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FR2796643B1 - Derives de 2-arylimino-2, 3-dihydrothiazoles, leurs procedes de preparation et leur utilisation therapeutique - Google Patents

Derives de 2-arylimino-2, 3-dihydrothiazoles, leurs procedes de preparation et leur utilisation therapeutique

Info

Publication number
FR2796643B1
FR2796643B1 FR9909496A FR9909496A FR2796643B1 FR 2796643 B1 FR2796643 B1 FR 2796643B1 FR 9909496 A FR9909496 A FR 9909496A FR 9909496 A FR9909496 A FR 9909496A FR 2796643 B1 FR2796643 B1 FR 2796643B1
Authority
FR
France
Prior art keywords
dihydrothiazoles
arylimino
derivatives
processes
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9909496A
Other languages
English (en)
Other versions
FR2796643A1 (fr
Inventor
Christophe Moinet
Carole Sackur
Christophe Thurieau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ipsen Pharma SAS
Original Assignee
Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS filed Critical Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Priority to FR9909496A priority Critical patent/FR2796643B1/fr
Priority to ARP000103722A priority patent/AR035321A1/es
Priority to RU2002104574/04A priority patent/RU2266287C2/ru
Priority to CA2382940A priority patent/CA2382940C/fr
Priority to CNB008107157A priority patent/CN100443479C/zh
Priority to CZ20020187A priority patent/CZ302073B6/cs
Priority to EP00958575A priority patent/EP1202980A1/fr
Priority to JP2001512509A priority patent/JP4063537B2/ja
Priority to PCT/FR2000/002095 priority patent/WO2001007424A1/fr
Priority to KR1020027000839A priority patent/KR100692352B1/ko
Priority to HU0202425A priority patent/HUP0202425A3/hu
Priority to AU70053/00A priority patent/AU782187B2/en
Priority to NZ516599A priority patent/NZ516599A/xx
Priority to PL00353831A priority patent/PL353831A1/xx
Priority to BR0012647-0A priority patent/BR0012647A/pt
Priority to MXPA02000723A priority patent/MXPA02000723A/es
Priority to IL14758200A priority patent/IL147582A0/xx
Priority to US10/031,429 priority patent/US6727269B1/en
Publication of FR2796643A1 publication Critical patent/FR2796643A1/fr
Priority to IL147582A priority patent/IL147582A/en
Priority to NO20020314A priority patent/NO322394B1/no
Priority to HK03100526.0A priority patent/HK1048314A1/xx
Priority to US10/615,481 priority patent/US7220765B2/en
Application granted granted Critical
Publication of FR2796643B1 publication Critical patent/FR2796643B1/fr
Priority to JP2006114071A priority patent/JP2006257093A/ja
Priority to IL185786A priority patent/IL185786A0/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
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  • Cardiology (AREA)
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  • Dermatology (AREA)
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  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
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  • Child & Adolescent Psychology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
FR9909496A 1999-07-22 1999-07-22 Derives de 2-arylimino-2, 3-dihydrothiazoles, leurs procedes de preparation et leur utilisation therapeutique Expired - Fee Related FR2796643B1 (fr)

Priority Applications (24)

