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FR2861080B1 - Anticorps presentant un taux de fucose et de galactose optimise - Google Patents

Anticorps presentant un taux de fucose et de galactose optimise

Info

Publication number
FR2861080B1
FR2861080B1 FR0312229A FR0312229A FR2861080B1 FR 2861080 B1 FR2861080 B1 FR 2861080B1 FR 0312229 A FR0312229 A FR 0312229A FR 0312229 A FR0312229 A FR 0312229A FR 2861080 B1 FR2861080 B1 FR 2861080B1
Authority
FR
France
Prior art keywords
fucose
galactose
antibodies
optimized
rate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0312229A
Other languages
English (en)
Other versions
FR2861080A1 (fr
Inventor
Nicolas Bihoreau
Romeuf Christophe De
Sylvie Jorieux
Emmanuel Nony
Dominique Bourel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LFB SA
Original Assignee
LFB SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0312229A priority Critical patent/FR2861080B1/fr
Application filed by LFB SA filed Critical LFB SA
Priority to EP04805250A priority patent/EP1675873A1/fr
Priority to PCT/FR2004/002686 priority patent/WO2005040221A1/fr
Priority to BRPI0415565-3A priority patent/BRPI0415565A/pt
Priority to CA002542881A priority patent/CA2542881A1/fr
Priority to JP2006534807A priority patent/JP2007533299A/ja
Priority to US10/575,333 priority patent/US20070015239A1/en
Priority to AU2004283924A priority patent/AU2004283924B2/en
Publication of FR2861080A1 publication Critical patent/FR2861080A1/fr
Application granted granted Critical
Publication of FR2861080B1 publication Critical patent/FR2861080B1/fr
Priority to IL174896A priority patent/IL174896A0/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A61P33/12—Schistosomicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/34—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood group antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Transplantation (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
FR0312229A 2003-10-20 2003-10-20 Anticorps presentant un taux de fucose et de galactose optimise Expired - Fee Related FR2861080B1 (fr)

Priority Applications (9)

Application Number Priority Date Filing Date Title
FR0312229A FR2861080B1 (fr) 2003-10-20 2003-10-20 Anticorps presentant un taux de fucose et de galactose optimise
PCT/FR2004/002686 WO2005040221A1 (fr) 2003-10-20 2004-10-20 Correlation du ratio taux de fucose / taux de galactose d’anticorps anti rhesus d et anti hla-dr avec l’activite adcc
BRPI0415565-3A BRPI0415565A (pt) 2003-10-20 2004-10-20 anticorpos que aresentam uma taxa de fucose e de galactose otimizada
CA002542881A CA2542881A1 (fr) 2003-10-20 2004-10-20 Anticorps possedant un ratio taux de fucose / taux de galactose optimise
EP04805250A EP1675873A1 (fr) 2003-10-20 2004-10-20 Correlation du ratio taux de fucose / taux de galactose d'anticorps anti rhesus d et anti hla-dr avec l'activite adcc
JP2006534807A JP2007533299A (ja) 2003-10-20 2004-10-20 抗ｒｈｅｓｕｓ−ｄおよび抗ｈｌａ−ｄｒ抗体のフコース含量／ガラクトース含量の比とａｄｃｃ活性の間の関連
US10/575,333 US20070015239A1 (en) 2003-10-20 2004-10-20 Correlation between the fucose content/galactose content ratio of anti-rhesus-d and anti-hla-dr antibodies and the adcc activity
AU2004283924A AU2004283924B2 (en) 2003-10-20 2004-10-20 Correlation between the fucose content / galactose content ratio of anti-rhesus-D and anti-HLA-DR antibodies and the ADCC activity
IL174896A IL174896A0 (en) 2003-10-20 2006-04-10 Correlation between the fucose conteny/galactose content ratio of anti-rhesus-d and anti-hla-dr antibodies and the adcc activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0312229A FR2861080B1 (fr) 2003-10-20 2003-10-20 Anticorps presentant un taux de fucose et de galactose optimise

