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FR2560878B1 - Derives de la 1-fluorophenybutyl-4-(2-pyrimidinyl) piperazine et leur application en tant qu'antipsychotiques - Google Patents

Derives de la 1-fluorophenybutyl-4-(2-pyrimidinyl) piperazine et leur application en tant qu'antipsychotiques

Info

Publication number
FR2560878B1
FR2560878B1 FR8503220A FR8503220A FR2560878B1 FR 2560878 B1 FR2560878 B1 FR 2560878B1 FR 8503220 A FR8503220 A FR 8503220A FR 8503220 A FR8503220 A FR 8503220A FR 2560878 B1 FR2560878 B1 FR 2560878B1
Authority
FR
France
Prior art keywords
fluorophenybutyl
antipsychotics
pyrimidinyl
application
piperazine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8503220A
Other languages
English (en)
Other versions
FR2560878A1 (fr
Inventor
Joseph P Yevich
Walter G Lobeck Jr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of FR2560878A1 publication Critical patent/FR2560878A1/fr
Application granted granted Critical
Publication of FR2560878B1 publication Critical patent/FR2560878B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/12—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Legs For Furniture In General (AREA)
  • Plural Heterocyclic Compounds (AREA)
FR8503220A 1984-03-06 1985-03-05 Derives de la 1-fluorophenybutyl-4-(2-pyrimidinyl) piperazine et leur application en tant qu'antipsychotiques Expired FR2560878B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58658084A 1984-03-06 1984-03-06
US06/683,309 US4605655A (en) 1984-03-06 1984-12-18 Antipsychotic 1-fluorophenylbutyl-4-(2-pyrimidinyl)piperazine derivatives

Publications (2)

Publication Number Publication Date
FR2560878A1 FR2560878A1 (fr) 1985-09-13
FR2560878B1 true FR2560878B1 (fr) 1988-10-14

Family

ID=27079753

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8503220A Expired FR2560878B1 (fr) 1984-03-06 1985-03-05 Derives de la 1-fluorophenybutyl-4-(2-pyrimidinyl) piperazine et leur application en tant qu'antipsychotiques

Country Status (27)

