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FR2659329B1 - Nouveaux derives d'imidazo [1,2-c] quinazoline, leur procede de preparation et les compositions pharmaceutiques les renfermant. - Google Patents

Nouveaux derives d'imidazo [1,2-c] quinazoline, leur procede de preparation et les compositions pharmaceutiques les renfermant.

Info

Publication number
FR2659329B1
FR2659329B1 FR9003003A FR9003003A FR2659329B1 FR 2659329 B1 FR2659329 B1 FR 2659329B1 FR 9003003 A FR9003003 A FR 9003003A FR 9003003 A FR9003003 A FR 9003003A FR 2659329 B1 FR2659329 B1 FR 2659329B1
Authority
FR
France
Prior art keywords
optionally substituted
amino
hydrogen
pharmaceutical compositions
preparation process
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9003003A
Other languages
English (en)
Other versions
FR2659329A1 (fr
Inventor
Bourguignon Jean-Jacques
Wermuth Camille-Georges
Renaud De La Fav Jean-Francois
Thollon Catherine
Lombet Alain
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR9003003A priority Critical patent/FR2659329B1/fr
Application filed by ADIR SARL filed Critical ADIR SARL
Priority to AT91400645T priority patent/ATE117303T1/de
Priority to AU72745/91A priority patent/AU633408B2/en
Priority to CA002037812A priority patent/CA2037812A1/fr
Priority to ES91400645T priority patent/ES2069841T3/es
Priority to JP3043610A priority patent/JPH07103122B2/ja
Priority to NZ237363A priority patent/NZ237363A/en
Priority to IE77091A priority patent/IE66181B1/en
Priority to PT96982A priority patent/PT96982A/pt
Priority to EP91400645A priority patent/EP0446141B1/fr
Priority to US07/666,802 priority patent/US5128338A/en
Priority to ZA911726A priority patent/ZA911726B/xx
Priority to OA59972A priority patent/OA09488A/fr
Priority to DE69106746T priority patent/DE69106746T2/de
Priority to DK91400645.7T priority patent/DK0446141T3/da
Publication of FR2659329A1 publication Critical patent/FR2659329A1/fr
Application granted granted Critical
Publication of FR2659329B1 publication Critical patent/FR2659329B1/fr
Priority to GR950400646T priority patent/GR3015514T3/el
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FR9003003A 1990-03-09 1990-03-09 Nouveaux derives d'imidazo [1,2-c] quinazoline, leur procede de preparation et les compositions pharmaceutiques les renfermant. Expired - Fee Related FR2659329B1 (fr)

Priority Applications (16)

