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FR2940651B1 - Derives de 2-pyridin-2-yl-pyrazol-3(2h)-one,leur preparation et leur application en therapeutique comme activateurs de hif - Google Patents

Derives de 2-pyridin-2-yl-pyrazol-3(2h)-one,leur preparation et leur application en therapeutique comme activateurs de hif

Info

Publication number
FR2940651B1
FR2940651B1 FR0807474A FR0807474A FR2940651B1 FR 2940651 B1 FR2940651 B1 FR 2940651B1 FR 0807474 A FR0807474 A FR 0807474A FR 0807474 A FR0807474 A FR 0807474A FR 2940651 B1 FR2940651 B1 FR 2940651B1
Authority
FR
France
Prior art keywords
pyrazol
pyridin
derivatives
preparation
therapeutic use
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0807474A
Other languages
English (en)
Other versions
FR2940651A1 (fr
Inventor
Jean Michel Altenburger
Valerie Fossey
Stephane Illiano
Geraldine Manette
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Aventis France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0807474A priority Critical patent/FR2940651B1/fr
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Priority to KR1020117017676A priority patent/KR20110099786A/ko
Priority to DK09805789.6T priority patent/DK2382205T3/da
Priority to MA34027A priority patent/MA32976B1/fr
Priority to PE2011001292A priority patent/PE20120416A1/es
Priority to JP2011542886A priority patent/JP5734870B2/ja
Priority to ES09805789.6T priority patent/ES2481042T3/es
Priority to EA201170899A priority patent/EA019591B1/ru
Priority to PCT/FR2009/052691 priority patent/WO2010076524A2/fr
Priority to BRPI0924060A priority patent/BRPI0924060A8/pt
Priority to MX2011007054A priority patent/MX2011007054A/es
Priority to CA2748411A priority patent/CA2748411A1/fr
Priority to MYPI2011003012A priority patent/MY179093A/en
Priority to PT98057896T priority patent/PT2382205E/pt
Priority to CN200980157590.6A priority patent/CN102333769B/zh
Priority to AU2009334569A priority patent/AU2009334569B2/en
Priority to SG2011047503A priority patent/SG172803A1/en
Priority to NZ593751A priority patent/NZ593751A/xx
Priority to SI200930983T priority patent/SI2382205T1/sl
Priority to EP09805789.6A priority patent/EP2382205B1/fr
Priority to PL09805789T priority patent/PL2382205T3/pl
Priority to ARP090105126A priority patent/AR074915A1/es
Priority to TW098145336A priority patent/TWI482763B/zh
Priority to PA20098856201A priority patent/PA8856201A1/es
Priority to UY0001032369A priority patent/UY32369A/es
Publication of FR2940651A1 publication Critical patent/FR2940651A1/fr
Priority to TN2011000267A priority patent/TN2011000267A1/fr
Priority to CL2011001496A priority patent/CL2011001496A1/es
Priority to EC2011011155A priority patent/ECSP11011155A/es
Priority to CR20110361A priority patent/CR20110361A/es
Priority to IL213789A priority patent/IL213789A/en
Priority to ZA2011/04783A priority patent/ZA201104783B/en
Priority to NI201100133A priority patent/NI201100133A/es
Priority to US13/172,305 priority patent/US8541455B2/en
Priority to CO11081326A priority patent/CO6400141A2/es
Application granted granted Critical
Publication of FR2940651B1 publication Critical patent/FR2940651B1/fr
Priority to HRP20140680AT priority patent/HRP20140680T1/hr
Priority to SM201400097T priority patent/SMT201400097B/xx
Priority to CY20141100553T priority patent/CY1115368T1/el
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Nutrition Science (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR0807474A 2008-12-29 2008-12-29 Derives de 2-pyridin-2-yl-pyrazol-3(2h)-one,leur preparation et leur application en therapeutique comme activateurs de hif Expired - Fee Related FR2940651B1 (fr)

Priority Applications (37)

