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FR2522325B1 - Nouveaux derives aryliques de la piperazine, de l'homopiperazine et de n,n'-dialkyl diamino-1,2 ethane, leur procede de preparation et leur application en therapeutique - Google Patents

Nouveaux derives aryliques de la piperazine, de l'homopiperazine et de n,n'-dialkyl diamino-1,2 ethane, leur procede de preparation et leur application en therapeutique

Info

Publication number
FR2522325B1
FR2522325B1 FR8203256A FR8203256A FR2522325B1 FR 2522325 B1 FR2522325 B1 FR 2522325B1 FR 8203256 A FR8203256 A FR 8203256A FR 8203256 A FR8203256 A FR 8203256A FR 2522325 B1 FR2522325 B1 FR 2522325B1
Authority
FR
France
Prior art keywords
arylic
homopiperazine
piperazine
ethane
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8203256A
Other languages
English (en)
Other versions
FR2522325A1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Delalande SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delalande SA filed Critical Delalande SA
Priority to FR8203256A priority Critical patent/FR2522325B1/fr
Priority to CH884/83A priority patent/CH657615A5/fr
Priority to CA000422056A priority patent/CA1246076A/fr
Priority to ZA831134A priority patent/ZA831134B/xx
Priority to GR70565A priority patent/GR77936B/el
Priority to GB08304846A priority patent/GB2116967B/en
Priority to SE8300987A priority patent/SE460788B/sv
Priority to DE19833306302 priority patent/DE3306302A1/de
Priority to BE0/210198A priority patent/BE896009A/fr
Priority to LU84658A priority patent/LU84658A1/fr
Priority to ES520089A priority patent/ES8403881A1/es
Priority to NL8300720A priority patent/NL8300720A/nl
Priority to AU11889/83A priority patent/AU1188983A/en
Priority to US06/469,968 priority patent/US4639452A/en
Priority to IT19764/83A priority patent/IT1193684B/it
Priority to JP58031708A priority patent/JPS58159484A/ja
Publication of FR2522325A1 publication Critical patent/FR2522325A1/fr
Priority to ES529265A priority patent/ES529265A0/es
Priority to GB08517123A priority patent/GB2163153B/en
Priority to GB08517122A priority patent/GB2163152B/en
Priority to GB08517121A priority patent/GB2163151B/en
Application granted granted Critical
Publication of FR2522325B1 publication Critical patent/FR2522325B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FR8203256A 1982-02-26 1982-02-26 Nouveaux derives aryliques de la piperazine, de l'homopiperazine et de n,n'-dialkyl diamino-1,2 ethane, leur procede de preparation et leur application en therapeutique Expired FR2522325B1 (fr)

Priority Applications (20)

