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FR2532431B1 - Procede et appareil pour distinguer de multiples sous-populations de cellules - Google Patents

Procede et appareil pour distinguer de multiples sous-populations de cellules

Info

Publication number
FR2532431B1
FR2532431B1 FR8312794A FR8312794A FR2532431B1 FR 2532431 B1 FR2532431 B1 FR 2532431B1 FR 8312794 A FR8312794 A FR 8312794A FR 8312794 A FR8312794 A FR 8312794A FR 2532431 B1 FR2532431 B1 FR 2532431B1
Authority
FR
France
Prior art keywords
multiple cell
cell subpopulations
distinguishing multiple
distinguishing
subpopulations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8312794A
Other languages
English (en)
Other versions
FR2532431A1 (fr
Inventor
Mack Jett Fulwyler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Becton Dickinson and Co
Original Assignee
Becton Dickinson and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Becton Dickinson and Co filed Critical Becton Dickinson and Co
Publication of FR2532431A1 publication Critical patent/FR2532431A1/fr
Application granted granted Critical
Publication of FR2532431B1 publication Critical patent/FR2532431B1/fr
Expired legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5094Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for blood cell populations
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966Animal cells
    • G01N33/56972White blood cells

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Ecology (AREA)
  • Dispersion Chemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
FR8312794A 1982-08-30 1983-08-03 Procede et appareil pour distinguer de multiples sous-populations de cellules Expired FR2532431B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/412,648 US4499052A (en) 1982-08-30 1982-08-30 Apparatus for distinguishing multiple subpopulations of cells

Publications (2)

Publication Number Publication Date
FR2532431A1 FR2532431A1 (fr) 1984-03-02
FR2532431B1 true FR2532431B1 (fr) 1986-06-06

Family

ID=23633834

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8312794A Expired FR2532431B1 (fr) 1982-08-30 1983-08-03 Procede et appareil pour distinguer de multiples sous-populations de cellules

Country Status (5)

Country Link
US (1) US4499052A (fr)
JP (1) JPS5960261A (fr)
DE (1) DE3331017C2 (fr)
FR (1) FR2532431B1 (fr)
GB (1) GB2126341B (fr)

