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FR2862965B1 - Nouveaux derives de phenoxyacetamides et leur utilisation pour la preparation de diphenylamides. - Google Patents

Nouveaux derives de phenoxyacetamides et leur utilisation pour la preparation de diphenylamides.

Info

Publication number
FR2862965B1
FR2862965B1 FR0313952A FR0313952A FR2862965B1 FR 2862965 B1 FR2862965 B1 FR 2862965B1 FR 0313952 A FR0313952 A FR 0313952A FR 0313952 A FR0313952 A FR 0313952A FR 2862965 B1 FR2862965 B1 FR 2862965B1
Authority
FR
France
Prior art keywords
diphenylamides
novel
preparation
phenoxyacetamide derivatives
phenoxyacetamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0313952A
Other languages
English (en)
Other versions
FR2862965A1 (fr
Inventor
Claude Lardy
Bernard Boudet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sante SAS
Original Assignee
Merck Sante SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0313952A priority Critical patent/FR2862965B1/fr
Application filed by Merck Sante SAS filed Critical Merck Sante SAS
Priority to CA002547281A priority patent/CA2547281A1/fr
Priority to US10/580,546 priority patent/US20070072915A1/en
Priority to AU2004293159A priority patent/AU2004293159A1/en
Priority to PCT/EP2004/012541 priority patent/WO2005051892A1/fr
Priority to EP04797651A priority patent/EP1687256A1/fr
Priority to ARP040104382A priority patent/AR046674A1/es
Publication of FR2862965A1 publication Critical patent/FR2862965A1/fr
Application granted granted Critical
Publication of FR2862965B1 publication Critical patent/FR2862965B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/18—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides
    • C07C235/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
FR0313952A 2003-11-27 2003-11-27 Nouveaux derives de phenoxyacetamides et leur utilisation pour la preparation de diphenylamides. Expired - Fee Related FR2862965B1 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
FR0313952A FR2862965B1 (fr) 2003-11-27 2003-11-27 Nouveaux derives de phenoxyacetamides et leur utilisation pour la preparation de diphenylamides.
US10/580,546 US20070072915A1 (en) 2003-11-27 2004-11-05 Novel phenoxyacetamide derivative and use thereof for preparation of diphenylamines
AU2004293159A AU2004293159A1 (en) 2003-11-27 2004-11-05 Novel phenoxyacetamide derivatives and use thereof for the preparation of diphenylamines
PCT/EP2004/012541 WO2005051892A1 (fr) 2003-11-27 2004-11-05 Nouveaux derives de phenoxyacetamides et utilisation de ces derives pour la preparation de diphenylamines
CA002547281A CA2547281A1 (fr) 2003-11-27 2004-11-05 Nouveaux derives de phenoxyacetamides et utilisation de ces derives pour la preparation de diphenylamines
EP04797651A EP1687256A1 (fr) 2003-11-27 2004-11-05 Nouveaux derives de phenoxyacetamides et utilisation de ces derives pour la preparation de diphenylamines
ARP040104382A AR046674A1 (es) 2003-11-27 2004-11-26 Derivados de fenoxiacetamida y su uso para la preparacion de difenilaminas

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0313952A FR2862965B1 (fr) 2003-11-27 2003-11-27 Nouveaux derives de phenoxyacetamides et leur utilisation pour la preparation de diphenylamides.

Publications (2)

Publication Number Publication Date
FR2862965A1 FR2862965A1 (fr) 2005-06-03
FR2862965B1 true FR2862965B1 (fr) 2007-09-07

Family

ID=34566200

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0313952A Expired - Fee Related FR2862965B1 (fr) 2003-11-27 2003-11-27 Nouveaux derives de phenoxyacetamides et leur utilisation pour la preparation de diphenylamides.

Country Status (7)

Country Link
US (1) US20070072915A1 (fr)
EP (1) EP1687256A1 (fr)
AR (1) AR046674A1 (fr)
AU (1) AU2004293159A1 (fr)
CA (1) CA2547281A1 (fr)
FR (1) FR2862965B1 (fr)
WO (1) WO2005051892A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2926297B1 (fr) 2008-01-10 2013-03-08 Centre Nat Rech Scient Molecules chimiques inhibitrices du mecanisme d'epissage pour traiter des maladies resultant d'anomalies d'epissage.
GB0813403D0 (en) * 2008-07-22 2008-08-27 Lectus Therapeutics Ltd Potassium ion channel modulators & uses thereof
US9079880B2 (en) 2010-07-07 2015-07-14 Boehringer Ingelheim International Gmbh Rho kinase inhibitors
US8697911B2 (en) 2010-07-07 2014-04-15 Boehringer Ingelheim International Gmbh Rho kinase inhibitors
JP5769326B2 (ja) 2010-10-19 2015-08-26 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｒｈｏキナーゼ阻害薬
EP2505198A1 (fr) 2011-04-01 2012-10-03 Société Splicos Composés pour leur utilisation en tant qu'agents thérapeutiques affectant l'expression et/ou l'activité de p53
CN104119266A (zh) * 2013-04-25 2014-10-29 浙江大学 从酚类化合物出发制备咔唑的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5475139A (en) * 1993-10-22 1995-12-12 Yung Shin Pharm. Ind. Co., Ltd. Method for the preparation of substituted derivatives of diphenyl amine
DK1489078T3 (da) * 2002-03-28 2010-03-15 Mitsubishi Tanabe Pharma Corp Benzofuranderivat

Also Published As

Publication number Publication date
WO2005051892A1 (fr) 2005-06-09
AR046674A1 (es) 2005-12-14
CA2547281A1 (fr) 2005-06-09
AU2004293159A1 (en) 2005-06-09
FR2862965A1 (fr) 2005-06-03
US20070072915A1 (en) 2007-03-29
EP1687256A1 (fr) 2006-08-09

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Legal Events

Date Code Title Description
ST Notification of lapse

Effective date: 20080930