FR2782639A1 - Composition for freezing skin contains hydrofluorocarbon and hydrofluoroether - Google Patents

Abstract

A composition for freezing the skin contains a hydrofluorocarbon (HFC) liquefied gas propellant and a material (I) to lower the temperature when the pressure is reduced. An Independent claim is also included for a container for storing and administering this mixture in which the spray system is adjustable.

Description

1 2782639

REFRIGERANT FOR THE SKIN

  The invention relates to a refrigerant for skin use, which can in particular be used in the medical field in preanesthesia, before

  injection, or, for example, to relieve muscle strain.

  There are many refrigerant mixtures containing refrigerant and non-flammable gases such as CFC (chlorofluorocarbon) such as

  monofluorotrichloromethane, difluorodichloromethane, tetrafluorodi-

chloroethane, for example.

  Products containing CFCs are found to be harmful to the environment and their use is now widely prohibited to preserve the ozone layer. These should therefore be replaced

  refrigerants with products that do not contain CFCs.

  The invention thus provides a CFC-free refrigerant for the skin.

  To this end, the invention relates to a refrigerant for the skin comprising a propellant liquefied gas and a pressure reducer intended to lower the temperature, characterized in that the propellant liquefied gas

is an HFC.

  HFCs (hydrofluorocarbons) protect the environment, especially the ozone layer. Their use in refrigerants therefore turns out

  very beneficial from an ecological point of view.

  Advantageously, the propellant liquefied gas is non-flammable.

  The pressure reducer can be an HFE (hydrofluoroether) or an HFC.

  Preferably, the proportion by weight of propellant liquefied gas is

between 30% and 90%.

  With such proportions, the refrigerant offers a cold effect

  sufficient and nevertheless tolerable by the skin, without risk of frostbite

this.

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  In a preferred embodiment, the proportion by weight of gas

liquefied propellant is 50%.

  Such a proportion offers a cold effect suitable for many

  applications (preanesthesia before injection, breakdown, ...).

  The invention also relates to a packaging for packaging the refrigerant of the invention, comprising a modular spraying system. Advantageously, the spraying system comprises a plurality of channels.

  The invention will be better understood using the following description of

  several embodiments of the refrigerant product of the invention, as well as an embodiment of its packaging packaging, with reference to the appended drawing, in which: - Figure 1 represents curves of the results of tests carried out on a mixture of HFE and HFC-1 34a from Table 1; - Figure 2 shows curves of the test results carried out on a mixture of CFC-12 and CFC-1 14 of Table 2; 3 shows a sectional view of an aerosol packaging push button and FIG. 4 represents a perspective view of the interior of a spray nozzle. The refrigerant of the invention is a mixture of a propellant liquefied gas and a pressure reducer intended to lower the temperature

of the product.

  Tables 1 and 2 as well as Figures 1 and 2 report the results of tests, carried out on various refrigerant mixtures explained below, having consisted of spraying these mixtures onto a surface equipped with a temperature sensor, by direct jet at using a capillary, and to measure the evolution of the temperature of this surface just after spraying,

  resulting from the cold effect produced.

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  The mixtures tested, the test results of which are reported in Table 1 (FIG. 1), contain a liquefied propellant gas HFC (hydrofluorocarbon), in this case HFC-134a (tetrafluoroethane), and a pressure reducer HFE ( hydrofluoroether), in this case an HFE

  sold under the reference HFE-7100 by the company 3M.

  HFC-134a and HFE have the advantage of being non-flammable and

soluble in each other.

  Nine refrigerant mixtures, differing from each other in their proportions by weight of HFE and HFC-134a, were tested. These mixtures, referenced from 1 to 9 in Table 1 and in Figure 1, include proportions by weight, indicated in percentages in the column "% HFE / HFC-134a" (Table 1), which vary from 90% to 10 %, for HFE, and from

% to 90%, for HFC-134a.

  With mixture 1 (90% HFE and 10% HFC-134a) and with mixture 2 (80% HFE and 20% HFC-134a), the minimum temperatures reached are approximately 4 C (degrees Celsius) and -7 C. The cold effect is therefore weak and in any case insufficient to be truly active. In addition, this weak cold effect is short-lived, which makes it even less effective. Such mixtures are therefore unusable for a

  use as refrigerants.

  With mixtures 3 to 9, the minimum temperatures vary, depending on the mixture, from -14 C to almost -50 C, which provides an effective cold effect. In addition, the duration of the cold effect, during which the skin temperature is below about 0 C, is sufficient

  long (greater than 80 milliseconds) to be effective.

