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FR2761070B1 - DIHYDROPYRAZINO [1,2-A] INDOLE-1-ONE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION - Google Patents

DIHYDROPYRAZINO [1,2-A] INDOLE-1-ONE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Info

Publication number
FR2761070B1
FR2761070B1 FR9703389A FR9703389A FR2761070B1 FR 2761070 B1 FR2761070 B1 FR 2761070B1 FR 9703389 A FR9703389 A FR 9703389A FR 9703389 A FR9703389 A FR 9703389A FR 2761070 B1 FR2761070 B1 FR 2761070B1
Authority
FR
France
Prior art keywords
dihydropyrazino
indole
derivatives
preparation
therapeutic application
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9703389A
Other languages
French (fr)
Other versions
FR2761070A1 (en
Inventor
Gary Mccort
Christian Hoornaert
Caroline Cadilhac
Olivier Duclos
Eric Guilpain
Genevieve Dellac
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Priority to FR9703389A priority Critical patent/FR2761070B1/en
Priority to EP98914929A priority patent/EP0971926A1/en
Priority to PCT/FR1998/000529 priority patent/WO1998042710A1/en
Priority to AU69240/98A priority patent/AU6924098A/en
Priority to ARP980101210A priority patent/AR012095A1/en
Priority to ZA982369A priority patent/ZA982369B/en
Publication of FR2761070A1 publication Critical patent/FR2761070A1/en
Application granted granted Critical
Publication of FR2761070B1 publication Critical patent/FR2761070B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR9703389A 1997-03-20 1997-03-20 DIHYDROPYRAZINO [1,2-A] INDOLE-1-ONE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION Expired - Fee Related FR2761070B1 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
FR9703389A FR2761070B1 (en) 1997-03-20 1997-03-20 DIHYDROPYRAZINO [1,2-A] INDOLE-1-ONE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
EP98914929A EP0971926A1 (en) 1997-03-20 1998-03-17 DIHYDROPYRAZINO 1,2-$i(A)-]INDOLE-1-ONE DERIVATIVES, PREPARATION AND APPLICATION THEREOF IN THERAPEUTICS
PCT/FR1998/000529 WO1998042710A1 (en) 1997-03-20 1998-03-17 Dihydropyrazino [1,2-a-]indole-1-one derivatives, preparation and application thereof in therapeutics
AU69240/98A AU6924098A (en) 1997-03-20 1998-03-17 Dihydropyrazino {1,2-(a)-}indole-1-one derivatives, preparation and application thereof in therapeutics
ARP980101210A AR012095A1 (en) 1997-03-20 1998-03-18 DIHYDROPIRAZINE [1,2-a] INDOL-1-ONA DERIVED COMPOUNDS, PROCEDURES FOR PREPARING SUCH DERIVATIVE COMPOUNDS AND MEDICINES AND PHARMACEUTICAL COMPOSITIONS THAT INCLUDE THEM.
ZA982369A ZA982369B (en) 1997-03-20 1998-03-19 Dihydropyrazino[1,2-a]indol-1-one derivatives their preparation and their use in therapy

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9703389A FR2761070B1 (en) 1997-03-20 1997-03-20 DIHYDROPYRAZINO [1,2-A] INDOLE-1-ONE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Publications (2)

Publication Number Publication Date
FR2761070A1 FR2761070A1 (en) 1998-09-25
FR2761070B1 true FR2761070B1 (en) 1999-04-23

Family

ID=9505000

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9703389A Expired - Fee Related FR2761070B1 (en) 1997-03-20 1997-03-20 DIHYDROPYRAZINO [1,2-A] INDOLE-1-ONE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Country Status (6)

Country Link
EP (1) EP0971926A1 (en)
AR (1) AR012095A1 (en)
AU (1) AU6924098A (en)
FR (1) FR2761070B1 (en)
WO (1) WO1998042710A1 (en)
ZA (1) ZA982369B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12144816B2 (en) 2022-12-09 2024-11-19 Vanderbilt University Substituted indole Mcl-1 inhibitors

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2248281T3 (en) 2000-02-18 2006-03-16 Meiji Seika Kaisha, Ltd. USEFUL PHENOXIALQUILAMINE DERIVATIVES AS AGONISTS OF DELTA OPIOID RECEIVER.
SI2825541T1 (en) 2012-03-16 2016-10-28 Vitae Pharmaceuticals, Inc. Liver x receptor modulators
BR112014022780A8 (en) 2012-03-16 2021-06-15 Vitae Pharmaceuticals Inc liver x receptor modulator compound, pharmaceutical composition comprising it and its use
AU2015235944B2 (en) * 2014-03-27 2020-06-25 Vanderbilt University Substituted indole Mcl-1 inhibitors
US9949965B2 (en) 2014-10-17 2018-04-24 Vanderbilt University Tricyclic indole Mcl-1 inhibitors and uses thereof
EA038143B1 (en) 2016-03-04 2021-07-13 Вандербилт Юниверсити SUBSTITUTED INDOLE Mcl-1 INHIBITORS

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2027898A6 (en) * 1991-01-24 1992-06-16 Espanola Prod Quimicos 2-Methoxyphenylpiperazine derivatives.
EP0572863A1 (en) * 1992-06-05 1993-12-08 F. Hoffmann-La Roche Ag CNS pyrazinoindoles

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12144816B2 (en) 2022-12-09 2024-11-19 Vanderbilt University Substituted indole Mcl-1 inhibitors

Also Published As

Publication number Publication date
AU6924098A (en) 1998-10-20
ZA982369B (en) 1998-09-23
FR2761070A1 (en) 1998-09-25
EP0971926A1 (en) 2000-01-19
AR012095A1 (en) 2000-09-27
WO1998042710A1 (en) 1998-10-01

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Legal Events

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TP Transmission of property
ST Notification of lapse