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FR2680786B1 - PROCESS FOR THE SYNTHESIS OF GLUCURONIDES OF 4,5-EPOXY MORPHINANES. - Google Patents

PROCESS FOR THE SYNTHESIS OF GLUCURONIDES OF 4,5-EPOXY MORPHINANES.

Info

Publication number
FR2680786B1
FR2680786B1 FR9110927A FR9110927A FR2680786B1 FR 2680786 B1 FR2680786 B1 FR 2680786B1 FR 9110927 A FR9110927 A FR 9110927A FR 9110927 A FR9110927 A FR 9110927A FR 2680786 B1 FR2680786 B1 FR 2680786B1
Authority
FR
France
Prior art keywords
morphinanes
glucuronides
epoxy
synthesis
epoxy morphinanes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9110927A
Other languages
French (fr)
Other versions
FR2680786A1 (en
Inventor
Alfred Mertz
Adolphe
Henri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IREPA
Original Assignee
IREPA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IREPA filed Critical IREPA
Priority to FR9110927A priority Critical patent/FR2680786B1/en
Priority to AU25555/92A priority patent/AU2555592A/en
Priority to EP92919332A priority patent/EP0602151A1/en
Priority to PCT/FR1992/000846 priority patent/WO1993005057A1/en
Publication of FR2680786A1 publication Critical patent/FR2680786A1/en
Application granted granted Critical
Publication of FR2680786B1 publication Critical patent/FR2680786B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR9110927A 1991-09-04 1991-09-04 PROCESS FOR THE SYNTHESIS OF GLUCURONIDES OF 4,5-EPOXY MORPHINANES. Expired - Fee Related FR2680786B1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
FR9110927A FR2680786B1 (en) 1991-09-04 1991-09-04 PROCESS FOR THE SYNTHESIS OF GLUCURONIDES OF 4,5-EPOXY MORPHINANES.
AU25555/92A AU2555592A (en) 1991-09-04 1992-09-04 Method for synthesizing glucuronides of 4,5-epoxy morphinanes
EP92919332A EP0602151A1 (en) 1991-09-04 1992-09-04 Method for synthesizing glucuronides of 4,5-epoxy morphinanes
PCT/FR1992/000846 WO1993005057A1 (en) 1991-09-04 1992-09-04 Method for synthesizing glucuronides of 4,5-epoxy morphinanes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9110927A FR2680786B1 (en) 1991-09-04 1991-09-04 PROCESS FOR THE SYNTHESIS OF GLUCURONIDES OF 4,5-EPOXY MORPHINANES.

Publications (2)

Publication Number Publication Date
FR2680786A1 FR2680786A1 (en) 1993-03-05
FR2680786B1 true FR2680786B1 (en) 1995-03-10

Family

ID=9416616

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9110927A Expired - Fee Related FR2680786B1 (en) 1991-09-04 1991-09-04 PROCESS FOR THE SYNTHESIS OF GLUCURONIDES OF 4,5-EPOXY MORPHINANES.

Country Status (4)

Country Link
EP (1) EP0602151A1 (en)
AU (1) AU2555592A (en)
FR (1) FR2680786B1 (en)
WO (1) WO1993005057A1 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9116909D0 (en) * 1991-08-06 1991-09-18 Salford Ultrafine Chem & Res Morphine derivatives
US5977326A (en) * 1991-08-06 1999-11-02 Salford Ultrafine Chemicals And Research Limited Process for making morphine-6-glucuronide or substituted morphine-6-glucuronide
GB9325065D0 (en) * 1993-12-07 1994-02-02 Salford Ultrafine Chem & Res An enzymatic process for making morphine-6-glucuronide or substituted morphine-6-glucuronide
DE4403709A1 (en) * 1994-02-07 1995-08-10 Lohmann Therapie Syst Lts Pharmaceutical composition for systemic transdermal administration with the active ingredient morphine-6-glucuronide
AT403162B (en) 1995-10-11 1997-11-25 Nycomed Austria Gmbh NEW MORPHINE-6-GLUCURONIDE CRYSTAL SHAPE
DE19541921A1 (en) * 1995-11-10 1997-05-15 Nycomed Arzneimittel Gmbh New crystalline form of morphone-6-glucuronide, useful as analgesic
CA2211596A1 (en) * 1995-11-29 1997-06-19 Gregori Valencia Parera Glycoconjugates of opiated substances
US5908927A (en) * 1996-05-22 1999-06-01 High Standard Products Corporation Synthesis of deuterated opiate glucuronides
GB9711118D0 (en) * 1997-05-29 1997-07-23 Rolabo Sl Compound
US6555665B1 (en) 1998-02-02 2003-04-29 Cenes Limited Glycosidation of 4,5-epoxymorphinan-6-ols
EP1077985A1 (en) 1998-05-13 2001-02-28 CeNes Limited Process for preparation of 4,5-epoxymorphinan-6-oxyglucuronides
PT1086114E (en) * 1998-06-06 2003-02-28 Cenes Ltd SYNTHESIS OF MORPHINE-6-GLUCURONIDE
US6740641B2 (en) * 2001-07-27 2004-05-25 Euro-Celtique, S.A. Sugar derivatives of hydromorphone, dihydromorphine and dihydromorphine, compositions thereof and uses for treating or preventing pain
GB0218811D0 (en) * 2002-08-14 2002-09-18 Cenes Ltd Salts of morphine-6-glucuronide
CN103421063B (en) * 2012-05-23 2016-04-06 宜昌人福药业有限责任公司 A kind of method of synthesizing morphine-6-β-D-Glucose aldehydic acid glycosides
AU2017345767A1 (en) 2016-10-21 2019-05-16 Somniferum Labs LLC Apparatus for controlled delivery of opioid and other medications
CN108727444B (en) * 2017-04-19 2020-10-23 宜昌人福药业有限责任公司 Synthesis method of morphine-6-beta-D-glucuronide and intermediate compound thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE92497T1 (en) * 1988-01-12 1993-08-15 Baker Norton Pharma GLUCURONIC ACID DERIVATIVES OF OPIOID ANTAGONISTS.

Also Published As

Publication number Publication date
WO1993005057A1 (en) 1993-03-18
EP0602151A1 (en) 1994-06-22
AU2555592A (en) 1993-04-05
FR2680786A1 (en) 1993-03-05

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Legal Events

Date Code Title Description
TP Transmission of property
ST Notification of lapse