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FR2869908B1 - Substrat peptidique reconnu par la toxine botulique de type a, bont/a et son utilisation pour detecter et/ou doser ladite toxine ou des inhibiteurs de son activite - Google Patents

Substrat peptidique reconnu par la toxine botulique de type a, bont/a et son utilisation pour detecter et/ou doser ladite toxine ou des inhibiteurs de son activite

Info

Publication number
FR2869908B1
FR2869908B1 FR0404817A FR0404817A FR2869908B1 FR 2869908 B1 FR2869908 B1 FR 2869908B1 FR 0404817 A FR0404817 A FR 0404817A FR 0404817 A FR0404817 A FR 0404817A FR 2869908 B1 FR2869908 B1 FR 2869908B1
Authority
FR
France
Prior art keywords
bont
dosing
inhibitors
activity
detecting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0404817A
Other languages
English (en)
Other versions
FR2869908A1 (fr
Inventor
Zaluski Marie Claude Fournie
Bernard Pierre Roques
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmaleads SA
Original Assignee
Pharmaleads SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0404817A priority Critical patent/FR2869908B1/fr
Application filed by Pharmaleads SA filed Critical Pharmaleads SA
Priority to US11/579,491 priority patent/US7875436B2/en
Priority to CA2565678A priority patent/CA2565678C/fr
Priority to EP05769759A priority patent/EP1743034B1/fr
Priority to ES05769759T priority patent/ES2297742T3/es
Priority to AT05769759T priority patent/ATE380880T1/de
Priority to CN2005800200721A priority patent/CN1969046B/zh
Priority to PCT/FR2005/001121 priority patent/WO2005121354A2/fr
Priority to DE602005003817T priority patent/DE602005003817T2/de
Publication of FR2869908A1 publication Critical patent/FR2869908A1/fr
Application granted granted Critical
Publication of FR2869908B1 publication Critical patent/FR2869908B1/fr
Priority to IL179035A priority patent/IL179035A/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
FR0404817A 2004-05-05 2004-05-05 Substrat peptidique reconnu par la toxine botulique de type a, bont/a et son utilisation pour detecter et/ou doser ladite toxine ou des inhibiteurs de son activite Expired - Fee Related FR2869908B1 (fr)

Priority Applications (10)

Application Number Priority Date Filing Date Title
FR0404817A FR2869908B1 (fr) 2004-05-05 2004-05-05 Substrat peptidique reconnu par la toxine botulique de type a, bont/a et son utilisation pour detecter et/ou doser ladite toxine ou des inhibiteurs de son activite
DE602005003817T DE602005003817T2 (de) 2004-05-05 2005-05-04 Mittels botulinumtoxin a (bont/a) erkennbare peptidsubstrate und verwendung
EP05769759A EP1743034B1 (fr) 2004-05-05 2005-05-04 Substrats peptidiques reconnus par la toxine botulique de type a, bont/a et leurs utilisations
ES05769759T ES2297742T3 (es) 2004-05-05 2005-05-04 Sustratos peptidicos reconocidos por la toxina botulinica de tipo a, bont/a y sus usos.
AT05769759T ATE380880T1 (de) 2004-05-05 2005-05-04 Mittels botulinumtoxin a (bont/a) erkennbare peptidsubstrate und verwendung
CN2005800200721A CN1969046B (zh) 2004-05-05 2005-05-04 由A型肉毒杆菌毒素BoNT/A识别的肽底物及其用途
US11/579,491 US7875436B2 (en) 2004-05-05 2005-05-04 Peptide substrates recognizable by a botulinum toxin A, BoNT/A and the use thereof
CA2565678A CA2565678C (fr) 2004-05-05 2005-05-04 Substrats peptidiques reconnus par la toxine botulique de type a, bont/a et leurs utilisations
PCT/FR2005/001121 WO2005121354A2 (fr) 2004-05-05 2005-05-04 Substrats peptidiques reconnus par la toxine botulique de type a, bont/a et leurs utilisations
IL179035A IL179035A (en) 2004-05-05 2006-11-02 Peptide substrate recognized by botulinum toxin a, its metabolites and methods and kits making use of the substrate for detecting the toxin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0404817A FR2869908B1 (fr) 2004-05-05 2004-05-05 Substrat peptidique reconnu par la toxine botulique de type a, bont/a et son utilisation pour detecter et/ou doser ladite toxine ou des inhibiteurs de son activite

Publications (2)

Publication Number Publication Date
FR2869908A1 FR2869908A1 (fr) 2005-11-11
FR2869908B1 true FR2869908B1 (fr) 2006-07-28

Family

ID=34946830

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0404817A Expired - Fee Related FR2869908B1 (fr) 2004-05-05 2004-05-05 Substrat peptidique reconnu par la toxine botulique de type a, bont/a et son utilisation pour detecter et/ou doser ladite toxine ou des inhibiteurs de son activite

Country Status (2)

Country Link
CN (1) CN1969046B (fr)
FR (1) FR2869908B1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5689113B2 (ja) * 2009-04-27 2015-03-25 メルツ ファルマ ゲーエムベーハー ウント コンパニー カーゲーアーアー ニューロトキシンポリペプチドの量の測定とその触媒及びタンパク質分解活性の測定のための手段及び方法
PT2491384E (pt) * 2009-10-21 2014-02-21 Merz Pharma Gmbh & Co Kgaa Sistema para determinar uma neurotoxina de tipo a processada e parcialmente processada
EP2715355B1 (fr) * 2011-06-01 2017-03-08 Biomadison, Inc. Dosage botulique sans fret
FR2997081B1 (fr) 2012-10-23 2015-11-27 Pharmaleads Inhibiteurs mixtes de l'aminopeptidase n et de la neprilysine

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2809733B1 (fr) * 2000-06-02 2004-04-30 Inst Nat Sante Rech Med Substrat peptidique reconnu par la toxine botulique de type bont/b et son utilisation pour doser et/ou detecter ladite toxine ou des inhibiteurs correspondants

Also Published As

Publication number Publication date
CN1969046A (zh) 2007-05-23
FR2869908A1 (fr) 2005-11-11
CN1969046B (zh) 2011-02-09

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Year of fee payment: 12

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Effective date: 20170131