Families Citing this family (192)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5071774A (en) * 1983-04-05 1991-12-10 Syntex (U.S.A.) Inc. Multiparameter particle analysis
US4584277A (en) * 1983-04-05 1986-04-22 Syntex (U.S.A.) Inc. Fluorescent multiparameter particle analysis
US4713348A (en) * 1983-04-05 1987-12-15 Syntex (U.S.A.) Inc. Fluorescent multiparameter particle analysis
DE3322373C2 (de) * 1983-05-19 1986-12-04 Ioannis Dr. 3000 Hannover Tripatzis Testmittel und Verfahren zum Nachweis von Antigenen und/oder Antikörpern
US4596035A (en) * 1983-06-27 1986-06-17 Ortho Diagnostic Systems Inc. Methods for enumerating 3-part white cell differential clusters
US4599304A (en) * 1983-10-07 1986-07-08 Becton, Dickinson And Company Method for monitoring activated cell subpopulations
US4628026A (en) * 1983-11-15 1986-12-09 Dietlind Gardell Method and apparatus for automated double fluorochromization analysis in lymphocytotoxicity testing
JPS60241884A (ja) * 1984-05-15 1985-11-30 Tokyo Daigaku 自動サイクリング反応装置およびこれを用いる自動分析装置
AU4406185A (en) * 1984-05-31 1985-12-31 Coulter Electronics Inc. A reagent system and method for identification, enumeration and examination of classes and subclasses of blood leukocytes
US5188935A (en) * 1984-05-31 1993-02-23 Coulter Electronics, Inc. Reagent system and method for identification, enumeration and examination of classes and subclasses of blood leukocytes
JPS61128169A (ja) * 1984-11-27 1986-06-16 Mitsubishi Chem Ind Ltd 免疫分析法
US4767206A (en) * 1984-12-24 1988-08-30 Flow Cytometry Standards Corporation Calibration method for flow cytometry using fluorescent microbeads and synthesis thereof
CA1279008C (fr) * 1985-10-11 1991-01-15 Smith Kline & French Canada Ltd. Methodes et reactifs pour etudier des sous-ensembles
ZA867698B (en) * 1985-10-11 1987-07-29 Smithkline Beckman Corp Methods and reagents for performing subset analysis
US5206143A (en) * 1985-11-01 1993-04-27 Smithkline Beecham Corporation Method and reagents for performing subset analysis using quantitative differences in fluorescence intensity
EP0241042A3 (fr) * 1986-04-11 1988-05-04 Hitachi, Ltd. Procédé d'analyse des cellules
US4777128A (en) * 1986-05-27 1988-10-11 Ethigen Corporation Fluorescence immunoassay involving energy transfer between two fluorophores
JPH0668491B2 (ja) * 1986-06-30 1994-08-31 株式会社日立製作所 細胞自動分類装置
CA1340806C (fr) * 1986-07-02 1999-11-02 James Merrill Prober Methode, systeme et reactifs pour le sequencage de l'adn
US4745285A (en) * 1986-08-21 1988-05-17 Becton Dickinson And Company Multi-color fluorescence analysis with single wavelength excitation
US4704891A (en) * 1986-08-29 1987-11-10 Becton, Dickinson And Company Method and materials for calibrating flow cytometers and other analysis instruments
EP0266881A3 (fr) * 1986-09-30 1990-04-04 Astromed Limited Procédé et appareil pour essai optique multiple
JPS63214668A (ja) * 1987-03-03 1988-09-07 Hitachi Ltd 細胞測定方法
US5223398A (en) * 1987-03-13 1993-06-29 Coulter Corporation Method for screening cells or formed bodies for enumeration of populations expressing selected characteristics
US6159740A (en) * 1987-03-13 2000-12-12 Coulter Corporation Method and apparatus for screening obscured or partially obscured cells
CA1311404C (fr) * 1987-03-13 1992-12-15 Kenneth H. Kortright Analyseur automatique et methode pour le depistage de cellules ou de corps formes, servant a compter les populations presentant des caracteristiques selectionnees
DE3708511A1 (de) * 1987-03-16 1988-09-29 Kratzer Michael Einrichtung zur selektiven zerstoerung von zellen
JPH07104349B2 (ja) * 1987-04-11 1995-11-13 株式会社日立製作所 細胞測定法
SE458968B (sv) * 1987-06-16 1989-05-22 Wallac Oy Biospecifikt analysfoerfarande foer flera analyter i vilket ingaar partikelraekning och maerkning med fluorescerande maerksubstanser
JP2642632B2 (ja) * 1987-07-03 1997-08-20 株式会社日立製作所 微粒子計測装置および微粒子計測方法
WO1990003576A1 (fr) * 1988-09-27 1990-04-05 Cetus Corporation Technique de triage de cellules et ses applications
FR2638849B1 (fr) * 1988-11-04 1994-03-18 Chemunex Sa Procede d'amplification d'un signal fluorescent pour la recherche specifique de la presence eventuelle de particules et application a la detection et a la numeration desdites particules
