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FR2781672B1 - Compositions a dissolution rapide ayant une activite analgesique et comprimes obtenus a partir de celles-ci - Google Patents

Compositions a dissolution rapide ayant une activite analgesique et comprimes obtenus a partir de celles-ci

Info

Publication number
FR2781672B1
FR2781672B1 FR9909655A FR9909655A FR2781672B1 FR 2781672 B1 FR2781672 B1 FR 2781672B1 FR 9909655 A FR9909655 A FR 9909655A FR 9909655 A FR9909655 A FR 9909655A FR 2781672 B1 FR2781672 B1 FR 2781672B1
Authority
FR
France
Prior art keywords
fast
obtained therefrom
analgesic activity
tablets obtained
dissolving compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR9909655A
Other languages
English (en)
Other versions
FR2781672A1 (fr
Inventor
Alessandro Grassano
Maurizio Marchiorri
Toro Mauro Di
Franco Castegini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zambon Group SpA
Zambon SpA
Original Assignee
Zambon Group SpA
Zambon SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Group SpA, Zambon SpA filed Critical Zambon Group SpA
Publication of FR2781672A1 publication Critical patent/FR2781672A1/fr
Application granted granted Critical
Publication of FR2781672B1 publication Critical patent/FR2781672B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR9909655A 1998-07-30 1999-07-26 Compositions a dissolution rapide ayant une activite analgesique et comprimes obtenus a partir de celles-ci Expired - Lifetime FR2781672B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1998MI001774A IT1301966B1 (it) 1998-07-30 1998-07-30 Composizioni farmaceutiche ad attivita' analgesica

Publications (2)

Publication Number Publication Date
FR2781672A1 FR2781672A1 (fr) 2000-02-04
FR2781672B1 true FR2781672B1 (fr) 2001-12-21

Family

ID=11380561

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9909655A Expired - Lifetime FR2781672B1 (fr) 1998-07-30 1999-07-26 Compositions a dissolution rapide ayant une activite analgesique et comprimes obtenus a partir de celles-ci

Country Status (14)

Country Link
US (1) US6197336B1 (fr)
EP (1) EP1100470B1 (fr)
AT (1) ATE234609T1 (fr)
AU (1) AU5158699A (fr)
BE (1) BE1012510A3 (fr)
CA (1) CA2338896C (fr)
DE (1) DE69906084T2 (fr)
ES (1) ES2192854T3 (fr)
FR (1) FR2781672B1 (fr)
GR (1) GR1003530B (fr)
IE (1) IE990557A1 (fr)
IT (1) IT1301966B1 (fr)
NL (1) NL1012533C2 (fr)
WO (1) WO2000006125A1 (fr)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1301966B1 (it) * 1998-07-30 2000-07-20 Zambon Spa Composizioni farmaceutiche ad attivita' analgesica
US6596312B1 (en) * 1999-09-29 2003-07-22 R.P. Scherer Technologies, Inc. Hydrolyzed cellulose granulations of salts of drugs
KR100523242B1 (ko) * 2000-05-18 2005-10-24 한미약품 주식회사 이부프로펜을 함유하는 정제 조성물
AU2002255190A1 (en) * 2001-04-10 2002-10-28 Fakhreddin Jamali Composition for enhanced absorption of nsaids
US6761905B2 (en) 2001-05-01 2004-07-13 Wei Ming Pharmaceutical Mfg. Co., Ltd. Process for the preparation of direct tabletting formulations and aids
CH693586A8 (de) * 2002-10-14 2003-12-15 Roche Consumer Health Ag Darreichungsform von Ibuprofen-Natrium.
WO2005021056A1 (fr) * 2003-08-21 2005-03-10 Cns, Inc. Systeme de distribution de materiau effervescent
US20050137262A1 (en) * 2003-12-22 2005-06-23 Hu Patrick C. Highly concentrated pourable aqueous solutions of potassium ibuprofen, their preparation and their uses
US8216610B2 (en) * 2004-05-28 2012-07-10 Imaginot Pty Ltd. Oral paracetamol formulations
WO2005115345A1 (fr) * 2004-05-28 2005-12-08 Imaginot Pty Ltd Systeme d'administration orale de compose therapeutique
US20060068009A1 (en) * 2004-09-30 2006-03-30 Scolr Pharma, Inc. Modified release ibuprofen dosage form
US20070077297A1 (en) 2004-09-30 2007-04-05 Scolr Pharma, Inc. Modified release ibuprofen dosage form
AU2006226293B2 (en) * 2005-03-22 2011-04-07 Losan Pharma Gmbh Solubilized ibuprofen
EP1800667A1 (fr) 2005-12-23 2007-06-27 Losan Pharma GmbH Granulate d'ibuprofen solubilisé rapidement
EP3263117A1 (fr) 2005-11-28 2018-01-03 Imaginot Pty Ltd. Système d'administration d'un composé thérapeutique oral
US20080014228A1 (en) * 2006-07-14 2008-01-17 Olivia Darmuzey Solid form
CN101134013B (zh) * 2006-08-30 2012-07-18 Ss制药株式会社 口服用制剂
US20080311162A1 (en) * 2007-05-16 2008-12-18 Olivia Darmuzey Solid form
CN101390844B (zh) * 2007-09-23 2011-11-09 天津医科大学 精氨酸布洛芬片剂及其制备方法
MX336494B (es) * 2007-10-16 2016-01-21 Paladin Labs Inc Composicion de bicapas para la liberacion controlada de acetaminofeno y tramadol.
US9629809B2 (en) 2008-07-21 2017-04-25 Si Group, Inc. High content sodium ibuprofen granules, their preparation and their use in preparing non-effervescent solid dosage forms
US9629806B2 (en) 2008-07-21 2017-04-25 Si Group, Inc. High content sodium ibuprofen granules, their preparation and their use in preparing non-effervescent solid dosage forms
CN101978945B (zh) * 2010-10-25 2016-03-30 北京世纪博康医药科技有限公司 一种布洛芬药物组合物
CN102008461B (zh) * 2010-10-25 2015-09-09 北京世纪博康医药科技有限公司 一种注射用布洛芬药物组合物
US20180078516A1 (en) * 2016-09-19 2018-03-22 Innovazone Labs LLC Pharmaceutical Composition of Ibuprofen Sodium for Oral Administration

