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FR2654726B1 - Nouveaux derives de l'isoindolone et leur preparation. - Google Patents

Nouveaux derives de l'isoindolone et leur preparation.

Info

Publication number
FR2654726B1
FR2654726B1 FR8915407A FR8915407A FR2654726B1 FR 2654726 B1 FR2654726 B1 FR 2654726B1 FR 8915407 A FR8915407 A FR 8915407A FR 8915407 A FR8915407 A FR 8915407A FR 2654726 B1 FR2654726 B1 FR 2654726B1
Authority
FR
France
Prior art keywords
preparation
derivatives
isoindolone derivatives
new
new isoindolone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR8915407A
Other languages
English (en)
French (fr)
Other versions
FR2654726A1 (fr
Inventor
Dubroucq Marie-Christine
Moutonnier Claude
Peyronel Jean-Francois
Tabart Michel
Truchon Alain
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Sante SA
Original Assignee
Rhone Poulenc Sante SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Sante SA filed Critical Rhone Poulenc Sante SA
Priority to FR8915407A priority Critical patent/FR2654726B1/fr
Priority to US07/616,044 priority patent/US5112988A/en
Priority to NZ236175A priority patent/NZ236175A/xx
Priority to JP2320570A priority patent/JPH03176468A/ja
Priority to SK5806-90A priority patent/SK278474B6/sk
Priority to NO905067A priority patent/NO174148C/no
Priority to FI905770A priority patent/FI94627C/fi
Priority to IL9644790A priority patent/IL96447A/en
Priority to IE423490A priority patent/IE64737B1/en
Priority to DK90403300.8T priority patent/DK0430771T3/da
Priority to ZA909370A priority patent/ZA909370B/xx
Priority to DE69010851T priority patent/DE69010851T2/de
Priority to KR1019900019099A priority patent/KR910009660A/ko
Priority to HU907249A priority patent/HU214574B/hu
Priority to CA002030570A priority patent/CA2030570A1/fr
Priority to ES90403300T priority patent/ES2057488T3/es
Priority to AT90403300T priority patent/ATE108774T1/de
Priority to EP90403300A priority patent/EP0430771B1/fr
Priority to AU66828/90A priority patent/AU635984B2/en
Priority to PT95983A priority patent/PT95983B/pt
Priority to PL90301462A priority patent/PL164955B1/pl
Priority to PL90287908A priority patent/PL164973B1/pl
Priority to YU223590A priority patent/YU47437B/sh
Publication of FR2654726A1 publication Critical patent/FR2654726A1/fr
Application granted granted Critical
Publication of FR2654726B1 publication Critical patent/FR2654726B1/fr
Priority to RU92004482A priority patent/RU2104269C1/ru
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
FR8915407A 1989-11-23 1989-11-23 Nouveaux derives de l'isoindolone et leur preparation. Expired - Lifetime FR2654726B1 (fr)

Priority Applications (24)

Application Number Priority Date Filing Date Title
FR8915407A FR2654726B1 (fr) 1989-11-23 1989-11-23 Nouveaux derives de l'isoindolone et leur preparation.
US07/616,044 US5112988A (en) 1989-11-23 1990-11-20 Isoindolone derivatives
NZ236175A NZ236175A (en) 1989-11-23 1990-11-21 Isoindole derivatives and their preparation
AT90403300T ATE108774T1 (de) 1989-11-23 1990-11-22 Isoindolonderivate, ihre herstellung und ihre verwendung als zwischenprodukte zur herstellung von substanz-p-antagonisten.
NO905067A NO174148C (no) 1989-11-23 1990-11-22 Nye isoindolonderivater
FI905770A FI94627C (fi) 1989-11-23 1990-11-22 Uusia isoindolonijohdannaisia niiden valmistus ja käyttö
IL9644790A IL96447A (en) 1989-11-23 1990-11-22 History of isoindolone and their preparation
IE423490A IE64737B1 (en) 1989-11-23 1990-11-22 New isoindolone derivatives and their preparation
DK90403300.8T DK0430771T3 (da) 1989-11-23 1990-11-22 Isoindolonderivater og deres fremstilling
ZA909370A ZA909370B (en) 1989-11-23 1990-11-22 New isoindolone derivatives and their preparation
DE69010851T DE69010851T2 (de) 1989-11-23 1990-11-22 Isoindolonderivate, ihre Herstellung und ihre Verwendung als Zwischenprodukte zur Herstellung von Substanz-P-Antagonisten.
KR1019900019099A KR910009660A (ko) 1989-11-23 1990-11-22 새로운 이소인돌론 유도체 및 이의 제조 방법
JP2320570A JPH03176468A (ja) 1989-11-23 1990-11-22 イソインドロン誘導体
CA002030570A CA2030570A1 (fr) 1989-11-23 1990-11-22 Derives de l'isoindolone et leur preparation
ES90403300T ES2057488T3 (es) 1989-11-23 1990-11-22 Nuevos derivados de la isoindolona y su preparacion.
SK5806-90A SK278474B6 (en) 1989-11-23 1990-11-22 Isoindolone derivatives, preparation method thereof and their use as intermediate products
EP90403300A EP0430771B1 (fr) 1989-11-23 1990-11-22 Dérivés de l'isoindolone, leur préparation et leur utilisation comme intermédiaires pour la préparation d'antagonistes de la substance P
AU66828/90A AU635984B2 (en) 1989-11-23 1990-11-22 New isoindolone derivatives and their preparation
HU907249A HU214574B (hu) 1989-11-23 1990-11-22 Eljárás izoindolonszármazékok előállítására
PT95983A PT95983B (pt) 1989-11-23 1990-11-23 Processo de preparacao de novos derivados de iso-indolona
PL90301462A PL164955B1 (en) 1989-11-23 1990-11-23 Method of obtaining novel indolone derivatives
PL90287908A PL164973B1 (pl) 1989-11-23 1990-11-23 Sposób wytwarzania nowych pochodnych izoindolonu PL PL
YU223590A YU47437B (sh) 1989-11-23 1990-11-23 Novi derivati izoindolona i njihovo dobivanje
RU92004482A RU2104269C1 (ru) 1989-11-23 1992-12-01 Производные изоиндолона или их соли с кислотами в качестве промежуточных соенинений для синтеза биологически активных соединений - пергидроизоиндолонов