FR2638848B1 (fr) * 1988-11-04 1993-01-22 Chemunex Sa Procede de detection et/ou de dosage dans un milieu liquide ou semi-liquide d'au moins une substance organique, biologique ou medicamenteuse soluble, par une methode d'agglutination
CA1339840C (fr) * 1988-12-16 1998-04-28 Kenneth Kortright Methode et appareil pour analyser des cellules ou des corps formes avec populations exprimant des caracteristiques choisies
US5480804A (en) * 1989-06-28 1996-01-02 Kirin Beverage Corporation Method of and apparatus for detecting microorganisms
JP2626738B2 (ja) * 1990-03-13 1997-07-02 三共株式会社 化学発光検出装置
DE4019025C2 (de) * 1990-06-14 1994-09-22 Triton Technology Inc Verfahren zur Messung der Durchblutung von Organ- und/oder Gewebeproben
US5154890A (en) * 1990-11-07 1992-10-13 Hewlett-Packard Company Fiber optic potassium ion sensor
JPH06509417A (ja) * 1991-07-16 1994-10-20 トランスメッド バイオテック インコーポレイテッド 多重検体の同時分析の方法と構成
US5451525A (en) * 1992-02-14 1995-09-19 Coulter Corporation Method and materials for determining particle count in a flow cytometer
CA2148483A1 (fr) * 1992-11-03 1994-05-11 Alexander Saunders Methodes et protocole de preparation de fractions erythrocytaires
ES2051651B1 (es) * 1992-12-10 1995-01-01 Univ Salamanca Procedimiento para la cuantificacion simultanea, en una sola medicion, de los principales tipos de linfocitos humanos y sus subpoblaciones.
GB9326277D0 (en) * 1993-12-23 1994-02-23 Marconi Gec Ltd Labelling
US5981180A (en) * 1995-10-11 1999-11-09 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
AU7398996A (en) * 1995-10-11 1997-04-30 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and method
US5837547A (en) * 1995-12-27 1998-11-17 Caribbean Microparticles Corporation Flow cytometer calibration method
US6387707B1 (en) * 1996-04-25 2002-05-14 Bioarray Solutions Array Cytometry
US6958245B2 (en) 1996-04-25 2005-10-25 Bioarray Solutions Ltd. Array cytometry
WO1997040385A1 (fr) * 1996-04-25 1997-10-30 Bioarray Solutions, Llc Assemblage electrocinetique de particules proches des surfaces regule par la lumiere
US7144119B2 (en) * 1996-04-25 2006-12-05 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
US7041510B2 (en) 1996-04-25 2006-05-09 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
US6449562B1 (en) 1996-10-10 2002-09-10 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and method
US6122396A (en) * 1996-12-16 2000-09-19 Bio-Tech Imaging, Inc. Method of and apparatus for automating detection of microorganisms
DE19706617C1 (de) * 1997-02-20 1998-04-30 Mueller Ruchholtz Wolfgang Pro Verfahren zur Zählung mikroskopischer Objekte
US6023540A (en) * 1997-03-14 2000-02-08 Trustees Of Tufts College Fiber optic sensor with encoded microspheres
US20030027126A1 (en) 1997-03-14 2003-02-06 Walt David R. Methods for detecting target analytes and enzymatic reactions
US6327410B1 (en) 1997-03-14 2001-12-04 The Trustees Of Tufts College Target analyte sensors utilizing Microspheres
US7622294B2 (en) * 1997-03-14 2009-11-24 Trustees Of Tufts College Methods for detecting target analytes and enzymatic reactions
US6406845B1 (en) 1997-05-05 2002-06-18 Trustees Of Tuft College Fiber optic biosensor for selectively detecting oligonucleotide species in a mixed fluid sample
US5994089A (en) * 1997-05-16 1999-11-30 Coulter International Corp. Simultaneous analyses of white blood cell subsets using multi-color, multi-intensity fluorescent markers in flow cytometry
DE69838067T2 (de) * 1997-05-23 2008-03-13 Bioarray Solutions Ltd. Farbkodierung und in situ abfrage von matrix-gekoppelten chemischen verbindungen
US7115884B1 (en) 1997-10-06 2006-10-03 Trustees Of Tufts College Self-encoding fiber optic sensor
US7348181B2 (en) 1997-10-06 2008-03-25 Trustees Of Tufts College Self-encoding sensor with microspheres
US6248542B1 (en) * 1997-12-09 2001-06-19 Massachusetts Institute Of Technology Optoelectronic sensor
EP1040340A4 (fr) * 1997-12-12 2008-01-09 Chemunex S A Cytometre en flux numerique
US6281018B1 (en) * 1998-02-26 2001-08-28 Coulter International Corp. Selective purification and enrichment sorting of flow cytometer droplets based upon analysis of droplet precursor regions