Application Number Priority Date Filing Date Title
FR0807474A FR2940651B1 (fr) 2008-12-29 2008-12-29 Derives de 2-pyridin-2-yl-pyrazol-3(2h)-one,leur preparation et leur application en therapeutique comme activateurs de hif
PCT/FR2009/052691 WO2010076524A2 (fr) 2008-12-29 2009-12-24 Derives de 2-pyridin-2-yl-pyrazol-3(2h)-one, leur preparation et leur application en therapeutique comme activateurs de hif
MA34027A MA32976B1 (fr) 2008-12-29 2009-12-24 Derives de 2-pyridin-2-yl-pyrazol-3(2h)-one, leur preparation et leur application en therapeutique comme activateurs de hif
EP09805789.6A EP2382205B1 (fr) 2008-12-29 2009-12-24 Dérivés de 2-pyridin-2-yl-pyrazol-3(2h)-one, leur préparation et leur application en thérapeutique comme activateurs de hif
JP2011542886A JP5734870B2 (ja) 2008-12-29 2009-12-24 ２−ピリジン−２−イル−ピラゾール−３（２ｈ）−オンの誘導体、これらの調製およびｈｉｆ活性化剤としての治療用途
ES09805789.6T ES2481042T3 (es) 2008-12-29 2009-12-24 Derivados de 2-piridin-2-il-pirazol-3(2H)-ona, su preparación y uso terapéutico como activadores de HIF
EA201170899A EA019591B1 (ru) 2008-12-29 2009-12-24 Производные 2-пиридин-2-ил-пиразол-3(2h)-она, их получение и применение в терапии в качестве активаторов hif
DK09805789.6T DK2382205T3 (da) 2008-12-29 2009-12-24 2-pyridin-2-yl-pyrazol-3(2h)-on-derivater, fremstilling deraf og terapeutisk anvendelse deraf som hif-aktivatorer
BRPI0924060A BRPI0924060A8 (pt) 2008-12-29 2009-12-24 derivados de 2-piridin-2-il-pirazol-3(2h)-ona, o respectivo preparo e a respectiva aplicação em terapêutica com ativadores de hif
MX2011007054A MX2011007054A (es) 2008-12-29 2009-12-24 Derivados de 2-il-pirazol-3(2h)-ona, su preparacion y su aplicacion en terapeutica como activadores de hif.
CA2748411A CA2748411A1 (fr) 2008-12-29 2009-12-24 Derives de 2-pyridin-2-yl-pyrazol-3(2h)-one, leur preparation et leur application en therapeutique comme activateurs de hif
MYPI2011003012A MY179093A (en) 2008-12-29 2009-12-24 Derivatives of 2-pyridin-2-yl-pyrazol-3(2h)-one, preparation and therapeutic use thereof as hif activators
PT98057896T PT2382205E (pt) 2008-12-29 2009-12-24 Derivados de 2-piridin-2-il-pirazol-3(2h)-ona, sua preparação e sua aplicação terapêutica como activadores de hif
CN200980157590.6A CN102333769B (zh) 2008-12-29 2009-12-24 2-吡啶-2-基-吡唑-3(2h)-酮的衍生物、其制备和作为hif激活剂的治疗用途
AU2009334569A AU2009334569B2 (en) 2008-12-29 2009-12-24 Derivatives of 2-pyridin-2-yl-pyrazol-3(2H)-one, preparation and therapeutic use thereof as HIF activators
SG2011047503A SG172803A1 (en) 2008-12-29 2009-12-24 Derivatives of 2-pyridin-2-yl-pyrazol-3(2h)-one, preparation and therapeutic use thereof as hif activators
NZ593751A NZ593751A (en) 2008-12-29 2009-12-24 Derivatives of 2-pyridin-2-yl-pyrazol-3(2h)-one, preparation and therapeutic use thereof as hif activators
SI200930983T SI2382205T1 (sl) 2008-12-29 2009-12-24 Derivati 2-piridin-2-il-pirazol-3(2H)-ona, njihova priprava in njihova terapevtska uporaba kot aktivatorji HIF
KR1020117017676A KR20110099786A (ko) 2008-12-29 2009-12-24 ２-피리딘-２-일-피라졸-３（２ｈ）-온의 유도체, 그의 제조법 및 ｈｉｆ 활성화제로서의 치료 용도
PL09805789T PL2382205T3 (pl) 2008-12-29 2009-12-24 Pochodne 2-pirydyn-2-ylopirazol-3(2H)-onu, ich wytwarzanie i ich zastosowanie w lecznictwie jako aktywatorów HIF
PE2011001292A PE20120416A1 (es) 2008-12-29 2009-12-24 Derivados de 2-piridin-2-il-pirazol-3(2h)-ona como activadores de hif y preparacion de los mismos
ARP090105126A AR074915A1 (es) 2008-12-29 2009-12-28 Derivados de 2-piridin-2-il-pirazol-3(2h)-ona, composiciones farmaceuticas que los comprenden y uso de los mismos para el tratamiento de trastornos del aparato cardiovascular, glaucoma y otras patologias.
TW098145336A TWI482763B (zh) 2008-12-29 2009-12-28 ２－吡啶－２－基－吡唑－３（２ｈ）－酮衍生物，其製備及其作為ｈｉｆ活化劑之醫療用途
PA20098856201A PA8856201A1 (es) 2008-12-29 2009-12-29 Derivados de 2-piridin-2-il-pirazol-3(2h)-ona, su preparación y su aplicacion en terapeutica como activadores de hif"
UY0001032369A UY32369A (es) 2008-12-29 2009-12-29 Derivados de 2-piridin-2-il-pirazol-3-(2h)-ona, su preparación y su aplicación en terapéutica como activadores de hif
TN2011000267A TN2011000267A1 (fr) 2008-12-29 2011-05-24 Derives de 2-pyridin-2-yl-pyrazol-3(2h)-one, leur preparation et leur application en therapeutique comme activateurs de hif
CL2011001496A CL2011001496A1 (es) 2008-12-29 2011-06-17 Compuestos derivados de 2-piridin-2-il-pirazol-3(2h)-ona, activadores de hif; composicion farmaceutica que los comprende; procedimiento de preparacion de estos; y su uso en el tratamiento de enfermedades cardiacas perifericas de origen isquemico, entre otras.
EC2011011155A ECSP11011155A (es) 2008-12-29 2011-06-22 DERIVADOS DE 2-PIRIDIN-2-IL-PIRAZOL-3(2H)-ONA, SU PREPARACIÓN Y SU APLICACIÓN EN TERAPÉUTICA COMO ACTIVADORES de HIF
CR20110361A CR20110361A (es) 2008-12-29 2011-06-23 Derivados de 2-piridin-2-il-pirazol-3(2h)-ona, su preparación y su aplicación en terapeutica como activadores de hif
IL213789A IL213789A (en) 2008-12-29 2011-06-27 2-Pyridine-2-Yl-Phospholizing-3 (2 h) Compound, Process for Preparation of the Compound, Drug, Pharmaceutical Preparation, Use of Compound in Preparation of Drug and Combination
ZA2011/04783A ZA201104783B (en) 2008-12-29 2011-06-28 Derivatives of 2-pyridin-2-yl-pyrazol-3(2h)-one,preparation and therapeutic use thereof as hif activators
NI201100133A NI201100133A (es) 2008-12-29 2011-06-28 Derivados de 2-piridin - 2 - il - pirazol - 3(2h) -ona, su preparación y su aplicación en terapéutica como activadores de hif.
US13/172,305 US8541455B2 (en) 2008-12-29 2011-06-29 Derivatives of 2-pyridin-2-yl-pyrazol-3(2H)-one, preparation and therapeutic use thereof as HIF activators
CO11081326A CO6400141A2 (es) 2008-12-29 2011-06-29 Derivados de 2-piridin - 2 il pirazol- 3 (2h)-ona, su preparación y su aplicación en terapeútica com activadores de hif
HRP20140680AT HRP20140680T1 (hr) 2008-12-29 2014-07-15 Derivati 2-piridin-2-ilpirazol-3(2h)-ona, njihovo dobivanje i njihova upotreba u terapiji kao aktivatora hif
SM201400097T SMT201400097B (it) 2008-12-29 2014-07-22 Derivati di 2 piridin-2-il-pirazol-3(2H)-one, loropreparazione e loro applicazione in campo terapeu tico come attivatori di hif
CY20141100553T CY1115368T1 (el) 2008-12-29 2014-07-23 Παραγωγα της 2-πυριδιν-2-υλο-πυραζολ-3(2η)-ονης, η παρασκευη τους και η εφαρμογη τους στη θεραπευτικη ως ενεργοποιητες του ηιf