Country Link
US (1) US4605655A (fr)
KR (3) KR920005113B1 (fr)
AT (1) AT390951B (fr)
AU (1) AU576555B2 (fr)
BE (1) BE901880A (fr)
CA (1) CA1256871A (fr)
CH (1) CH663022A5 (fr)
CY (1) CY1545A (fr)
DE (1) DE3507983A1 (fr)
DK (1) DK166149C (fr)
ES (1) ES8607254A1 (fr)
FI (1) FI84478C (fr)
FR (1) FR2560878B1 (fr)
GB (1) GB2155925B (fr)
GR (1) GR850561B (fr)
HK (1) HK82890A (fr)
HU (1) HU193949B (fr)
IE (1) IE58338B1 (fr)
IT (1) IT1183483B (fr)
LU (1) LU85796A1 (fr)
MX (1) MX9203177A (fr)
MY (1) MY102240A (fr)
NL (1) NL8500628A (fr)
PT (1) PT80058B (fr)
SE (1) SE462429B (fr)
SG (1) SG35590G (fr)
ZA (1) ZA851486B (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4668687A (en) * 1984-07-23 1987-05-26 Bristol-Myers Company Psychogeriatric 1-(2-pyrimidinyl)piperazinyl derivatives of 1-pyrrolidin-2-ones
US4677104A (en) * 1985-05-06 1987-06-30 Bristol-Myers Company Antipsychotic fused-ring pyridinylpiperazine derivatives
US4766215A (en) * 1987-02-27 1988-08-23 American Home Products Corporation Histamine H1 -receptor antagonists
SE8701375D0 (sv) * 1987-04-02 1987-04-02 Leo Ab Novel pyridyl- and pyrimidyl derivatives
US4826844A (en) * 1987-09-30 1989-05-02 American Home Products Corporation Substituted 1-(aralkyl-piperazinoalkyl) cycloalkanols
HU206109B (en) * 1987-10-26 1992-08-28 Pfizer Process for producing heterocyclic carbonylpropyl pyrimidinyl piperazine derivatives and pharmaceutical compositions comprising same
US4882432A (en) * 1989-01-09 1989-11-21 American Home Products Corporation Polycyclic-carbamic acid piperazinoalkyl esters and amides
GB8909209D0 (en) * 1989-04-22 1989-06-07 Wyeth John & Brother Ltd Piperazine derivatives
FI93832C (fi) * 1989-04-22 1995-06-12 Wyeth John & Brother Ltd Menetelmä terapeuttisesti aktiivisten piperatsiniijohdannaisten valmistamiseksi
US4994460A (en) * 1989-06-01 1991-02-19 Bristol-Myers Squibb Co. Agents for treatment of brain ischemia
US5055470A (en) * 1989-06-01 1991-10-08 Bristol-Myers Squibb Co. Method of treatment of ischemia in brain
FR2672052B1 (fr) * 1991-01-28 1995-05-24 Esteve Labor Dr Derives d'aryl (ou heteroaryl)-piperazinyl-alkyl-azoles, leur preparation et leur application en tant que medicaments.
US5633377A (en) 1990-12-28 1997-05-27 Neurogen Corporation 4-piperidino- and piperazinomethyl-2-cyclohexyl imidazole derivatives; dopamine receptor subtype specific ligands
US5681956A (en) * 1990-12-28 1997-10-28 Neurogen Corporation 4-aryl substituted piperazinylmethyl phenylimidazole derivatives; a new class of dopamine receptor subtype specific ligands
US5512584A (en) * 1991-04-16 1996-04-30 Basf Aktiengesellschaft 1,3,4-trisubstituted piperidine derivatives, the preparation and use thereof
EP0538693A3 (en) * 1991-10-23 1994-08-17 Squibb & Sons Inc Stereoselective preparation of halophenyl alcohols
CA2081062A1 (fr) * 1991-10-24 1993-04-25 Frank D. Yocca Traitement de l'anxiete chez les patients en sevrage des benzodiazepines
SE9201239D0 (sv) * 1992-04-21 1992-04-21 Kabi Pharmacia Ab Agents for treating substance abuse disorders
US5324662A (en) * 1992-05-15 1994-06-28 E. R. Squibb & Sons, Inc. Stereoselective microbial or enzymatic reduction of 3,5-dioxo esters to 3-hydroxy-5-oxo, 3-oxo-5-hydroxy, and 3,5-dihydroxy esters
DE4219973A1 (de) * 1992-06-19 1993-12-23 Basf Ag N-substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung
DE4243287A1 (de) * 1992-06-19 1993-12-23 Basf Ag N-Substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung
ES2074946B1 (es) * 1993-07-19 1996-06-16 Ferrer Int Nuevos compuestos derivados de la 1,2-etanodiamina-n,n,n',n'-tetrasustituida.
DE4341403A1 (de) * 1993-12-04 1995-06-08 Basf Ag N-substituierte 3-Azabicycloalkan-Derivate, ihre Herstellung und Verwendung
US5650406A (en) * 1994-04-18 1997-07-22 Asahi Kasei Kogyo Kabushiki Kaisha Adamantane derivative, process for producing the same, and use thereof
US5607936A (en) * 1994-09-30 1997-03-04 Merck & Co., Inc. Substituted aryl piperazines as neurokinin antagonists
ES2104509B1 (es) * 1995-06-13 1998-07-01 Ferrer Int Nuevos compuestos derivados de 2-(3,4-disustituido-1-piperazinil)-5-fluoropirimidina.
US6166205A (en) * 1998-09-02 2000-12-26 Neurogen Corporation 2-Aryl-4-(1-[4-heteroaryl]piperazin-1-yl)methylimidazoles: dopamine . D.sub4 receptor subtype ligands
JP5387917B2 (ja) * 2007-05-14 2014-01-15 エスケー バイオファーマスティカルズ カンパニー リミテッド 新規なカルバモイルオキシアリールアルカノイルアリールピペラジン化合物、該化合物を含む薬剤組成物及び該化合物の投与による疼痛、不安神経症及びうつ病を治療する方法
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
US20230190870A1 (en) 2020-05-20 2023-06-22 The Board Of Trustees Of The University Of Illinois Method for Treating Lysosomal Storage Diseases with Histatin Peptides