Application Number Priority Date Filing Date Title
FR8203256A FR2522325B1 (fr) 1982-02-26 1982-02-26 Nouveaux derives aryliques de la piperazine, de l'homopiperazine et de n,n'-dialkyl diamino-1,2 ethane, leur procede de preparation et leur application en therapeutique
CH884/83A CH657615A5 (fr) 1982-02-26 1983-02-17 Derives aryliques de la piperazine, leur procede de preparation.
CA000422056A CA1246076A (fr) 1982-02-26 1983-02-21 Derives aryliques de piperazine, leur preparation, et leur emploi a des fins therapeutiques
ZA831134A ZA831134B (en) 1982-02-26 1983-02-21 New derivatives of piperazine,the method of preparing same and their application in therapeutics
GR70565A GR77936B (fr) 1982-02-26 1983-02-22
GB08304846A GB2116967B (en) 1982-02-26 1983-02-22 Piperazine derivatives
SE8300987A SE460788B (sv) 1982-02-26 1983-02-23 Piperazinderivat, foerfarande foer framstaellning av dessa och farmaceutisk komposition med stimulerande, skyddande och/eller korrigerande verkan paa hjaernfunktionerna
DE19833306302 DE3306302A1 (de) 1982-02-26 1983-02-23 Piperazinarylderivate, verfahren zu deren herstellung und deren therapeutische anwendung
LU84658A LU84658A1 (fr) 1982-02-26 1983-02-24 Nouveaux derives aryliques de la piperazine,leur procede de preparation et leur application en therapeutique
BE0/210198A BE896009A (fr) 1982-02-26 1983-02-24 Nouveaux derives aryliques de la piperazine, leur procede de preparation et leur application en therapeutique
ES520089A ES8403881A1 (es) 1982-02-26 1983-02-25 Procedimiento para la fabricacion de nuevos derivados arilicos de la piperacina.
NL8300720A NL8300720A (nl) 1982-02-26 1983-02-25 Nieuwe arylpiperazineverbindingen, werkwijze voor hun bereiding en hun toepassing als geneesmiddel.
AU11889/83A AU1188983A (en) 1982-02-26 1983-02-25 Acyl piperazines
US06/469,968 US4639452A (en) 1982-02-26 1983-02-25 Arylic derivatives of piperazine, the method of preparing same and their application in therapeutics
IT19764/83A IT1193684B (it) 1982-02-26 1983-02-25 Derivati arilici della piperazina,loro procedimento di preparazione e loro applicazione in terapia
JP58031708A JPS58159484A (ja) 1982-02-26 1983-02-26 新規なピペラジン誘導体およびその製造方法
ES529265A ES529265A0 (es) 1982-02-26 1984-01-30 Procedimiento para la fabricacion de derivados de la piperacina
GB08517123A GB2163153B (en) 1982-02-26 1985-07-05 New arylic derivatives of piperazine, the method of preparing same and their application in therapeutics
GB08517122A GB2163152B (en) 1982-02-26 1985-07-05 New arylic derivatives of piperazine, the method of preparing same and their application in therapeutics
GB08517121A GB2163151B (en) 1982-02-26 1985-07-05 New arylic derivatives of piperazine, the method of preparing same and their application in therapeutics

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8203256A FR2522325B1 (fr) 1982-02-26 1982-02-26 Nouveaux derives aryliques de la piperazine, de l'homopiperazine et de n,n'-dialkyl diamino-1,2 ethane, leur procede de preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
FR2522325A1 FR2522325A1 (fr) 1983-09-02
FR2522325B1 true FR2522325B1 (fr) 1985-08-09

Family

ID=9271396

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8203256A Expired FR2522325B1 (fr) 1982-02-26 1982-02-26 Nouveaux derives aryliques de la piperazine, de l'homopiperazine et de n,n'-dialkyl diamino-1,2 ethane, leur procede de preparation et leur application en therapeutique

Country Status (16)