US6210910B1 (en) 1998-03-02 2001-04-03 Trustees Of Tufts College Optical fiber biosensor array comprising cell populations confined to microcavities
ATE423314T1 (de) 1998-06-24 2009-03-15 Illumina Inc Dekodierung von matrixartig-angeordneten sensoren durch mikropartikel
US6429027B1 (en) 1998-12-28 2002-08-06 Illumina, Inc. Composite arrays utilizing microspheres
US7510841B2 (en) 1998-12-28 2009-03-31 Illumina, Inc. Methods of making and using composite arrays for the detection of a plurality of target analytes
US6846460B1 (en) 1999-01-29 2005-01-25 Illumina, Inc. Apparatus and method for separation of liquid phases of different density and for fluorous phase organic syntheses
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US20030207295A1 (en) * 1999-04-20 2003-11-06 Kevin Gunderson Detection of nucleic acid reactions on bead arrays
US6355431B1 (en) 1999-04-20 2002-03-12 Illumina, Inc. Detection of nucleic acid amplification reactions using bead arrays
US6544732B1 (en) * 1999-05-20 2003-04-08 Illumina, Inc. Encoding and decoding of array sensors utilizing nanocrystals
CA2374390A1 (fr) * 1999-05-20 2000-12-14 Illumina, Inc. Decodage combinatoire de jeux d'acides nucleiques aleatoires
US8481268B2 (en) 1999-05-21 2013-07-09 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
US8080380B2 (en) * 1999-05-21 2011-12-20 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
AU775380B2 (en) 1999-08-18 2004-07-29 Illumina, Inc. Compositions and methods for preparing oligonucleotide solutions
AU2246601A (en) 1999-08-30 2001-04-10 Illumina, Inc. Methods for improving signal detection from an array
US7167615B1 (en) 1999-11-05 2007-01-23 Board Of Regents, The University Of Texas System Resonant waveguide-grating filters and sensors and methods for making and using same
US6458326B1 (en) 1999-11-24 2002-10-01 Home Diagnostics, Inc. Protective test strip platform
AU3806701A (en) 2000-02-07 2001-08-14 Illumina Inc Nucleic acid detection methods using universal priming
US7955794B2 (en) 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
US8076063B2 (en) * 2000-02-07 2011-12-13 Illumina, Inc. Multiplexed methylation detection methods
EP1259643B1 (fr) * 2000-02-07 2008-10-15 Illumina, Inc. Procedes de detection d'acide nucleique par amorcage universel
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US20050214825A1 (en) * 2000-02-07 2005-09-29 John Stuelpnagel Multiplex sample analysis on universal arrays
US7611869B2 (en) * 2000-02-07 2009-11-03 Illumina, Inc. Multiplexed methylation detection methods
US7361488B2 (en) * 2000-02-07 2008-04-22 Illumina, Inc. Nucleic acid detection methods using universal priming
US6913884B2 (en) * 2001-08-16 2005-07-05 Illumina, Inc. Compositions and methods for repetitive use of genomic DNA
US6770441B2 (en) * 2000-02-10 2004-08-03 Illumina, Inc. Array compositions and methods of making same
EP1257805B1 (fr) * 2000-02-10 2015-10-14 Illumina, Inc. Composant comprenant un substrat ayant une pluralité d'emplacements pour l'analyse simultanée de plusieurs échantillons a base de microspheres, dispositif comprenant le composant, et procédé de fabrication pour le composant
CA2400457A1 (fr) 2000-02-16 2001-08-23 Illumina, Inc. Genotypage parallele de plusieurs echantillons preleves sur des patients
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
AU2001272993B2 (en) * 2000-06-21 2005-03-10 Bioarray Solutions, Ltd. Multianalyte molecular analysis
AU2001288751A1 (en) * 2000-09-05 2002-03-22 Illumina, Inc. Cellular arrays comprising encoded cells
US7057704B2 (en) * 2000-09-17 2006-06-06 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
US20030045005A1 (en) * 2000-10-17 2003-03-06 Michael Seul Light-controlled electrokinetic assembly of particles near surfaces
US20040018491A1 (en) * 2000-10-26 2004-01-29 Kevin Gunderson Detection of nucleic acid reactions on bead arrays
AU2002256992B2 (en) * 2001-02-07 2007-06-07 Massachusetts Institute Of Technology Optoelectronic detection system
US7422860B2 (en) * 2001-02-07 2008-09-09 Massachusetts Institute Of Technology Optoelectronic detection system