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8915407A FR2654726B1 (fr) 1989-11-23 1989-11-23 Nouveaux derives de l'isoindolone et leur preparation.

Publications (2)

Publication Number Publication Date
FR2654726A1 FR2654726A1 (fr) 1991-05-24
FR2654726B1 true FR2654726B1 (fr) 1992-02-14

Family

ID=9387708

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8915407A Expired - Lifetime FR2654726B1 (fr) 1989-11-23 1989-11-23 Nouveaux derives de l'isoindolone et leur preparation.

Country Status (23)

Country Link
US (1) US5112988A (fi)
EP (1) EP0430771B1 (fi)
JP (1) JPH03176468A (fi)
KR (1) KR910009660A (fi)
AT (1) ATE108774T1 (fi)
AU (1) AU635984B2 (fi)
CA (1) CA2030570A1 (fi)
DE (1) DE69010851T2 (fi)
DK (1) DK0430771T3 (fi)
ES (1) ES2057488T3 (fi)
FI (1) FI94627C (fi)
FR (1) FR2654726B1 (fi)
HU (1) HU214574B (fi)
IE (1) IE64737B1 (fi)
IL (1) IL96447A (fi)
NO (1) NO174148C (fi)
NZ (1) NZ236175A (fi)
PL (2) PL164973B1 (fi)
PT (1) PT95983B (fi)
RU (1) RU2104269C1 (fi)
SK (1) SK278474B6 (fi)
YU (1) YU47437B (fi)
ZA (1) ZA909370B (fi)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2676442B1 (fr) * 1991-05-17 1993-08-06 Rhone Poulenc Rorer Sa Nouveau derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
FR2688219B1 (fr) 1992-03-03 1994-07-08 Sanofi Elf Sels d'ammonium quaternaires de composes aromatiques amines, leur preparation et compositions pharmaceutiques les contenant.
FR2689889B1 (fr) * 1992-04-10 1994-06-10 Rhone Poulenc Rorer Sa Nouveaux derives de perhydroisoindole, et leur preparation.
US5830854A (en) * 1992-12-14 1998-11-03 Merck Sharp & Dohme, Limited Method of treating cystic fibrosis using a tachykinin receptor antagonist
FR2703679B1 (fr) * 1993-04-05 1995-06-23 Rhone Poulenc Rorer Sa Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
FR2710913B1 (fr) * 1993-10-07 1995-11-24 Rhone Poulenc Rorer Sa Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent.
TW365603B (en) * 1993-07-30 1999-08-01 Rhone Poulenc Rorer Sa Novel perhydroisoindole derivatives, their preparation and pharmaceutical compositions which contain them
FR2709752B1 (fr) * 1993-07-30 1995-10-06 Rhone Poulenc Rorer Sa Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent.
US5543530A (en) * 1993-12-23 1996-08-06 Ortho Pharmaceutical Corporation 4-arylisoindole analgesics
FR2728169A1 (fr) 1994-12-19 1996-06-21 Oreal Utilisation d'un antagoniste de substance p pour le traitement des prurits et des dysesthesies oculaires ou palpebrales
FR2728166A1 (fr) 1994-12-19 1996-06-21 Oreal Composition topique contenant un antagoniste de substance p
FR2728165A1 (fr) 1994-12-19 1996-06-21 Oreal Utilisation d'un antagoniste de substance p pour le traitement des rougeurs cutanees d'origine neurogene
FR2729954B1 (fr) 1995-01-30 1997-08-01 Sanofi Sa Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2741262B1 (fr) 1995-11-20 1999-03-05 Oreal Utilisation d'un antagoniste de tnf-alpha pour le traitement des rougeurs cutanees d'origine neurogene
FR2755013B1 (fr) * 1996-10-29 1998-11-27 Rhone Poulenc Rorer Sa Nouvelle application therapeutique des antagonistes de la substance p
US7163949B1 (en) 1999-11-03 2007-01-16 Amr Technology, Inc. 4-phenyl substituted tetrahydroisoquinolines and use thereof
BR0015320A (pt) 1999-11-03 2002-07-09 Albany Molecular Res Inc Composto, composição, métodos de tratamento de um distúrbio que e criado pela, ou é dependente da, disponibilidade diminuìda de serotonina, norepinefrina ou dopamina, para inibir a captação da serotonina, da dopamina e de norepinefrina sinápticas em um paciente em necessidade destes, e, kit
NZ523456A (en) 2000-07-11 2004-11-26 Albany Molecular Res Inc Novel 4-phenyl substituted tetrahydroisoquinolines and therapeutic use thereof
CN101119969B (zh) 2004-07-15 2014-04-09 阿尔巴尼分子研究公司 芳基和杂芳基取代的四氢异喹啉及其阻断去甲肾上腺素、多巴胺和血清素的重摄取的应用
ATE550019T1 (de) 2005-05-17 2012-04-15 Merck Sharp & Dohme Cis-4-ä(4-chlorophenyl)sulfonylü-4-(2,5- difluorophenyl)cyclohexanepropansäure zur behandlug von krebs