Country Link
US (1) US4639452A (fr)
JP (1) JPS58159484A (fr)
AU (1) AU1188983A (fr)
BE (1) BE896009A (fr)
CA (1) CA1246076A (fr)
CH (1) CH657615A5 (fr)
DE (1) DE3306302A1 (fr)
ES (2) ES8403881A1 (fr)
FR (1) FR2522325B1 (fr)
GB (4) GB2116967B (fr)
GR (1) GR77936B (fr)
IT (1) IT1193684B (fr)
LU (1) LU84658A1 (fr)
NL (1) NL8300720A (fr)
SE (1) SE460788B (fr)
ZA (1) ZA831134B (fr)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2552762B1 (fr) * 1983-09-30 1986-07-25 Delalande Sa Nouveaux amides piperaziniques et homopiperaziniques derives de l'acide 3,4-dioxymethylene cinnamique, leur procede de preparation et leur application en therapeutique
SE8500573D0 (sv) * 1985-02-08 1985-02-08 Ferrosan Ab Novel piperazinecarboxamides having a phenoxyalkyl or thiophenoxyalkyl side chain
GB8530602D0 (en) * 1985-12-12 1986-01-22 Fujisawa Pharmaceutical Co Heterocyclic compounds
EP0240233B1 (fr) * 1986-03-29 1991-01-23 Suntory Limited Dérivés d'amide d'acide benzoquinonylphényl alcanoique
MY102447A (en) * 1986-06-16 1992-06-30 Ciba Geigy Ag Disubtituted piperazines
US5232923A (en) * 1988-03-18 1993-08-03 Mitsui Toatsu Chemicals, Incorporated Catechol derivatives and pharmaceutical preparations containing same
DE4102024A1 (de) * 1991-01-24 1992-07-30 Thomae Gmbh Dr K Biphenylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US6677343B2 (en) * 2000-02-22 2004-01-13 Cv Therapeutics, Inc. Substituted piperazine compounds
JPWO2004046110A1 (ja) * 2002-11-15 2006-03-16 アステラス製薬株式会社 メラニン凝集ホルモン受容体拮抗剤
BRPI0408136A (pt) * 2003-03-07 2006-03-01 Astellas Pharma Inc derivados heterocìclicos contendo nitrogênio tendo estirila 2,6-dissubstituìda
AU2005278469A1 (en) * 2004-09-01 2006-03-09 Astellas Pharma Inc. Piperidine derivative or pharmaceutically acceptable salt thereof
WO2009010429A2 (fr) 2007-07-19 2009-01-22 F. Hoffmann-La Roche Ag Nouveaux composés hétérocyclyles
CN101591310B (zh) * 2008-12-19 2012-03-21 王绍杰 一种马来酸桂哌齐特的制备方法
US8673920B2 (en) 2009-05-06 2014-03-18 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
CN101906085B (zh) * 2009-06-04 2013-12-11 天津药物研究院 治疗心脑血管疾病的化合物、组合物、制备方法及用途
CN101921247B (zh) * 2009-06-12 2016-04-20 福州璐珈医药科技有限公司 1-(肉桂酰基)-4-哌啶基酰胺哌嗪化合物及其制备方法
EP2632465B1 (fr) 2010-10-27 2015-12-30 Merck Sharp & Dohme Corp. Inhibiteurs du canal potassique de la médullaire externe rénale
WO2012058134A1 (fr) 2010-10-29 2012-05-03 Merck Sharp & Dohme Corp. Inhibiteurs du canal à potassium de la medulla externe du rein
US9062070B2 (en) 2011-08-19 2015-06-23 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
US9527830B2 (en) 2011-09-16 2016-12-27 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
US8999990B2 (en) 2011-10-25 2015-04-07 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
EP2771004B1 (fr) 2011-10-25 2016-05-18 Merck Sharp & Dohme Corp. Inhibiteurs du canal potassique médullaire externe rénal
US9139585B2 (en) 2011-10-31 2015-09-22 Merck Sharp & Dohme Corp. Inhibitors of the Renal Outer Medullary Potassium channel
EP2773351B1 (fr) 2011-10-31 2017-08-23 Merck Sharp & Dohme Corp. Inhibiteurs du canal potassique médullaire externe rénal
EP2773206B1 (fr) 2011-10-31 2018-02-21 Merck Sharp & Dohme Corp. Inhibiteurs du canal potassique médullaire externe rénal
EP2790511B1 (fr) 2011-12-16 2016-09-14 Merck Sharp & Dohme Corp. Inhibiteurs du canal à potassium de la medulla externe du rein
AR092031A1 (es) 2012-07-26 2015-03-18 Merck Sharp & Dohme Inhibidores del canal de potasio medular externo renal
WO2014085210A1 (fr) 2012-11-29 2014-06-05 Merck Sharp & Dohme Corp. Inhibiteurs du canal potassique médullaire extérieur rénal
EP2934533B1 (fr) 2012-12-19 2017-11-15 Merck Sharp & Dohme Corp. Inhibiteurs du canal potassique médullaire externe rénal
US9604998B2 (en) 2013-02-18 2017-03-28 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
WO2014150132A1 (fr) 2013-03-15 2014-09-25 Merck Sharp & Dohme Corp. Inhibiteurs du canal potassique médullaire extérieur rénal
US9751881B2 (en) 2013-07-31 2017-09-05 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
WO2016127358A1 (fr) 2015-02-12 2016-08-18 Merck Sharp & Dohme Corp. Inhibiteurs du canal potassique médullaire externe rénal