US8216797B2 (en) * 2001-02-07 2012-07-10 Massachusetts Institute Of Technology Pathogen detection biosensor
US7157047B2 (en) * 2001-02-09 2007-01-02 Pss Bio Instruments, Inc. Device for containing, reacting and measuring, and method of containing, reacting and measuring
US6562625B2 (en) 2001-02-28 2003-05-13 Home Diagnostics, Inc. Distinguishing test types through spectral analysis
US6525330B2 (en) 2001-02-28 2003-02-25 Home Diagnostics, Inc. Method of strip insertion detection
US6541266B2 (en) 2001-02-28 2003-04-01 Home Diagnostics, Inc. Method for determining concentration of an analyte in a test strip
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
US7479630B2 (en) 2004-03-25 2009-01-20 Bandura Dmitry R Method and apparatus for flow cytometry linked with elemental analysis
US8148171B2 (en) 2001-10-09 2012-04-03 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
US20050164261A1 (en) * 2001-10-09 2005-07-28 Chandler Don J. Multiplexed analysis of clinical specimens apparatus and methods
WO2003034029A2 (fr) 2001-10-15 2003-04-24 Bioarray Solutions, Ltd. Analyse multiplexee de loci polymorphes par interrogation et detection a mediation enzymatique simultanees
US20030092008A1 (en) * 2001-11-14 2003-05-15 Bell Michael L. Method and apparatus for multiplex flow cytometry analysis of diverse mixed analytes from bodily fluid samples
US6838289B2 (en) * 2001-11-14 2005-01-04 Beckman Coulter, Inc. Analyte detection system
EP1448800A4 (fr) 2001-11-21 2007-05-16 Applera Corp Dosage biologique numerique
KR100989710B1 (ko) * 2002-01-17 2010-10-26 프레시죤 시스템 사이언스 가부시키가이샤 담체수용처리장치 및 담체수용처리방법
AU2003215240A1 (en) 2002-02-14 2003-09-04 Illumina, Inc. Automated information processing in randomly ordered arrays
US20050214734A1 (en) * 2002-04-01 2005-09-29 Seishi Kato Cell population provided with identification codes and method of screening cell population
US20040038318A1 (en) * 2002-08-23 2004-02-26 Bell Michael L. Creatine kinase isoenzyme determination in multiplexed assays
US7595883B1 (en) 2002-09-16 2009-09-29 The Board Of Trustees Of The Leland Stanford Junior University Biological analysis arrangement and approach therefor
US20040058333A1 (en) * 2002-09-23 2004-03-25 Bell Michael L. Assay products and procedures
WO2004047007A1 (fr) 2002-11-15 2004-06-03 Bioarray Solutions, Ltd. Analyse d'images de reseaux, acces securise a ces images et transmission de ces images
US7326573B2 (en) * 2003-01-10 2008-02-05 Beckman Coulter, Inc. Assay procedures and apparatus
WO2004065000A1 (fr) * 2003-01-21 2004-08-05 Illumina Inc. Moniteur de reactions chimiques
US6943768B2 (en) 2003-02-21 2005-09-13 Xtellus Inc. Thermal control system for liquid crystal cell
US7927796B2 (en) * 2003-09-18 2011-04-19 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
JP4564959B2 (ja) * 2003-09-22 2010-10-20 バイオアレイ ソリューションズ リミテッド 生体分子に共有結合できる、複数の官能基を持つ表面固定化高分子電解質
US7563569B2 (en) * 2003-10-28 2009-07-21 Michael Seul Optimization of gene expression analysis using immobilized capture probes
US20050089916A1 (en) * 2003-10-28 2005-04-28 Xiongwu Xia Allele assignment and probe selection in multiplexed assays of polymorphic targets
ES2533876T3 (es) 2003-10-29 2015-04-15 Bioarray Solutions Ltd Análisis multiplexado de ácidos nucleicos mediante fragmentación de ADN bicatenario
EP1702216B1 (fr) 2004-01-09 2015-11-04 Life Technologies Corporation Billes codees avec des particules de phosphore
US7363170B2 (en) * 2004-07-09 2008-04-22 Bio Array Solutions Ltd. Transfusion registry network providing real-time interaction between users and providers of genetically characterized blood products
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
CA2589195A1 (fr) * 2004-11-29 2006-06-01 Perkinelmer Las, Inc. Dosage multiplex a base de particules pour l'identification de la glycosylation
US20060246576A1 (en) * 2005-04-06 2006-11-02 Affymetrix, Inc. Fluidic system and method for processing biological microarrays in personal instrumentation
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
WO2007081410A2 (fr) 2005-09-13 2007-07-19 True Materials Incorporated Microparticules codées
US8178278B2 (en) * 2005-09-13 2012-05-15 Affymetrix, Inc. Miniaturized microparticles