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4548990A (en) 1983-08-15 1985-10-22 Ciba-Geigy Corporation Crosslinked, porous polymers for controlled drug delivery
US4681897A (en) 1984-01-16 1987-07-21 The Procter & Gamble Company Pharmaceutical products providing enhanced analgesia
IT1209667B (it) 1985-11-12 1989-08-30 Zambon Spa Composizione effeverscente adattivita' analgesica.
US4873231A (en) 1986-04-08 1989-10-10 Smith Walton J Decreasing the toxicity of an ibuprofen salt
IT1197038B (it) 1986-08-01 1988-11-25 Zambon Spa Composizione farmaceutica ad attivita' analgesica
US5519057A (en) 1986-11-14 1996-05-21 Johnson & Johnson--Merck Pharmaceuticals Co. Ibuprofen-containing medicament
US4851444A (en) 1987-07-10 1989-07-25 Analgesic Associates Onset-hastened/enhanced analgesia
US5240712A (en) 1987-07-17 1993-08-31 The Boots Company Plc Therapeutic agents
US4837031A (en) 1987-09-17 1989-06-06 Mallinckrodt, Inc. Compositions containing ibuprofen
US5034416A (en) 1988-01-19 1991-07-23 Smith Walton J Carboxylic acid compositions
GB8813682D0 (en) 1988-06-09 1988-07-13 Reckitt & Colmann Prod Ltd Pharmaceutical compositions
DE3838431A1 (de) 1988-11-12 1990-05-17 Bayer Ag Ibuprofen-brausezubereitungen
US4911921A (en) 1989-02-02 1990-03-27 Mallinckrodt, Inc. High ibuprofen content granulations
US5104648A (en) 1989-02-02 1992-04-14 Mallinckrodt Specialty Chemicals Company High ibuprofen content granulations
US5238831A (en) 1989-04-28 1993-08-24 Gist-Brocades Stabilization of carboxyl esterase
ZA903759B (en) 1989-05-16 1991-02-27 Puetter Medice Chem Pharm Process for preparing optically active 2-aryl alkanoic acids,in particular 2-aryl propionic acids
US5262179A (en) 1989-09-13 1993-11-16 Nicholas Kiwi Pty Ltd. Non-effervescent ibuprofen compositions
US5200558A (en) 1989-10-17 1993-04-06 Merck & Co., Inc. S(+)-ibuprofen-L-amino acid and S(+)-ibuprofen-D-amino acid as onset-hastened enhanced analgesics
US5262171A (en) 1991-11-25 1993-11-16 Isp Investments Inc. Pharmaceutical tablet with PVP having enhanced drug dissolution rate
WO1993009763A1 (fr) 1991-11-15 1993-05-27 Isp Investments Inc. Comprime pharmaceutique a pvp ayant une vitesse de dissolution de medicament amelioree
GB9200114D0 (en) 1992-01-04 1992-02-26 Scras Dual inhibitors of no synthase and cyclooxygenase
GB9207990D0 (en) 1992-04-10 1992-05-27 Smithkline Beecham Plc Pharmaceutical composition
US5288507A (en) 1992-07-29 1994-02-22 Merck & Co., Inc. Ibuprofen antacid combinations