Application Number Priority Date Filing Date Title
FR9003003A FR2659329B1 (fr) 1990-03-09 1990-03-09 Nouveaux derives d'imidazo [1,2-c] quinazoline, leur procede de preparation et les compositions pharmaceutiques les renfermant.
US07/666,802 US5128338A (en) 1990-03-09 1991-03-08 Imidazo [1,2-c] quinazoline compounds
CA002037812A CA2037812A1 (fr) 1990-03-09 1991-03-08 Derives d'imidazo [1,2-c] quinazoline, leur procede de preparation et les compositions pharmaceutiques les renfermant
ES91400645T ES2069841T3 (es) 1990-03-09 1991-03-08 Nuevos derivados de imidazo-(1,2-c)-quinazolina, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
JP3043610A JPH07103122B2 (ja) 1990-03-09 1991-03-08 イミダゾ〔１，２−ｃ〕キナゾリン誘導体、これらの製造方法、及びそれらを含む狭心症薬
NZ237363A NZ237363A (en) 1990-03-09 1991-03-08 Imidazo(1,2-c)quinazoline derivatives, preparation and pharmaceutical compositions thereof
IE77091A IE66181B1 (en) 1990-03-09 1991-03-08 New imidazo [1,2-c] quinazoline derivatives process for preparing these and pharmaceutical compositions containing them
PT96982A PT96982A (pt) 1990-03-09 1991-03-08 Processo para a preparacao de novos derivados de imidazo {1,2-c}quinazolina e de composicoes farmaceuticas que os contem
AT91400645T ATE117303T1 (de) 1990-03-09 1991-03-08 Imidazo(1,2-c>chinazolinderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen.
AU72745/91A AU633408B2 (en) 1990-03-09 1991-03-08 New imidazo (1,2-c) derivatives, process for the preparation thereof and pharmaceutical compositions containing them
ZA911726A ZA911726B (en) 1990-03-09 1991-03-08 Imidazo(1,2-c)quinazoline derivatives,process for preparing these and pharmaceutical compositions containing them
OA59972A OA09488A (fr) 1990-03-09 1991-03-08 "Nouveaux dérivés d'imidazo (1,2-c) quinazoline, leur procédé de préparation et les compositions pharmaceutiques les renfermant".
DE69106746T DE69106746T2 (de) 1990-03-09 1991-03-08 Imidazo[1,2-c]chinazolinderivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen.
DK91400645.7T DK0446141T3 (da) 1990-03-09 1991-03-08 Imidazo(1,2-c)quinazolinderivater og fremgangsmåde til fremstilling deraf samt farmaceutiske midler indeholdende dem
EP91400645A EP0446141B1 (fr) 1990-03-09 1991-03-08 Nouveaux dérivés d'imidazo [1,2-C] quinazoline leur procédé de préparation et les compositions pharmaceutiques les renfermant
GR950400646T GR3015514T3 (en) 1990-03-09 1995-03-21 Imidazo[1,2-c]quinazoline derivatives, process for their preparation and pharmaceutical compositions containing them.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9003003A FR2659329B1 (fr) 1990-03-09 1990-03-09 Nouveaux derives d'imidazo [1,2-c] quinazoline, leur procede de preparation et les compositions pharmaceutiques les renfermant.

Publications (2)

Publication Number Publication Date
FR2659329A1 FR2659329A1 (fr) 1991-09-13
FR2659329B1 true FR2659329B1 (fr) 1994-06-03

Family

ID=9394556

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9003003A Expired - Fee Related FR2659329B1 (fr) 1990-03-09 1990-03-09 Nouveaux derives d'imidazo [1,2-c] quinazoline, leur procede de preparation et les compositions pharmaceutiques les renfermant.

Country Status (16)