  It therefore follows from the tests carried out that the mixtures of HFE and HFC-

  134a, containing proportions of HFC-134a varying from 30% to 90%, are

  suitable for use as cooling products for the skin.

  It will be noted here that mixture 3 (30% of HFC-134a and 70% of HFE) is very suitable for treating muscle breakdowns, while mixture 9 (90% of HFC-134a and 10% of HFE) is more suitable in preanesthesia before injection. As for mixture 5 (50% of HFC and 50% of

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  HFE), it is not intended for a specific use and is therefore suitable

  very good for various applications.

  Comparative tests, similar to those carried out on HFE / HFC-134a mixtures (Table 2 and Figure 2), were carried out on prior art 10-12 refrigerant mixtures containing CFC-12 (difluorodichloromethane) and CFC -114 (tetrafluorodichloroethane), in proportions varying from 10% to 60%, for CFC-12, and from 90% to 40%,

for CFC-14.

  As can be seen in FIG. 2, the temperature drop curves for mixtures 10 to 12 are comparable to the temperature drop curves for mixtures 1 to 9. It can however be noted that with mixtures of the invention, the minimum temperatures reached are lower and the duration of the cold effect is longer. The effectiveness of the refrigerant products of the invention is therefore better than that of the products

of the prior art.

  The HFE / HFC-134a refrigerant mixture is packaged in a package, in this case an aerosol, comprising a modular diffusion system, to

  flow control and comprising a plurality of channels.

  By modulating the flow, the cold effect is managed.

  With reference to FIGS. 3 and 4, the push button 20 of the aerosol packaging, which is, moreover, perfectly conventional, comprises, downstream of the path

  21 of the refrigerant mixture, an interchangeable nozzle module 22.

  FIG. 4 shows a nozzle 22 here with four large channels 23a, 23b, 23c, 23d. It is also possible to have in the button 20 a nozzle with smaller channels, of constant or convergent section towards the orifice 24 of the nozzle, and in different numbers. By modifying the size of the orifice of the valve body of the packaging not shown, that of the orifice of the nozzle and the

  size and number of its channels, we can regulate the flow.

  Thus, this modulates, regulates, the temperature of the surface of the

  skin to which the refrigerant is applied.

  Instead of HFE, as a pressure reducer, an HFC could also be used in the same proportions as that of the HFE of

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  mixtures 3 to 9 described above (that is to say in proportions varying from 10% to 70%), tests having shown the ability of certain HFCs to

lower the temperature.

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Table 1

  Refrigerant mixtures of HFE and HFC-134a References 1 2 3 4 5 6 7 8 9 HFE / HFC-134a 90/10 80/20 70/30 60/40 50/50 40/60 30/70 20/80 10 / 90 HFE / HFC-134ai

0 37 37 37 37 37 37 37 37 37 37

-20

4 -7 -14 -25 -28 -35

-44

-35

-25

-10 - -36

-20 -39

0

-30 -46

-10 -20

0

10

-10

-30 -40

-20

-10

10 0

-30

-20

E

= _ = -10

0

-20

0

-10

205 10

215 -10

230 0

240 0

250 10

295 10

300 0

315 _ 10

335 10

410 10

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Table 2

  Refrigerant mixtures of CFC-12 and CFC-114 References 10 11 12

% 12/114 10/90 40/60 60/40

0 37 37 37

-33

-34

- -41

-33

-30

-36 -40

-20

= =

-10

-30

0 4 _

0 -30

E 130

"" '140 -20 C. 145 -20

E 160 I-- 165 170 -10

-10

10

210 0

215 0

310 10

320 10

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Claims (8)

  1- Refrigerant for the skin comprising a liquefied propellant gas and a pressure reducer intended to lower the temperature, characterized by   fact that the propellant liquefied gas is an HFC.   2- Product according to claim 1, wherein the propellant liquefied gas is non-flammable.   3- Product according to one of claims 1 and 2, wherein the reducer pressure is an HFE.   4- Product according to one of claims 1 and 2, wherein the reducer pressure is an HFC.   - Product according to one of claims 1 to 4, wherein the proportion in   weight of propellant liquefied gas is between 30% and 90%.   6- Product according to one of claims 1 to 5, wherein the proportion in   weight of propellant liquefied gas is 50%.   7- Packaging for packaging the refrigerant according to one of the   Claims 1 to 6, comprising a modular spraying system.   8- Packaging according to claim 7, wherein the system of   spraying is flow controlled.   9. Packaging according to claim 8, in which the spraying system comprises a nozzle (22) in which is formed a plurality of channels (23).