ES2134796T3 (es) 1992-12-01 1999-10-16 Spirig Ag Pharmazeutische Prap Composiciones farmaceuticas que contienen s(+)-ibuprofeno.
FR2698788B1 (fr) 1992-12-09 1995-03-03 Union Pharma Scient Appl Composition pharmaceutique effervescente contenant de l'ibuprofène et son procédé de préparation.
DE4303846A1 (de) 1993-02-10 1994-08-11 Merck Patent Gmbh Verfahren zur Herstellung einer S-Ibuprofen enthaltenden Tablette
IT1272149B (it) 1993-03-26 1997-06-11 Zambon Spa Composizione farmeceutiche ad attivita' analgesica
US5431916A (en) 1993-04-29 1995-07-11 The Procter & Gamble Company Pharmaceutical compositions and process of manufacture thereof
IT1264855B1 (it) 1993-06-21 1996-10-17 Zambon Spa Composizioni farmaceutiche contenenti sali dell'acido s(+)-2-(4-isobutilfenil) propionico con amminoacidi basici
IT1264856B1 (it) 1993-06-21 1996-10-17 Zambon Spa Composizione farmaceutica ad attivita' analgesica
AT401871B (de) 1994-01-28 1996-12-27 Gebro Broschek Gmbh Verfahren zur herstellung von s(+)-ibuprofen- partikeln mit verbesserten fliesseigenschaften und deren verwendung zur arzneimittelherstellung
US5458879A (en) 1994-03-03 1995-10-17 The Procter & Gamble Company Oral vehicle compositions
US5567439A (en) 1994-06-14 1996-10-22 Fuisz Technologies Ltd. Delivery of controlled-release systems(s)
US5560913A (en) 1995-01-27 1996-10-01 The Procter & Gamble Company Pharmaceutical compositions
TW442287B (en) 1995-06-13 2001-06-23 American Home Produits Corp Organoleptically acceptable oral pharmaceutical composition comprising the S(+)1,8-diethyl-1-1,3,4,9-tetrahydropyrano[3,4-b] indole-1-acetic acid (Etodolac)
GB9603699D0 (en) 1996-02-21 1996-04-17 Boots Co Plc Therapeutic composition
DE19628617A1 (de) 1996-07-16 1998-01-22 Basf Ag Direkttablettierhilfsmittel
IT1301966B1 (it) 1998-07-30 2000-07-20 Zambon Spa Composizioni farmaceutiche ad attivita' analgesica

Also Published As

Publication number Publication date
ITMI981774A1 (it) 2000-01-30
NL1012533C2 (nl) 2000-03-15
BE1012510A3 (fr) 2000-11-07
EP1100470B1 (fr) 2003-03-19
DE69906084T2 (de) 2003-12-11
GR1003530B (el) 2001-02-21
GR990100254A (el) 2000-02-29
US6197336B1 (en) 2001-03-06
IT1301966B1 (it) 2000-07-20
IE990557A1 (en) 2000-04-05
CA2338896A1 (fr) 2000-02-10
NL1012533A1 (nl) 2000-02-01
AU5158699A (en) 2000-02-21
ITMI981774A0 (it) 1998-07-30
ATE234609T1 (de) 2003-04-15
EP1100470A1 (fr) 2001-05-23
WO2000006125A1 (fr) 2000-02-10
ES2192854T3 (es) 2003-10-16
FR2781672A1 (fr) 2000-02-04
DE69906084D1 (de) 2003-04-24
CA2338896C (fr) 2007-11-27

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