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0807474A FR2940651B1 (fr) 2008-12-29 2008-12-29 Derives de 2-pyridin-2-yl-pyrazol-3(2h)-one,leur preparation et leur application en therapeutique comme activateurs de hif

Publications (2)

Publication Number Publication Date
FR2940651A1 FR2940651A1 (fr) 2010-07-02
FR2940651B1 true FR2940651B1 (fr) 2013-05-03

Family

ID=40635747

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0807474A Expired - Fee Related FR2940651B1 (fr) 2008-12-29 2008-12-29 Derives de 2-pyridin-2-yl-pyrazol-3(2h)-one,leur preparation et leur application en therapeutique comme activateurs de hif

Country Status (1)

Country Link
FR (1) FR2940651B1 (fr)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4023488A1 (de) * 1990-07-24 1992-01-30 Bayer Ag 1-(pyri(mi)dyl-(2)) -5-hydroxy-pyrazol-mikrobizide
DE102005019712A1 (de) * 2005-04-28 2006-11-09 Bayer Healthcare Ag Dipyridyl-dihydropyrazolone und ihre Verwendung
DE102006050516A1 (de) * 2006-10-26 2008-04-30 Bayer Healthcare Ag Substituierte Dihydropyrazolone und ihre Verwendung
WO2008121861A2 (fr) * 2007-03-28 2008-10-09 Xenon Pharmaceuticals Inc. Composés à base de pyrazole et de pyrrole utiles dans le traitement de troubles du métabolisme du fer

Also Published As

Publication number Publication date
FR2940651A1 (fr) 2010-07-02

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Effective date: 20160831