EP1969372A4 (fr) * 2005-12-23 2009-04-22 Perkinelmer Las Inc Procédés et compositions permettant de détecter l'activité enzymatique
US7932037B2 (en) 2007-12-05 2011-04-26 Perkinelmer Health Sciences, Inc. DNA assays using amplicon probes on encoded particles
US20090104613A1 (en) * 2005-12-23 2009-04-23 Perkinelmer Las, Inc. Methods and compositions relating to multiplexed genomic gain and loss assays
JP6148428B2 (ja) * 2005-12-23 2017-06-14 パーキンエルマー エルエーエス, インコーポレイテッド コードされた多重粒子での比較ゲノムハイブリダイゼーション
US20100009373A1 (en) * 2005-12-23 2010-01-14 Perkinelmer Health Sciences, Inc. Methods and compositions relating to multiplex genomic gain and loss assays
EP1969337A4 (fr) * 2005-12-23 2010-01-27 Perkinelmer Las Inc Analyses multiplex effectuees au moyen de particules magnetiques et de particules non magnetiques
WO2007127988A2 (fr) * 2006-04-28 2007-11-08 Perkinelmer Las, Inc. Détection d'activité de phospho-transfert
US20080003667A1 (en) * 2006-05-19 2008-01-03 Affymetrix, Inc. Consumable elements for use with fluid processing and detection systems
US9465036B2 (en) 2006-11-02 2016-10-11 Fluidigm Canada Inc. Particles containing detectable elemental code
EP2092084B1 (fr) * 2006-11-13 2016-02-24 PerkinElmer LAS, Inc. Detection d'interactions moleculaires
US8288110B2 (en) * 2006-12-04 2012-10-16 Perkinelmer Health Sciences, Inc. Biomarkers for detecting cancer
DE102007010860B4 (de) * 2007-03-01 2014-05-15 PolyAn Gesellschaft zur Herstellung von Polymeren für spezielle Anwendungen und Analytik mbH Verfahren zur Identifikation eines Partikels mit zwei oder mehr monodispers eingebetteten Fluorophoren
US20080279874A1 (en) * 2007-05-07 2008-11-13 Wyeth Compositions and methods for modulation of plk1 kinase activity
EP2167687B1 (fr) 2007-06-08 2013-03-27 Biogen Idec MA Inc. Biomarqueurs pour prédire une réactivité ou non réactivité anti-tnf
EP2157599A1 (fr) * 2008-08-21 2010-02-24 Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO Procédé et appareil d'identification de matériaux biologiques
GB0913258D0 (en) 2009-07-29 2009-09-02 Dynex Technologies Inc Reagent dispenser
US9523701B2 (en) 2009-07-29 2016-12-20 Dynex Technologies, Inc. Sample plate systems and methods
WO2011028533A2 (fr) * 2009-08-24 2011-03-10 Perkinelmer Health Sciences, Inc. Procédés de détection de méthylation d'adn à l'aide de particules codées
CA2774116A1 (fr) 2009-09-25 2011-03-31 Signature Genomics Laboratories Llc Reseaux a brins multiplexes (+/-) et essais pour detecter des anomalies chromosomiques associees au cancer et autres maladies
WO2011100503A1 (fr) 2010-02-11 2011-08-18 Dana Farber Cancer Institute, Inc. Procédés pour prédire la probabilité de réponse à un traitement
US20120065092A1 (en) 2010-09-14 2012-03-15 Wai Hobert Fusion analyte cytometric bead assay, and systems and kits for performing the same
DE102010043276A1 (de) * 2010-11-03 2012-05-03 Siemens Aktiengesellschaft Magnetische Zelldetektion
WO2013041901A1 (fr) 2011-09-20 2013-03-28 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés de préparation de microréseau d'adn à anticorps à domaine unique
EP2791679A1 (fr) 2011-12-15 2014-10-22 INSERM - Institut National de la Santé et de la Recherche Médicale Méthodes et kits pour diagnostiquer l'infection tuberculeuse latente (ltbi)
WO2013152919A1 (fr) 2012-04-11 2013-10-17 Institut National De La Sante Et De La Recherche Medicale (Inserm) Détection de cd31 détaché dérivé de plaquettes
WO2013174988A1 (fr) 2012-05-24 2013-11-28 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés de prédiction et de surveillance d'une réponse de traitement chez des sujets atteints du vhc et du vhc/vih
US9218949B2 (en) 2013-06-04 2015-12-22 Fluidigm Canada, Inc. Strategic dynamic range control for time-of-flight mass spectrometry
EP2813850A1 (fr) 2013-06-10 2014-12-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés pour prédire une réponse de traitement de l'arthrite rhumatoïde
WO2016156576A1 (fr) 2015-04-02 2016-10-06 Hmnc Value Gmbh Méthode de traitement utilisant les prédicteurs génétiques d'une réponse à un traitement basé sur des antagonistes du crhr1