Publications (2)

Publication Number Publication Date
FR2861080A1 FR2861080A1 (fr) 2005-04-22
FR2861080B1 true FR2861080B1 (fr) 2006-02-17

Family

ID=34385294

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0312229A Expired - Fee Related FR2861080B1 (fr) 2003-10-20 2003-10-20 Anticorps presentant un taux de fucose et de galactose optimise

Country Status (9)

Country Link
US (1) US20070015239A1 (fr)
EP (1) EP1675873A1 (fr)
JP (1) JP2007533299A (fr)
AU (1) AU2004283924B2 (fr)
BR (1) BRPI0415565A (fr)
CA (1) CA2542881A1 (fr)
FR (1) FR2861080B1 (fr)
IL (1) IL174896A0 (fr)
WO (1) WO2005040221A1 (fr)

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FR2892724B1 (fr) * 2005-11-02 2008-01-04 Lab Francais Du Fractionnement Anticorps cytotoxiques diriges contre des anticorps inhibiteurs du facteur viii.
US7846724B2 (en) 2006-04-11 2010-12-07 Hoffmann-La Roche Inc. Method for selecting CHO cell for production of glycosylated antibodies
EP2073842B2 (fr) * 2006-09-10 2023-10-18 Glycotope GmbH Utilisation des cellules humaines provenant d'une leucémie myéloïde pour l'expression d'anticorps
AU2013203482B2 (en) * 2006-09-10 2015-08-27 Glycotope Gmbh Fully human high yield production system for improved antibodies and proteins
US7846434B2 (en) 2006-10-24 2010-12-07 Trubion Pharmaceuticals, Inc. Materials and methods for improved immunoglycoproteins
PL1920781T3 (pl) 2006-11-10 2015-06-30 Glycotope Gmbh Kompozycje zawierające core-1-dodatnie mikroorganizmy i ich zastosowanie w leczeniu lub profilaktyce nowotworów
US20080227669A1 (en) * 2007-03-12 2008-09-18 Halliburton Energy Services, Inc. Corrosion-inhibiting additives, treatment fluids, and associated methods
EP1995309A1 (fr) * 2007-05-21 2008-11-26 Vivalis Production de protéine recombinante dans des cellules aviaires EBx
EP2340305A1 (fr) 2008-09-26 2011-07-06 Eureka Therapeutics, Inc. Lignées cellulaires et protéines avec motif de glycosylation variant
AU2010233994A1 (en) * 2009-04-07 2011-09-22 Roche Glycart Ag Bispecific anti-ErbB-3/anti-c-Met antibodies
SI2493922T1 (sl) 2009-10-26 2017-06-30 F. Hoffmann-La Roche Ag Postopek za proizvodnjo glikoziliranega imunoglobulina
WO2011124635A1 (fr) 2010-04-07 2011-10-13 Humalys Molécules de liaison au virus du chikungunya et leurs utilisations
EP2374816B1 (fr) 2010-04-07 2016-09-28 Agency For Science, Technology And Research Molécules liant le virus du Chikungunya et leurs utilisations
EP2409712A1 (fr) 2010-07-19 2012-01-25 International-Drug-Development-Biotech Anticorps Anti-CD19 doté de fonctions ADCC et CDC et d'un profil de glycosylation amélioré
EP2409989A1 (fr) 2010-07-19 2012-01-25 International-Drug-Development-Biotech Procédé pour améliorer le profile de glycosylation d'un anticorps
EP2409993A1 (fr) 2010-07-19 2012-01-25 International-Drug-Development-Biotech Anticorps Anti-CD19 doté d'une fonction ADCC et d'un profil de glycosylation amélioré
JPWO2012105699A1 (ja) * 2011-02-03 2014-07-03 株式会社イーベック 補体依存性生物活性の高い抗体の産生法