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2985657A (en) * 1959-10-12 1961-05-23 Paul A J Janssen 1-(aroylalkyl)-4-heterocyclylpiperazines
US2973360A (en) * 1959-10-12 1961-02-28 Paul A J Janssen Certain 1-(2-theonyl lower alkyl)-4-(heterocyclic substituted)-piperazines
US2979508A (en) * 1959-10-12 1961-04-11 Paul A J Janssen Heterocyclic derivatives of 1-phenyl-omega-(piperazine) alkanols
NL127996C (fr) * 1963-11-19
GB1259685A (en) * 1969-04-03 1972-01-12 Soc D Etudes Prod Chimique Amino-pyrimidine derivatives
BE758380A (fr) * 1969-11-04 1971-04-16 Sumitomo Chemical Co Procede de preparation de derives d'aryl-cetones
GB1307256A (en) * 1970-09-15 1973-02-14 Science Union & Cie Piperazine derivatives and a process for their preparation
BE882836A (fr) * 1979-05-15 1980-08-18 Soc D Etudes Prod Chimique Nouveaux derives halogenes de l'isopropylamino pyrimidine, leur preparation et leur utilisaton therapeutique
US4316899A (en) * 1979-08-24 1982-02-23 Beecham Group Limited Chromanone derivatives, a process for their preparation and compositions containing them
DE3321969A1 (de) * 1983-06-18 1984-12-20 Troponwerke GmbH & Co KG, 5000 Köln 2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel

Also Published As

Publication number Publication date
CA1256871A (fr) 1989-07-04
SE8501067D0 (sv) 1985-03-05
FI84478C (fi) 1991-12-10
AU3944985A (en) 1985-09-12
HUT37781A (en) 1986-02-28
DE3507983A1 (de) 1985-09-12
DK166149B (da) 1993-03-15
FI850850A0 (fi) 1985-03-01
AU576555B2 (en) 1988-09-01
ATA64985A (de) 1990-01-15
IE850546L (en) 1985-09-06
DK100685A (da) 1985-09-07
US4605655A (en) 1986-08-12
FR2560878A1 (fr) 1985-09-13
PT80058B (pt) 1987-10-20
SE8501067L (sv) 1985-09-07
ZA851486B (en) 1985-11-27
LU85796A1 (fr) 1985-12-12
HK82890A (en) 1990-10-19
PT80058A (en) 1985-04-01
GB2155925A (en) 1985-10-02
AT390951B (de) 1990-07-25
KR920005694B1 (ko) 1992-07-13
GB8505662D0 (en) 1985-04-03
IT1183483B (it) 1987-10-22
HU193949B (en) 1987-12-28
CY1545A (en) 1991-03-22
ES540901A0 (es) 1986-05-16
SG35590G (en) 1990-07-13
IT8519773A0 (it) 1985-03-05
KR920005114B1 (ko) 1992-06-26
DK166149C (da) 1993-08-09
KR920005113B1 (ko) 1992-06-26
GB2155925B (en) 1987-11-25
SE462429B (sv) 1990-06-25
BE901880A (fr) 1985-09-05
GR850561B (fr) 1985-07-03
ES8607254A1 (es) 1986-05-16
FI850850L (fi) 1985-09-07
MX9203177A (es) 1992-07-01
MY102240A (en) 1992-05-15
NL8500628A (nl) 1985-10-01
KR850006402A (ko) 1985-10-05
FI84478B (fi) 1991-08-30
DK100685D0 (da) 1985-03-05
CH663022A5 (de) 1987-11-13
IE58338B1 (en) 1993-09-08

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