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FR2755699B1 - Nouvelles constructions et vecteurs pour l'expression ciblee et inductible des genes - Google Patents

Nouvelles constructions et vecteurs pour l'expression ciblee et inductible des genes

Info

Publication number
FR2755699B1
FR2755699B1 FR9613691A FR9613691A FR2755699B1 FR 2755699 B1 FR2755699 B1 FR 2755699B1 FR 9613691 A FR9613691 A FR 9613691A FR 9613691 A FR9613691 A FR 9613691A FR 2755699 B1 FR2755699 B1 FR 2755699B1
Authority
FR
France
Prior art keywords
inductible
vectors
targeted
gene expression
new constructions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9613691A
Other languages
English (en)
Other versions
FR2755699A1 (fr
Inventor
Patrick Benoit
Nicolas Duverger
Laurence Berthou
Didier Branellec
Patrice Denefle
Abderrahim Mahfoudi
Bart Staels
Johan Auwerx
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Rhone Poulenc Rorer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR9613691A priority Critical patent/FR2755699B1/fr
Application filed by Rhone Poulenc Rorer SA filed Critical Rhone Poulenc Rorer SA
Priority to US09/297,910 priority patent/US20020144302A1/en
Priority to SK614-99A priority patent/SK61499A3/sk
Priority to KR1019990704102A priority patent/KR20000053163A/ko
Priority to CA002269864A priority patent/CA2269864A1/fr
Priority to EP97913264A priority patent/EP0946740A1/fr
Priority to IL12959397A priority patent/IL129593A0/xx
Priority to AU50578/98A priority patent/AU5057898A/en
Priority to PCT/FR1997/001992 priority patent/WO1998021349A1/fr
Priority to JP52223498A priority patent/JP2001503279A/ja
Priority to BR9713981-5A priority patent/BR9713981A/pt
Priority to HU9904235A priority patent/HUP9904235A3/hu
Priority to CZ991633A priority patent/CZ163399A3/cs
Priority to ZA9710114A priority patent/ZA9710114B/xx
Publication of FR2755699A1 publication Critical patent/FR2755699A1/fr
Application granted granted Critical
Publication of FR2755699B1 publication Critical patent/FR2755699B1/fr
Priority to NO992153A priority patent/NO992153D0/no
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
FR9613691A 1996-11-08 1996-11-08 Nouvelles constructions et vecteurs pour l'expression ciblee et inductible des genes Expired - Fee Related FR2755699B1 (fr)

Priority Applications (15)

Application Number Priority Date Filing Date Title
FR9613691A FR2755699B1 (fr) 1996-11-08 1996-11-08 Nouvelles constructions et vecteurs pour l'expression ciblee et inductible des genes
BR9713981-5A BR9713981A (pt) 1996-11-08 1997-11-06 Vetor recombinante para a expressão induzìvel e hepatoespecìfica de uma molécula, adenovìrus recombinante, vetor adenoviral, variante do promotor do gene da apolipoproteìna aii humana, célula, composição farmacêutica, processo para produção de uma proteìna recombinante, e, utilização de um adenovìrus
KR1019990704102A KR20000053163A (ko) 1996-11-08 1997-11-06 표적화된 유도가능한 유전자 발현을 위한 신규 작제물 및 벡터
CA002269864A CA2269864A1 (fr) 1996-11-08 1997-11-06 Nouvelles constructions et vecteurs pour l'expression ciblee et inductible de genes
EP97913264A EP0946740A1 (fr) 1996-11-08 1997-11-06 Nouvelles constructions et vecteurs pour l'expression ciblee et inductible de genes
IL12959397A IL129593A0 (en) 1996-11-08 1997-11-06 Novel constructs and vectors for the targeted and inducible expression of genes
AU50578/98A AU5057898A (en) 1996-11-08 1997-11-06 Novel constructs and vectors for the targeted and inducible expression of genes
PCT/FR1997/001992 WO1998021349A1 (fr) 1996-11-08 1997-11-06 Nouvelles constructions et vecteurs pour l'expression ciblee et inductible de genes
US09/297,910 US20020144302A1 (en) 1996-11-08 1997-11-06 Novel constructs and vectors for the targeted and inducible expression of genes
SK614-99A SK61499A3 (en) 1996-11-08 1997-11-06 Novel constructs and vectors for the targeted and inducible expression of genes
HU9904235A HUP9904235A3 (en) 1996-11-08 1997-11-06 Novel constructs and vectors for the targeted and inducible expression of genes
CZ991633A CZ163399A3 (cs) 1996-11-08 1997-11-06 Rekombinantní vektor pro cílenou a indukovanou expresi genů a farmaceutický přípravek obsahující takový vektor
JP52223498A JP2001503279A (ja) 1996-11-08 1997-11-06 ターゲットを定めて遺伝子を誘導発現させるための新規な構築物及びベクター
ZA9710114A ZA9710114B (en) 1996-11-08 1997-11-10 Method for the expression of genes.
NO992153A NO992153D0 (no) 1996-11-08 1999-05-04 Nye konstruktur og vektorer for mÕlstyrt og induktibel ekspresjon av gener