WO2016156575A2 (fr) 2015-04-02 2016-10-06 Hmnc Value Gmbh Prédicteurs génétiques d'une réponse à un traitement par des antagonistes de crhr1
US20190086392A1 (en) 2016-03-21 2019-03-21 Inserm (Institut National De La Sante Et De La Recherch Medicale) Methods for diagnosis and treatment of solar lentigo
WO2017167763A1 (fr) 2016-03-29 2017-10-05 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthodes de diagnostic de plaques d'athérothrombose hémorragiques
US10525462B2 (en) 2016-04-21 2020-01-07 Georgia Tech Research Corporation Methods, devices, and systems for sorting particles
WO2018007555A1 (fr) 2016-07-07 2018-01-11 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédé de diagnostic d'un cancer
US11439684B2 (en) 2017-02-21 2022-09-13 Mayo Foundation For Medical Education And Research Lymphocyte and monocyte populations in cancer patients and autologous stem cell preparations, and uses thereof
WO2018189335A1 (fr) 2017-04-13 2018-10-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés de diagnostic et de traitement d'un adénocarcinome canalaire pancréatique
WO2018189403A1 (fr) 2017-04-14 2018-10-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthodes et compositions pharmaceutiques destinées au traitement du cancer
WO2018202792A1 (fr) 2017-05-04 2018-11-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés de prédiction du syndrome de détresse respiratoire aiguë
WO2019046288A1 (fr) 2017-08-31 2019-03-07 Massachusetts Institute Of Technology Compositions et dosages multiplexes pour caractériser des protéases actives et leurs inhibiteurs
WO2019072888A1 (fr) 2017-10-11 2019-04-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthodes de prédiction de la réponse thérapeutique dans le cancer hépatocellulaire
WO2019081454A1 (fr) 2017-10-24 2019-05-02 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés et compositions permettant de prédire et traiter l'anévrisme intracrânien
WO2019106126A1 (fr) 2017-12-01 2019-06-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Modulateurs mdm2 pour le diagnostic et le traitement du liposarcome
WO2019121872A1 (fr) 2017-12-20 2019-06-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés de diagnostic et de traitement du cancer du foie
WO2019234196A1 (fr) 2018-06-06 2019-12-12 Fundació Institut D'investigació En Ciències De La Salut Germans Trias I Pujol Méthode in vitro de diagnostic ou de détection de mycobactéries non tuberculeuses
WO2019234221A1 (fr) 2018-06-08 2019-12-12 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés de stratification et de traitement d'un patient souffrant de leucémie lymphoïde chronique
US20210290633A1 (en) 2018-07-19 2021-09-23 INSERM (Insstitut National de la Santé et de la Recherche Médicale) Combination for treating cancer
EP3911669A1 (fr) 2019-01-16 2021-11-24 INSERM (Institut National de la Santé et de la Recherche Médicale) Variants d'érythroferrone et leur utilisation
WO2020201362A2 (fr) 2019-04-02 2020-10-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthodes de prédiction et de prévention du cancer chez des patients ayant des lésions prémalignes
WO2020249769A1 (fr) 2019-06-14 2020-12-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés et compositions pour le traitement de maladies oculaires associées à la maintenance d'adn mitochondrial
CA3157889A1 (fr) 2019-10-17 2021-04-22 Inserm (Institut National De La Sante Et De La Recherche Medicale) Procedes de diagnostic d'adenocarcinomes du type intestinal nasal
EP4061967A1 (fr) 2019-11-21 2022-09-28 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés et compositions pour le diagnostic et le traitement de la leucémie myélomonocytaire chronique (lmmc)
EP4110955A1 (fr) 2020-02-28 2023-01-04 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés de diagnostic, de pronostic et de gestion du traitement du cancer du sein
EP4004547B1 (fr) 2020-04-14 2023-10-11 (INSERM) Institut National de la Santé et de la Recherche Médicale Procédés de détection de la présence d'anticorps spécifiques de coronavirus chez un sujet
WO2022043415A1 (fr) 2020-08-27 2022-03-03 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthodes de détection de la présence d'auto-anticorps spécifiques à un pemphigus dans un échantillon