JP5258561B2 (ja) 2005-07-15 2013-08-07 アルバニー モレキュラー リサーチ， インコーポレイテッド アリール置換およびヘテロアリール置換テトラヒドロベンズアゼピンならびにノルエピネフリン、ドーパミンおよびセロトニンの再取り込みを遮断するためのその使用
GB0603041D0 (en) 2006-02-15 2006-03-29 Angeletti P Ist Richerche Bio Therapeutic compounds
US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
AR064777A1 (es) 2007-01-10 2009-04-22 Inst Di Reserche D Biolog Mole Indazoles sustituidos con amida como inhibidores de poli (adp- ribosa) polimerasa (parp)
EP2170076B1 (en) 2007-06-27 2016-05-18 Merck Sharp & Dohme Corp. 4-carboxybenzylamino derivatives as histone deacetylase inhibitors
AR071997A1 (es) 2008-06-04 2010-07-28 Bristol Myers Squibb Co Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina
US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
US8691825B2 (en) 2009-04-01 2014-04-08 Merck Sharp & Dohme Corp. Inhibitors of AKT activity
CN102638982B (zh) 2009-05-12 2015-07-08 百时美施贵宝公司 (S)-7-([1,2,4]三唑并[1,5-a]吡啶-6-基)-4-(3,4-二氯苯基)-1,2,3,4-四氢异喹啉的晶型及其用途
ES2662072T3 (es) 2009-05-12 2018-04-05 Albany Molecular Research, Inc. 7-([1,2,4]triazolo[1,5-a]piridin-6-il)-4-(3,4-diclorofenil)-1,2,3,4-tetrahidroisoquinolina y uso de la misma
AU2010247849B2 (en) 2009-05-12 2015-11-19 Albany Molecular Research, Inc. Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof
EA023838B1 (ru) 2009-10-14 2016-07-29 Мерк Шарп Энд Домэ Корп. ЗАМЕЩЕННЫЕ ПИПЕРИДИНЫ, КОТОРЫЕ ПОВЫШАЮТ АКТИВНОСТЬ p53, И ИХ ПРИМЕНЕНИЕ
BR112012018897A2 (pt) * 2010-01-27 2017-10-03 Ab Pharma Ltd Compostos poli-heterocíclicos altamente potentes como inibidores de hcv
CA2805265A1 (en) 2010-08-02 2012-02-09 Merck Sharp & Dohme Corp. Rna interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (ctnnb1) gene expression using short interfering nucleic acid (sina)
CN108676800B (zh) 2010-08-17 2022-11-11 瑟纳治疗公司 使用短干扰核酸(siNA)的乙型肝炎病毒(HBV)基因表达的RNA干扰介导的抑制
WO2012027236A1 (en) 2010-08-23 2012-03-01 Schering Corporation NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS
EP2613782B1 (en) 2010-09-01 2016-11-02 Merck Sharp & Dohme Corp. Indazole derivatives useful as erk inhibitors
US9242981B2 (en) 2010-09-16 2016-01-26 Merck Sharp & Dohme Corp. Fused pyrazole derivatives as novel ERK inhibitors
EP3766975A1 (en) 2010-10-29 2021-01-20 Sirna Therapeutics, Inc. Rna interference mediated inhibition of gene expression using short interfering nucleic acid (sina)
EP2654748B1 (en) 2010-12-21 2016-07-27 Merck Sharp & Dohme Corp. Indazole derivatives useful as erk inhibitors
JP2014514321A (ja) 2011-04-21 2014-06-19 メルク・シャープ・アンド・ドーム・コーポレーション インスリン様増殖因子１受容体阻害剤
WO2013063214A1 (en) 2011-10-27 2013-05-02 Merck Sharp & Dohme Corp. Novel compounds that are erk inhibitors
EP3919620A1 (en) 2012-05-02 2021-12-08 Sirna Therapeutics, Inc. Short interfering nucleic acid (sina) compositions
JP6280554B2 (ja) 2012-09-28 2018-02-14 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． Ｅｒｋ阻害剤である新規化合物
LT2925888T (lt) 2012-11-28 2018-01-10 Merck Sharp & Dohme Corp. Vėžio gydymo kompozicijos ir būdai
CA2895504A1 (en) 2012-12-20 2014-06-26 Merck Sharp & Dohme Corp. Substituted imidazopyridines as hdm2 inhibitors
EP2951180B1 (en) 2013-01-30 2018-05-02 Merck Sharp & Dohme Corp. 2,6,7,8 substituted purines as hdm2 inhibitors
WO2015034925A1 (en) 2013-09-03 2015-03-12 Moderna Therapeutics, Inc. Circular polynucleotides
EP3525785A4 (en) 2016-10-12 2020-03-25 Merck Sharp & Dohme Corp. KDM5 INHIBITORS
WO2019094312A1 (en) 2017-11-08 2019-05-16 Merck Sharp & Dohme Corp. Prmt5 inhibitors
US10947234B2 (en) 2017-11-08 2021-03-16 Merck Sharp & Dohme Corp. PRMT5 inhibitors
EP3833668A4 (en) 2018-08-07 2022-05-11 Merck Sharp & Dohme Corp. PRMT5 INHIBITORS
WO2020033284A1 (en) 2018-08-07 2020-02-13 Merck Sharp & Dohme Corp. Prmt5 inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2858314A (en) * 1954-06-07 1958-10-28 Georgian Vlasios Hydrocarbazolenines
US4042707A (en) * 1976-02-19 1977-08-16 E. I. Du Pont De Nemours And Company 3α-Arylhydroisoindoles
US4494547A (en) * 1981-03-30 1985-01-22 North Carolina Central University 2H-isoindolediones, their synthesis and use as radiosensitizers