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9613691A FR2755699B1 (fr) 1996-11-08 1996-11-08 Nouvelles constructions et vecteurs pour l'expression ciblee et inductible des genes

Publications (2)

Publication Number Publication Date
FR2755699A1 FR2755699A1 (fr) 1998-05-15
FR2755699B1 true FR2755699B1 (fr) 1998-12-18

Family

ID=9497481

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9613691A Expired - Fee Related FR2755699B1 (fr) 1996-11-08 1996-11-08 Nouvelles constructions et vecteurs pour l'expression ciblee et inductible des genes

Country Status (15)

Country Link
US (1) US20020144302A1 (fr)
EP (1) EP0946740A1 (fr)
JP (1) JP2001503279A (fr)
KR (1) KR20000053163A (fr)
AU (1) AU5057898A (fr)
BR (1) BR9713981A (fr)
CA (1) CA2269864A1 (fr)
CZ (1) CZ163399A3 (fr)
FR (1) FR2755699B1 (fr)
HU (1) HUP9904235A3 (fr)
IL (1) IL129593A0 (fr)
NO (1) NO992153D0 (fr)
SK (1) SK61499A3 (fr)
WO (1) WO1998021349A1 (fr)
ZA (1) ZA9710114B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7098025B1 (en) 1997-07-25 2006-08-29 Ligand Pharmaceuticals Incorporated Human peroxisome proliferator activated receptor gamma (pparγ) gene regulatory sequences and uses therefor
WO2000078986A1 (fr) * 1999-06-22 2000-12-28 Aventis Pharma S.A. Systeme de regulation de l'expression utilisant les recepteurs nucleaires ppar
FR2795425B1 (fr) * 1999-06-22 2003-12-05 Aventis Pharma Sa Systeme de regulation pharmacologique de l'expression utilisant les recepteurs nucleaires par et leurs ligands
EP1263978B1 (fr) * 2000-03-14 2005-12-07 Universite Pierre Et Marie Curie Promoteurs hybrides inductibles par l'inflammation, vecteurs les contenant et utilisations
FR2806418B1 (fr) * 2000-03-14 2004-07-16 Aventis Pharma Sa Promoteurs hybrides inductibles par l'inflammation, vecteurs les contenant et utilisations
AU2002333682A1 (en) * 2001-08-02 2003-02-17 Gencell S.A. Inducible expression systems employing ppar transcriptional activators
EP1288303A1 (fr) * 2001-08-23 2003-03-05 Aventis Pharma S.A. Systèmes d'expression inductibles utilisant PPAR comme activateurs transcriptionnels
US10610606B2 (en) 2018-02-01 2020-04-07 Homology Medicines, Inc. Adeno-associated virus compositions for PAH gene transfer and methods of use thereof
US11306329B2 (en) 2018-02-19 2022-04-19 City Of Hope Adeno-associated virus compositions for restoring F8 gene function and methods of use thereof
TW202140791A (zh) 2020-01-13 2021-11-01 美商霍蒙拉奇醫藥公司 治療苯酮尿症之方法
TW202208632A (zh) 2020-05-27 2022-03-01 美商同源醫藥公司 用於恢復ｐａｈ基因功能的腺相關病毒組成物及其使用方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2070058A1 (fr) * 1991-05-31 1992-12-01 Robert A. Gadski Vecteurs et methodes pour determiner la regulation de la synthese de l'apolipoproteine ai
FR2704556B1 (fr) * 1993-04-30 1995-07-13 Rhone Poulenc Rorer Sa Virus recombinants et leur utilisation en thérapie génique.
FR2718329B1 (fr) * 1994-03-21 2002-09-20 Rhone Poulenc Rorer Sa Lapin transgénique sensibilisé aux dyslipoprotéinémies.
FR2726285B1 (fr) * 1994-10-28 1996-11-29 Centre Nat Rech Scient Adenovirus depourvus de particules contaminantes viables, preparation et utilisation

Also Published As

Publication number Publication date
JP2001503279A (ja) 2001-03-13
US20020144302A1 (en) 2002-10-03
CZ163399A3 (cs) 1999-08-11
IL129593A0 (en) 2000-02-29
HUP9904235A2 (hu) 2000-04-28
NO992153L (no) 1999-05-04
ZA9710114B (en) 1998-06-08
HUP9904235A3 (en) 2003-03-28
EP0946740A1 (fr) 1999-10-06
WO1998021349A1 (fr) 1998-05-22
FR2755699A1 (fr) 1998-05-15
AU5057898A (en) 1998-06-03
SK61499A3 (en) 2000-02-14
NO992153D0 (no) 1999-05-04
KR20000053163A (ko) 2000-08-25
CA2269864A1 (fr) 1998-05-22
BR9713981A (pt) 2000-05-02

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