis Process, and Crystalline Form of 4-{3-[cis-Hexahydrocyclopenta[c]pyrrol-2(1H)-yl]propoxy}Benzamide Hydrochloride and Pharmaceutical Compositions Containing It
SG2012038055A SG186546A1 (en) 2011-06-08 2012-05-24 Synthesis process, and crystalline form of 4-{3-[cis-hexa-hydrocyclopenta[c]pyrrol-2(1h)-yl]propoxy} benzamide hydrochloride and pharmaceutical compositions containing it
TNP2012000254A TN2012000254A1 (en) 2011-06-08 2012-05-24 PROCESS FOR THE SYNTHESIS AND CRYSTALLINE FORM OF 4- {3- [CIS-HEXAHYDROCYCLOPENTA [C] PYRROL-2 (1H) -YL] PROPOXY} BENZAMIDE HYDROCHLORIDE AS WELL AS PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
AP2012006280A AP2012006280A0 (en) 2011-06-08 2012-05-28 Synthesis process, and crystalline form of 4-ä3-ÄCis-hexahydrocyclopentaÄCÜpyrrol-2(1H)-YLÜpropoxyübenzamide hydrochloride and pharmaceutical compositions containing it.
CA2779045A CA2779045C (en) 2011-06-08 2012-05-30 Synthesis process and crystalline form of benzamide 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1h)-yl]propoxy} hydrochloride as well as the pharmaceutical compositions in which it is found
CU2012000087A CU20120087A7 (en) 2011-06-08 2012-05-31 HYDROCHLORIDE SYNTHESIS AND CRYSTAL FORM OF 4- (3- (CIS-HEXAHYDROCICLOPENTA (C) PIRROL-2 (1H) -IL) PROPOXI) BENZAMIDE AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING IT
UY0001034110A UY34110A (en) 2011-06-08 2012-05-31 HYDROCHLORIDE SYNTHESIS AND CRYSTAL FORM OF 4- {3- [CIS- HEXAHYDROCICLOPENTA [C] PIRROL-2 (1H) -IL] PROPOXI} BENZAMIDA AS WELL AS THE S PHARMACEUTICAL COMPOSITIONS CONTAINING IT
ECSP12011941 ECSP12011941A (en) 2011-06-08 2012-06-01 HYDROCHLORIDE SYNTHESIS AND CRYSTAL METHOD OF 4- {3- [CIS-HEXAHYDROCICLOPENTA [C] PIRROL-2 (1H) -IL] PROPOXI} BENZAMIDE AS WELL AS THE PHARMACEUTICAL COMPOSITIONS CONTAINING IT
MA34937A MA33883B1 (en) 2011-06-08 2012-06-04 The process of formation and crystalline form of hydrochloride 4} 3] c-hexanhydrochlopitan [c] pyrrol-2 (1h)-[yl propoxy {benzamide and the pharmaceutical formulations it contains
KR1020120060635A KR20120136296A (en) 2011-06-08 2012-06-05 Synthesis process, and crystalline form of 4- {3-[cis-hexahydrocyclopenta[c]pyrrol-2(1h)-yl]propoxy} benzamide hydrochloride and pharmaceutical compositions containing it
BRBR102012013573-6A BR102012013573A2 (en) 2011-06-08 2012-06-05 synthesis process, and crystalline form of 4- {3- [cis-hexahydrocyclopenta [c] pyrrol-2 (1h) -yl] propoxybenzamide hydrochloride and pharmaceutical compositions containing the same
GEAP201212735A GEP20156395B (en) 2011-06-08 2012-06-05 Synthesis process, and crystalline form of 4-{3-[cis-hexahydrocyclopenta[c]pyrr ol-2(1h)-yl]propoxy}benzamide hydrochloride and pharmaceutical compositions containing thereof
SV2012004237A SV2012004237A (en) 2011-06-08 2012-06-06 HYDROCHLORIDE SYNTHESIS AND CRYSTAL METHOD OF 4- {3- [CIS-HEXAHYDROCICLOPENTA [C] PIRROL-2 (1H) -IL] PROPOXI} BENZAMIDE AS WELL AS THE PHARMACEUTICAL COMPOSITIONS CONTAINING IT
CO12095647A CO6580197A1 (en) 2011-06-08 2012-06-06 Synthesis procedure and crystalline form of 4- {3- [cis-hewahydrocyclopenta [c] pyrrole} -2 (1h) -yl] propoxy} benzamide hydrochloride as well as the pharmaceutical compositions containing it