Country Link
US (1) US5128338A (fr)
EP (1) EP0446141B1 (fr)
JP (1) JPH07103122B2 (fr)
AT (1) ATE117303T1 (fr)
AU (1) AU633408B2 (fr)
CA (1) CA2037812A1 (fr)
DE (1) DE69106746T2 (fr)
DK (1) DK0446141T3 (fr)
ES (1) ES2069841T3 (fr)
FR (1) FR2659329B1 (fr)
GR (1) GR3015514T3 (fr)
IE (1) IE66181B1 (fr)
NZ (1) NZ237363A (fr)
OA (1) OA09488A (fr)
PT (1) PT96982A (fr)
ZA (1) ZA911726B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK588489D0 (da) * 1989-11-22 1989-11-22 Ferrosan As Heterocykliske forbindelser, deres fremstilling og anvendelse
DK588389D0 (da) * 1989-11-22 1989-11-22 Ferrosan As Heterocykliske forbindelser, deres fremstilling og anvendelse
US5512677A (en) * 1991-08-13 1996-04-30 National Science Council 3-substituted methyl-2,3-dihydroimidazo 1,2-c!quinazoline derivatives, the preparation and use thereof
US5158953A (en) * 1991-08-13 1992-10-27 National Science Council 2-substituted methyl-2,3-dihydroimidazo[1,2-c]quinazolin-5(6H)-ones (thiones), the preparation and use thereof
US5212310A (en) * 1991-12-19 1993-05-18 Neurogen Corporation Certain aryl fused imidazopyrimidines; a new class of GABA brain receptor ligands
US5792766A (en) * 1996-03-13 1998-08-11 Neurogen Corporation Imidazo 1,5-c! quinazolines; a new class of GABA brain receptor ligands
AU727482B2 (en) 1996-10-01 2000-12-14 Daiichi Pharmaceutical Co., Ltd. Mitochondrial membrane stabilizer
FR2778564B1 (fr) * 1998-05-13 2001-07-13 Sanofi Sa Utilisation de composes reduisant l'apoptose
WO1999058117A1 (fr) * 1998-05-13 1999-11-18 Sanofi-Synthelabo Utilisation de composes reduisant l'apoptose
ES2246588T3 (es) 1998-12-18 2006-02-16 Scios Inc. Tratamiento de enfermedades que implican formacion de quistes.
DE69932449T2 (de) 1998-12-18 2007-03-15 Scios Inc., Fremont Agonisten und antagonisten von benzodiazepinrezeptoren des peripheren typs
EP1607744A3 (fr) * 1998-12-18 2009-09-30 Scios Inc. Traitements des maladies incluants la formation des cystes, avec des combinaisons comprenants un agoniste de PTBR
WO2003030937A1 (fr) * 2001-10-05 2003-04-17 Ono Pharmaceutical Co., Ltd. Remedes contre des maladies liees au stress comprenant des antagonistes de recepteurs mithochondriaux de la benzodiazepine
KR100864364B1 (ko) * 2005-12-13 2008-10-17 주식회사 엘지화학 신규한 이미다조퀴나졸린 유도체, 이의 제조방법 및 이를이용한 유기전기소자
SG11201408397SA (en) * 2012-06-18 2015-01-29 Dart Neuroscience Cayman Ltd Substituted thiophene- and furan-fused azolopyrimidine-5-(6h)-one compounds
JP6420400B2 (ja) * 2017-04-12 2018-11-07 ダート・ニューロサイエンス・（ケイマン）・リミテッド 置換ピリジンアゾロピリミジン−５−（６ｈ）−オン化合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4129653A (en) * 1977-01-05 1978-12-12 Ortho Pharmaceutical Corporation Substituted pyrrolo [1,2-c] quinazolines and pharmaceutical compositions and methods employing them
US4110452A (en) * 1977-10-17 1978-08-29 E. R. Squibb & Sons, Inc. Pyrazolo (1,5-c) quinazoline derivatives and related compounds
DE3046366A1 (de) * 1980-12-09 1982-07-08 Bayer Ag, 5090 Leverkusen Tricyclische cytosinderivate zur verwendung in arzneimitteln und verfahren zu ihrer herstellung
US4713383A (en) * 1984-10-01 1987-12-15 Ciba-Geigy Corporation Triazoloquinazoline compounds, and their methods of preparation, pharmaceutical compositions, and uses
DK155524C (da) * 1987-03-18 1989-09-11 Ferrosan As Kondenserede imidazolderivater og farmaceutiske praeparater indeholdende disse

Also Published As

Publication number Publication date
JPH07103122B2 (ja) 1995-11-08
US5128338A (en) 1992-07-07
ZA911726B (en) 1991-12-24
NZ237363A (en) 1992-12-23
GR3015514T3 (en) 1995-06-30
AU7274591A (en) 1991-09-12
EP0446141A1 (fr) 1991-09-11
IE66181B1 (en) 1995-12-13
PT96982A (pt) 1991-10-31
IE910770A1 (en) 1991-09-11
EP0446141B1 (fr) 1995-01-18
OA09488A (fr) 1992-11-15
JPH04217682A (ja) 1992-08-07
ES2069841T3 (es) 1995-05-16
CA2037812A1 (fr) 1991-09-10
FR2659329A1 (fr) 1991-09-13
DE69106746T2 (de) 1995-08-31
DK0446141T3 (da) 1995-05-15
ATE117303T1 (de) 1995-02-15
AU633408B2 (en) 1993-01-28
DE69106746D1 (de) 1995-03-02

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Legal Events

Date Code Title Description
ST Notification of lapse