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1139934A (en) * 1966-08-18 1969-01-15 Delalande Sa Cinnamylpiperazine preparations
GB1168108A (en) * 1967-09-29 1969-10-22 Delalande Sa Amide Derivatives of 1-Piperazine Acetic Acid and Process for their Preparation
GB1218591A (en) * 1968-04-03 1971-01-06 Delalande Sa Derivatives of n-(3,4,5-trimethoxy cennamoyl) piperazine and their process of preparation
FR2068407A6 (fr) * 1969-10-17 1971-08-27 Delalande Sa
US3753984A (en) * 1971-05-26 1973-08-21 Delalande Sa Amides derived from the esters of 1-piperazine propionic acid, their method of preparation and their application to therapeutics
FR2262521A1 (en) * 1973-08-08 1975-09-26 Delalande Sa 3-(3,4,5-Trimethoxyphenyl)piperazines - with coronary vasodilator, hypotensive, antiinflammatory, analgesic, and antiulcer activity
FR2244518A1 (en) * 1973-08-10 1975-04-18 Delalande Sa N-sinapyl-N'-alkoxyalkyl or-aminocarbonylmethyl-piperazines - as vasodilators, diuretics, antihypertensive and antiulcer agents
FR2240734A1 (en) * 1973-08-13 1975-03-14 Delalande Sa N-(dihydro sinapyl) piperazine derivs - having antiulcer, hypertensive and diuretic props
BE833291A (fr) * 1974-09-12 1976-03-11 Nouveaux derives cycloaklyles de 1-aryloxy-3-amino-2-propanols, leurs procedes de preparation, et leurs utilisations therapeutiques
GB1473262A (en) * 1974-11-20 1977-05-11 Delalande Sa Derivatives of n-3,4,5-trimethoxy cinnamoyl-piperazine their process of preparation and their therapeutic application
JPS5210284A (en) * 1975-07-11 1977-01-26 Tanabe Seiyaku Co Ltd Process for preparing piperazine derivatives
US4166116A (en) * 1977-11-11 1979-08-28 Canadian Patents And Development Limited Pharmaceutical compositions containing piperazinyl acylhydroxamic acid derivatives to treat inflammation or anaphylactic allergy conditions
JPS5732255A (en) * 1980-08-05 1982-02-20 Kowa Co Trimethoxyphenyl derivative

Also Published As

Publication number Publication date
GB2163153A (en) 1986-02-19
ES8500254A1 (es) 1984-10-01
CH657615A5 (fr) 1986-09-15
JPS58159484A (ja) 1983-09-21
SE460788B (sv) 1989-11-20
DE3306302A1 (de) 1983-09-08
JPH0518830B2 (fr) 1993-03-15
GB8517122D0 (en) 1985-08-14
IT1193684B (it) 1988-07-21
GB8304846D0 (en) 1983-03-23
BE896009A (fr) 1983-08-24
ES529265A0 (es) 1984-10-01
GR77936B (fr) 1984-09-25
SE8300987D0 (sv) 1983-02-23
GB2116967B (en) 1986-07-16
DE3306302C2 (fr) 1992-04-02
GB8517121D0 (en) 1985-08-14
GB2163151A (en) 1986-02-19
ES520089A0 (es) 1984-04-16
AU1188983A (en) 1983-09-01
GB2163151B (en) 1986-07-23
GB8517123D0 (en) 1985-08-14
FR2522325A1 (fr) 1983-09-02
GB2116967A (en) 1983-10-05
ES8403881A1 (es) 1984-04-16
CA1246076A (fr) 1988-12-06
NL8300720A (nl) 1983-09-16
GB2163152B (en) 1986-07-23
GB2163153B (en) 1986-07-16
US4639452A (en) 1987-01-27
LU84658A1 (fr) 1984-11-08
ZA831134B (en) 1983-11-30
SE8300987L (sv) 1983-08-27
IT8319764A0 (it) 1983-02-25
GB2163152A (en) 1986-02-19

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