Application Number Priority Date Filing Date Title
FR9909496A FR2796643B1 (fr) 1999-07-22 1999-07-22 Derives de 2-arylimino-2, 3-dihydrothiazoles, leurs procedes de preparation et leur utilisation therapeutique
ARP000103722A AR035321A1 (es) 1999-07-22 2000-07-19 Derivados de 2-arilimino-2,3-dihidrotiazoles, procedimiento para su preparacion, y uso de los mismos para preparar medicamentos y composiciones farmaceuticas
MXPA02000723A MXPA02000723A (es) 1999-07-22 2000-07-21 2-arilimino-2,3-dihidrotiazoles y su uso como ligandos de receptores de somatostatina.
CNB008107157A CN100443479C (zh) 1999-07-22 2000-07-21 2-芳基亚氨基-2,3-二氢噻唑和它们作为生长激素释放抑制因子受体配体的用途
CZ20020187A CZ302073B6 (cs) 1999-07-22 2000-07-21 2-Arylimino-2,3-dihydrothiazoly a jejich použití jako ligandu somatostatinových receptoru
EP00958575A EP1202980A1 (fr) 1999-07-22 2000-07-21 2-arylimino-2,3-dihydrothiazoles et leur utilisation comme ligands des recepteurs de la somatostatine
JP2001512509A JP4063537B2 (ja) 1999-07-22 2000-07-21 ２−アリールイミノ−２，３−ジヒドロチアゾール類及びそのソマトスタチンレセプターのリガンドとしての使用
PCT/FR2000/002095 WO2001007424A1 (fr) 1999-07-22 2000-07-21 2-arylimino-2,3-dihydrothiazoles et leur utilisation comme ligands des recepteurs de la somatostatine
KR1020027000839A KR100692352B1 (ko) 1999-07-22 2000-07-21 2-아릴이미노-2,3-디히드로티아졸 및 그의 소마토스타틴수용체 리간드로서의 용도
HU0202425A HUP0202425A3 (en) 1999-07-22 2000-07-21 2-arylimino-2,3-dihydrothiazoles, their preparation and use thereof as somatostatin receptor ligands
AU70053/00A AU782187B2 (en) 1999-07-22 2000-07-21 2-arylimino-2,3-dihydrothiazoles, and their use thereof as somatostatin receptor ligands
NZ516599A NZ516599A (en) 1999-07-22 2000-07-21 2-arylimino-2,3-dihydrothiazoles, and their use thereof as somatostatin receptor ligands
RU2002104574/04A RU2266287C2 (ru) 1999-07-22 2000-07-21 2-арилимино-2,3-дигидротиазолы, способы их получения и фармацевтическая композиция, их содержащая
BR0012647-0A BR0012647A (pt) 1999-07-22 2000-07-21 Composto, processo de preparação do mesmo, produto, composição farmacêutica, e utilização do produto
CA2382940A CA2382940C (fr) 1999-07-22 2000-07-21 2-arylimino-2,3-dihydrothiazoles et leur utilisation comme ligands des recepteurs de la somatostatine
IL14758200A IL147582A0 (en) 1999-07-22 2000-07-21 2-arylimino-2, 3-dihydrothiazoles, and their use thereof as somatostatin receptor ligands
US10/031,429 US6727269B1 (en) 1999-07-22 2000-07-21 2-Arylimino-2,3-dihydrothiazoles, and their use thereof as somatostatin receptor ligands
PL00353831A PL353831A1 (en) 1999-07-22 2000-07-21 2-arylimino-2,3-dihydrothiazoles, and their use thereof as somatostatin receptor ligands
IL147582A IL147582A (en) 1999-07-22 2002-01-10 2 - Arylamino - 2,3 - Dihydrotiazoles, their preparation, their use in the preparation of medicinal preparations, and medicinal preparations containing them
NO20020314A NO322394B1 (no) 1999-07-22 2002-01-21 2-arylimino-2,3-dihydrotiazoler, fremgangsmate for fremstilling av disse, farmasoytiske preparater inneholdende disse samt deres anvendelse for fremstilling av medikamenter for behandling av tilstander eller sykdommer der somatostatinreseptorene er innvolvert.
HK03100526.0A HK1048314A1 (en) 1999-07-22 2003-01-22 2-arylimino-2,3-dihydrothiazoles, and their use thereof as somatostatin receptor ligands
US10/615,481 US7220765B2 (en) 1999-07-22 2003-07-08 Derivatives of 2-arylimino-2,3-dihydrothiazoles, their preparation processes and their therapeutic use
JP2006114071A JP2006257093A (ja) 1999-07-22 2006-04-18 ２−アリールイミノ−２，３−ジヒドロチアゾール類及びそのソマトスタチンレセプターのリガンドとしての使用
IL185786A IL185786A0 (en) 1999-07-22 2007-09-06 2-arylimino-2,3-dihydrothiazoles, and their use thereof as somatostatin receptor ligands

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AR035321A1 (es) 2004-05-12
MXPA02000723A (es) 2002-09-17
NO322394B1 (no) 2006-10-02
BR0012647A (pt) 2002-04-09
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CN1362952A (zh) 2002-08-07
RU2266287C2 (ru) 2005-12-20
KR100692352B1 (ko) 2007-03-12
CZ302073B6 (cs) 2010-09-29
HK1048314A1 (en) 2003-03-28
HUP0202425A3 (en) 2002-12-28
IL147582A0 (en) 2002-08-14
AU7005300A (en) 2001-02-13
CZ2002187A3 (cs) 2002-06-12
WO2001007424A1 (fr) 2001-02-01
PL353831A1 (en) 2003-12-01
JP4063537B2 (ja) 2008-03-19
HUP0202425A2 (en) 2002-10-28
FR2796643A1 (fr) 2001-01-26
KR20020088405A (ko) 2002-11-27
IL185786A0 (en) 2008-01-06
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US6727269B1 (en) 2004-04-27
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