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1346301A (en) * 1965-06-04 1974-02-06 Adler Auto Precision Ltd Methods for mixing and or dispensing liquids and apparatus therefor
US3497690A (en) * 1967-09-21 1970-02-24 Bausch & Lomb Method and apparatus for classifying biological cells by measuring the size and fluorescent response thereof
US3657537A (en) * 1970-04-03 1972-04-18 Bausch & Lomb Computerized slit-scan cyto-fluorometer for automated cell recognition
US3684377A (en) * 1970-07-13 1972-08-15 Bio Physics Systems Inc Method for analysis of blood by optical analysis of living cells
US3864571A (en) * 1971-02-10 1975-02-04 Wheeler International Inc Method and Apparatus for Automatically, Identifying and Counting Various Cells in Body Fluids
BE793185A (fr) * 1971-12-23 1973-04-16 Atomic Energy Commission Appareil pour analyser et trier rapidement des particules telles que des cellules biologiques
US3826364A (en) * 1972-05-22 1974-07-30 Univ Leland Stanford Junior Particle sorting method and apparatus
US4146604A (en) * 1973-05-31 1979-03-27 Block Engineering, Inc. Differential counting of leukocytes and other cells
US3916205A (en) * 1973-05-31 1975-10-28 Block Engineering Differential counting of leukocytes and other cells
US3916197A (en) * 1973-11-28 1975-10-28 Particle Technology Inc Method and apparatus for classifying biological cells
DE2656654C3 (de) * 1976-12-14 1981-02-12 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaftense.V., 3400 Goettingen Vorrichtung zur Messung des Volumens und bestimmter optischer Eigenschaften von Partikeln
JPS5949221B2 (ja) * 1977-07-06 1984-12-01 花王株式会社 3−アシルアミノ−4−ホモイソツイスタンの製造法
US4284412A (en) * 1979-07-13 1981-08-18 Ortho Diagnostics, Inc. Method and apparatus for automated identification and enumeration of specified blood cell subclasses
JPS5745454A (en) * 1980-09-02 1982-03-15 Fuji Photo Film Co Ltd Immunochemical measuring method for various minor components

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JPS5960261A (ja) 1984-04-06
GB8322581D0 (en) 1983-09-28
DE3331017C2 (de) 1986-05-28
JPH0447265B2 (fr) 1992-08-03
FR2532431A1 (fr) 1984-03-02
GB2126341B (en) 1985-10-09
US4499052A (en) 1985-02-12
DE3331017A1 (de) 1984-03-08
GB2126341A (en) 1984-03-21

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