Also Published As

Publication number Publication date
PT95983A (pt) 1991-09-13
JPH03176468A (ja) 1991-07-31
PT95983B (pt) 1998-01-30
ES2057488T3 (es) 1994-10-16
SK580690A3 (en) 1997-07-09
PL164955B1 (en) 1994-10-31
ATE108774T1 (de) 1994-08-15
NO174148B (no) 1993-12-13
NO905067L (no) 1991-05-24
IE64737B1 (en) 1995-09-06
DK0430771T3 (da) 1994-08-29
KR910009660A (ko) 1991-06-28
YU223590A (sh) 1993-05-28
CA2030570A1 (fr) 1991-05-24
AU635984B2 (en) 1993-04-08
HUT55756A (en) 1991-06-28
FI905770A (fi) 1991-05-24
NZ236175A (en) 1993-03-26
IE904234A1 (en) 1991-06-05
IL96447A0 (en) 1991-08-16
NO174148C (no) 1994-03-23
HU214574B (hu) 1998-04-28
EP0430771A1 (fr) 1991-06-05
YU47437B (sh) 1995-03-27
NO905067D0 (no) 1990-11-22
SK278474B6 (en) 1997-07-09
FI94627C (fi) 1995-10-10
PL164973B1 (pl) 1994-10-31
FI94627B (fi) 1995-06-30
PL287908A1 (en) 1991-12-02
FR2654726A1 (fr) 1991-05-24
ZA909370B (en) 1991-10-30
EP0430771B1 (fr) 1994-07-20
AU6682890A (en) 1991-05-30
HU907249D0 (en) 1991-05-28
IL96447A (en) 1995-03-15
DE69010851D1 (de) 1994-08-25
RU2104269C1 (ru) 1998-02-10
FI905770A0 (fi) 1990-11-22
DE69010851T2 (de) 1994-11-24
US5112988A (en) 1992-05-12

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