NZ600474A NZ600474B (en) 2011-06-08 2012-06-06 Synthesis process, and crystalline form of 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1h)-yl]propoxy}benzamide hydrochloride and pharmaceutical compositions containing it
US13/489,691 US8664408B2 (en) 2011-06-08 2012-06-06 Synthesis process, and crystalline form of 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1H)-yl]proxy}benzamide hydrochloride and pharmaceutical compositions containing it
EP12171118.8A EP2532651B1 (en) 2011-06-08 2012-06-07 Synthesis process, and crystalline form of 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1h)-yl]propoxy}benzamide hydrochloride and its free base as well as the pharmaceutical compositions containing them
SI201230309T SI2532651T1 (en) 2011-06-08 2012-06-07 Synthesis process, and crystalline form of 4-(3-(cis-hexahydrocyclopenta(c)pyrrol-2(1h)-yl)propoxy)benzamide hydrochloride and its free base as well as the pharmaceutical compositions containing them
DK12171118.8T DK2532651T3 (en) 2011-06-08 2012-06-07 Synthesis process and the crystal form of 4- {3- [cis-hexahydrocyclopenta [c] pyrrole-2 (1 H) -yl] propoxy} benzamide hydrochloride and the free base thereof, and the pharmaceutical compositions containing them
ES12171118.8T ES2554933T3 (en) 2011-06-08 2012-06-07 Synthesis procedure and crystalline form of 4- {3- [cis-hexahydrocyclopenta [c] pyrrol-2 (1H) -yl] propoxy} benzamide hydrochloride, as well as the associated free base and the pharmaceutical compositions containing them
CL2012001500A CL2012001500A1 (en) 2011-06-08 2012-06-07 Preparation process of 4- {3- [cis-hexahydrocyclopenta [c] pyrrol-2 (1h) -yl] propoxy} benzamide hydrochloride; crystalline forms of the free base and hydrochloride; intermediary compounds; pharmaceutical compositions containing them; and its use in the treatment of cognitive disorders and neurodegenerative diseases.
PL12171118T PL2532651T3 (en) 2011-06-08 2012-06-07 Synthesis process, and crystalline form of 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1h)-yl]propoxy}benzamide hydrochloride and its free base as well as the pharmaceutical compositions containing them
RS20150642A RS54279B1 (en) 2011-06-08 2012-06-07 Synthesis process, and crystalline form of 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1h)-yl]propoxy}benzamide hydrochloride and its free base as well as the pharmaceutical compositions containing them
JP2012129440A JP5680022B2 (en) 2011-06-08 2012-06-07 Synthesis method and crystalline form of 4- {3- [cis-hexahydrocyclopenta [c] pyrrol-2 (1H) -yl] propoxy} benzamide hydrochloride, and pharmaceutical composition containing the same
ARP120102010A AR086848A1 (en) 2011-06-08 2012-06-07 SYNTHESIS AND CRYSTAL METHOD OF HYDROCHLORIDE 4- {3- [CIS-HEXAHYDROCICLOPENTA [C] PIRROL-2- (1H) -IL] PROPOXI} BENZAMIDA AS WELL AS THE PHARMACEUTICAL COMPOSITIONS CONTAINING IT
MX2012006525A MX2012006525A (en) 2011-06-08 2012-06-07 Synthesis process, and crystalline form of 4-{3-[cis-hexahydrocyc lopenta[c]pyrrol-2(1h)-yl]propoxy}benzamide hydrochloride and its free base as well as the pharmaceutical compositions containing them.