US9062106B2 (en) 2011-04-27 2015-06-23 Abbvie Inc. Methods for controlling the galactosylation profile of recombinantly-expressed proteins
CN104168913A (zh) * 2011-08-10 2014-11-26 法国化学与生物科技实验室 高半乳糖基化抗体
CN103814123A (zh) 2011-08-22 2014-05-21 葛莱高托普有限公司 携带肿瘤抗原的微生物
US9150645B2 (en) 2012-04-20 2015-10-06 Abbvie, Inc. Cell culture methods to reduce acidic species
US9067990B2 (en) 2013-03-14 2015-06-30 Abbvie, Inc. Protein purification using displacement chromatography
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AU2014217561B2 (en) * 2013-02-13 2018-11-15 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Highly galactosylated anti-TNF-alpha antibodies and uses thereof
EP2830651A4 (fr) 2013-03-12 2015-09-02 Abbvie Inc Anticorps humains qui se lient au tnf-alpha et leurs procédés de préparation
US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
US9499614B2 (en) 2013-03-14 2016-11-22 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides
EP3052640A2 (fr) 2013-10-04 2016-08-10 AbbVie Inc. Utilisation d'ions métaux pour la modulation des profils de glycosylation de protéines recombinantes
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EP3191527B1 (fr) * 2014-09-10 2020-01-15 F.Hoffmann-La Roche Ag Anticorps 1 d'immunoglobuline galactosynthétisée in vitro
FR3035879A1 (fr) * 2015-05-07 2016-11-11 Lab Francais Du Fractionnement Mutants fc a activite fonctionnelle modifiee
US11780934B2 (en) 2016-02-05 2023-10-10 Institut Pasteur Use of inhibitors of ADAM12 as adjuvants in tumor therapies
JP7279011B2 (ja) 2017-07-10 2023-05-22 インターナショナル－ドラッグ－ディベロップメント－バイオテック 抗ｃｄ２０抗体または化学療法薬と併用して非フコシル化アポトーシス促進性抗ｃｄ１９抗体を用いるｂ細胞悪性の治療
EP3508499A1 (fr) 2018-01-08 2019-07-10 iOmx Therapeutics AG Anticorps ciblant et d'autres modulateurs d'un gène d'immunoglobuline associé à une résistance contre des réponses immunitaires antitumorales et leurs utilisations
RS64379B1 (sr) 2018-05-18 2023-08-31 Glycotope Gmbh Anti-muc1 antitelo
CN114401992A (zh) 2019-07-05 2022-04-26 艾欧麦克斯治疗股份公司 结合igsf11（vsig3）的igc2的抗体及其用途
EP3822288A1 (fr) 2019-11-18 2021-05-19 Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts Anticorps ciblant et autres modulateurs de l'antigène cd276 et leurs utilisations
WO2022008027A1 (fr) 2020-07-06 2022-01-13 Iomx Therapeutics Ag Anticorps de liaison à l'igv d'igsf11 (vsig3) et leurs utilisations
WO2024133940A2 (fr) 2022-12-23 2024-06-27 Iomx Therapeutics Ag Protéines de liaison à un antigène (abp) inter-spécifiques ciblant une sous-famille b1 de récepteur de type immunoglobuline leucocytaire (lilrb1) et lilrb2, combinaisons et utilisations associées

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Also Published As

Publication number Publication date
AU2004283924A1 (en) 2005-05-06
FR2861080A1 (fr) 2005-04-22
EP1675873A1 (fr) 2006-07-05
US20070015239A1 (en) 2007-01-18
BRPI0415565A (pt) 2007-01-02
JP2007533299A (ja) 2007-11-22
CA2542881A1 (fr) 2005-05-06
WO2005040221A1 (fr) 2005-05-06
IL174896A0 (en) 2006-08-20
AU2004283924B2 (en) 2010-12-02

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Effective date: 20140630