MEP-2015-148A ME02346B (en) 2011-06-08 2012-06-07 Synthesis process, and crystalline form of 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1h)-yl]propoxy} benzamide hydrochloride and its free base as well as the pharmaceutical compositions containing them
PCT/FR2012/051272 WO2012168657A1 (en) 2011-06-08 2012-06-07 Process for synthesis and crystalline form of 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1h)-yl]propoxy}benzamide hydrochloride, in addition to the associated free base and the pharmaceutical compositions containing same
ZA2012/04183A ZA201204183B (en) 2011-06-08 2012-06-07 Synthesis process, and crystalline form of 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1h)-yl]propoxy}benzamide hydrochloride and pharmaceutical compositions containing it
PT121711188T PT2532651E (en) 2011-06-08 2012-06-07 Synthesis process, and crystalline form of 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1h)-yl]propoxy}benzamide hydrochloride and its free base as well as the pharmaceutical compositions containing them
HUE12171118A HUE028050T2 (en) 2011-06-08 2012-06-07 Synthesis process, and crystalline form of 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1h)-yl]propoxy}benzamide hydrochloride and its free base as well as the pharmaceutical compositions containing them
GT201200182A GT201200182A (en) 2011-06-08 2012-06-07 HYDROCHLORIDE SYNTHESIS AND CRYSTAL FORM OF 4- {3- [CIS-HEXAHYDROCICLOPENTA [C] PIRROL-2 (1H) -IL] PROPOXI} BENZAMIDA AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING IT
RU2013158817/04A RU2013158817A (en) 2011-06-08 2012-06-07 METHOD OF SYNTHESIS AND CRYSTALLIC FORM OF 4- {3- [CIS-HEXAHYDROCYCLOPENT [C] PYRROL-2 (1H) -YL] PROXY} BENZAMIDE AND PHARMACEZESITICAL HYDROCHLORIDE HYDROCHLORIDE
MDA20120049A MD4345C1 (en) 2011-06-08 2012-06-07 Synthesis process, and crystalline forms of 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1H)-yl]propoxy]benzamide hydrochloride and of free base, pharmaceutical compositions containing them for the treatment of cognitive and psycho-behavioural disorders
TW101120546A TWI499584B (en) 2011-06-08 2012-06-07 Synthesis process, and crystalline form of 4-{3-(cis-hexahydrocyclopenta(c)pyrrol-2(1h)-yl)propoxy}benzamide hydrochloride and pharmaceutical compositions containing it
EA201200726A EA022741B1 (en) 2011-06-08 2012-06-08 Synthesis process, and crystalline form of 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1h)-yl]propoxy}benzamide hydrochloride, and pharmaceutical compositions containing same
NI201200102A NI201200102A (en) 2011-06-08 2012-06-08 PROCEDURE FOR THE SYNTHESIS AND CRYSTALLINE FORM OF THE HYDROCHLORIDE OF 4 - {3 - [CIS - HEXAHYDROCYCLOPENTA [C] PYRROL - 2 (1H) - IL] PROPOXI} BENZAMIDE AS WELL AS THE PHARMACEUTICAL COMPOSITIONS THAT CONTAIN IT.
CN201210189156XA CN102816102A (en) 2011-06-08 2012-06-08 Synthesis process, and crystalline form of 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1H)-yl]propoxy} benzamide hydrochloride and pharmaceutical compositions containing it
US14/103,006 US8952179B2 (en) 2011-06-08 2013-12-11 Synthesis process, and crystalline form of 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1H)-yl]propoxy} benzamide hydrochloride and pharmaceutical compositions containing it
US14/174,272 US20140155453A1 (en) 2011-06-08 2014-02-06 SYNTHESIS PROCESS, AND CRYSTALLINE FORM OF 4-{3[CIS-HEXAHYDROCYCLOPENT A[CjPYRROL-2( 1 H)-YLjPROPOXYj BENZAMI DE HYDROCHLORI DE AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT
KR1020140063712A KR20140079346A (en) 2011-06-08 2014-05-27 Synthesis process, and crystalline form of 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1h)-yl]propoxy}benzamide hydrochloride and pharmaceutical compositions containing it
JP2014223181A JP2015044840A (en) 2011-06-08 2014-10-31 Synthesis method and crystal form of 4-{3-[cis-hexahydrocyclopenta[c]pyrrole-2(1h)-yl]propoxy} benzamide hydrochloride and pharmaceutical composition comprising the same
CY20151100875T CY1116739T1 (en) 2011-06-08 2015-10-02 METHOD OF SYNTHESIS AND crystalline form of 4- {3- [CIS-hexahydrocyclopenta [C] pyrrol-2 (1H) -yl] propoxy} benzamide The AND WORKING FREE BASE AND PHARMACEUTICAL COMPOSITIONS WHICH CONTAIN THE
HRP20151073TT HRP20151073T1 (en) 2011-06-08 2015-10-09 Synthesis process, and crystalline form of 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1h)-yl]propoxy}benzamide hydrochloride and its free base as well as the pharmaceutical compositions containing them

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